IL10 Cancer Research Results

IL10, Interleukin-10: Click to Expand ⟱

Source:

Type:

IL-10 is a multifaceted immune-suppressive cytokine and possesses immune-regulatory and angiogenic functions.
It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions.
The role of IL-10 in tumor pathogenesis is currently highly controversial, with some findings showing that IL-10 promotes tumor development and angiogenesis, while others supporting that it inhibits tumor growth and metastasis.

IL-10 is often expressed in various cancers, including breast cancer, colorectal cancer, melanoma, and lymphoma. Its expression can vary significantly depending on the tumor type and the immune context.
Elevated levels of IL-10 are frequently associated with the presence of tumor-infiltrating immune cells, particularly Tregs and M2 macrophages.

Scientific Papers found: Click to Expand⟱

7936-

TQ,

Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial

Trial,

Asthma,

*Dose↝, 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.
*FEV1↑, FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group.
*PEF↑, FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group.
*IgE↓, FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline
*IFN-γ↑, Both doses of N sativa produced a significant increase in the serum IFN-γ at 12 weeks vs baseline
*eff↑, Significantly fewer patients had exacerbations in the NS-1 group
*IL4∅, The levels of IL-4, IL-10, IL-17A and the eotaxins did not change significantly in any of the three groups at any of the follow up visits.
*IL10∅,
*IL17∅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

FEV1↑, 1, IgE↓, 1, PEF↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1, IL10∅, 1, IL17∅, 1, IL4∅, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1, eff↑, 1,
Total Targets: 9

Scientific Paper Hit Count for: IL10, Interleukin-10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells