IronCh Cancer Research Results

IronCh, Iron Chelator: Click to Expand ⟱
Source:
Type:
Iron Chelator
Scientific Papers found: Click to Expand⟱
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, Early reports fueled concerns that high dietary phytate intake could contribute to mineral deficiencies, albeit without direct scientific evidence, particularly in populations lacking dietary diversity
ChemoSen↑, Preclinical and clinical research indicate that IP6, alone or in tandem with inositol (Ins), selectively targets cancer cells and enhances chemotherapy efficacy.
*cardioP↑, Growing evidence also suggests that IP6 plays a protective role in cardiovascular health, neurodegenerative disorders, and metabolic diseases
neuroP↑,
IronCh∅, confirmed that life-time consumption of IP6±Inositol did not cause any reduction in Ca, Mg, Fe, or Zn levels in the blood or bones of rats and mice
P21↓, IP6 downregulates cell cycle regulators such as p21 and p27, inhibits phosphorylation of retinoblastoma protein (pRB), and suppresses PI3K/protein kinase B (PI3K/Akt)
p27/CDKN1B↓,
p‑pRB↓,
PI3K↓,
Akt↓,
NF-kB↓, decreased NF-kB activity and inflammatory responses
Inflam↓,
TumW↓, After 12 days of treatment, IP6-treated mice exhibited a 3.4-fold lesser tumor weight as compared to controls
TumCI↓, figure 3
TumMeta↓,
Imm↑,
Diff↑,
selectivity↑, the growth of non-cancerous MCF-10A epithelial breast cells remained unaffected, further illustrating IP6’s capacity to differentiate between cancerous and normal cells
toxicity↓, Importantly, no adverse effects have been reported in studies administering IP6 or Ins to humans or animal models, even at high doses
RenoP↑, Plant-based food diets are often recommended to individuals with chronic kidney disease, where the protective effects of the diet are ascribed to IP6
QoL↑, Clinical trials, though still sparse, have yielded encouraging results regarding IP6’s synergistic enhancement of chemotherapy efficacy and improvement of patients’ quality of life.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Metal & Cofactor Biology(tgid=2) ⓘ

IronCh∅, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p27/CDKN1B↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑pRB↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   QoL↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumW↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Iron∅, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: IronCh, Iron Chelator
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:835  State#:%  Dir#:6
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