survivin Cancer Research Results

survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6463- 1,8-Cin,    Antitumor effect of 1, 8-cineole against colon cancer
- vitro+vivo, Colon, HCT116
TumCP↓, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3↑, TumVol↓,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
9256- Acai, EO,    Pro-apoptotic activities of polyphenolics from açai (Euterpe oleracea Martius) in human SW-480 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, Colon, SW480
TumCG↓, *toxicity↓, selectivity↑, ROS↓, NF-kB↓, ICAM-1↓, VCAM-1↓, Sp1/3/4↓, Bcl-2↓, VEGF↓, survivin↓, cl‑Cyt‑c↑, cl‑Casp3↑, PARP1↓,
4405- AgNPs,    Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis
- in-vitro, OS, NA
Apoptosis↑, other↑, ROS↑, eff↑, P53↝, Apoptosis↑, cl‑Casp3↑, survivin↓, MMP↓, Cyt‑c↑,
379- AgNPs,    Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo
- in-vivo, Lung, H1299
NF-kB↓, Bcl-2↓, Casp3↑, survivin↑, TumCG↓,
9226- AITC,  Cisplatin,    Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo
- vitro+vivo, Var, NA
ChemoSen↑, Apoptosis↑, Bcl-2↓, survivin↓, TumCG↓, toxicity↓, TumCCA↑, β-Tubulin↓, CDC2↓, CycB/CCNB1↓, CDC25↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, Var, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, Synergy↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
259- ALA,    Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
- in-vitro, Liver, HepG2 - in-vitro, Liver, FaO
Cyc↓, P21↑, ROS↑, p‑P53↑, BAX↑, Cyt‑c↑, Casp↑, survivin↓, JNK↑, Akt↓,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
- in-vitro, PC, NA
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, Synergy↑,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, Var, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, Synergy↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, ChemoSen↑, Synergy↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
208- Api,    Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer
- in-vivo, Pca, PC3 - in-vivo, Pca, DU145
XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, BAX↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, Var, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
565- ART/DHA,    Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma
- in-vitro, HCC, NA
STAT↓, IL6↓, pro‑Casp3↝, Bcl-xL↝, survivin↝,
1360- Ash,  immuno,    Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer
- in-vitro, Lung, H1650 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP/DDIT3↑, p‑eIF2α↑, ICD↑, eff↑,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP/DDIT3↑, DR5↑, Dose↝, BG↓, DNMTs↓,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2/PTGS2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
1142- Ash,    Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
- Review, BC, MCF7 - NA, BC, MDA-MB-231 - NA, Nor, HMEC
Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,
1053- Ba,  docx,    Baicalin, a Potent Inhibitor of NF-κB Signaling Pathway, Enhances Chemosensitivity of Breast Cancer Cells to Docetaxel and Inhibits Tumor Growth and Metastasis Both In Vitro and In Vivo
- in-vivo, BC, 4T1
TumCP↓, Apoptosis↑, ROS↑, Bax:Bcl2↑, NF-kB↓, ChemoSen↑, survivin↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, Synergy↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
2603- Ba,    Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, Apoptosis↑, Cav1↓, p‑Akt↓, p‑mTOR↓, Bax:Bcl2↑, survivin↓, cl‑PARP↑, BioAv↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
5556- BBM,    Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells
- in-vitro, Melanoma, NA
TumCP↓, ChemoSen↑, TumCCA↑, IKKα↓, p65↓, Bcl-xL↓, BID↓, survivin↓,
5550- BBM,  docx,  Chit,    Co-Delivery of Docetaxel and Berbamine by Chitosan/Sulfobutylether-β-Cyclodextrin Nanoparticles for Enhancing Bioavailability and Anticancer Activities
- in-vivo, Var, NA
eff↑, BioAv↑, Apoptosis↑, survivin↓,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
5548- BBR,    Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway
- in-vitro, HCC, SMMC-7721 cell
TumCG↓, Apoptosis↑, Cyt‑c↑, BAX↑, P53↑, Bcl-2↓, survivin↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, VEGF↓, TumVol↓, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, TumCP↓, TumCMig↓, TumCG↓, Dose↝,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
- in-vitro, Var, NA
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2/PTGS2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,
2745- BetA,    Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
- in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vivo, NA, NA
Apoptosis↑, TumCG↓, Sp1/3/4↓, survivin↓, VEGF↓, p65↓, EGFR↓, cycD1/CCND1↓, ROS↑, MMP↓,
2754- BetA,    Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
- in-vitro, Pca, LNCaP
VEGF↓, survivin↓, Sp1/3/4↓, Casp↑, PARP↑, survivin↓, angioG↓,
5720- BF,    Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- in-vitro, NSCLC, NA
STAT3↓, CycB/CCNB1↓, CDC2↓, Mcl-1↓, survivin↓, VEGF↓, Bcl-2↓, BAX↑, Casp3↑,
9206- BITC,    Inhibitory effects of benzyl isothiocyanate on the proliferation of prostate and breast cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Dose↝, tumCV↓, TumCP↓, eff↝, survivin↓, TGFβR1↓, Casp3↑,
9171- BITC,    Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
p‑P53↑, Apoptosis↑, cl‑PARP↑, Ki-67↓, survivin↓, XIAP↓, p‑ERK↑, p‑CREB↑, MDM2↑,
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31/PECAM-1↓, NF-kB↓, COX2/PTGS2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
1422- Bos,    Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family
- in-vitro, CRC, NA - in-vivo, NA, NA
5LO↓, TumCG↓, Let-7↑, miR-200b↑, NF-kB↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, VEGF↓, Bcl-xL↓, survivin↓, IAP1↓, XIAP↓, TumCG↓, CDK6↓, Vim↓, E-cadherin↑,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
5697- BRU,    Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
- in-vitro, HNSCC, NA
NRF2↓, STAT3↓, proCasp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, Hif1a↓, cMyc↓, JNK↑, MAPK↑, tumCV↓, ROS∅,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5877- CA,    Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↑, Casp9↑, Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↓, MDM2↓, ROS↑, eff↓, STAT3↓, survivin↓, cycD1/CCND1↓,
5866- CA,    Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480 - in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, Synergy↑,
5836- CAP,    In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, Bxpc-3
tumCV↓, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, survivin↓, Cyt‑c↑, AIF↑, selectivity↑, JNK↑, TumCG↓,

Showing Research Papers: 1 to 50 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   antiOx⇅, 1,   Catalase↓, 1,   Copper↑, 1,   Fenton↑, 1,   frataxin↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 14,   GSH↑, 2,   GSTs↑, 2,   HO-1↓, 5,   HO-1↑, 9,   HO-2↓, 1,   lipid-P↓, 3,   lipid-P↑, 3,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 3,   NRF2↓, 7,   NRF2↑, 13,   Prx4↑, 1,   ox-PrxI↑, 1,   ROS↓, 9,   ROS↑, 97,   ROS⇅, 5,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 3,   SOD↓, 2,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC?, 1,   TAC↑, 1,   Thiols↓, 1,   Trx2↓, 1,   TrxR↓, 3,   TrxR1↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 7,   CDC25↓, 11,   compI↓, 1,   compIII↓, 1,   ETC↓, 1,   HSP60/HSPD1↓, 3,   HTRA2/Omi/PARK13↑, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PHB↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 2,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 10,   ATP↓, 11,   ECAR↝, 1,   FASN↓, 1,   FBI-1↓, 1,   GLO-I↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 11,   GSK‐3β↓, 10,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 3,   LDHA↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 4,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 6,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 116,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 70,   BAX⇅, 1,   Bax:Bcl2↑, 16,   Bcl-2↓, 115,   Bcl-2↑, 4,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 57,   Bcl-xL↝, 1,   BID↓, 3,   BID↑, 6,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 1,   Casp↑, 22,   Casp↝, 2,   cl‑Casp↑, 1,   Casp10↑, 3,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 90,   cl‑Casp3↑, 14,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↝, 1,   Casp7?, 1,   Casp7↑, 17,   cl‑Casp7↑, 3,   Casp8↑, 24,   cl‑Casp8↑, 5,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 56,   cl‑Casp9↑, 8,   proCasp9↑, 1,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 50,   Cyt‑c↝, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 11,   DR5↓, 1,   DR5↑, 21,   FADD↑, 4,   Fas↓, 1,   Fas↑, 13,   FasL↑, 7,   Ferroptosis↑, 4,   IAP1↓, 21,   IAP1↑, 1,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 33,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 5,   p38↑, 15,   p‑p38↓, 2,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 6,   Pyro↑, 1,   survivin↓, 238,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↑, 1,   XIAP?, 1,   XIAP↓, 63,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 63,   Akt↑, 6,   p‑Akt↓, 14,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CIP2A↓, 2,   CK2↓, 2,   cMET↓, 5,   p‑cMET↑, 1,   p‑CREB↑, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   ERK↓, 21,   ERK↑, 3,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 12,   IκB↓, 2,   IκB↑, 1,   JAK↓, 4,   JAK1↓, 5,   JAK2↓, 17,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 14,   p‑JNK↓, 1,   p‑JNK↑, 1,   cl‑JNK↑, 1,   MAPK↓, 12,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 1,   mTOR↓, 39,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   NIK↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   PI3K↓, 42,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PIAS-3↑, 1,   PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 17,   PTPN6↑, 1,   Raf↓, 2,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 5,   RIP1↓, 1,   p‑RSK↑, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 3,   c-Src↓, 1,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 61,   p‑STAT3↓, 12,   p‑STAT3↑, 1,   STAT5↓, 3,   STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 2,   ATF4↝, 1,   CBP↓, 1,   cJun↑, 2,   cMyc↓, 42,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMTs↓, 7,   EZH2↓, 2,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↑, 2,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 18,   HDAC1↓, 4,   HDAC2↓, 1,   HDAC3↓, 3,   HDAC6↓, 2,   HDAC8↓, 2,   HES1↓, 2,   IRF1↑, 1,   miR-134↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-375↑, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 11,   OCT4↑, 1,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 5,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 2,   SOX9↓, 2,   tumCV↓, 39,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 13,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP27↑, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 9,   HTRA↓, 2,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 3,   LC3II↑, 5,   LC3s↑, 2,   p62↓, 3,   p62↑, 1,   RUBCN↓, 1,   TumAuto↑, 19,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 22,   DNArepair↓, 1,   ERCC1↓, 2,   HR↓, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   p16↑, 4,   P53↓, 1,   P53↑, 58,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↑, 12,   cl‑PARP↑, 61,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 17,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 1,   TOP2↓, 3,   UHRF1↓, 1,   γH2AX↑, 6,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1?, 1,   CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 17,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 17,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 16,   cycD1/CCND1↓, 83,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 5,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 19,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 4,   P21↑, 44,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 19,   PLK1↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 82,   WEE1↑, 4,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 3,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 5,   CD34↓, 1,   cFos↓, 2,   CSCs↓, 22,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 6,   HH↓, 4,   IGF-1↓, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 19,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 3,   Nanog↓, 9,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH2↓, 1,   NOTCH3↓, 1,   OGFr↑, 2,   p300↓, 2,   PTCH1↓, 5,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 4,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 50,   TumCG↑, 1,   TumCP↓, 74,   Wnt↓, 19,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   Ca+2↓, 3,   Ca+2↑, 9,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   Cav1↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 15,   EM↑, 1,   EMT↓, 32,   EMT↑, 1,   EpCAM↓, 1,   FAK↓, 10,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB6↓, 1,   LEF1↓, 3,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 40,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 55,   MMPs↓, 17,   MUC4↓, 3,   N-cadherin↓, 11,   NCAM↑, 1,   pax↓, 1,   PDGF↓, 2,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 12,   Smad1↓, 1,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 1,   SMAD4↑, 1,   Snail↓, 22,   TET1↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 6,   TIMP2↑, 9,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 39,   TumCI↑, 1,   TumCMig↓, 30,   TumMeta↓, 37,   TumMeta↑, 3,   Twist↓, 14,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 19,   Zeb1↓, 8,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 29,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 1,   CD31/PECAM-1↓, 3,   Endoglin↑, 1,   HIF-1↓, 3,   Hif1a↓, 26,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 71,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 48,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 8,   COX1↓, 1,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 16,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↑, 1,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 5,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 23,   IL7↓, 1,   IL8↓, 4,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 17,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 87,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NLRP3↑, 1,   p50↓, 1,   p65↓, 6,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 8,   PSA↓, 3,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TCF↓, 2,   TLR4↝, 1,   TNF-α↓, 17,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 9,   ER-α36↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 14,   BioAv↑, 19,   BioAv↝, 7,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 71,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 3,   Dose↓, 1,   Dose↝, 29,   Dose∅, 2,   eff↓, 24,   eff↑, 34,   eff↝, 4,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP↓, 1,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 2,   RadioS↑, 17,   selectivity?, 1,   selectivity↑, 32,   Synergy↑, 38,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AR↓, 9,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 23,   LDH↓, 1,   Myc↓, 5,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 3,   PSADT↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 17,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 3,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 1,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 2,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 1,   QoL∅, 1,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↓, 1,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 3,   TumVol↓, 20,   TumW↓, 10,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 4,  
Total Targets: 776

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 24,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 8,   GPx1↑, 1,   GSH↑, 7,   GSTs↑, 4,   HO-1?, 1,   HO-1↑, 4,   lipid-P↓, 8,   MDA↓, 4,   MPO↑, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 8,   ROS↓, 26,   ROS↑, 1,   ROS∅, 3,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   5LO↝, 1,   ALAT↓, 2,   AMPK↑, 1,   FASN↓, 1,   glucose↝, 1,   GSK‐3β↓, 1,   NAD↑, 1,   NADPH↑, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Cyt‑c↓, 1,   Fas↓, 1,   FasL↓, 1,   IAP1↓, 1,   iNOS↓, 3,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↑, 1,   JAK2↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP27↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   MMP13↓, 1,   MMP3↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   NO↓, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MUC5AC↓, 1,   TRPA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 8,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 8,   IL4↓, 1,   IL5↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 26,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 10,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 6,   BioAv↝, 6,   CompStab↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 1,   GSTA1↑, 1,   Half-Life↝, 5,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   CRP↓, 1,   IL6↓, 9,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 8,   AntiArt↑, 4,   AntiCan↑, 5,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 7,   memory↑, 1,   neuroP↑, 17,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 3,   Stroke↓, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 5,   Bacteria↑, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 151

Scientific Paper Hit Count for: survivin, BIRC5
19 Thymoquinone
8 Resveratrol
7 Curcumin
7 EGCG (Epigallocatechin Gallate)
7 Quercetin
6 Sulforaphane (mainly Broccoli)
6 Gambogic Acid
6 Ginkgetin
6 Silymarin (Milk Thistle) silibinin
5 Matrine
4 Artemisinin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Boswellia (frankincense)
4 Fisetin
4 Garcinol
4 Honokiol
4 Licochalcone A
4 Nimbolide
4 Marjoram (Origanum majorana)
4 Piperlongumine
3 Cisplatin
3 Apigenin (mainly Parsley)
3 Docetaxel
3 Berbamine
3 Berberine
3 Beta-Caryophyllene
3 Betulinic acid
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 Capsaicin
3 Deguelin
3 Eugenol
3 Ginger/6-Shogaol/Gingerol
3 Magnolol
3 Luteolin
3 Magnetic Fields
3 Morin
2 1,8-Cineole
2 5-fluorouracil
2 Silver-NanoParticles
2 Allyl isothiocyanate
2 Alpha-Lipoic-Acid
2 immunotherapy
2 Carnosic acid
2 Chemotherapy
2 Cucurbitacin
2 Dichloroacetate
2 Ellagic acid
2 Emodin
2 Fucoidan
2 doxorubicin
2 Geraniol
2 Isoliquiritigenin
2 lambertianic acid
2 low dose naltrexone
2 Licorice
2 Lycopene
2 Mangiferin
2 Naringin
2 Terpinen-4-ol / Tea Tree Oil
2 Rosmarinic acid
2 salinomycin
2 Aflavin-3,3′-digallate
1 Coenzyme Q10
1 Açaí, Euterpe oleracea
1 Andrographis
1 Gemcitabine (Gemzar)
1 chitosan
1 Bufalin/Huachansu
1 Isothiocyanates
1 brusatol
1 Bruteridin(bergamot juice)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 chaetocin
1 Chlorophyllin
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Radiotherapy/Radiation
1 Cynaropicrin
1 Dandelion Root
1 Butyrate
1 Genistein (soy isoflavone)
1 Eurycomanone
1 Fennel Oil/Foeniculum vulgare
1 Flaxseed/Linseed
1 Grapeseed extract
1 HydroxyTyrosol
1 Indole-3-carbinol
1 Isobavachalcone
1 iodine
1 MCT, metronomic chemo
1 Juglone
1 Vitamin C (Ascorbic Acid)
1 Kaempferol
1 Methyl Jasmonate
1 Moringin
1 Melatonin
1 Mushroom Shiitake, AHCC
1 Neem
1 Oleuropein
1 Phenylbutyrate
1 Purple Corn / Purple Maize
1 Piperine
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Shikonin
1 Selenite (Sodium)
1 Ursolic acid
1 Urolithin
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:299  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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