TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
Type:
Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
2499- FBZ,  VitE,    Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells
- in-vitro, Pca, PC3
TumCP∅, After testing E8 cell line singly with FBZ then VES, we determined that neither FBZ at 22.5 ng/ml nor VES at 25 μg/ml had any significant inhibitory effect on proliferation, at least during the four days of exposure
TumCP↓, However, when we used a lower concentration of FBZ (14 ng/ml) together with VES (25 μg/ml), beginning at the third day, a synergistic inhibitory effect on proliferation was observed that became robust in the subsequent days
toxicity↓, FBZ, VES, or a VES+FBZ combination administered in the feed for 206 days at which point they were humanely euthanized ... no abnormalities were observed
eff↑, In summary, combination therapy with VES and FBZ deserves further investigation as a possible treatment modality for prostate cancer

6963- Form,    Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
eff↝, Its pharmacological effects in vivo may be either estrogenic or anti-estrogenic, mainly depending upon the estrogen levels.
TumCP↓, formononetin inhibited the proliferation of ER-positive MCF-7 cells and T47D cells.
TumCP∅, In contrast, formononetin could not inhibit the cell of growth of ER-negative breast cancer cells such as MDA-MB-435 S cells.
MAPK↑, formononetin activated MAPK signaling pathway in a dose-dependent manner, which resulted in the increased ratio of Bax/Bcl-2, and induced apoptosis on MCF-7 cells.
Bax:Bcl2↑,
Apoptosis↑,

7847- ISQ,    Research on the bioactivity of isoquercetin extracted from marestail on bladder cancer EJ cell and the mechanism of its occurrence
- in-vitro, Bladder, NA
TumCP∅, All of these suggested that isoquercetin could not inhibit the proliferation of bladder cancer EJ cells.
NA∅, isoquercetin did not inhibit the STAT3 signal pathway of bladder cancer EJ cells, which may be one of the reasons that cause the tolerance of EJ cells to isoquercetin

528- MF,  Caff,    Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells
- in-vitro, GBM, U373MG
Ca+2↑, After exposure to electromagnetic fields the basal [Ca(2+)](i) levels increased significantly from 143 +/- 46 nM to 278 +/- 125 nM
TumCP∅, Moreover the electromagnetic fields that affected [Ca(2+)](i) did not cause cell proliferation or cell death and the proliferation indexes remained unchanged after exposure.
TumCD∅,
eff↑, However, the [Ca 2+]i levels in normal and caffeine-treated cells were signicantly higher after EMF exposure than in sham exposed cells exposed cells

1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑,
TumCP∅, SMP showed no effect on the proliferation of the tumor cells
IL4↑,
IL6↑,
IFN-γ↑,
TLR4↑,
TLR1↑,
TLR2↑,
p‑JNK↑,
p‑ERK↑,
IKKα↑,


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA∅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   p‑JNK↑, 1,   MAPK↑, 1,   TumCD∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   TumCP↓, 2,   TumCP∅, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1,   IKKα↑, 1,   IL4↑, 1,   IL6↑, 1,   T-Cell↑, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
1 Fenbendazole
1 Vitamin E
1 Formononetin
1 isoquercitrin
1 Magnetic Fields
1 Caffeine
1 Salvia miltiorrhiza
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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