IL4 Cancer Research Results

IL4, interleukin 4: Click to Expand ⟱

Source:

Type:

A cytokine that regulates humoral and adaptive immunity, and is involved in allergies and regulates inflammation.
IL-4 produced by cancer cells promotes resistance to immune checkpoint blockade (ICB). The close correlation between interleukin-4 (IL-4) and tumor progression has been observed in plenty of studies.

IL-4 is expressed in various cancers, including breast cancer, lung cancer, colorectal cancer, and hematological malignancies. Its expression can vary depending on the tumor type and the immune context.
Elevated levels of IL-4 are often associated with the presence of tumor-infiltrating immune cells, particularly Th2 cells and other immune cells that produce IL-4.
IL-4 is often considered a pro-tumorigenic cytokine. It can promote tumor growth and survival by enhancing the proliferation and survival of cancer cells. IL-4 can activate signaling pathways such as the STAT6 pathway, which is associated with cell proliferation and survival.
In some cancers, IL-4 can also promote angiogenesis, the formation of new blood vessels, which is critical for tumor growth and metastasis.

Scientific Papers found: Click to Expand⟱

7936-

TQ,

Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial

Trial,

Asthma,

*Dose↝, 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.
*FEV1↑, FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group.
*PEF↑, FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group.
*IgE↓, FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline
*IFN-γ↑, Both doses of N sativa produced a significant increase in the serum IFN-γ at 12 weeks vs baseline
*eff↑, Significantly fewer patients had exacerbations in the NS-1 group
*IL4∅, The levels of IL-4, IL-10, IL-17A and the eotaxins did not change significantly in any of the three groups at any of the follow up visits.
*IL10∅,
*IL17∅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

FEV1↑, 1, IgE↓, 1, PEF↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1, IL10∅, 1, IL17∅, 1, IL4∅, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1, eff↑, 1,
Total Targets: 9

Scientific Paper Hit Count for: IL4, interleukin 4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells