iNOS Cancer Research Results

iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE/β-secretase↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, Synergy↑, Catalase↑, other↑,
402- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7
P53↑, iNOS↑, NF-kB↑, Bcl-2↓, miR-125b↓, ROS↑, SOD↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, Var, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, Var, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, Var, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2/PTGS2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
3666- ART/DHA,    Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
- in-vivo, AD, NA
*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *cognitive↑,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1/CCL2↓, *NO↓, *iNOS↓, *IκB↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
1522- Ba,    Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
- in-vitro, Nor, RAW264.7
*p‑STAT1↓, *p‑STAT3↓, *p‑JAK1↓, *p‑JAK2↓, *iNOS↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
9199- BITC,    Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways
- in-vitro, GC, NA
TumCMig↓, TumCI↓, ERK↓, RAS↓, GRB2↓, Rho↓, iNOS↓, COX2/PTGS2↓, MMP2↓, MMP7↓, MMP9↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
3515- Bor,    EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *MIP‑1α/CCL3↓, *iNOS↓, *NF-kB↓,
3507- Bor,    Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling
- in-vivo, Nor, NA
*MMP↑, *Cyt‑c↓, *Apoptosis↓, *Casp3↓, *NO↓, *iNOS↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
8973- BRice,    Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways
- in-vitro, Nor, RAW264.7
*Ingr↝, *Inflam↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *NF-kB↓, *AP-1↓, *p‑ERK↓, *p‑p38↓, *p‑JNK↓, *MAPK↓,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
6549- BSB,    (-)-α-bisabolol prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *Dose↝, *neuroP↑, *motorD↑, *memory↑, *MPO↓, *TNF-α↓, *iNOS↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
7946- BuckWS,    Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7)
- Study, Nor, NA
*ROS↓, *IronCh↑, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓,
1011- CA,    Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways
- in-vivo, Nor, NA
*iNOS↓, *IL6↓, *SOX9↑, *NF-kB↓, *MAPK↓, *Cartilage↑,
4264- CA,    Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, AD, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
5875- CA,    Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway
- in-vivo, IBD, NA
*antiOx↑, *Weight↑, *p65↓, *cJun↓, *NLRP3↓, *Casp1↓, *NRF2↑, *GSH↑, *SOD↑, *MDA↓, *iNOS↓, other↝,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2/PTGS2↓, iNOS↓, NF-kB↓, chemoP↑,

Showing Research Papers: 1 to 50 of 198
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 198

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 3,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 9,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 4,   HO-1↑, 6,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 4,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 11,   ROS↓, 12,   ROS↑, 50,   ROS⇅, 4,   SOD↑, 6,   SOD2↓, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compIV↓, 1,   EGF↓, 1,   mitResp↓, 1,   MKK7↓, 2,   mtDam↑, 4,   OCR↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   ACSL4↑, 1,   ALAT↓, 1,   ALAT↝, 1,   AMPK↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ATP↓, 3,   ECAR↝, 1,   FASN↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↑, 40,   BAD↓, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 24,   Bax:Bcl2↑, 3,   Bcl-2↓, 30,   Bcl-xL↓, 7,   BID↓, 1,   BID↑, 3,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 6,   Casp↝, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 31,   cl‑Casp3↑, 3,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 20,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 18,   Diablo↑, 3,   DR5↑, 6,   Endon↑, 1,   Fap1↓, 1,   Fas↑, 6,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP1↓, 3,   ICAD↓, 1,   iNOS↓, 55,   iNOS↑, 3,   Mcl-1↓, 7,   MDM2↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 2,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 1,   survivin↓, 14,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 2,   XIAP↓, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 28,   Akt↑, 2,   p‑Akt↓, 8,   cMET↓, 2,   EGFR↓, 7,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 5,   GRB2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 4,   JNK↑, 4,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 3,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   p‑mTOR↓, 2,   P70S6K↓, 3,   PI3K↓, 23,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PKA↓, 1,   PKCδ↓, 4,   PTEN↑, 7,   RAS↓, 4,   SHP1↑, 1,   Sp1/3/4↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 22,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   CBP↓, 1,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 7,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC1↓, 3,   HDAC6↓, 1,   HDAC8↓, 1,   Matr↓, 1,   miR-125b↓, 1,   miR-21↓, 1,   miR-34a↓, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 3,   other↓, 3,   other↑, 4,   other↝, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 1,   SOX9↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 12,   GRP78/BiP↑, 2,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   HSP90↑, 1,   HSPs↓, 1,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 6,   p62↓, 4,   p62↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 14,   ERCC1↓, 1,   hTERT/TERT↓, 3,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 28,   P53↝, 1,   PARP↓, 2,   PARP↑, 6,   cl‑PARP↑, 9,   PARP1↑, 1,   PCNA↓, 7,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 1,   TOP2↓, 1,   TP53↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK4↓, 9,   CDK4/6↓, 1,   CDK6↓, 6,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 2,   Chk2↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 25,   cycE/CCNE↓, 6,   cycE/CCNE↑, 2,   E2Fs↓, 2,   E2Fs↑, 1,   Ki-67↓, 5,   P21↓, 3,   P21↑, 16,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 36,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 8,   FGF↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   Ki-67↓, 5,   mTORC1↓, 1,   Nanog↓, 2,   NICD↓, 1,   NOTCH↓, 3,   NOTCH1↓, 6,   NOTCH1↑, 1,   p300↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 11,   TumCG↑, 1,   TumCP↓, 27,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 3,   ASAP2↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 2,   i-Ca+2?, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 9,   EpCAM↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   Fibronectin↓, 2,   ITGA5↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MMP-10↓, 2,   MMP1↓, 1,   MMP2↓, 19,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 29,   MMPs↓, 10,   N-cadherin↓, 8,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 4,   SMAD3↓, 1,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 4,   pol-TregCell↓, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 17,   TumCMig↓, 21,   TumMeta↓, 16,   TumMeta↑, 1,   Twist↓, 5,   uPA↓, 4,   Vim↓, 9,   Zeb1↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↑, 2,   HIF-1↓, 1,   Hif1a↓, 19,   LOX1↓, 1,   NO↓, 8,   VCAM-1↓, 1,   VEGF↓, 29,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   CLDN2↓, 1,   MMP↓, 19,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 3,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 46,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 5,   CXCR4↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 6,   IL1↓, 5,   IL10↓, 7,   IL12↓, 2,   IL1β↓, 12,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL4↓, 2,   IL6↓, 22,   IL8↓, 7,   Imm↑, 3,   Inflam↓, 15,   LRIG1↑, 1,   M1↓, 1,   MCP1/CCL2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 43,   NF-kB↑, 5,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 3,   PD-L1↓, 2,   PGE2↓, 8,   PSA↓, 2,   RAGE↓, 1,   TLR4↓, 4,   TNF-α↓, 24,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 2,   PPARα↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 5,   BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 20,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1B1↑, 1,   Dose↑, 2,   Dose↝, 8,   Dose∅, 7,   eff↓, 2,   eff↑, 19,   eff⇅, 1,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↑, 7,   selectivity↑, 9,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 2,   AST↝, 1,   BP↓, 1,   BRCA1↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EGFR↑, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 3,   IL6↓, 22,   LDH↓, 4,   i-LDH↓, 1,   Myc↓, 2,   PD-L1↓, 2,   PSA↓, 2,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 13,   antiNeop↑, 1,   AntiTum↑, 4,   cardioP↑, 3,   chemoP?, 1,   chemoP↑, 9,   chemoPv↑, 6,   ChemoSideEff↓, 1,   cognitive?, 1,   cognitive↑, 1,   hepatoP↑, 4,   neuroP↑, 2,   OS↑, 2,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 523

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

3-NT↓, 1,   antiOx↓, 4,   antiOx↑, 62,   ARE↑, 2,   Bil↑, 2,   Catalase↑, 35,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 23,   GSH↑, 44,   GSR↓, 2,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 3,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 40,   HO-1⇅, 1,   hyperG↝, 1,   Iron↓, 1,   Keap1↓, 5,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 35,   MDA↓, 44,   MPO↓, 10,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 9,   NRF2↓, 1,   NRF2↑, 56,   Prx↑, 2,   RNS↓, 5,   ROS↓, 106,   ROS↑, 2,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 58,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 5,   Trx↑, 2,   Trx1↑, 1,   TrxR↑, 2,   uricA↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↑, 1,   mtDam↓, 2,   mtDam↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 11,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 5,   cAMP↑, 2,   CRM↑, 1,   FABP4↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 2,   GSK‐3β↓, 5,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NADPH↑, 1,   PKM2↓, 1,   SIRT1↓, 1,   SIRT1↑, 7,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 18,   BAX↓, 12,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 6,   Casp1↓, 3,   Casp3↓, 15,   Casp3↑, 1,   Casp3∅, 2,   cl‑Casp3↓, 2,   Casp6↓, 1,   Casp8↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 8,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 2,   Fas↓, 3,   Ferroptosis↓, 1,   iNOS↓, 138,   iNOS↑, 6,   necrosis↓, 2,   p38↓, 7,   p38↑, 1,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 7,   AMPKα↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 7,   ERK↑, 3,   p‑ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   p‑JAK1↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 2,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 3,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PKA↑, 1,   PKCδ?, 1,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RIP1↓, 1,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3?, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 2,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 1,   HDAC↓, 2,   HDAC↑, 1,   MEF2D↑, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 2,   other↝, 4,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   ER Stress↓, 5,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 7,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 4,   PARP∅, 1,   cl‑PARP↓, 1,   Telomerase↓, 2,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↓, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 2,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 4,   AP-1↓, 3,   ARG1/2↑, 2,   Ca+2↓, 5,   Ca+2↝, 1,   Cartilage↑, 4,   COL1↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 4,   MMP2↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 6,   MMPs↓, 3,   MMPs↑, 1,   MUC1↑, 2,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 3,   TGF-β↑, 2,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TXNIP↓, 2,   uPA↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 4,   NO↓, 42,   NO↑, 1,   VCAM-1↓, 6,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 15,   BBB↝, 2,   BBB∅, 2,   CLDN1↑, 3,   CLDN3↑, 1,   GastroP↑, 2,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 3,   memfluid↑, 1,   MMP↑, 10,   MMP∅, 1,   MUC2↑, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↑, 2,   TJ↑, 2,   VGSC↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 92,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 5,   IFN-γ↓, 8,   IL1↓, 6,   IL10↓, 5,   IL10↑, 6,   IL12↓, 4,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 62,   IL1β↑, 1,   IL2↓, 7,   IL4↓, 3,   IL4↑, 2,   IL6↓, 70,   IL6↑, 2,   IL8↓, 7,   Imm↓, 1,   Imm↑, 1,   Imm↝, 1,   INF-γ↓, 2,   Inflam↓, 97,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 2,   LTA/TNF-β↓, 1,   MCP1/CCL2↓, 5,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   MyD88↓, 3,   NeuroI↓, 5,   NF-kB↓, 78,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 15,   p65↓, 2,   p‑p65↓, 1,   PGE1↓, 1,   PGE2↓, 28,   PGE2↑, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 15,   TNF-α↓, 89,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 3,   AChE↓, 20,   AChE↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 7,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 4,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 2,   NGF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   BACE/β-secretase↓, 10,   tau↓, 5,   p‑tau↓, 5,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   GR↑, 1,   PPARα↑, 3,   PPARγ↓, 1,   PPARγ↑, 6,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 24,   BioAv↝, 10,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↑, 2,   Dose↝, 14,   eff↓, 1,   eff↑, 12,   eff↝, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 7,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALB↑, 1,   AST↓, 12,   BG↓, 1,   Bil↑, 2,   BMD↑, 1,   BP↓, 4,   colonLen↑, 1,   creat↓, 3,   CRP↓, 3,   EGFR↓, 1,   IL6↓, 70,   IL6↑, 2,   LDH↓, 6,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll?, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 7,   antiCG↑, 1,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 24,   chemoP↑, 4,   chemoPv↑, 1,   cognitive↑, 32,   cognitive↝, 1,   hepatoP↓, 2,   hepatoP↑, 25,   Learn↑, 2,   memory↑, 33,   motorD↑, 4,   neuroP↑, 73,   NP/CIPN↓, 1,   Obesity↓, 4,   Pain↓, 8,   radioP↑, 6,   RenoP↑, 12,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 6,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 7,   Diar↓, 2,   GutMicro↑, 14,   Inf↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 446

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
11 Silymarin (Milk Thistle) silibinin
9 Quercetin
7 Curcumin
7 Thymoquinone
6 Magnetic Fields
5 Baicalein
5 Propolis -bee glue
4 Alpha-Lipoic-Acid
4 Beta-Caryophyllene
4 Ferulic acid
4 isoorientin
4 Luteolin
4 Lycopene
4 Resveratrol
4 Sulforaphane (mainly Broccoli)
3 α-Bisabolol / Chamomile oil
3 Cichoric acid / Chicoric acid
3 Fisetin
3 Licorice
3 Pterostilbene
3 Rutin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Artemisinin
2 Benzyl isothiocyanate
2 Phenethyl isothiocyanate
2 Boron
2 buckwheat sprouts
2 Caffeic acid
2 Carnosic acid
2 Capsaicin
2 Chrysin
2 Echinacea
2 Crocetin
2 EGCG (Epigallocatechin Gallate)
2 Eugenol
2 Gambogic Acid
2 Ginkgo biloba
2 Ginger/6-Shogaol/Gingerol
2 Isovitexin
2 Kaempferol
2 Magnolol
2 Melatonin
2 Mung Bean Sprouts
2 Rosmarinic acid
2 Shikonin
2 Aflavin-3,3′-digallate
2 Vitamin K2
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Cisplatin
1 Biochanin A
1 xanthohumol
1 Allyl isothiocyanate
1 Bromelain
1 Boswellia (frankincense)
1 Beetroot
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Carvacrol
1 Celastrol
1 Chlorogenic acid
1 Chocolate
1 Lecithin
1 Dichloroacetate
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Emodin
1 Formononetin
1 Gamma-aminobutyric acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Grapeseed extract
1 Siegesbeckia glabrescens
1 Hops (Humulus lupulus)
1 Hyperoside
1 Vitexin
1 Licochalcone A
1 Lutein
1 MBE, Maqui berry
1 Magnetic Field Rotating
1 Moringin
1 Moringa oleifera
1 Morin
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Piperlongumine
1 Sinapic acid
1 acetaminophen
1 Taurine
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:159  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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