iNOS Cancer Research Results

iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF-7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, eff↑, Catalase↑, other↑,
402- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF-7
P53↑, iNOS↑, NF-kB↑, Bcl-2↓, miR-125b↓, ROS↑, SOD↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- NA, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, NA, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
3666- ART/DHA,    Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
- NA, AD, NA
*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2↓, *cognitive↑,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1↓, *NO↓, *iNOS↓, *IκB↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, NA, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
1522- Ba,    Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
- in-vitro, Nor, RAW264.7
*p‑STAT1↓, *p‑STAT3↓, *p‑JAK1↓, *p‑JAK2↓, *iNOS↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1↑, IL2↓, IL4↓, IFN-γ↓, COX2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
3515- Bor,    EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *MIP‑1α↓, *iNOS↓, *NF-kB↓,
3507- Bor,    Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling
*MMP↑, *Cyt‑c↓, *Apoptosis↓, *Casp3↓, *NO↓, *iNOS↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
1011- CA,    Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways
- in-vivo, NA, NA
iNOS↓, IL6↓, SOX9↑, NF-kB↓, MAPK↓,
4264- CA,    Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2↓, ROS↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
1792- CUR,  LEC,    Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanism
- in-vitro, Arthritis, RAW264.7 - NA, NA, HCC-38
*Inflam↓, *NF-kB↓, *iNOS↓, *COX2↓, *NO↓, *PGE2↓, *MMPs↑, *TIMP1↑, *BioEnh↑,
158- CUR,    Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
MMP9↓, Matr↓, Inflam↓, antiOx↓, NF-kB↓, COX2↓, iNOS↓, TumCMig↓, TumCI↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
4829- CUR,    Dual Action of Curcumin as an Anti- and Pro-Oxidant from a Biophysical Perspective
- Review, Var, NA
*antiOx↑, ROS↑, *lipid-P↓, *iNOS↓, *BioAv↓,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
1874- DCA,    Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, MDAH-2774
Apoptosis↑, MPO↓, iNOS↓, Hif1a↓, SOD↑, Casp3↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
3712- FA,    Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- Review, AD, NA
*antiOx↑, *Inflam↓, *ROS↓, *Aβ↓, *HO-1↑, *HSP70/HSPA5↑, *ERK↑, *Akt↑, *iNOS↓, *COX2↓, *cardioP↑, *memory↑, *IL2↓, *cognitive↑, *APP↓, *SOD↑, *Catalase↑, *Akt↑, *BioAv↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
3723- Gb,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,

Showing Research Papers: 1 to 50 of 123
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 123

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   GSH↓, 2,   HO-1↓, 4,   HO-1↑, 1,   HO-2↓, 1,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MPO↓, 2,   NRF2↓, 2,   NRF2↑, 4,   ROS↓, 2,   ROS↑, 14,   ROS⇅, 3,   SOD↑, 4,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   CDC2↓, 1,   CDC25↓, 1,   MMP↓, 3,   MMP↑, 1,   MPT↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ACSL4↑, 1,   ALAT↓, 1,   ALAT↝, 1,   AMPK↓, 1,   p‑AMPK↑, 1,   cMyc↓, 3,   p‑cMyc↑, 1,   ECAR↝, 1,   FASN↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 1,   PDK1?, 2,   PDK1↓, 1,   PKM2↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 6,   Bak↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 2,   Bcl-2↓, 7,   Bcl-xL↓, 3,   BID↑, 1,   Casp↑, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 11,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 9,   Diablo↑, 2,   DR5↑, 3,   Fap1↓, 1,   Fas↑, 2,   HGF/c-Met↓, 1,   hTERT/TERT↓, 2,   ICAD↓, 1,   iNOS↓, 15,   iNOS↑, 2,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 3,   Mcl-1↓, 3,   MDM2↓, 2,   Myc↓, 1,   NICD↓, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 1,   PUMA↑, 1,   survivin↓, 4,   Telomerase↓, 3,   TRPV1↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

SOX9↓, 1,   SOX9↑, 1,  

Transcription & Epigenetics ⓘ

Matr↓, 1,   other↓, 1,   other↑, 2,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 2,   Beclin-1↑, 2,   BNIP3↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 4,   DNMTs↓, 1,   P53?, 1,   P53↑, 10,   PARP↑, 2,   cl‑PARP↑, 5,   SIRT6↑, 1,  

Cell Cycle & Senescence ⓘ

p‑CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 2,   cycE/CCNE↑, 2,   P21↓, 1,   P21↑, 5,   p‑RB1↓, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CDK8↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 5,   p‑ERK↓, 3,   FOXM1↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   IGF-1↓, 1,   IGF-1R↓, 1,   miR-125b↓, 1,   mTOR↓, 4,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   PI3K↓, 3,   PTEN↑, 2,   RAS↓, 1,   STAT3↓, 6,   p‑STAT3↓, 1,   TAZ↓, 1,   TOP1↓, 1,   TOP2↓, 1,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AEG1↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   i-Ca+2?, 1,   cal2↓, 1,   CLDN1↓, 1,   E-cadherin↑, 2,   p‑FAK↓, 2,   Fibronectin↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   Twist↓, 3,   uPA↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 3,   Endoglin↑, 1,   Hif1a↓, 10,   NO↓, 2,   VEGF↓, 11,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

NHE1↓, 1,   P-gp⇅, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 10,   COX2↑, 1,   CRP↓, 1,   CXCR4↓, 1,   IFN-γ↓, 3,   IL1↓, 1,   IL10↓, 3,   IL1β↓, 5,   IL2↓, 1,   IL4↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 3,   JAK↓, 1,   M1↓, 1,   NF-kB↓, 12,   NF-kB↑, 2,   p‑NF-kB↑, 1,   PD-L1↓, 1,   PGE2↓, 3,   TLR4↓, 1,   TNF-α↓, 7,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 6,   Dose↝, 3,   Dose∅, 4,   eff↓, 1,   eff↑, 9,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 2,   AST↝, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   FOXM1↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 9,   LDH↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   cardioP↑, 2,   chemoP↑, 2,   chemoPv↑, 3,   cognitive?, 1,   neuroP↑, 1,   RenoP↑, 2,   Risk↓, 1,  
Total Targets: 275

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 18,   ARE↑, 1,   Bil↑, 2,   Catalase↑, 7,   Fenton↓, 2,   Ferroptosis↓, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 4,   GSH↑, 8,   GSR↓, 1,   GSR↑, 1,   GSTs↑, 3,   H2O2↓, 1,   HO-1↑, 10,   Keap1↓, 1,   lipid-P↓, 10,   MDA↓, 12,   MPO↓, 2,   NOX4↓, 2,   NQO1↑, 4,   NRF2↓, 1,   NRF2↑, 15,   RNS↓, 2,   ROS↓, 26,   SOD↓, 1,   SOD↑, 15,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 3,   Trx1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 2,   Insulin↑, 1,   MMP↑, 1,   MMP∅, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 3,   AMPK↑, 1,   p‑AMPK↑, 1,   cAMP↑, 2,   CRM↑, 1,   GlucoseCon↑, 1,   H2S↑, 1,   LDH↓, 4,   NADPH↑, 1,   PPARα↑, 1,   PPARγ↑, 2,   SIRT1↑, 2,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 3,   Apoptosis↓, 5,   BAX↓, 2,   BAX↑, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 4,   Casp3∅, 2,   Casp6↓, 1,   Casp9↓, 3,   Casp9∅, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 2,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 33,   iNOS↑, 1,   JNK↓, 4,   p‑JNK↓, 1,   MAPK↓, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   p38↓, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 2,   HSP70/HSPA5↑, 3,  

DNA Damage & Repair ⓘ

P53↓, 1,   PARP∅, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 2,   ERK↑, 2,   GSK‐3β↓, 4,   HDAC↓, 1,   IGF-1R↓, 1,   PI3K↓, 2,   STAT↓, 1,   p‑STAT1↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   APP↓, 3,   Ca+2↓, 3,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↑, 1,   TIMP1↑, 1,   TXNIP↓, 1,   VCAM-1↓, 4,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 1,   NO↓, 12,   NO↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 9,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 20,   ICAM-1↓, 4,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 15,   IL1β↑, 1,   IL2↓, 5,   IL4↓, 1,   IL6↓, 16,   IL8↓, 4,   INF-γ↓, 2,   Inflam↓, 22,   Inflam↑, 1,   IκB↑, 1,   JAK↓, 1,   p‑JAK1↓, 1,   p‑JAK2↓, 1,   MCP1↓, 1,   MIP‑1α↓, 1,   NF-kB↓, 18,   p‑NF-kB↓, 2,   PGE2↓, 9,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 22,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 2,   AChE↓, 4,   BDNF↑, 2,   ChAT↑, 3,   MAOA↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 8,   BACE↓, 3,   MAOB↓, 1,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 8,   BioAv↑, 7,   BioAv↝, 3,   BioEnh↑, 1,   Dose↝, 2,   eff↑, 4,   Half-Life↓, 1,   Half-Life↝, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   AST↓, 4,   Bil↑, 2,   BP↓, 3,   creat↓, 2,   GutMicro↑, 4,   IL6↓, 16,   LDH↓, 4,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 7,   cognitive↑, 14,   cognitive↝, 1,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 11,   neuroP↑, 19,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 3,   toxicity↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Diar↓, 1,  
Total Targets: 200

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
11 Silymarin (Milk Thistle) silibinin
9 Quercetin
7 Thymoquinone
6 Magnetic Fields
5 Baicalein
5 Curcumin
5 Propolis -bee glue
4 Alpha-Lipoic-Acid
4 Lycopene
4 Resveratrol
4 Sulforaphane (mainly Broccoli)
3 Ferulic acid
3 Pterostilbene
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Artemisinin
2 Boron
2 Caffeic acid
2 Chrysin
2 Fisetin
2 Luteolin
2 Magnolol
2 Rosmarinic acid
2 Rutin
2 Shikonin
2 Aflavin-3,3′-digallate
2 Vitamin K2
1 Anthocyanins
1 alpha Linolenic acid
1 Andrographis
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Cisplatin
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Lecithin
1 Dichloroacetate
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Ginkgo biloba
1 Melatonin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Oleocanthal
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Piperine
1 Piperlongumine
1 Kaempferol
1 acetaminophen
1 Taurine
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:159  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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