p38 Cancer Research Results

p38, p38: Click to Expand ⟱
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P38, or p38 MAPK (p38 mitogen-activated protein kinase), is a protein kinase that plays a significant role in cellular responses to stress, inflammation, and apoptosis (programmed cell death). It is part of the MAPK signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and survival.
It can have both tumor-suppressive and tumor-promoting effects, depending on the type of cancer and the cellular context.

-p38 activation can contribute to tumor progression by influencing inflammatory signaling and cell-cycle regulation.
-Overexpression can correlate with poor prognosis in some studies.
Scientific Papers found: Click to Expand⟱
4428- AgNPs,    p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells
- in-vitro, AML, Jurkat
toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,
4430- AgNPs,    Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells
- in-vitro, Colon, HCT116 - in-vitro, Nor, NCM460
*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,
335- AgNPs,  PDT,    Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy
- Review, NA, NA
ROS↑, GSH↓, GPx↑, Catalase↓, SOD↓, p38↑, BAX↑, Bcl-2↓,
324- AgNPs,  CPT,    Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
- in-vitro, Cerv, HeLa
ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
2000- AL,    Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, NA
selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,
246- AL,    Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway
- in-vitro, GC, MGC803
Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
249- AL,    Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway
- in-vitro, GC, MGC803
Casp3↑, p38↑, BAX↑, Bcl-2↓, p38↑, MAPK↑,
241- AL,    Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells
- in-vitro, neuroblastoma, SK-N-SH
Casp3↑, Casp9↑, p38↑, MAPK↑, Cyt‑c↑, Apoptosis↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
298- ALA,  Rad,    Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1
- in-vitro, BC, MDA-MB-231
Apoptosis↑, P53↑, p38↑, NF-kB↑, TumCCA↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1150- Api,    Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement
- in-vitro, Lung, EAhy926
eNOS↓, MMP9↓, Akt↓, p38↓, JNK↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
416- Api,    In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma
- vitro+vivo, NA, NA
Bax:Bcl2↑, P53↑, ROS↑, Casp9↑, Casp8↑, cl‑PARP1↑, p‑ERK⇅, p‑JNK↓, p‑p38↑, p‑Akt↓, cJun↓, NF-kB↓, EGFR↓, TumCCA↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
3392- ART/DHA,    Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways
- in-vitro, Nor, Hep3B - in-vivo, NA, NA
*Inflam↓, *NF-kB↓, *ROS↓, *p‑p38↓, *p‑ERK↓,
1148- ART/DHA,    Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
- in-vitro, AML, THP1
MMP9↓, EMMPRIN↓, p‑PKCδ↓, p‑JNK↓, p‑p38↓, p‑ERK↓,
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
5389- AsP,  Tras,    ASCORBYL PALMITATE ENHANCES ANTI-PROLIFERATIVE EFFECT OF TRASTUZUMAB IN HER2-POSITIVE BREAST CANCER CELLS
tumCV↓, eff↑, P53↑, BAX↑, Casp3↑, Casp8↑, Bcl-2↓, Apoptosis↑, p‑p38↓, ERK↓, PI3K↓,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, NA, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
1390- BBR,  Rad,    Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
- in-vitro, Pca, PC3
RadioS↑, Apoptosis↑, ROS↑, eff↑, BAX↑, Casp3↑, P53↑, p38↑, JNK↑, Bcl-2↓, ERK↓, HO-1↓,
2690- BBR,    Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice
- in-vivo, Diabetic, NA
*Inflam↓, *Th17↓, *Th1 response↓, *ERK↑, *p38↓, *JNK↓, *STAT1↓, *STAT4↓, *MAPK↓,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
3679- BBR,    Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway
- in-vivo, AD, NA
*Beclin-1↑, *LC3B↑, *p62↓, *ROS↓, *lipid-P↓, *MDA↓, *Ferroptosis↓, *TfR1/CD71↓, *FTH1↑, *memory↑, *JNK↓, *p38↓, *Aβ↓, *Inflam↓,
5182- BBR,    Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9
- in-vitro, SCC, SCC4
TumCMig↓, TumCI↓, p‑JNK↝, p‑ERK↝, p‑p38↝, IKKα↝, NF-kB↝, MMP2↓, MMP9↓,
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,
2758- BetA,    Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *GSH↑, *p‑p38↓, *p‑JNK↓, *p‑ERK↓, *NRF2↑, *HO-1↑, *MAPK↓, *heparanase↑, *antiOx↑,
2743- BetA,    Betulinic acid and the pharmacological effects of tumor suppression
- Review, Var, NA
ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumCCA↑, Sp1/3/4↓, STAT3↓, NF-kB↓, EMT↓, TOP1↓, MAPK↑, p38↑, JNK↑, Casp↑, Bcl-2↓, BAX↑, VEGF↓, LAMs↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
1421- Bos,    Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes
- in-vitro, AML, HL-60 - in-vitro, Nor, NA
ROS↑, NADPH↝, 5LO↓, Ca+2↑, p38↑, p42↑,
1298- CGA,    Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells
- in-vitro, Lung, A549
Bcl-2↓, BAX↑, Casp3↑, p38↑, JNK↑, Nanog↓, SOX2↓, OCT4↓,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
159- CUR,    Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment
- in-vitro, Pca, DU145
ROS↑, p‑Jun↑, p‑p38↑, TumAuto↑, Casp8↑, Casp9↑, Akt↓, ERK↓, p38↓,
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
TumAuto↑, LC3II↑, Beclin-1↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
p38↓, MKP5↑, TNF-α↓, COX2↓, NF-kB↓,
691- EGCG,    Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer
- Review, NA, NA
Apoptosis↑, necrosis↑, TumAuto↑, ERK↓, p38↓, NF-kB↓, VEGF↓,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2850- FIS,    Fisetin regulates TPA-induced breast Cancer cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways
- in-vitro, BC, MCF-7
TumCI↓, PKCδ↓, ROS↓, ERK↑, p38↓, NF-kB↓, MMP9↓,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,

Showing Research Papers: 1 to 50 of 140
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 140

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↓, 1,   ATF3↑, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 3,   GSR↑, 1,   GSTs↓, 1,   HO-1↓, 1,   HO-1↑, 3,   Iron↑, 1,   lipid-P↑, 2,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 27,   ROS⇅, 2,   SIRT3↑, 1,   SOD↓, 3,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   mitResp↓, 1,   MKP5↑, 1,   MMP↓, 13,   MPT↑, 1,   p42↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ACC↑, 1,   AMPK↓, 1,   AMPK↑, 2,   cMyc↓, 1,   p‑CREB↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 2,   LDHA↓, 1,   NADPH↑, 2,   NADPH↝, 1,   p‑PDK1↓, 1,   p‑PIK3R1↓, 1,   PKM2↓, 1,   PPARγ↑, 2,   p‑S6↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 12,   p‑Akt↓, 6,   p‑Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 15,   mt-Apoptosis↑, 1,   BAD↑, 3,   Bak↑, 1,   BAX↑, 20,   Bax:Bcl2↑, 2,   Bcl-2↓, 19,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↑, 1,   BIM↑, 2,   Casp↑, 5,   Casp12↑, 2,   Casp3↑, 19,   cl‑Casp3↑, 3,   Casp6↑, 1,   Casp7↑, 1,   Casp8↑, 8,   Casp9↑, 11,   cl‑Casp9↑, 1,   Chk2↓, 1,   p‑Chk2↓, 1,   CK2↓, 1,   Cyt‑c↑, 16,   Diablo↑, 2,   DR5↑, 4,   FADD↑, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 1,   HEY1↓, 1,   hTERT/TERT↓, 1,   ICAD↓, 1,   iNOS↓, 1,   JNK↓, 2,   JNK↑, 8,   p‑JNK↓, 2,   p‑JNK↑, 2,   p‑JNK↝, 1,   MAPK↓, 1,   MAPK↑, 11,   Mcl-1↓, 4,   MDM2↓, 1,   Myc↓, 1,   necrosis↑, 1,   p27↑, 2,   p38↓, 7,   p38↑, 26,   p‑p38↓, 4,   p‑p38↑, 6,   p‑p38↝, 1,   p‑RSK↓, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   RET↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

cJun↓, 2,   p‑cJun↑, 1,   H3↑, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   eIF2α↓, 1,   ER Stress↑, 5,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 2,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   BNIP3↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

CHK1↓, 2,   DNAdam↑, 8,   p16↑, 1,   P53↑, 11,   PARP↑, 3,   cl‑PARP↑, 4,   cl‑PARP1↑, 1,   PCNA↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 3,   p‑CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 6,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   CycD3↓, 1,   cycE/CCNE↓, 3,   P21↑, 8,   p‑RB1↓, 2,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

p‑4E-BP1↓, 1,   AR-V7?, 1,   CD44↓, 1,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 4,   EMT↓, 5,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 4,   p‑ERK↑, 2,   p‑ERK⇅, 1,   p‑ERK↝, 1,   FOXM1↓, 1,   FOXO3↑, 2,   Gli↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC10↑, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1↓, 1,   Jun↓, 1,   p‑Jun↑, 1,   MAP2K1/MEK1↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 7,   PI3K↑, 2,   PTEN↑, 1,   SCF↓, 1,   SOX2↓, 2,   STAT3↓, 7,   STAT3↑, 1,   p‑STAT3↓, 1,   p‑STAT5↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TumCG?, 1,   Wnt?, 1,   Wnt↓, 3,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 8,   CAFs/TAFs↓, 1,   cal2↓, 1,   E-cadherin↑, 2,   EMMPRIN↓, 1,   ER-α36↓, 2,   FAK↓, 2,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   Ki-67↓, 1,   LAMs↓, 1,   MET↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 11,   MMPs↓, 2,   N-cadherin↓, 2,   PKCδ↓, 1,   p‑PKCδ↓, 1,   Slug↓, 2,   Snail?, 1,   Snail↓, 2,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 2,   Twist↓, 4,   uPA↓, 5,   Vim↓, 2,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   ATF4↓, 1,   ATF4↑, 1,   EGFR↓, 2,   eNOS↓, 2,   Hif1a↓, 4,   NO↓, 1,   PDGFR-BB↓, 1,   VEGF↓, 11,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   CRP↓, 1,   IFN-γ↓, 1,   IKKα↑, 1,   IKKα↝, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 2,   IL8↓, 2,   Inflam↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   M2 MC↓, 1,   NF-kB↓, 13,   NF-kB↑, 2,   NF-kB↝, 2,   p65↓, 1,   SOCS1↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 2,   CDK6↑, 1,   CYP19?, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 5,   eff↑, 13,   eff↝, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 2,   CRP↓, 1,   E6↓, 3,   E7↓, 3,   EGFR↓, 2,   FOXM1↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 1,   RenoP↑, 1,   toxicity↝, 2,  
Total Targets: 305

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 10,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 2,   Fenton↓, 1,   Ferroptosis↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GSH↑, 4,   GSTs↑, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 4,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 6,   Prx↑, 1,   ROS↓, 7,   ROS∅, 1,   SOD↑, 4,   SOD2↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,   IronCh↑, 2,   TfR1/CD71↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ALAT↓, 1,   AMPK↑, 1,   glucose↑, 1,   H2S↑, 1,   LDH↓, 2,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   Casp3?, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   JNK↓, 4,   p‑JNK↓, 2,   MAPK↓, 2,   MAPK↑, 1,   p‑MAPK↓, 1,   p38↓, 5,   p38↑, 1,   p‑p38↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B↑, 1,   p62↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 3,   p‑ERK↓, 2,   PI3K↓, 1,   PI3K↑, 1,   PTEN↓, 1,   STAT1↓, 1,   STAT4↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↓, 1,   heparanase↑, 1,   MMP3↓, 1,   MMP9↓, 1,   PKCδ↑, 1,   VCAM-1↓, 2,  

Angiogenesis & Vasculature ⓘ

eNOS↑, 1,   NO↓, 2,   NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 3,   ICAM-1↓, 1,   IL1β↓, 2,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 8,   NF-kB↓, 5,   PGE2↓, 3,   PGE2↑, 1,   Th1 response↓, 2,   Th17↓, 1,   Th2↑, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   ChAT↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   Bil↑, 1,   BP↓, 1,   creat↓, 1,   GutMicro↑, 2,   IL6↓, 3,   LDH↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 4,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 4,   memory↑, 3,   neuroP↑, 4,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 112

Scientific Paper Hit Count for: p38, p38
10 Thymoquinone
8 Allicin (mainly Garlic)
8 Quercetin
7 Fisetin
6 Magnetic Fields
6 Piperlongumine
6 Silymarin (Milk Thistle) silibinin
6 Shikonin
5 Berberine
5 Resveratrol
5 Sulforaphane (mainly Broccoli)
4 Silver-NanoParticles
4 Artemisinin
4 Curcumin
4 Luteolin
4 Vitamin K2
3 Radiotherapy/Radiation
3 Apigenin (mainly Parsley)
3 Betulinic acid
3 Chrysin
3 Lycopene
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Boswellia (frankincense)
2 EGCG (Epigallocatechin Gallate)
2 Hydrogen Gas
2 Juglone
2 Phenylbutyrate
2 Piperine
2 Vitamin C (Ascorbic Acid)
1 Photodynamic Therapy
1 Camptothecin
1 alpha Linolenic acid
1 Ascorbyl Palmitate
1 Trastuzumab
1 Chlorogenic acid
1 Ginger/6-Shogaol/Gingerol
1 Ferulic acid
1 Gambogic Acid
1 doxorubicin
1 Ginkgo biloba
1 Grapeseed extract
1 Magnolol
1 Magnetic Field Rotating
1 Mushroom Chaga
1 Myricetin
1 Naringin
1 Propolis -bee glue
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Phenethyl isothiocyanate
1 Kaempferol
1 raloxifen
1 tamoxifen
1 Genistein (soy isoflavone)
1 Rosmarinic acid
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 5-fluorouracil
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:235  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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