ALAT Cancer Research Results

ALAT, ALT, alanine aminotransferase: Click to Expand ⟱
Source:
Type: enzyme
(or ALT) -Used to be called serum glutamic-pyruvic transaminase (SGPT)
Most common in the liver.
An enzyme your body needs to break down proteins into energy.
It plays a crucial role in amino acid metabolism and is often measured in blood tests to assess liver function.
The catabolism of alanine by alanine aminotransferase 2 (ALT2) to pyruvate, was critical for the survival of non-small cell lung carcinoma (NSCLC) cells during glucose starvation. After knockdown of ALT2, cells were significantly more sensitive to glucose withdrawal compared to wildtype cells, which were rescued when supplemented with pyruvate.
Alanine aminotransferase (ALT) expression is highly elevated in the serum of patients with hepatocellular carcinoma.
A common example of dietary cancer therapy is the ketogenic diet, providing a fat-rich, low carbohydrate diet. The rationale is to reduce circulating glucose levels and induce ketosis.
Used as a clinical biomarker for Liver function.


Scientific Papers found: Click to Expand⟱
6646- Cen,    Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke
- Trial, Stroke, NA
*eff↑, indicating that gotu kola is as effective as folic acid in improving poststroke VCI.
*memory↑, Gotu kola was shown to be more effective than folic acid in improving memory domain.
*cognitive↑, This study suggested that gotu kola extract is effective in improving cognitive function after stroke.
*AST∅, The analysis showed no significant difference between AST and ALT levels before and after treatment with p value of all groups
*ALAT∅,
*AChE↓, The aqueous extract of the entire gotu kola plant has been revealed to show improvement in learning and memory, inhibition of AChE activity,
*toxicity↓, Gotu kola extract either in 750 mg or in 1000 mg was well tolerated with minimal side effects.

6194- Cuc,    Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats
- in-vivo, Nor, NA
*BioAv↓, absolute oral bioavailability of cucurbitacin B was approximately 10%.
*Half-Life↝, maximum concentration in plasma after normalization by dose ranged from 4.85–7.81 μg/L and the time to reach maximum value was approximately within 30 min after oral dosing.
*AST∅, The results demonstrated that after treatment, neither AST nor ALT changed significantly compared to prior treatment.
*ALAT∅,
*RenoP↝, Kidney function was determined by using creatinine as a biomarker and the results demonstrated that there was no difference between pre- and post-dosing.
*Half-Life↝, The elimination half-life was calculated from intravenous data and the value was approximately 5.08 ± 2.87 h.

6561- Ger,    Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes
- in-vivo, Nor, NA
*Inflam↓, Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects.
*antiOx↑,
*neuroP↑,
*AntiCan↑,
*BioAv↝, The absolute bioavailability values of oral formulations (50 mg/kg) of emulsified geraniol or fiber-adsorbed geraniol were 92 and 16%, respectively.
*Dose↝, Following emulsified oral administration, geraniol amounts in the cerebrospinal fluid of rats ranged between 0.72 ± 0.08 μg/mL and 2.6 ± 0.2 μg/mL within 60 min.
*toxicity↓, Mice treated with 120 mg/kg of geraniol for 4 weeks showed increased anti-oxidative defenses with no signs of liver toxicity.
*Catalase↑, catalase (CAT) was induced up to 29% (P < 0.01), NADPH quinone reductase (NQO1) up to 211% (P < 0.01) and oxidized glutathione reductase (GSSG-red) up to 56% (P < 0.01) with respect to controls
*NADPH↑,
*GSR↑,
*ALAT∅, geraniol treatment did not affect ALT and AST blood concentrations or serum lipid values.
*AST∅,

1415- HCA,    Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status
- in-vivo, Nor, NA
*OS↑, mice treated with HC exhibited significant delays in spontaneous early mortality at 70%–90% mice survival in the longevity study
*toxicity↓, suggesting that chronic exposure to HC does not produce toxicity at the given dose
*AST∅, (AST) and ALT markers of liver damage were not altered
*ALAT∅,
*Strength↑, Remarkably, HC produced an increase in wire hang performance
*memory∅, HC did not produce remarkable effects in neurocognitive health and muscle strength in HFD‐fed mice
*other↑, HC promotes a rich energetic status in the liver
*other↑, HC potentiates muscle regeneration in vivo
*other↑, HC potentiates muscle regeneration in vivo

2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, Luteolin induced a lethal endoplasmic reticulum stress response and mitochondrial dysfunction in glioblastoma cells by increasing intracellular reactive oxygen species (ROS) levels.
ROS↑,
PERK↑, Luteolin induced expression of ER stress-associated proteins, including phosphorylation of PERK, eIF2α, ATF4, CHOP and cleaved-caspase 12.
eIF2α↑,
ATF4↑,
CHOP↑,
Casp12↑,
eff↓, Inhibition of ROS production by anti-oxidant N-acetylcysteine could reverse luteolin-induced ER stress and mitochondrial pathways activation as well as apoptosis.
UPR↑, Researches indicate that abnormalities in ER function can cause ER stress, resulting in unfolded protein response (UPR),
MMP↓, integrity of mitochondrial membranes potential decreased in U87MG cells after treatment of 40 uM luteolin
Cyt‑c↑, release of cytochrome C to cytoplasm was elevated in U251MG cells
Bcl-2↓, significantly decreased the expression of anti-apoptotic protein Bcl-2 and increased the expression of pro-apoptotic protein Bax in U251MG and U87MG glioblastoms cells.
BAX↑,
TumCG↓, Luteolin inhibited tumor growth in a xenograft mouse model
Weight∅, luteolin did not affect body weight, alanine aminotransferase (ALT) or aspartate transaminase (AST)
ALAT∅,
AST∅,


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT∅, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp12↑, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   PERK↑, 1,   UPR↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 1,   AST∅, 1,  

Functional Outcomes(tgid=23) ⓘ

Weight∅, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT∅, 4,   NADPH↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 4,   AST∅, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cognitive↑, 1,   memory↑, 1,   memory∅, 1,   neuroP↑, 1,   OS↑, 1,   RenoP↝, 1,   Strength↑, 1,   toxicity↓, 3,  
Total Targets: 24

Scientific Paper Hit Count for: ALAT, ALT, alanine aminotransferase
1 Centella asiatica / Gotu kola → asiaticoside
1 Cucurbitacin
1 Germacranolide
1 HydroxyCitric Acid
1 Luteolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:554  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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