cognitive Cancer Research Results
cognitive, cognitive: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
*antiOx↑, Alpha lipoic acid (ALA) is a naturally occurring antioxidant that plays an important role in the functioning of enzymes involved in mitochondrial oxidative metabolism
*Inflam↓, act as antioxidant and anti-inflammatory agents
*lipid-P↓, ALA supplementation has been shown to decrease lipid peroxidation in healthy controls but not in patients with schizophrenia
*adiP↑, ALA has also been shown to improve adiponectin levels, prevent weight gain or weight loss
*cognitive∅, no significant difference between placebo and the ALA groups in scores of cognitive functions
*BDNF↑, median BDNF levels increased from 5.06 to 5.50 ng/mL
*antiOx↑, (ALA), a known antioxidant compound abundant in vegetables and animal tissues, in reducing oxidative stress in the aging brain and preventing cognitive decline.
*ROS↓,
*cognitive∅, no statistically significant effects either on cognitive function, executive function, or mood were found
*lipid-P↓, ALA has been shown to reduce lipid peroxidation and increase the activity of antioxidant molecules in different areas of the brain of experimental animals
*memory↑, ALA has been suggested to improve memory by increasing the activity of choline acetyltransferase (ChAT)
*ChAT↑,
*Acetyl-CoA↑, a crucial step in the biosynthesis of acetylcholine, in the hippocampi of treated rats
*Aβ↓, ALA administration can inhibit the formation of beta-amyloid fibrils and their expansion, thus exerting a direct effect on a known mechanism involved in neurodegenerative diseases
*BioAv↑, ALA is abundantly present in vegetables and animal tissues [17], is promptly bioavailable, and has no known toxic effects on animals and human subjects
*BBB↑, ALA has been demonstrated to successfully cross the blood–brain barrier in animal models
*toxicity∅, and no collateral effects have been observed at the oral daily doses currently employed as supplements (from 50 to 2400 mg/day)
*cognitive∅, Overall, this review found that there is a low quality of evidence regarding the efficacy of cognitive function and safety of herbal and nutritional medicines for older adults with and without SCI, due to a high risk of bias across studies.
*cognitive∅, There was no difference between B. monnieri and the placebo or donepezil in the treatment of Alzheimer disease based on very low certainty evidence.
*other↑, All 5 studies were deemed to have a high risk of bias.
*cognitive↑, The evidence from the broader systematic review suggests that CGA from coffee may need to be consumed chronically over a sustained period to produce cognitive benefits.
*cognitive∅, meta-analysis of RCT showed no benefits of coffee CGA intake on cognitive function
*cognitive∅, Although saffron extract co-administration had no effect on cognitive performance of mice,
*MAOA↓, reversed significantly the Al-induced changes in MAO activity and the levels of MDA and GSH.
*MDA↓,
*GSH↑,
*AChE↓, AChE activity was further significantly decreased in cerebral tissues of Al+saffron group.
*cognitive∅, unable to demonstrate clinical or biochemical evidence of efficacy of Curcumin C3 Complex® in AD in this 24-week placebo-controlled trial although preliminary data suggest limited bioavailability of this compound.
*BioAv↑, The levels of native curcumin measured in plasma were low (7.32 ng/mL).
*Strength↑, All the patients of the exercise group had significantly better left upper body strength, higher aerobic endurance, and left and right balance maintenance time than those of the no-exercise group
*QoL↑, Moreover, the exercise group had significantly lesser unexpected hospitalization than the no-exercise group in the patients with mild dementia
*cognitive∅, However, in the mild and moderate dementia subgroups, age, sex, education years, and MMSE showed no significant differences between the groups
cognitive∅, no beneficial effect of 750 mcg of folic acid per day on measures of cognition or mood in older healthy women.
*homoC↓, Although the vitamin supplement regimen was effective in reducing homocysteine levels (active −2.42±3.35; placebo -0.86±2.59; p<0.001), it had no beneficial effect on the primary cognitive measure, rate of change in ADAS-Cog over 18 months
*cognitive∅,
*cognitive↑, Huperzine A showed a significant beneficial effect on the improvement of cognitive function as measured by Mini-Mental State Examination (MMSE) at 8 weeks, 12 weeks and 16 weeks
*cognitive∅, One trial demonstrated no significant change in cognitive function as measured by Alzheimer’s disease Assessment Scale-Cognitive Subscale (ADAS-Cog)
*AChE↓, Huperzia serrata, was identified by scientists in China in the 1980s as a potent, reversible, selective inhibitor of acetylcholinesterase (AChE)
*cognitive∅, Evidence from randomized trials does not support the use of lecithin in the treatment of patients with dementia.
*other↑, Subjects on the active supplement (for both AD and non-AD controls) exhibited statistically significant improvement in serum concentrations of L, Z, MZ, and MP
*other↑, Supplementation with the macular carotenoids (MZ, Z, and L) benefits patients with AD, in terms of clinically meaningful improvements in visual function and in terms of MP augmentation.
*cognitive∅, no significant changes in any of the cognitive function outcome variables measured
*Weight∅, body weight of rats showed no difference compared with the control group.
*memory∅, application of ELF-EMF did not induce any cognitive and memory impairment compared with the sham-exposure group.
*cognitive∅,
*Aβ∅, Aβ showed no significant change between the two groups,
*neuroP↑, Despite neurocognitive and neurobiological effects of H. erinaceus being seen in both healthy and transgenic mice,
*cognitive↑, Tau mice given H. erinaceus had significantly shorter latencies to enter the center of the open field (OF) (p < 0.05) and spent significantly more time in the open arms of the elevated zero maze (EZM) (p < 0.001) compared to tau control mice
*cognitive∅, While H. erinaceus had anxiolytic effects, no improvements were seen in spatial memory or activities of daily living.
*BBB↑, cross the blood brain barrier (BBB)
*NGF↑, Additional benefits of H. erinaceus include the promotion of nerve growth factor (NGF)
*BDNF↑, promotion of brain-derived neurotrophic factor (BDNF), improvement of cognitive function
*NO↓, reduction in nitric oxide (NO)
*memory↑, Mice receiving H. erinaceus had improved recognition memory and exploratory behavior in the novel object recognition task; this increased exploratory behavior toward novel objects was indicative of lower levels of anxiety
*Aβ↓, Researchers have also found that H. erinaceus can reduce Aβ plaque formation in the APPswe/PS1dE9 mouse model receiving erinacine
*Risk∅, High vitamin B6 concentrations showed no significant benefit on cognition and dementia risk.
*cognitive↑, Higher levels of vitamin B12 (OR = 0.77, 95% CI = 0.61-0.97) and folate concentration (OR = 0.68, 95% CI = 0.51-0.90) were associated with better cognition in cross-sectional studies
*cognitive∅, but not in sensitivity analyses or prospective studies
*cognitive∅, we did not find evidence of B12 levels being associated with late-onset Alzheimer's disease risk with a more comprehensively examined set of genetic variants for vitamin B12 and a much larger Alzheimer's disease data set.
*cognitive∅, Three trials of vitamin B6 and 6 of vitamin B12 found no effect overall in a variety of doses, routes of administration, and populations.
*cognitive↑, One of 3 trials of folic acid found a benefit in cognitive function in people with cognitive impairment and low baseline serum folate levels.
Showing Research Papers: 1 to 18 of 18
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18
Pathway results for Effect on Cancer / Diseased Cells:
Functional Outcomes ⓘ
cognitive∅, 1,
Total Targets: 1
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 2, GSH↑, 1, lipid-P↓, 2, MDA↓, 1, ROS↓, 1,
Core Metabolism/Glycolysis ⓘ
Acetyl-CoA↑, 1, adiP↑, 1, homoC↓, 1,
Transcription & Epigenetics ⓘ
other↑, 3,
Angiogenesis & Vasculature ⓘ
NO↓, 1,
Barriers & Transport ⓘ
BBB↑, 2,
Immune & Inflammatory Signaling ⓘ
Inflam↓, 1,
Synaptic & Neurotransmission ⓘ
AChE↓, 2, BDNF↑, 2, ChAT↑, 1, MAOA↓, 1, NGF↑, 1,
Protein Aggregation ⓘ
Aβ↓, 2, Aβ∅, 1,
Drug Metabolism & Resistance ⓘ
BioAv↑, 2,
Functional Outcomes ⓘ
cognitive↑, 5, cognitive∅, 17, memory↑, 2, memory∅, 1, neuroP↑, 1, QoL↑, 1, Risk∅, 1, Strength↑, 1, toxicity∅, 1, Weight∅, 1,
Total Targets: 30
Scientific Paper Hit Count for: cognitive, cognitive
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:557 State#:% Dir#:6
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