BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
1615- EA,    Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
- Human, Nor, NA
*BioAv∅, 800 mg of extract. Results indicate that ellagic acid (EA) from the extract is bioavailable, with an observed C(max) of 33 ng/mL at t(max) of 1 h.
*ROS∅, whereas the generation of reactive oxygen species (ROS) was not affected

1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, A pharmacokinetic study in healthy individuals receiving single doses of EGCGrevealed that plasma concentrations exceeded 1 μM only with doses of >1 g
Half-Life∅, peak levels observed between 1.3 and 2.2 h (and a half-life (t1/2z) of 1.9 to 4.6 h)
BioAv∅, oral bioavailability of 20.3% relative to intravenous admistration
BBB↑, EGCG can cross the blood–brain barrier, allowing it to reach the brain
toxicity∅, Isbrucher et al. found no evidence of genotoxicity in rats following oral administration of EGCG at doses of 500, 1000, or 2000 mg/kg, or intravenous injections of 10, 25, or 50 mg/kg/day.
eff↓, interaction with the folate transporter has been reported, leading to reduced bioavailability of folic acid
Apoptosis↑,
Casp3↑,
Cyt‑c↑, cytochrome c release
cl‑PARP↑,
DNMTs↓,
Telomerase↓,
angioG↓,
Hif1a↓,
NF-kB↓,
MMPs↓,
BAX↑,
Bak↑,
Bcl-2↓,
Bcl-xL↓,
P53↑,
PTEN↑,
IGF-1↓,
H3↓,
HDAC1↓,
*LDH↓, reduces LDL cholesterol, decreases oxidative stress by neutralizing ROS
*ROS↓,

5797- RES,    Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution?
- Review, Nor, NA
*AntiAge↑, potentially slowing the aging process
*Dose↑, generally 5 g per day [23,45,54]. These doses demonstrate that a Cmax of approximately 4 µM is attainable in human plasma
*BioAv↑, combining various food and beverage consumption with resveratrol administration, with the notion that the combination of resveratrol with multiple polyphenols is ultimately responsible for the “French Paradox”
*BioAv↑, standard breakfast with 2000 mg resveratrol supplementation yielded a significantly greater Cmax and AUC than that obtained following a high fat breakfast.
*BioAv∅, no major differences in bioavailability parameters between fed and fasted conditions following 400 mg of resveratrol administration
*BioAv↑, SRT501, the patented formulation of resveratrol which is micronized with particle sizes < 5 µm and solubilized (fourfold increase)
*BioAv↑, For this reason, it has been suggested that combining resveratrol with other polyphenols which are targeted by these enzymes may increase bioavailability
*BioAv↑, Piperine, a polyphenol found in black pepper, has been shown to substantially increase serum Cmax and AUC of resveratrol in rats
*BioAv↑, Resveratrol loaded onto lipid-core nanocapsules improved tissue concentration in the brain, liver, and kidney of healthy rats compared to free resveratrol


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   Telomerase↓, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC1↓, 1,   IGF-1↓, 1,   PTEN↑, 1,  

Migration ⓘ

MMPs↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv∅, 1,   eff↓, 1,   Half-Life∅, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,   ROS∅, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 6,   BioAv∅, 2,   Dose↑, 1,   Dose∅, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: BioAv, bioavailability
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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