CDK6 Cancer Research Results

CDK6, Cyclin-dependent kinase 6: Click to Expand ⟱
Source:
Type:
Cyclin-dependent kinase 6 (CDK6) is another important regulator of the cell cycle, particularly involved in the transition from the G1 phase to the S phase.
CDK6 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker. Targeting CDK6 with specific inhibitors, such as palbociclib (which also targets CDK4), has shown promise in clinical settings, particularly in hormone receptor-positive breast cancer.


Scientific Papers found: Click to Expand⟱
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓,
TumCI↓,
TumCMig↓,
Apoptosis↑,
ROS↑,
miR-21↓,
miR-130a↓,
Casp8∅, Caspase-8, Caspase-10, Cyclin D1, Cyclin D2, CDK6, CDK4, FADD, TRADD, FAS, DR4 and DR5 gene mRNA expression changes were found insignificant in boric acid treated group compared with control
Casp10∅,
cycD1/CCND1∅,
CDK6∅,
CDK4∅,
FADD∅,
DR4∅,
DR5∅,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp10∅, 1,   Casp8∅, 1,   DR4∅, 1,   DR5∅, 1,   FADD∅, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Cell Cycle & Senescence ⓘ

CDK4∅, 1,   cycD1/CCND1∅, 1,  

Migration ⓘ

miR-130a↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6∅, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDK6, Cyclin-dependent kinase 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:895  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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