TumCMig Cancer Research Results

TumCMig, Tumor cell migration: Click to Expand ⟱
Source:
Type:
Tumor cell migration is a critical process in cancer progression and metastasis, which is the spread of cancer cells from the primary tumor to distant sites in the body.
Scientific Papers found: Click to Expand⟱
962- TQ,    Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
- in-vitro, PC, PANC1 - in-vitro, Nor, hTERT-HPNE - in-vitro, PC, AsPC-1 - in-vitro, PC, Bxpc-3
TumCMig↓,
TumCI↓,
Apoptosis↑, no significant effects on hTERT-HPNE cells (normal cells) ****
Hif1a↓, TQ significantly reduced the mRNA and protein expression levels of HIF-1α in PANC-1, AsPC-1, and BxPC-3 cells.
PI3k/Akt/mTOR↓,
TumCCA↑, possible mechanism of TQ's influence on PC cell cycle was that TQ inhibited the proliferation of cancer cells (reducing the proportion of S phase) and damaged the DNA of cancer cells (increasing the proportion of G2/M phase). No effect on normal cell
*toxicity↓, TQ had no significant effect on the viability of hTERT-HPNE cells
*TumCI∅, no significant difference in the invasion ability of the hTERT-HPNE cells
*TumCMig∅, no significant effect on the migration and invasion of normal pancreatic ductal epithelial cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Migration ⓘ

TumCI∅, 1,   TumCMig∅, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: TumCMig, Tumor cell migration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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