RUNX2 Cancer Research Results
RUNX2, Runt-related transcription factor 2: Click to Expand ⟱
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RUNX2 (Runt-related transcription factor 2) is a transcription factor that plays a crucial role in the regulation of bone development and osteoblast differentiation.
RUNX2 is overexpressed in: breast, prostate, lung, osteosarcoma.
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Scientific Papers found: Click to Expand⟱
*PPARγ↓, PPARg2
*p‑JNK↑, p-JNK
*Wnt↑,
*ALP∅, ELF-MF had no effects on the expression of ALP, COL1a1, Runx2, and OCN
*COL1∅,
*RUNX2∅,
*OCN∅,
*FABP4↓, ELF-MF exposure for 15 days resulted in a decrease in PPARg2 and FABP4
*p‑JNK↑, p-JNK was increased after ELF-MF exposure
*Diff↓, adipogenic differentiation of MSCs could be inhibited by ELF-MF of 7.5 Hz, 0.4 T, suggesting the inhibitory effect of ELF-MF on obesity may be attributed to the inhibition of differentiation of MSCs into adipocytes.
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Total Targets: 0
Pathway results for Effect on Normal Cells:
Core Metabolism/Glycolysis ⓘ
FABP4↓, 1, PPARγ↓, 1,
Cell Death ⓘ
p‑JNK↑, 2,
Kinase & Signal Transduction ⓘ
OCN∅, 1,
Proliferation, Differentiation & Cell State ⓘ
Diff↓, 1, RUNX2∅, 1, Wnt↑, 1,
Migration ⓘ
COL1∅, 1,
Clinical Biomarkers ⓘ
ALP∅, 1,
Total Targets: 9
Scientific Paper Hit Count for: RUNX2, Runt-related transcription factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:776 State#:% Dir#:6
wNotes=on sortOrder:rid,rpid
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