BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱

Source:

Type: Proapototic protein

BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.

Scientific Papers found: Click to Expand⟱

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

-

in-vitro,

CRC,

NA

AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5434-

AG,

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview

-

Review,

Liver,

NA

AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

5436-

AG,

Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice

-

in-vivo,

HCC,

NA

HCC H22-bearing mice

TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,

5238-

AgNPs,

β-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

-

in-vitro,

HCC,

HepG2

TumCP↓, ROS↑, NRF2↑, BAX↑, P53↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓,

4388-

AgNPs,

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

-

in-vitro,

Cerv,

NA

47.5 nm

tumCV↓, CSCs↓, selectivity↑, Apoptosis↑, ROS↑, LDH↓, Casp3↑, BAX↑, Bak↑, cMyc↑, MMP↓,

4417-

AgNPs,

Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways

-

in-vitro,

BC,

MDA-MB-231

ROS↑, MDA↑, COX2↑, IL1β↑, TNF-α↑, GSH↓, Cyt‑c↑, Casp3↑, BAX↑, Bcl-2↓, LDH↓, cycD1/CCND1↓, CDK2↓, TumCCA↑, mt-Apoptosis↑,

4416-

AgNPs,

Efficacy of curcumin-synthesized silver nanoparticles on MCF-7 breast cancer cells

-

in-vitro,

BC,

MCF-7

TumCMig↓, Apoptosis↑, BAX↑, P53↑, Bcl-2↓,

4415-

AgNPs,

SDT,

CUR,

Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells

-

in-vitro,

BC,

MCF-7

29.3 ± 5.6 nm

 48.23 µg/ml

SDT was performed using an US frequency of 1 MHz, intensity of 2 W/cm2, and a distance of 2 cm.

tumCV↓, BAX↑, Casp3↑, Bcl-2↓, eff↑, ROS↑, sonoS↑, eff↑, MMP↓, Cyt‑c↑,

4427-

AgNPs,

Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells

-

in-vitro,

Lung,

A549

tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,

4430-

AgNPs,

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

-

in-vitro,

Colon,

HCT116

20 nm

-

in-vitro,

Nor,

NCM460

*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

4584-

AgNPs,

Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells

-

in-vitro,

Pca,

DU145

selectivity↑, ROS↑, BAX↑, cl‑Casp3↑, p‑PARP↑, TumCCA↑, cycD1/CCND1↓, p27↑, P21↑, AntiCan↑,

343-

AgNPs,

Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma

-

in-vitro,

PC,

PANC1

 3.19 or 1.67 ug/mL

BAX↑, Bcl-2↓, P53↑, TumAuto↑,

335-

AgNPs,

PDT,

Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy

-

Review,

NA,

NA

ROS↑, GSH↓, GPx↑, Catalase↓, SOD↓, p38↑, BAX↑, Bcl-2↓,

324-

AgNPs,

CPT,

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells

-

in-vitro,

Cerv,

HeLa

ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,

369-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, GSH↓, DNAdam↑, lipid-P↝, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Casp9↑, Casp3↑, JNK↑,

363-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

ROS↑, lipid-P↑, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, JNK↑,

348-

AgNPs,

Induction of p53 mediated mitochondrial apoptosis and cell cycle arrest in human breast cancer cells by plant mediated synthesis of silver nanoparticles from Bergenia ligulata (Whole plant)

-

in-vitro,

BC,

MCF-7

Apoptosis↑, ROS↑, MMP↓, P53↑, BAX↑, cl‑Casp3↑,

350-

AgNPs,

Cytotoxic and Apoptotic Effects of Green Synthesized Silver Nanoparticles via Reactive Oxygen Species-Mediated Mitochondrial Pathway in Human Breast Cancer Cells

-

in-vitro,

BC,

MCF-7

 40ug/mL

ROS↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

397-

AgNPs,

GEM,

Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

-

in-vitro,

Ovarian,

A2780S

50 nM GEM, 50 nM AgNPs

6nm

P53↑, P21↑, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, MMP↓,

396-

AgNPs,

Systemic Evaluation of Mechanism of Cytotoxicity in Human Colon Cancer HCT-116 Cells of Silver Nanoparticles Synthesized Using Marine Algae Ulva lactuca Extract

-

in-vitro,

Colon,

HCT116

P53↑, BAX↑, P21↑, Bcl-2↓,

395-

AgNPs,

The apoptotic and genomic studies on A549 cell line induced by silver nitrate

-

in-vitro,

Lung,

A549

13.5uM@72hr

BAX↑, MMP↓,

393-

AgNPs,

Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity

-

in-vitro,

NA,

HCT116

mtDam↑, ROS↑, TumCCA↑, Casp3↑, BAX↑, Bcl-2↓, P53↑,

381-

AgNPs,

Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression

-

in-vitro,

Bladder,

5637

 51.12 µg/mL

 more toxic with smaller NPs (this was 30nm)

ROS↑, BAX↑, Bcl-2↓, Casp3↑, Casp7↑, Apoptosis↑,

382-

AgNPs,

Investigation the apoptotic effect of silver nanoparticles (Ag-NPs) on MDA-MB 231 breast cancer epithelial cells via signaling pathways

-

in-vitro,

BC,

MDA-MB-231

Apoptosis↑, BAX↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, p‑ERK↓, cycD1/CCND1↓,

383-

AgNPs,

In vitro and in vivo evaluation of anti-tumorigenesis potential of nano silver for gastric cancer cells

-

in-vitro,

GC,

MKN45

 22.4 µg/mL

Ki-67↓, TumCP↓, CD34↓, BAX↑,

386-

AgNPs,

Tam,

Synergistic anticancer effects and reduced genotoxicity of silver nanoparticles and tamoxifen in breast cancer cells

-

in-vitro,

BC,

MCF-7

35uM(AgNP)+20uM(Tam)

-

in-vitro,

BC,

MDA-MB-231

P53↑, BAX↑, Bcl-2↓, Casp3↑, DNAdam↑, TumCCA↑,

387-

AgNPs,

Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells

-

in-vitro,

Colon,

HT-29

33.45 μg/mL

Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1↑, CHOP↑, LC3s↑, XBP-1↑,

388-

AgNPs,

Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells

-

in-vitro,

BC,

MCF-7

 5 and 10 µg/mL

ROS↑, Casp3↑, BAX↑, P53↑, Casp↑, Cyt‑c↑, MMP↓, DNAdam↑, Bcl-2↓, BAX↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

-

in-vitro,

Testi,

F9

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

2287-

AgNPs,

Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine

-

in-vitro,

Nor,

HUVECs

*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,

5356-

AL,

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects

-

Review,

GC,

NA

Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

-

Review,

GC,

NA

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

1290-

AL,

Effect of allicin on the expression of Bcl-2 and Bax protein in LM-8 cells

-

in-vitro,

OS,

LM8

5.0, 10.0 and 15.0 mg/L) for 24, 48 and 72

Bcl-2↓, BAX↑, Apoptosis↑, TumCG↓,

245-

AL,

Allicin: a promising modulator of apoptosis and survival signaling in cancer

-

Review,

Var,

NA

Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,

246-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

-

in-vitro,

GC,

MGC803

 0-10ug/ml

Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,

248-

AL,

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

-

in-vitro,

GBM,

U87MG

Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,

249-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

-

in-vitro,

GC,

MGC803

  0.1, 1 and 10 μg/ml

Casp3↑, p38↑, BAX↑, Bcl-2↓, p38↑, MAPK↑,

251-

AL,

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

-

in-vitro,

ESCC,

Eca109

 0-100ug/ml

-

in-vitro,

ESCC,

EC9706

-

in-vivo,

NA,

NA

5mg/kg/bw

mice

Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,

254-

AL,

Allicin and Cancer Hallmarks

-

Review,

Var,

NA

NRF2⇅, BAX↑, Bcl-2↓, Fas↑, MMP↓, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Casp12↑, GSH↓, TumCCA↑, ROS↑, antiOx↓,

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

-

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

235-

AL,

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

-

in-vitro,

GBM,

U87MG

 90 μM

Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

277-

ALA,

α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation

-

in-vitro,

Pca,

22Rv1

 500 μM

-

in-vitro,

Pca,

C4-2B

ROS↑, Hif1a↑, JNK↑, Casp3↑, P21↑, BAX↑, Bcl-xL↓, cFos↓,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

-

Review,

NA,

NA

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

259-

ALA,

Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells

-

in-vitro,

Liver,

HepG2

500 µM for 24, 48 and 72 h

-

in-vitro,

Liver,

FaO

Cyc↓, P21↑, ROS↑, p‑P53↑, BAX↑, Cyt‑c↑, Casp↑, survivin↓, JNK↑, Akt↓,

260-

ALA,

The effects of alpha-lipoic acid on breast of female albino rats exposed to malathion: Histopathological and immunohistochemical study

-

in-vivo,

BC,

NA

 rats exposed to malathion

PCNA↓, P53↓, Apoptosis↑, BAX↑,

258-

ALA,

Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells

-

in-vitro,

BC,

MDA-MB-231

  250, 500, and 1000 µmol/L

TumCG↓, p‑Akt↓, Akt↓, HER2/EBBR2↓, Bcl-2↓, BAX↑, Casp3↑,

Showing Research Papers: 1 to 50 of 440
Page 1 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 440

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

antiOx↓, 2, Catalase↓, 1, Ferroptosis↑, 1, frataxin↑, 1, GPx↓, 1, GPx↑, 1, GPx4↓, 2, GSH↓, 6, c-Iron↑, 1, lipid-P↑, 2, lipid-P↝, 1, MDA↑, 1, NRF2↑, 2, NRF2⇅, 1, ROS↑, 29, SOD↓, 2, xCT↓, 1,

Mitochondria & Bioenergetics ⓘ

AIF↑, 2, MMP↓, 16, mtDam↑, 2, Raf↓, 1,

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1, AMPK↑, 1, cMyc↑, 1, H2S↑, 1, LDH↓, 3, LDH↑, 1, LDHA↓, 1, NADPH↓, 1, PDH↑, 1, PI3k/Akt/mTOR↝, 1, SIRT1↓, 1, SREBP1↓, 1,

Cell Death ⓘ

Akt↓, 6, p‑Akt↓, 2, Apoptosis↓, 1, Apoptosis↑, 20, mt-Apoptosis↑, 1, Bak↑, 2, BAX↑, 51, Bax:Bcl2↑, 2, Bcl-2↓, 35, Bcl-2↑, 2, Bcl-xL↓, 3, BID↑, 2, Casp↑, 4, Casp12↑, 2, Casp3↑, 29, cl‑Casp3↑, 3, Casp6↑, 1, Casp7↑, 1, Casp8↑, 5, Casp9↑, 17, Cyt‑c↑, 17, Fas↑, 6, Ferroptosis↑, 1, hTERT/TERT↓, 1, JNK↓, 1, JNK↑, 7, MAPK↓, 1, MAPK↑, 4, Mcl-1↓, 1, p27↑, 2, p38↑, 7, p‑p38↑, 1, survivin↓, 3, Telomerase↓, 1, TumCD↑, 1,

Kinase & Signal Transduction ⓘ

AMPKα↑, 1, HER2/EBBR2↓, 1,

Transcription & Epigenetics ⓘ

sonoS↑, 1, tumCV↓, 5,

Protein Folding & ER Stress ⓘ

CHOP↑, 1, ER Stress↑, 2, XBP-1↑, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2, LC3s↑, 1, TumAuto↑, 2,

DNA Damage & Repair ⓘ

CHK1↑, 1, DNA-PK↑, 1, DNAdam↑, 9, MGMT↓, 1, P53↓, 1, P53↑, 17, p‑P53↑, 2, PARP↑, 1, p‑PARP↑, 1, cl‑PARP↑, 1, PCNA↓, 1, γH2AX↑, 1,

Cell Cycle & Senescence ⓘ

CDK1↓, 1, CDK2↓, 2, CDK4↓, 2, Cyc↓, 1, CycB/CCNB1↓, 1, CycB/CCNB1↑, 1, cycD1/CCND1↓, 6, cycE/CCNE↓, 2, P21↑, 13, TumCCA↑, 12,

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1, CD34↓, 1, CD44↓, 1, cFos↓, 1, CSCs↓, 2, EMT↓, 3, ERK↓, 1, ERK↑, 1, p‑ERK↓, 1, p‑ERK↑, 1, GSK‐3β↓, 2, MAP2K1/MEK1↓, 1, mTOR↓, 3, Nanog↓, 1, NOTCH1↓, 2, NOTCH3↓, 1, OCT4↓, 1, PI3K↓, 4, PTEN↑, 2, TumCG↓, 6, Wnt↓, 2,

Migration ⓘ

Ca+2↑, 2, FAK↓, 1, ITGB1↓, 1, ITGB3↓, 1, Ki-67↓, 1, miR-133a-3p↑, 1, MMP2↓, 1, MMP9↓, 2, MMPs↓, 1, PKCδ↓, 1, Snail↓, 1, TGF-β↓, 2, TumCI↓, 1, TumCMig↓, 1, TumCP↓, 5, TumMeta↓, 1, Vim↓, 3, Zeb1↓, 1, β-catenin/ZEB1↓, 2,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, EGFR↓, 1, EPR↑, 1, HIF-1↓, 1, Hif1a↓, 2, Hif1a↑, 1, VEGF↓, 1,

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

COX2↑, 1, CXCR4↓, 1, IL12↑, 1, IL1β↑, 1, IL2↑, 2, IL6↑, 1, Imm↑, 2, Inflam↓, 1, NF-kB↓, 3, NF-kB↑, 1, PD-L1↓, 1, TNF-α↑, 3,

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1, CDK6↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 1, ChemoSen↑, 6, eff↓, 2, eff↑, 8, MDR1↓, 1, RadioS↑, 1, selectivity↑, 5,

Clinical Biomarkers ⓘ

EGFR↓, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, IL6↑, 1, Ki-67↓, 1, LDH↓, 3, LDH↑, 1, PD-L1↓, 1,

Functional Outcomes ⓘ

AntiCan↑, 5, AntiTum↑, 2, chemoP↑, 1, QoL↑, 2, toxicity↓, 1, toxicity↝, 1,
Total Targets: 184

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, GSH↓, 1, MDA↑, 1, NRF2↑, 1, ROS↓, 1, ROS↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↓, 1, MMP↓, 1,

Cell Death ⓘ

BAX↑, 1, Bcl-2↓, 1, Casp3↑, 1,

Autophagy & Lysosomes ⓘ

LC3II↑, 1, p62↑, 1,

Migration ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, eff↓, 1,

Clinical Biomarkers ⓘ

GutMicro↑, 1,

Functional Outcomes ⓘ

chemoP↑, 1, toxicity↓, 1, toxicity∅, 1,

Infection & Microbiome ⓘ

Bacteria↓, 1,
Total Targets: 21

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX

29 Silver-NanoParticles
27 Quercetin
23 Curcumin
19 Thymoquinone
17 Baicalein
14 Apigenin (mainly Parsley)
12 Allicin (mainly Garlic)
12 Propolis -bee glue
11 EGCG (Epigallocatechin Gallate)
10 Betulinic acid
10 Lycopene
9 Ashwagandha(Withaferin A)
9 Sulforaphane (mainly Broccoli)
9 Berberine
9 Luteolin
9 Resveratrol
8 Fisetin
8 Magnetic Fields
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
7 Garcinol
7 Graviola
7 Phenethyl isothiocyanate
6 Artemisinin
6 Ellagic acid
6 Emodin
6 Juglone
5 Cisplatin
5 Alpha-Lipoic-Acid
5 Chrysin
5 Honokiol
5 Rosmarinic acid
4 5-fluorouracil
4 Astragalus
4 Andrographis
4 Melatonin
4 Astaxanthin
4 Bufalin/Huachansu
4 Boron
4 Boswellia (frankincense)
4 Paclitaxel
4 Gambogic Acid
4 Magnolol
4 Urolithin
3 Gemcitabine (Gemzar)
3 Chemotherapy
3 Caffeic acid
3 chitosan
3 Ursolic acid
3 Ferulic acid
3 Oleuropein
3 Piperlongumine
3 Parthenolide
3 Aflavin-3,3′-digallate
2 tamoxifen
2 Metformin
2 immunotherapy
2 beta-glucans
2 Berbamine
2 Radiotherapy/Radiation
2 Biochanin A
2 borneol
2 Capsaicin
2 Crocetin
2 Docetaxel
2 HydroxyTyrosol
2 Laetrile B17 Amygdalin
2 Naringin
2 Nimbolide
2 Propyl gallate
2 Piperine
2 Plumbagin
2 Pterostilbene
2 salinomycin
2 Selenium
2 Selenite (Sodium)
2 Vitamin K2
1 Coenzyme Q10
1 SonoDynamic Therapy UltraSound
1 Photodynamic Therapy
1 Camptothecin
1 Aspirin -acetylsalicylic acid
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Brucea javanica
1 Bromelain
1 Butyrate
1 Carvacrol
1 Chlorogenic acid
1 Prebiotic
1 Citric Acid
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Date Fruit Extract
1 Electrical Pulses
1 Gallic acid
1 carboplatin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Hydroxycinnamic-acid
1 Hyperthermia
1 Licorice
1 Magnetic Field Rotating
1 Phenylbutyrate
1 sericin
1 Psoralidin
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Auranofin
1 doxorubicin
1 Salvia miltiorrhiza
1 Taurine
1 triptolide
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 VitK3,menadione
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:26  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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