Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
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The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5142- AgNPs,    Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells
- in-vitro, CRC, HUH7
ROS↑, Apoptosis↑, eff↑, ChemoSen↑, EPR↑, Casp↑, MAPK↑,
4403- AgNPs,    Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, GL26 - in-vitro, Cerv, HeLa - in-vitro, CRC, RKO
AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,
361- AgNPs,    Annona muricata assisted biogenic synthesis of silver nanoparticles regulates cell cycle arrest in NSCLC cell lines
- in-vitro, Lung, A549
Apoptosis↑, Casp↑, TumCCA↑,
388- AgNPs,    Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells
- in-vitro, BC, MCF7
ROS↑, Casp3↑, BAX↑, P53↑, Casp↑, Cyt‑c↑, MMP↓, DNAdam↑, Bcl-2↓, BAX↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
2647- AL,    The Mechanism in Gastric Cancer Chemoprevention by Allicin
- Review, GC, NA
ChemoSen↓, TumCG↓, TumCCA↑, ER Stress↑, Apoptosis↑, Casp↑, DR5↑,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
3442- ALA,    α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B - in-vitro, Nor, 3T3
tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,
282- ALA,    Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression
- in-vitro, Pca, PC3
MMP↓, Casp↑, MMP9↓,
259- ALA,    Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
- in-vitro, Liver, HepG2 - in-vitro, Liver, FaO
Cyc↓, P21↑, ROS↑, p‑P53↑, BAX↑, Cyt‑c↑, Casp↑, survivin↓, JNK↑, Akt↓,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, Var, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
6393- ANE,    Anethole in cancer therapy: Mechanisms, synergistic potential, and clinical challenges
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCCA↑, TumCP↓, angioG↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, Casp↓, ChemoSen↑,
6394- ANE,    Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis
- in-vitro, Var, NA
TNF-α↓, NF-kB↓, Casp↑, tumCV↓,
6397- ANE,  Cisplatin,    Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways
- in-vitro, SCC, Ca9-22
AntiCan↑, ChemoSen↑, TumCP↓, MMP↓, ROS↑, MAPK↓, β-catenin/ZEB1↓, NF-kB↓, EMT↓, Casp↑,
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
1564- Api,    Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
- in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
MDM2↓, NF-kB↓, p65↓, P21↑, ROS↑, GSH↓, MMP↓, Cyt‑c↑, Apoptosis↑, P53↑, eff↓, Bcl-xL↓, Bcl-2↓, BAX↑, Casp↑, TumCG↓, TumVol↓, TumW↓,
2632- Api,    Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress
- in-vitro, EC, NA
TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP/DDIT3↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
5129- ART/DHA,    Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds
- in-vitro, AML, HL-60
Casp↑, Apoptosis↑, MMP↓, TumCCA↑, eff↑, eff↑,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2/PTGS2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- Review, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, Synergy↑, OS↑, Remission↑,
2699- BBR,    Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line
- in-vitro, Lung, A549
HDAC↓, TumCCA↑, TNF-α↓, COX2/PTGS2↓, MMP2↓, MMP9↓, P21↑, P53↑, Casp↑, ac‑H3↑, ac‑H4↑, ROS↑, MMP↓,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5584- BetA,    Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
- in-vitro, GBM, A172 - in-vitro, GBM, U118MG - in-vitro, GBM, U251
Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,
2743- BetA,    Betulinic acid and the pharmacological effects of tumor suppression
- Review, Var, NA
ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumCCA↑, Sp1/3/4↓, STAT3↓, NF-kB↓, EMT↓, TOP1↓, MAPK↑, p38↑, JNK↑, Casp↑, Bcl-2↓, BAX↑, VEGF↓, LAMs↓,
2748- BetA,    Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy
- Review, Var, NA
Bcl-2↓, MMP↓, Cyt‑c↑, Casp↑, Diablo↑, AIF↑, angioG↓, BioAv↓, NF-kB↓,
2754- BetA,    Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
- in-vitro, Pca, LNCaP
VEGF↓, survivin↓, Sp1/3/4↓, Casp↑, PARP↑, survivin↓, angioG↓,
5721- BF,    Bufalin Suppresses Triple-Negative Breast Cancer Stem Cell Growth by Inhibiting the Wnt/β-Catenin Signaling Pathway
- in-vitro, BC, NA
CSCs↓, TumCCA↑, cMyc↓, cycD1/CCND1↓, CDK4↓, MMP↓, Casp↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, SOX2↓, Wnt↓, β-catenin/ZEB1↓, EGFR↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
1450- Bos,  Cisplatin,    3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
- in-vitro, Pca, DU145
ROS↑, MMP↓, Casp↑, Apoptosis↑, Bax:Bcl2↑, TumCCA?, cycD1/CCND1↓, CDK4↓, P21↑, p27/CDKN1B↑, NOTCH↓, ChemoSen↑,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
6545- BSB,    The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes
- in-vitro, Cerv, HeLa - in-vitro, AML, Jurkat
MPT↑, Casp↑, TumAuto↑, Apoptosis↑, TumCD↑, Dose↝, MMP↓, ROS↑, mtDam↑,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2/PTGS2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, Synergy↑, RadioS↑, HCAR2↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, Synergy↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, Synergy↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, Synergy↑, Synergy↑, Synergy↑,
5923- CA,  RosA,    Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
- Review, Var, NA
TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,
5835- CAP,    Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+-mediated mitochondrial pathway
- in-vitro, GBM, U251
tumCV↓, Apoptosis↑, selectivity↑, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Casp↑, eff↑, MPT↑, ETC↓, Casp3↑, Casp9↑,
5831- CAP,    Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
- Review, Var, NA
TRPV1↑, Ca+2↑, AntiCan↑, TumCP↓, Pain↓, TumCG↓, ChemoSen↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑,
5826- CAP,    Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload
- in-vitro, Thyroid, NA
TRPV1↑, tumCV↓, Ca+2↑, mtDam↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, Apoptosis↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, Synergy↑,

Showing Research Papers: 1 to 50 of 205
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 205

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 3,   GSH↓, 10,   GSH↑, 2,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA↓, 1,   MDA↑, 3,   NADH↓, 2,   mt-NADH↓, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↑, 7,   ROS↓, 11,   ROS↑, 131,   ROS⇅, 3,   ROS↝, 1,   i-ROS?, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 1,   SOD↑, 2,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 1,   Trx↑, 1,   TrxR↓, 2,   TrxR↑, 1,   TrxR1↓, 4,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IRP1↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC↓, 4,   mitResp↓, 3,   mtDam↑, 16,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 4,   PDH↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACSL4↑, 1,   AMP↓, 1,   AMPK?, 1,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 16,   mt-ATP↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 11,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   H2S↑, 1,   HK2↓, 7,   HMG-CoA↓, 2,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 3,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 10,   PDK3↑, 1,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 126,   mt-Apoptosis↑, 4,   BAD↑, 4,   Bak↑, 4,   BAX↑, 44,   Bax:Bcl2↑, 13,   Bcl-2↓, 56,   Bcl-2↑, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 19,   Bcl-xL↑, 2,   BID↑, 3,   BIM↓, 1,   BIM↑, 4,   BNIP3↓, 1,   BTG3↑, 1,   Casp↓, 5,   Casp↑, 184,   Casp↝, 3,   Casp∅, 1,   cl‑Casp↑, 6,   proCasp↑, 1,   Casp3↓, 1,   Casp3↑, 24,   cl‑Casp3↑, 5,   Casp6↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 3,   Casp8↑, 3,   cl‑Casp8↑, 3,   Casp9↑, 9,   cl‑Casp9↑, 6,   Cupro↑, 1,   Cyt‑c↑, 63,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 9,   Endon↑, 1,   FADD↑, 2,   Fas?, 1,   Fas↓, 2,   Fas↑, 9,   FasL↑, 4,   Ferroptosis↑, 7,   GSDME↑, 1,   cl‑GSDME↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 6,   Mcl-1↓, 5,   MDM2↓, 3,   MLKL↑, 1,   MOMP↑, 3,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 5,   p38↑, 7,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↑, 1,   survivin↓, 25,   TNFR 1↑, 2,   TRAIL↑, 3,   TumCD↑, 8,   XIAP↓, 8,   XIAP↑, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 55,   p‑Akt↓, 7,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 10,   ERK↓, 14,   ERK↑, 4,   p‑ERK↓, 4,   HCAR2↑, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   Hippo↓, 1,   IKKα↓, 2,   IκB↓, 1,   JAK1↓, 1,   JAK2↓, 8,   JAK3↓, 1,   JNK↓, 2,   JNK↑, 8,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 17,   MAPK↑, 9,   MEK↓, 3,   mTOR↓, 33,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 1,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDGFRA↓, 1,   PI3K↓, 38,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PKCδ↓, 2,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 6,   Raf↓, 3,   e-Raf↓, 1,   RAS↓, 4,   RIP1↓, 1,   Sp1/3/4↓, 5,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3↓, 29,   p‑STAT3↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF4↑, 5,   cJun↓, 2,   cJun↑, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 4,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 11,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC6↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↝, 1,   miR-34a↑, 1,   miR-375↑, 1,   NDRG1↑, 1,   OCT4↓, 4,   other↑, 3,   other↝, 5,   PhotoS↑, 1,   SOX2↓, 4,   TCF-4↓, 2,   TFAP2A↓, 1,   TFE3↑, 1,   tumCV↓, 30,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 17,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 2,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 2,   LC3I↓, 1,   LC3II↑, 5,   LC3s↑, 1,   lysoMP↑, 1,   p62↓, 4,   p62↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 15,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   DNAdam↓, 1,   DNAdam↑, 34,   DNArepair↓, 2,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 2,   P53↑, 38,   P53↝, 2,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 6,   PARP↝, 1,   cl‑PARP↑, 36,   cl‑PARP1↑, 2,   PCNA↓, 8,   SIRT6↓, 1,   Telomerase↓, 6,   TOP1↓, 6,   TOP2↓, 4,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 11,   p‑CDK2↓, 1,   CDK4↓, 12,   CDK4↑, 1,   CDK6↓, 4,   CDK6↑, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 4,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 23,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 10,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 8,   mitA↓, 1,   mitA↑, 2,   P21↑, 28,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 11,   PLK1↓, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 88,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH1A1↓, 1,   BMI1↓, 1,   CD133↓, 2,   cFos↓, 3,   CSCs↓, 13,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 2,   IGFBP3↑, 2,   Ki-67↓, 8,   mTORC1↓, 5,   Nanog↓, 4,   NOTCH↓, 2,   NOTCH1↓, 3,   NOTCH1↑, 1,   NOTCH2↑, 1,   SCF↓, 1,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 39,   TumCG↑, 2,   TumCP↓, 60,   TumCP↑, 3,   Wnt↓, 13,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 6,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 22,   cal2↑, 1,   CCN2/CTGF↓, 2,   COL1↓, 1,   E-cadherin↑, 13,   EMT↓, 19,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 26,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 29,   MMP9↑, 2,   MMPs↓, 10,   MMPs↝, 1,   MUC4↓, 1,   N-cadherin↓, 7,   PAK1↑, 1,   PDGF↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TSC1↑, 2,   TSP-1↑, 1,   TumCI↓, 23,   TumCI↑, 1,   TumCMig↓, 22,   TumCMig↑, 1,   TumMeta↓, 25,   TumMeta↑, 3,   Twist↓, 4,   uPA↓, 8,   Vim↓, 10,   Zeb1↓, 3,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 37,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 3,   HIF-1↓, 2,   Hif1a↓, 17,   Hif1a↑, 1,   NO↓, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 41,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   EPR↑, 4,   GLUT1↓, 4,   GLUT4↓, 2,   MMP?, 2,   MMP↓, 78,   MMP↝, 1,   MPT↑, 10,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   CD44↓, 3,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 3,   Eos↑, 1,   HCAR2↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL12↑, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 10,   IL8↓, 1,   Imm↑, 8,   Inflam↓, 11,   M2 MC↓, 1,   MCT1↓, 1,   MDSCs↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 55,   NF-kB↑, 3,   NF-kB↝, 1,   NK cell↑, 1,   NLRP3↓, 2,   p50↓, 1,   p65↓, 3,   PD-1↝, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 5,   PSA↓, 2,   TCF↝, 1,   TLR4↓, 1,   TNF-α↓, 15,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 16,   BioAv↑, 16,   BioAv↝, 4,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 64,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 25,   Dose∅, 5,   eff↓, 33,   eff↑, 37,   eff↝, 6,   eff∅, 1,   GSTA1↑, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 6,   Half-Life↝, 2,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P450↓, 2,   RadioS↑, 20,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 40,   selectivity↝, 1,   Synergy↑, 41,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 8,   BMD↑, 1,   BRCA1↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 10,   EZH2↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 10,   LDH↓, 1,   LDH↑, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 21,   AntiTum↑, 9,   AntiTum↝, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 5,   ChemoSideEff↓, 1,   fatigue↓, 2,   hepatoP↑, 5,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   NP/CIPN↑, 1,   Obesity↓, 1,   OS↑, 4,   Pain↓, 2,   QoL↑, 1,   radioP↑, 4,   Remission↑, 2,   RenoP↑, 1,   Risk↓, 7,   Sleep↑, 1,   toxicity↓, 12,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 2,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 629

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 23,   Catalase↑, 11,   GPx↑, 9,   GSH↑, 7,   GSR↑, 2,   GSTs↑, 2,   HO-1↑, 8,   Keap1↓, 2,   lipid-P↓, 6,   MDA↓, 4,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 14,   ROS↓, 27,   ROS↝, 1,   ROS∅, 2,   SOD↑, 12,   SOD2↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   ETC↑, 1,   Insulin↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↓, 1,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glyC↓, 1,   NAD↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp↓, 5,   Ferroptosis↓, 1,   iNOS↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↑, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 2,   PKCδ↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   p‑cMyc↑, 1,   other↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   Ca+2↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   MMP↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 3,   IL6↓, 8,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 33,   Inflam↑, 1,   NeuroI↓, 1,   NF-kB↓, 7,   NK cell↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   AChE∅, 1,   BChE∅, 1,   BDNF↑, 1,   proBDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 5,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 2,   CompStab↑, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 3,   Half-Life∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 3,   AntiArt↑, 3,   AntiCan↑, 4,   antiD↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   ANXi↓, 1,   cardioP↑, 8,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 4,   hepatoP↑, 6,   memory↑, 3,   Mood↑, 1,   neuroP↑, 15,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 1,   Sleep↑, 1,   Stroke↓, 3,   toxicity?, 1,   toxicity↓, 5,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 4,  
Total Targets: 149

Scientific Paper Hit Count for: Casp, caspase
7 Thymoquinone
6 Betulinic acid
6 Capsaicin
6 Fisetin
4 Silver-NanoParticles
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Carvacrol
4 Curcumin
4 Graviola
4 Sulforaphane (mainly Broccoli)
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Anethole/trans-Anethole
3 Cucurbitacin
3 Dichloroacetate
3 Gambogic Acid
3 Ginkgetin
3 Licochalcone A
3 Melatonin
3 Nimbolide
3 α-Santalol/Sandalwood oil
3 Selenite (Sodium)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Rosmarinic acid
2 Thymol-Thymus vulgaris
2 chaetocin
2 Selenium
2 Chrysin
2 Gemcitabine (Gemzar)
2 Chlorella (Chlorella vulgaris)
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Isoliquiritigenin
2 Garcinol
2 HydroxyTyrosol
2 Isobavachalcone
2 iodine
2 isoquercitrin
2 Phenethyl isothiocyanate
2 Kaempferol
2 Luteolin
2 Matrine
2 methylseleninic acid
2 Magnetic Fields
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Isovitexin
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenate
1 Chlorophyllin
1 Cinnamon
1 Cranberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Indole-3-carbinol
1 Deguelin
1 Diindolylmethane
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Eugenol
1 Ferulic acid
1 Fenbendazole
1 Formononetin
1 Flaxseed Oil
1 Fucoidan
1 verapamil
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginseng
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperthermia
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Ivermectin
1 Geldanamycin
1 Licorice
1 Linalool
1 Methylene blue
1 Magnolol
1 mebendazole
1 Paclitaxel/Taxol
1 Metformin
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Naringin
1 Phenylbutyrate
1 Phycocyanin
1 Pterostilbene
1 Rhein
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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