IGF-1 Cancer Research Results

IGF-1, insulin-like growth factor-1: Click to Expand ⟱
Source:
Type:
Higher blood levels of IGF-1, a growth factor, are linked to increased risk of several types of cancer, including thyroid, melanoma and myeloma. IGF-1 is what some call "a growth-promoter" because it has been shown to promote the growth of cancer cells.
The IGF-1 signaling pathway promotes cancer progression; its downregulation is associated with lowered risk.
Scientific Papers found: Click to Expand⟱
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2695- BBR,    The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial
- Trial, BC, NA
IGF-1↓, PPARγ↓, VEGF↓, Hif1a↓, angioG↓,
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
746- Bor,    Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
- Review, Var, NA
eff↑, *toxicity↓, ROS↑, LAT↓, AntiCan↑, AR↓, PSMB5↓, IGF-1↓, PSA↓, TumVol↓, eff↑, Rho↓, Cdc42↓, Ca+2↓, eff↑,
706- Bor,    Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice
- in-vivo, Pca, LNCaP
TumVol↓, IGF-1↓, PSA↓,
732- Bor,    Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment
- in-vitro, GBM, NA
eff↑, IGF-1↝, Glycolysis↝,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, Var, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
4624- Bor,  VitD3,    Boron as a Medicinal Ingredient in Oral Natural Health Products
- Review, Pca, NA
*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,
3518- Bor,    Boron Report
- Review, Var, NA - Review, AD, NA
Risk↓, serineP↓, PSA↓, TumVol↓, IGF-1↓, *Mag↑, *Calcium↑, *VitD↑, *COX2/PTGS2↓, *5LO↓, *PGE2↓, *NF-kB↓, *cognitive↑,
6142- Cin,    Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, SW48 - in-vitro, CRC, HCT116
E-cadherin↑, MMP2↓, MMP9↓, PI3K↓, Akt↓, IGF-1↓, Apoptosis↑, BAX↑, cl‑PARP↑, PARP↓, Bcl-2↓, TumCI↓,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *Synergy↑, *LDL↓, *HDL↑, *Synergy↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
446- CUR,    The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells
- in-vitro, CRC, SW480
IR↓, IGF-1↓, Myc↓, TumCMig↓, TumCP↓,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1852- dietFMD,  Chemo,    Starvation Based Differential Chemotherapy: 
A Novel Approach for Cancer Treatment
- Review, Var, NA
ChemoSideEff↓, *toxicity↓, mTOR↓, IGF-1↓, IGFBP1↑, BG↓, ROS↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, Synergy↑, ROS↑, Akt↑, Casp3↑,
1855- dietFMD,    Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study
- Trial, Var, NA
ChemoSideEff↓, QoL↑, IGF-1↓, Insulin↓,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, Var, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1843- dietFMD,  BTZ,    Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia
- in-vivo, CLL, NA
AntiTum↓, Apoptosis↑, IGF-1↓, eff↑, OS↑, eff↑,
1842- dietFMD,    Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment
- Trial, Var, NA
Strength∅, Weight∅, IGF-1↓, IGFBP3↑, IGFBP1↑, eff↑,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
5067- dietFMD,    Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling
- in-vitro, BC, NA
mTORC1↓, IGF-1↓, RAS↓,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27/CDKN1B↑, Insulin↓, IGF-1↓,
2265- dietMet,    Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
- in-vivo, Nor, NA
*SCD1↓, *Weight↓, *Insulin↓, *IGF-1↓, *adiP↑, *eff↓,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27/CDKN1B↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
5192- dietMet,    Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
- in-vivo, Nor, NA
OS↑, eff↝, IGF-1↓, adiP↑, Leptin↓, Weight↓,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
5065- dietSTF,  dietFMD,    Nutrition, GH/IGF-I Signaling, and Cancer
- Review, Var, NA
GH↓, IGF-1↓, glucose↓, IGFBP1↑, OS↑, Imm↑, neuroP↑, BMD↑, Dose↝, Risk↓, other↑, TumCP↓,
5066- dietSTF,    Intermittent and Periodic Fasting, Hormones, and Cancer Prevention
- Review, Var, NA
IGF-1↓, OS↑, AntiAge↑, glucose↓, Insulin↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
6266- DL,    Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓, IGF-1↑, TumCCA↑, TumCP↓,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*Dose∅, *Half-Life∅, *BioAv∅, *BBB↑, *toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
649- EGCG,  CUR,  PI,    Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
*BioEnh↑, EGFR↓, HER2/EBBR2↓, IGF-1↓, MAPK↓, ERK↓, RAS↓, Raf↓, NF-kB↓, p‑pRB↓, TumCCA↑, Glycolysis↓, Warburg↓, HK2↓, Pyruv↓,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, Cerv, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27/CDKN1B↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
5231- Ex,    Regular Physical Exercise Increase Of Growth Hormone (GH) And Insulin-Like Growth Factor-1 (IGF-1) Activity in Elderly Improve the Aging Process and Quality of Life: A Mini Review
- Human, Nor, NA
*GH↑, *IGF-1↑,
5232- Ex,    Resistance training effect on serum insulin-like growth factor 1 in the serum: a meta-analysis
- Review, Nor, NA
*IGF-1↑, *IGF-1↓,
5233- Ex,    The effect of resistance training on serum insulin-like growth factor 1(IGF-1): A systematic review and meta-analysis
- Review, Nor, NA
*IGF-1↑,
5234- Ex,    Intense Walking Exercise Affects Serum IGF-1 and IGFBP3
- Trial, Nor, NA
*IGF-1↓, *IGFBP3↓,
5235- Ex,    Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
- Trial, Nor, NA
Insulin↓, IGF-1↓, IGFBP1↑, eff↑,
5230- Ex,    Effects of an acute maximal exercise bout on serum insulin-like growth factor-1 in adults with MDD
- Trial, Nor, NA
*IGF-1↑, Dose↝,
5057- Ex,    Exercise and the growth hormone–insulin-like growth factor axis
- Review, Nor, NA
*IGF-1↑,
5059- Ex,    Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly
- Review, Nor, NA
*IGF-1↑,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2/PTGS2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,

Showing Research Papers: 1 to 50 of 88
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 88

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 1,   Catalase↑, 1,   GPx↑, 2,   GSH↓, 2,   GSH↑, 3,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 3,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NRF2↓, 2,   NRF2↑, 3,   ROS↑, 23,   SAM-e↝, 1,   SOD↓, 2,   SOD↑, 3,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 10,   OCR↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   adiP↑, 2,   AMPK↑, 4,   ATGL/PNPLA2↓, 1,   ATP↓, 3,   ATP↑, 1,   CRM↑, 1,   FASN↓, 2,   FASN↑, 1,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose∅, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 5,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PFK↓, 1,   polyA↓, 1,   Pyruv↓, 1,   SIRT1↑, 3,   TS↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 16,   BAD↑, 1,   Bak↑, 2,   BAX↑, 11,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-xL↓, 4,   BID↑, 1,   BNIP3↑, 1,   Casp↑, 2,   Casp10↑, 1,   Casp12↑, 1,   Casp3↑, 13,   cl‑Casp3↑, 3,   Casp7↑, 1,   cl‑Casp7↑, 2,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 2,   Cyt‑c↑, 9,   Diablo↑, 2,   DR5↑, 1,   Fas↓, 1,   Fas↑, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 1,   Mcl-1↓, 2,   MDM2↑, 1,   necrosis↑, 1,   p38↑, 3,   PUMA↑, 1,   survivin↓, 1,   TumCD↑, 2,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 17,   Akt↑, 1,   p‑Akt↓, 5,   BRAF↝, 1,   Brk/PTK6↓, 1,   CK2↓, 4,   EGFR↓, 7,   ERK↓, 8,   ERK↑, 1,   p‑ERK↓, 1,   HER2/EBBR2↓, 4,   HGF/c-Met↓, 1,   IGF-1R↓, 4,   IGFR↓, 2,   IKKα↓, 1,   IR↓, 1,   JAK1↓, 1,   JAK2↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↝, 1,   p‑MEK↓, 1,   mTOR↓, 10,   p‑mTOR↓, 1,   p‑p70S6↓, 1,   PDE3B↓, 1,   PI3K↓, 16,   PI3K↑, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   p‑PKA↓, 1,   PKCδ↓, 1,   PTEN↑, 3,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 3,   Rictor↓, 1,   Src↑, 1,   STAT↓, 1,   STAT3↓, 5,   STAT5↓, 3,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cMyc↓, 2,   DNMTs↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO4↓, 1,   H3↓, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC3↓, 1,   miR-106b↓, 1,   miR-21↓, 1,   Myc↓, 1,   other↑, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 2,   HSPs↓, 1,   HSPs↑, 1,   PSMB5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LAMP2↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 5,   P53?, 1,   P53↓, 1,   P53↑, 8,   PARP↓, 1,   cl‑PARP↑, 8,   PCNA↓, 1,   POLD1↓, 1,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 6,   CDK6↓, 4,   Cyc↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 8,   CycD3↓, 1,   cycE/CCNE↓, 2,   Ki-67↓, 4,   P21↓, 1,   P21↑, 8,   p27/CDKN1B↑, 7,   p‑pRB↓, 2,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD24↓, 1,   CSCs↓, 4,   GH↓, 1,   Gli↓, 1,   IGF-1?, 1,   IGF-1↓, 59,   IGF-1↑, 3,   IGF-1↝, 1,   IGF-1∅, 1,   p‑IGF-1↓, 1,   IGF-2↓, 4,   IGFBP1↓, 1,   IGFBP1↑, 5,   IGFBP3↓, 1,   IGFBP3↑, 6,   Ki-67↓, 4,   mTORC1↓, 2,   TumCG↓, 12,   TumCP↓, 11,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   cal2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 6,   EMT↓, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB4↓, 1,   MMP1↓, 2,   MMP2↓, 7,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 10,   MMPs↓, 3,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   serineP↓, 1,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TIMP1↑, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumMeta↓, 6,   Twist↓, 3,   uPA↓, 1,   Vim?, 1,   Vim↓, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   HIF-1↓, 3,   Hif1a↓, 11,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 13,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT2↓, 1,   LAT↓, 1,   MMP↓, 7,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↓, 1,   CD44↓, 1,   CD8+↑, 3,   COX2/PTGS2↓, 8,   CXCR4↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 3,   IL4↑, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 1,   M2 MC↓, 2,   NF-kB↓, 12,   NK cell↑, 2,   p50↓, 1,   PD-1↓, 1,   PGE1↓, 1,   PGE2↓, 3,   PSA↓, 9,   PSA∅, 1,   Resistin↓, 1,   Th1 response↑, 1,   TNF-α↓, 6,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   EstroRS/ERS↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 2,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 18,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   Dose↑, 3,   Dose↝, 9,   eff↓, 3,   eff↑, 24,   eff↝, 6,   Half-Life↓, 1,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 7,   selectivity↑, 2,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   BG↓, 5,   BMD↑, 2,   BRAF↝, 1,   BRCA1↑, 1,   CEC↝, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EstroRS/ERS↓, 1,   Ferritin↓, 1,   HER2/EBBR2↓, 4,   HOMA↓, 1,   IL6↓, 7,   Myc↓, 1,   PSA↓, 9,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 11,   AntiTum↓, 1,   BowelM↑, 1,   cachexia↓, 1,   chemoP↑, 4,   chemoPv↑, 4,   ChemoSideEff↓, 6,   neuroP↑, 1,   OS↑, 8,   QoL↑, 6,   QoL∅, 1,   radioP↑, 1,   Risk↓, 7,   Strength∅, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 7,   Weight↓, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 367

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 9,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 7,   GSR↑, 2,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 3,   NRF2∅, 1,   ROS↓, 10,   mt-ROS↓, 1,   SAM-e↑, 1,   SOD↑, 7,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 2,   mtDam↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   adiP↑, 2,   AMPK↑, 1,   ATP↝, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 3,   Glycolysis↑, 1,   Glycolysis↝, 1,   H2S↑, 1,   HK2↑, 2,   LDHA↑, 1,   LDL↓, 5,   lipidLev↓, 1,   NAD↝, 1,   PFK↑, 1,   PKM2↑, 2,   SCD1↓, 1,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   CREB↑, 1,   ERK↑, 1,   IGFR↓, 1,   IKKα↓, 1,   MAPK↓, 4,   mTOR↓, 1,   PDGFR-BB↑, 1,   PI3K↓, 1,   PKCδ↓, 1,   RAS↓, 1,   Src↓, 1,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   other↓, 1,   other↑, 1,   other↝, 1,   other∅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   FGF↑, 1,   GH↑, 1,   IGF-1↓, 9,   IGF-1↑, 16,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   Cartilage↑, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   MMP9↑, 1,   serineP↓, 1,   TGF-β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   MMP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 14,   M2 MC↑, 1,   NF-kB↓, 4,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 6,   VitD↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   EndoR↑, 1,   GABA↑, 1,   monoA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 2,   PPARα↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   BioAv↝, 1,   BioAv∅, 1,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 7,   Dose∅, 1,   eff↓, 1,   eff↑, 2,   GSTA1↑, 1,   Half-Life↝, 2,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   BP↓, 2,   Calcium↑, 2,   colonLen↑, 1,   CRP↓, 2,   hs-CRP↓, 2,   IL6↓, 2,   IRes↓, 1,   LDH↓, 1,   Mag↑, 2,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 4,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 5,   hepatoP↑, 2,   memory↓, 1,   memory↑, 4,   motorD↓, 1,   motorD↑, 2,   neuroP↑, 9,   OS↑, 4,   Pain↓, 1,   QoL↑, 2,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 176

Scientific Paper Hit Count for: IGF-1, insulin-like growth factor-1
16 Exercise
14 diet FMD Fasting Mimicking Diet
7 Boron
5 diet Methionine-Restricted Diet
5 diet Short Term Fasting
5 Resveratrol
4 Formononetin
3 EGCG (Epigallocatechin Gallate)
3 Methylsulfonylmethane
2 Apigenin (mainly Parsley)
2 Curcumin
2 Chemotherapy
2 Lycopene
2 Quercetin
1 Alpha-Lipoic-Acid
1 Berberine
1 Betulinic acid
1 Vitamin D3
1 Cinnamon
1 Coenzyme Q10
1 Selenium
1 Vitamin C (Ascorbic Acid)
1 Bortezomib
1 D-limonene
1 Piperine
1 Fisetin
1 Flaxseed/Linseed
1 Indole-3-carbinol
1 Inositol
1 SDG/lignans
1 Luteolin
1 Docetaxel
1 Magnolol
1 Cisplatin
1 Magnetic Field Rotating
1 Magnetic Fields
1 tamoxifen
1 Propolis -bee glue
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rosmarinic acid
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:415  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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