PGM1 Cancer Research Results

PGM1, Phosphoglucomutase 1: Click to Expand ⟱

Source:

Type:

Phosphoglucomutase 1 (PGM1) is an enzyme that plays a crucial role in glycogen metabolism. Recent studies have shown that PGM1 is overexpressed in various types of cancer, and its expression is associated with cancer progression and prognosis.

Scientific Papers found: Click to Expand⟱

1226-

OLST,

Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation

vitro+vivo,

GC,

PGM1∅, Correlation and enrichment analyses suggested that PGM1 was closely associated with cell viability, proliferation and metabolism. PGM1 was overexpressed in GC tissues and cell lines. High PGM1 expression served as an indicator of shorter survival
FASN↓, Orlistat, as a drug that was designed to inhibit FASN activity
Apoptosis↑,
lipidLev↑,
GlucoseCon↑, However, orlistat conversely increased glycolytic levels.
eff↑, Orlistat exhibited more significant inhibitive effects on GC progression after knockdown of PGM1 under glucose deprivation

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

FASN↓, 1, GlucoseCon↑, 1, lipidLev↑, 1, PGM1∅, 1,

Cell Death ⓘ

Apoptosis↑, 1,

Drug Metabolism & Resistance ⓘ

eff↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PGM1, Phosphoglucomutase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells