TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱
Source:
Type:
Tumor Cell Death
Scientific Papers found: Click to Expand⟱
6696- DFC,  MET,    Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma
- in-vitro, GBM, GBM
compI↓, Previous research has shown that metformin, which is an inhibitor of complex I of the respiratory chain, may inhibit some brain tumor initiating cells (BTICs), albeit at dosages that are too high for clinical use.
Glycolysis↓, explored whether a combined treatment of metformin and diclofenac, which is a non-steroidal anti-inflammatory drug (NSAID) shown to inhibit glycolysis
OCR↓, However, we observed that metformin inhibited cellular oxygen consumption and increased extracellular lactate levels, indicating glycolytic rescue mechanisms
Glycolysis↑,
lactateProd↓, Combined treatment inhibited metformin-induced lactate increase.
eff↑, Combined treatment may reduce the effective doses of the single agents and prevent metabolic rescue mechanisms.
TumCP↓, Combined Treatment of Metformin and Diclofenac Impairs Cell Proliferation and Migration
TumCMig↓,
TumCD∅, Metformin, Diclofenac, and Combined Treatment at Low Doses Do Not Increase Cell Death

6890- Fer,    Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues
- vitro+vivo, Var, NA
TumMeta↓, Our results suggest that ferumoxytol could be applied ‘off label’ to protect the liver from metastatic seeds and potentiate macrophage-modulating cancer immunotherapies.
TumCD∅, ferumoxytol demonstrated no direct cytotoxic effects on cancer cells at clinically relevant doses.
Casp3↑, We found significantly increased caspase-3 expression by cancer cells incubated with macrophages plus ferumoxytol, compared with cancer cells incubated with either macrophages or ferumoxytol alone
ROS↑, Thus, ferumoxytol enhances the production of ROS by macrophages, which increases cancer cell cytotoxicity.
H2O2↑, Co-cultures of cancer cells, macrophages and ferumoxytol demonstrated an 11-fold increase in hydrogen peroxide and a 16-fold increase in hydroxyl radical production compared with co-cultures of cancer cells and macrophages alone
TumCG↓, In vivo inhibition of mammary tumour growth
Dose↝, We found significant tumour growth inhibition for all ferumoxytol-treated mice compared with untreated controls, with maximum tumour growth inhibition for the lowest quantity of ferumoxytol-exposed cancer cells (0.01 × 106;
other↑, Since ferumoxytol is FDA-approved for treatment of iron deficiency19, it could be applied ‘off label’ to protect the liver from metastatic seeds and potentiate TAM-modulating cancer immunotherapies in patients.

528- MF,  Caff,    Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells
- in-vitro, GBM, U373MG
Ca+2↑, After exposure to electromagnetic fields the basal [Ca(2+)](i) levels increased significantly from 143 +/- 46 nM to 278 +/- 125 nM
TumCP∅, Moreover the electromagnetic fields that affected [Ca(2+)](i) did not cause cell proliferation or cell death and the proliferation indexes remained unchanged after exposure.
TumCD∅,
eff↑, However, the [Ca 2+]i levels in normal and caffeine-treated cells were signicantly higher after EMF exposure than in sham exposed cells exposed cells

3017- RosA,  Per,    Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells
- in-vitro, Lung, A549
TumCD∅, We found that PSO and RA-RF were not toxic to TNF-α-induced A549 cells.
ROS↓, Both extracts significantly decreased the generation of reactive oxygen species (ROS) in this cell line.
IL1β↓, mRNA expression levels of IL-1β, IL-6, IL-8, TNF-α, and COX-2 were significantly decreased by the treatment of PSO and RA-RF.
IL6↓,
IL8↓,
TNF-α↓,
COX2/PTGS2↓,
SOD2↓, MnSOD, FOXO1, and NF-κB and phosphorylation of JNK were also significantly diminished by PSO and RA-RF treatment
FOXO1↓,
NF-kB↓,
JNK↓,
antiOx↑, PSO and RA-RF act as antioxidants
tumCV∅, PSO and RA-RF had no effect on A549 cell viability.


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   compI↓, 1,   H2O2↑, 1,   ROS↓, 1,   ROS↑, 1,   SOD2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   Glycolysis↑, 1,   lactateProd↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↑, 1,   JNK↓, 1,   TumCD∅, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   tumCV∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO1↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumCP∅, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumCD, Tumor Cell Death
1 Diclofenac
1 Metformin
1 ferumoxytol
1 Magnetic Fields
1 Caffeine
1 Rosmarinic acid
1 Perilla
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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