SVCT-2 Cancer Research Results

SVCT-2, Sodium-dependent Vitamin C Transporter 2: Click to Expand ⟱
Source:
Type:
SVCT-2 is a protein that plays a role in the transport of vitamin C (ascorbic acid) into cells.
SVCT-2 is expressed in: 70% breast, 60% lung, 80% CRC, 50% Prostate, 70% ovarian, 60% Pancreatic, 50% liver, 60% stomach, 50% esophageal, 60% Head and Neck, 50% Melanoma, 70% GBM, 60% Medulloblastoma.
SVCT-2 was involved in the transport of vitamin C into lung cancer cells and that its inhibition reduced cancer cell growth and survival.
Scientific Papers found: Click to Expand⟱
636- VitC,    Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation
- in-vivo, NA, NA
pH↓, Acute addition of Vitamin C to the basolateral membrane maintains low intracellular pH for a longer period which could halt and/or prevent tumor formation.
SVCT-2∅, Vitamin C could potentially be transported via SVCT2

632- VitC,    High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
- Review, NA, NA
SVCT-2∅, vitamin C entry into cells is tightly regulated by SVCT
ROS↑, well-recognized pro-oxidant effects
Hif1a↓, HIF-1α proteasomal degradation
PARP∅, Moreover, vitamin C action at DNA levels may provide the rationale basis for combination therapies with PARP inhibitors and hypomethylating agents.
TET2↑, However, the ability of vitamin C to restore TET2 activity seems to depend on N- and C-terminal lysine acetylation and type of TET2 mutations

631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, response to VC was correlated with sodium-dependent vitamin C transporter 2 (SVCT-2) expressions. Most importantly, SVCT-2 was highly expressed in liver CSCs
ROS↑,
DNAdam↑,
ATP↓,
TumCCA↑,
Apoptosis↑,
OS↑, VC use was linked to improved disease-free survival (DFS) in HCC patients
CD133↓, CD133+
EpCAM↓, EpCAM+
OV6↓, OV6+
γH2AX↑, p-H2AX induced by VC


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

OV6↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   PARP∅, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   EpCAM↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

SVCT-2∅, 3,  

Cellular Microenvironment ⓘ

pH↓, 1,  

Drug Metabolism & Resistance ⓘ

TET2↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SVCT-2, Sodium-dependent Vitamin C Transporter 2
3 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:814  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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