other Cancer Research Results
other, other: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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in-vitro, |
Lung, |
A549 |
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in-vitro, |
BC, |
MCF-7 |
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in-vitro, |
Melanoma, |
A375 |
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in-vitro, |
Colon, |
HCT15 |
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in-vitro, |
Cerv, |
HeLa |
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TrxR↓, In particular, [Au(PTA)4]PF6 was able to decrease by 50% TrxR activity at 4.2 nM
eff↓, C 50 value calculated for [Ag(PTA) 4]PF6 was 10.3 nM.
eff↓, Conversely, [Cu(PTA)4]PF6 was found to be much less effective in inhibiting this cytosolic selenoenzyme, with an IC50 value of 89.5 nM, roughly from 9 to 21 times higher than those calculated for silver and gold derivatives,
other∅, To the best of our knowledge, this is the first example of a phosphino silver complex acting as TrxR inhibitor.
*BioAv↓, egins in the stomach where a very small amount of it is passively absorbed. Followed by the action of microbial esterases in the colon, the caffeic acid is cleaved in free form and absorbed by the intestinal mucosa (most 95%)
ROS⇅, antioxidant and pro-oxidant properties
selectivity↑, exhibits pro-oxidative properties in cancer cells that are associated with oxidative DNA (deoxyribonucleic acid) damage
other∅, caffeic acid phenethyl ester, the main representative component of propolis
VEGF↓,
MMP2↓,
MMP9↓,
other∅, No significant difference in disease progression was noted between the two groups at days 14 (p=0.33), 28 (p=0.67) or 56 (p=0.50).
OS∅, There was no difference in survival between both groups from study entry to censor date (p=0.38).
other∅, In this substudy analysis, treatment with CBD oil did not affect disease progression or survival over the course of 56 days in patients with advanced cancer.
*other∅, Neither cholesterol nor egg intake is associated with an increased risk of incident dementia or AD in Eastern Finnish men.
*cognitive↑, Instead, moderate egg intake may have a beneficial association with certain areas of cognitive performance.
other∅, True cinnamon or Ceylon cinnamon or Mexican cinnamon (Cinnamomum zeylanicum)
cognitive↑, Cinnamon contains phytochemicals which boost the brains ability to utilize glucose.
antiOx↑, The antioxidant property is due to the eugenol component which inhibited peroxynitrite-induced nitration and lipid peroxidation in in vitro models.
lipid-P↓,
Apoptosis↑, to induce apoptosis in tumor cells and also by inhibiting the activity of NFκB.
NF-kB↓,
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Review, |
AD, |
NA |
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Review, |
Park, |
NA |
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*AntiAge↑, supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics.
*cardioP↑, Cardiovascular disease and inflammation are alleviated by the antioxidant effect of CoQ10
*Inflam↓, Administration of CoQ10 in doses ranging from 60 to 500 mg/day for a 1-week to 4-month intervention period significantly decreased production of inflammatory cytokines
*antiOx↑,
*lipid-P↓, The concentrations of CoQ10 in the plasma of elderly people are positively correlated with levels of physical activity and cholesterol concentrations (Del Pozo-Cruz et al., 2014a,b), as well as with lower lipid oxidative damage.
*QoL↑, Older individuals given a combination of selenium and CoQ10 over a 4-year period reported an improvement in vitality, physical performance, and quality of life
*neuroP↑, health benefits in elderly people by preventing chronic oxidative stress associated with cardiovascular and neurodegenerative diseases
*Dose↝, the highest dose for CoQ10 supplementation is 1200 mg daily according to well-designed randomized, controlled human trials, although doses as high as 3000 mg/day have been used in shorter clinical trials
*BP↓, These authors interpreted the results to indicate a significant reduction in systolic blood pressure without improvements in other CVD risk factors, such as diastolic blood pressure, total cholesterol, LDL- and high-density lipoprotein (HDL)-choleste
*IGF-1↑, elderly healthy participants who received selenium and CoQ10 supplementation for over 4 years, an increase in insulin-like growth factor 1 (IGF-1) and postprandial insulin-like growth factor-binding protein 1 (IGFBP-1) levels
*IGFBP1↑,
*eff↑, A combination of CoQ10 with red yeast rice, berberina, policosanol, astaxanthin, and folic acid significantly decreased total cholesterol, LDL-cholesterol, triglycerides, and glucose in the blood while increasing HDL-cholesterol levels
*LDL↓,
*HDL↑,
*eff↑, 60 patients suffering from statin-associated myopathy were enrolled in a 3-month study to test for efficacy of CoQ10 and selenium treatment. A consistent reduction in their symptoms, including muscle pain, weakness, cramps, and fatigue was observed
*other↑, Because of its capacity to reduce the side-effects of statins, CoQ10 has been proposed to prevent and/or slow the progression of frailty and sarcopenia in the elderly chronically treated with statins.
*RenoP↑, experiments performed on rats showed a promising protective effect of ubiquinol in the kidneys
*ROS↓, 65 patients undergoing hemodialysis, supplementation with high amounts of CoQ10 (1200 mg/day) lowered F2-isoprostane plasma levels indicative of a reduction in oxidative stress
*TNF-α↓, low grade inflammation, respond well to CoQ10 supplementation with significant decrease in TNF-α plasma levels without having an effect on C-reactive protein and IL-6 production
*IL6↓, Another study reported that CoQ10 therapy in doses ranging from 60 to 300 mg/day caused no significant decrease in C-reactive protein while eliciting a significant reduction in IL-6 levels
*other↝, Preclinical studies demonstrated that CoQ can preserve mitochondrial function and reduce the loss of dopaminergic neurons in the case of Parkinson's disease
*other∅, There was no improvement observed in oxidative stress or neurodegeneration markers in a randomized clinical trial in Alzheimer's Disease patients with CoQ10 supplementation at a dose of 400 mg/day for 16 weeks
*other∅, These results suggest that these values are not related with the risk for AD or VD.
AntiAg↑, EGCG significantly reduced ADP- and COL-induced platelet aggregation in dose-dependent manner
eff↑, no further increase of bleeding risk by EGCG in the participants who were already taking other anti-platelet agents.
Half-Life↝, half-life of EGCG is approximately 3 hours
other∅, EGCG significantly inhibited the human platelet aggregation without any changes on P-selectin and PAC-1 expressions.
other∅, injectable form of amygdalin is highly recommended more than its oral administration to avoid the release of cyanide through the decomposition of amygdalin by the gut microfloral B-glucosidase enzyme.
TumCCA↑,
COX2↝,
E-cadherin↑,
other∅, amygdalin exhibited no or low treatment efficiency in preclinical in vivo studies.
other∅, Considering its proven toxicity and unconvincing clinical effects, amygdalin cannot currently be recommended to oncology patients as a supportive treatment.
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in-vitro, |
Nor, |
SH-SY5Y |
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in-vitro, |
GBM, |
T98G |
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in-vitro, |
Nor, |
HDFa |
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other∅, did not show any negative effect of the generated EMF on either normal cells or tumor cell lines
MGO↑, MG levels rise under high-glucose conditions, such as diabetes
ROS↑, MG induces protein and nucleotide modification (advanced glycation end-products, AGEs), reactive oxygen species (ROS), and apoptosis
other↝, To combat MG's cytotoxic effects, GLO1 enzymatically converts MG into the less reactive substance, d-lactate
GABA↑, MG's mechanism of action in behavior: GABAA receptor activation
other∅, GLO1 inhibition was shown to increase MG concentration and reduce anxiety-like behavior in vivo
Risk↓, Selenium (Se) may help prevent breast cancer (BC) development.
other∅, Higher Se status does not appear to be associated with BC risk, although activity of the selenoenzyme GPX3 may be inversely associated with premenopausal BC risk, and SNPs in the Se pathway alone or in combination with suboptimal Se status may influe
*other↓, We have shown that drinking up to 1 L of a silicon-rich mineral water each day for 12 weeks facilitated the removal of aluminum via the urine in both patient and control groups
*other∅, without any concomitant affect upon the urinary excretion of the essential metals, iron and copper
*cognitive↑, cognitive performance showed clinically relevant improvements in at least 3 out of 15 individuals.
Showing Research Papers: 1 to 14 of 14
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1, lipid-P↓, 1, MGO↑, 1, ROS↑, 1, ROS⇅, 1, TrxR↓, 1,
Cell Death ⓘ
Apoptosis↑, 1,
Transcription & Epigenetics ⓘ
other↝, 1, other∅, 12,
Cell Cycle & Senescence ⓘ
TumCCA↑, 1,
Migration ⓘ
AntiAg↑, 1, E-cadherin↑, 1, MMP2↓, 1, MMP9↓, 1,
Angiogenesis & Vasculature ⓘ
VEGF↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↝, 1, NF-kB↓, 1,
Synaptic & Neurotransmission ⓘ
GABA↑, 1,
Drug Metabolism & Resistance ⓘ
eff↓, 2, eff↑, 1, Half-Life↝, 1, selectivity↑, 1,
Functional Outcomes ⓘ
cognitive↑, 1, OS∅, 1, Risk↓, 1,
Total Targets: 25
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1, HDL↑, 1, lipid-P↓, 1, ROS↓, 1,
Core Metabolism/Glycolysis ⓘ
LDL↓, 1,
Transcription & Epigenetics ⓘ
other↓, 1, other↑, 1, other↝, 1, other∅, 4,
Proliferation, Differentiation & Cell State ⓘ
IGF-1↑, 1, IGFBP1↑, 1,
Immune & Inflammatory Signaling ⓘ
IL6↓, 1, Inflam↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1, Dose↝, 1, eff↑, 2,
Clinical Biomarkers ⓘ
BP↓, 1, IL6↓, 1,
Functional Outcomes ⓘ
AntiAge↑, 1, cardioP↑, 1, cognitive↑, 2, neuroP↑, 1, QoL↑, 1, RenoP↑, 1,
Total Targets: 25
Scientific Paper Hit Count for: other, other
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:767 State#:% Dir#:6
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