Iron Cancer Research Results

Iron, Iron: Click to Expand ⟱
Source:
Type:
Iron is an essential nutrient that is crucial for various cellular processes, including DNA synthesis, cell proliferation, and oxygen transport.
Cancer cells often have increased iron requirements due to their rapid growth and proliferation. Some tumors can acquire iron through various mechanisms, including upregulating iron transport proteins. This can support their growth and survival.
Excess iron can lead to the production of reactive oxygen species (ROS) through Fenton reactions, which can cause oxidative damage to DNA, proteins, and lipids. This oxidative stress can contribute to cancer development and progression.
Scientific Papers found: Click to Expand⟱
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
3284- ALA,    Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
- vitro+vivo, Park, NA
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT/SLC7A11↓, MMP↓, ATP↓,
3387- ART/DHA,    Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment
- Review, Var, NA
BioAv↓, lipid-P↑, Ferroptosis↑, Iron↑, GPx4↓, GSH↓, P53↑, ER Stress↑, PERK↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑, ROS↑, NRF2↑,
3390- ART/DHA,    Ferroptosis: The Silver Lining of Cancer Therapy
Ferroptosis↑, Iron↑, NCOA4↝, ROS↑, Fenton↑, Tf↓,
5379- ART/DHA,    Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation
Ferritin↓, Iron↑, Fenton↑, lipid-P↑, ChemoSen↑, ROS↑, eff↝,
5378- ART/DHA,    Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives
- Review, Var, NA
Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,
5377- ART/DHA,    Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein
- in-vitro, AML, NA
AntiCan↑, Ferroptosis↑, Iron↑, Mets↑, eff↑, GSH↝, eff↑, other↓, eff↑, other↓,
5376- ART/DHA,    Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, SW48 - in-vitro, BC, MDA-MB-453
Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,
568- ART/DHA,    Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity
- in-vitro, NA, MDA-MB-231 - in-vitro, NA, HeLa - in-vitro, NA, SkBr3 - in-vitro, NA, HCT116
Iron↝,
1076- ART/DHA,    The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
- Review, NA, NA
Ferroptosis↑, ROS↑, ER Stress↑, i-Iron↓, TumAuto↑, AMPK↑, mTOR↑, P70S6K↑, Fenton↑, lipid-P↑, ROS↑, ChemoSen↑, NRF2↑, NRF2↓,
5132- ART/DHA,    Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
Iron↓, TfR1/CD71↓, ROS↑,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
1447- Bos,    Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, BC, 4T1 - in-vitro, Nor, MCF10
tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,
5700- BRU,    Brusatol modulates the Nrf2/GCLC pathway to enhance ferroptosis in the treatment of oral squamous cell carcinoma
- in-vitro, Oral, CAL27
TumCG↓, Ferroptosis↑, TumCMig↓, NRF2↓, i-GSH↓, Iron↑, ROS↑,
5883- CAR,    Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study
- Trial, Nor, NA
*Dose↝, *HDL↓, *Bil↓, *Iron↓, *toxicity↓,
3700- Chol,    Eggs and Health Special Issue
- Review, Nor, NA
*other↑, *other↑, *Inflam↓, *ROS↓, *antiOx↑, *Iron↑, *cardioP∅,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
404- CUR,    Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1↑, LC3s↑, p62↓, Ferroptosis↑,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP/DDIT3↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,
5007- DSF,  Cu,    Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
- vitro+vivo, Oral, NA
AntiTum↑, TumCP↓, Ferroptosis↑, Iron↑, lipid-P↑, NRF2↓, HO-1↓,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, eff↑, NRF2↑, HO-1↑,
6891- Fer,    Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
- vitro+vivo, lymphoma, NA
TumCG↓, Ferroptosis↑, i-Iron↑, lipid-P↑, GPx4↓, ROS↑, Fenton↑, TfR1/CD71↝, FPN↝, LIP↑, TumCP↓, Apoptosis↑, TumCG↓,
6893- Fer,  VitC,    MRI Detection and Therapeutic Enhancement of Ferumoxytol Internalization in Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, U118MG
eff↑, i-Iron↑, AntiCan↑, ROS↓, H2O2↑,
948- Fuc,    Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia
- vitro+vivo, Bladder, T24/HTB-9 - in-vitro, Nor, HUVECs
p‑PI3k/Akt/mTOR↓, p‑p70S6↓, p‑4E-BP1↓, angioG↓, Hif1a↓, VEGF↑, TumCG↓, TumVol↓, TumW↓, Iron∅, ROS↓,
7046- GA,    Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, Ferroptosis↑, THBS1↓, EGR1↓, TGF-β1↓, SMAD2↓, SMAD3↓, GPx4↓, ROS↑, i-MDA↑, i-Iron↑,
7215- GBE,  Cisplatin,    Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer
- vitro+vivo, NSCLC, NA
AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,
7242- Gink,  Cisplatin,    Ginkgetin reverses cisplatin resistance in cervical cancer by regulating the Nrf2/HO-1 signaling pathway to induce ferroptosis
- in-vitro, Cerv, HeLa
TumCP↓, NRF2↓, ROS↑, i-Iron↑, GSH↓, SOD↓, Catalase↓, lipid-P↑, ACSL4↑, NO↓, GPx4↓, Ferroptosis↑,
1633- HCA,    Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
- in-vivo, NA, NA - in-vitro, Nor, HUVECs
*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,
2081- HNK,    Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, SW48 - in-vitro, Colon, HT-29 - in-vitro, Colon, LS174T - in-vitro, Colon, HCT8 - in-vitro, Colon, SW480 - in-vivo, NA, NA
tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
7562- HYP,  doxoR,    Hyperoside Inhibits Doxorubicin-Induced Ferroptosis in Cardiomyocytes via the Nrf2/GPX4 Pathway
- in-vivo, Nor, NA
*ROS↓, *Ferroptosis↓, *Apoptosis↓, *cardioP↑, *MDA↓, *SOD↑, *GPx↑, *i-Iron↓, *4-HNE↓, *GSH↑, *Ferritin↑, *ACSL4↓, *NRF2↑, *GPx4↑,
7803- IBC,    Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response
- in-vivo, Nor, NA - in-vitro, NA, HepG2
*hepatoP↓, *ALAT↑, *AST↑, *ROS↑, *MDA↑, *Catalase↓, *GSH↓, *GPx↓, *i-Iron↑,
7698- IP6,    Dietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability-A Narrative Review of Human Interventions
- Review, Nor, NA
*Iron↓, *Zn2+↓, *other↝, *IronCh↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7700- IP6,    A84 THE USE OF PHYTASE TO ENHANCE DIETARY IRON AND ZINC ABSORPTION - A SCOPING REVIEW
- Review, Nor, NA
*Iron↓, *eff↑,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7766- ISL,    Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice
- in-vivo, Stroke, NA
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
7777- ISL,    Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
- vitro+vivo, Gall, SGC996
TumCP↓, Ferroptosis↑, HO-1↑, GPx4↓, i-Iron↑, ROS↑, lipid-P↑, GSH/GSSG↓, TumCG↓, NRF2↑,
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,
7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *OS↑, *antiOx↑, *Aβ42↓, *AChE↓, *Aβ↓, *IRes↓, *p‑tau↓, *ROS↓, *Apoptosis↓, *Inflam↓, *Iron↝,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,

Showing Research Papers: 1 to 50 of 80
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 80

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FPN↝, 1,   LIP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Fenton↑, 5,   Ferroptosis↑, 30,   GPx↓, 3,   GPx4↓, 19,   GSH↓, 14,   GSH↝, 1,   i-GSH↓, 1,   GSH/GSSG↓, 2,   H2O2↑, 2,   HO-1↓, 3,   HO-1↑, 7,   Iron↓, 1,   Iron↑, 26,   Iron↝, 1,   Iron∅, 1,   i-Iron↓, 1,   i-Iron↑, 8,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↑, 18,   MDA↑, 9,   i-MDA↑, 2,   Mets↑, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NRF2↓, 7,   NRF2↑, 7,   OXPHOS↓, 2,   ROS↓, 2,   ROS↑, 32,   SOD↓, 2,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh∅, 1,   NCOA4↑, 3,   NCOA4↝, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 2,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   ETC↓, 1,   MMP↓, 5,   mtDam↑, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 3,   ALDOA↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ATG7↑, 1,   ENO1↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   HK2↓, 2,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 2,   MCT4↓, 1,   PDK1↓, 1,   PFKP↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PKM2↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   Apoptosis↑, 9,   BAX↑, 4,   Bcl-2↓, 3,   BIM↑, 1,   Casp↑, 2,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   Ferroptosis↑, 30,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↑, 1,   MCT1↓, 1,   MOMP↑, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   p38↑, 2,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   p‑p70S6↓, 1,   RET↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   p‑pRB↓, 1,   tumCV↓, 2,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   ATFs↑, 1,   CHOP/DDIT3↑, 4,   eIF2α↓, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   autolysosome↑, 1,   Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 2,   p‑p62↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNMTs↓, 1,   P53↑, 2,   cl‑PARP↑, 1,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   P21↓, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   CD44↓, 1,   cMET↓, 1,   CSCs↓, 1,   Diff↑, 1,   EMT↓, 2,   p‑ERK↑, 1,   FOSL1↑, 1,   GDF15↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 6,   mTOR↑, 1,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH1↓, 2,   P70S6K↑, 1,   PI3K↓, 4,   SOX2↓, 1,   STAT3↓, 2,   STAT3↑, 1,   TumCG↓, 12,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   BACH1↑, 1,   Ca+2↓, 1,   Ki-67↓, 1,   MMPs↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   SOX4↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 10,   TumMeta↓, 3,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   ATF4↑, 1,   EGR1↓, 1,   Hif1a↓, 4,   NO↓, 1,   REL↑, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT4↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   IL12↑, 1,   IL2↑, 1,   Imm↑, 3,   Inflam↓, 1,   IκB↑, 1,   NF-kB↓, 4,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 1,   TLR1↑, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 13,   eff↓, 7,   eff↑, 11,   eff↝, 1,   Half-Life↓, 1,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   Ferritin↓, 3,   GutMicro↑, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 1,   chemoP↑, 1,   neuroP↑, 1,   QoL↑, 2,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 3,   TumW↓, 4,  
Total Targets: 228

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Aβ42↓, 1,   IRes↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 4,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 1,   Ferroptosis↓, 2,   GPx↓, 1,   GPx↑, 2,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 3,   HDL↓, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↓, 7,   Iron↑, 1,   Iron↝, 1,   Iron∅, 1,   i-Iron↓, 2,   i-Iron↑, 1,   lipid-P↓, 1,   MDA↓, 4,   MDA↑, 1,   NRF2↑, 4,   ROS↓, 10,   ROS↑, 1,   i-ROS↑, 1,   SOD↓, 1,   SOD↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 2,   Zn2+↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 2,   ALAT↑, 1,   CREB↑, 1,   LDH↑, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Bax:Bcl2↓, 1,   Casp3↑, 1,   Ferroptosis↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 2,   other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   Zn2+↓, 1,  

Migration(tgid=13) ⓘ

PKA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 2,   PSD95↑, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   AST↑, 1,   Bil↓, 1,   Ferritin↑, 1,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 2,   cardioP∅, 1,   cognitive↑, 2,   hepatoP↓, 1,   hepatoP↑, 1,   motorD↑, 1,   neuroP↑, 4,   OS↑, 1,   toxicity↓, 3,  
Total Targets: 79

Scientific Paper Hit Count for: Iron, Iron
9 Artemisinin
6 Shikonin
5 Curcumin
4 Vitamin C (Ascorbic Acid)
4 salinomycin
4 Selenite (Sodium)
3 Cisplatin
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Isoliquiritigenin
2 Disulfiram
2 Copper and Cu NanoParticles
2 ferumoxytol
2 Huperzine A/Huperzia serrata
2 Luteolin
2 Mung Bean Sprouts
2 Myricetin
2 Quercetin
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Ashwagandha(Withaferin A)
1 Boswellia (frankincense)
1 brusatol
1 Carvacrol
1 Choline
1 Citric Acid
1 diet FMD Fasting Mimicking Diet
1 EGCG (Epigallocatechin Gallate)
1 Fucoidan
1 Gallic acid
1 Ginkgo biloba
1 Ginkgetin
1 HydroxyCitric Acid
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 doxorubicin
1 Isobavachalcone
1 isoorientin
1 Juglone
1 Melatonin
1 Metformin
1 Magnetic Fields
1 immunotherapy
1 Phenethyl isothiocyanate
1 Sulfasalazine
1 Spermidine
1 erastin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:160  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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