CDK2 Cancer Research Results

CDK2, Cyclin-dependent kinase 2: Click to Expand ⟱
Source:
Type:
(CDK2) complex is significantly over-activated in many cancers.
CDK2 (Cyclin-Dependent Kinase 2) is a serine/threonine kinase that regulates late G1 and S phase of the cell cycle.
CDK2 interacts with and phosphorylates proteins in pathways such as DNA damage, intracellular transport, protein degradation, signal transduction, DNA and RNA metabolism and translation.
Scientific Papers found: Click to Expand⟱
4417- AgNPs,    Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways
- in-vitro, BC, MDA-MB-231
ROS↑, MDA↑, COX2/PTGS2↑, IL1β↑, TNF-α↑, GSH↓, Cyt‑c↑, Casp3↑, BAX↑, Bcl-2↓, LDH↓, cycD1/CCND1↓, CDK2↓, TumCCA↑, mt-Apoptosis↑,
347- AgNPs,    The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
- Review, Var, NA
ROS↑, TumCCA↑, ER Stress↑, TumCG↓, TumCP↓, DNAdam↑, P53↑, MMP2↓, MMP9↓, angioG↓, TumMeta↓, MMP↓, Casp3↑, cycD1/CCND1↓, PCNA↓, TNF-α↓, IL6↓, P21↑, p27/CDKN1B↑, CDK2↓, CDK4↓, Fas↑, FADD↑, BAX↑, PUMA↑, Bcl-2↓, Bcl-xL↓, ATP↓, PDK1 / PDPK1↓, Glycolysis↓, Cyt‑c↑, cl‑PARP↑, TRF2↓, hTERT/TERT↓, ETC↓, GSH↓, eff↑, ChemoSen↑, EMT↓,
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
207- Api,    Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells
- in-vitro, Pca, LNCaP
PSA↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, P21↑, AR↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, Synergy↑, Synergy↑, Synergy↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
5551- BBM,    Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
- vitro+vivo, Bladder, NA
tumCV↓, TumCP↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, EMT↓, TumMeta↓, p65↓, p‑p65↓, IKKα↓, NF-kB↑, ROS↑, NRF2↓, HO-1↓, SOD2↓, GPx1↓, Bax:Bcl2↑, TumVol↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5178- BBR,    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, Synergy↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, Synergy↑, MMP1↓, MMP2↓, Synergy↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑, *antiAll↑,
1427- Bos,    Acetyl-keto-β-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, CRC, LS174T
TumCG↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, P21↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5761- CAPE,    Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCCA↑, AMPK↓, NF-kB↓, β-catenin/ZEB1↓, CREB↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6129- CHr,    A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
- vitro+vivo, Melanoma, NA
ATP↓, TumCCA↑, CDK2↓, CDK4↓, TumW↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27/CDKN1B↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
- Review, CardioV, NA
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, Synergy↑, PhotoS↑, eff↑, ROS↑, GSH↓,
137- CUR,    Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
- in-vitro, Pca, DU145
NOTCH1↓, cycD1/CCND1↓, CDK2↓, P21↑, p27/CDKN1B↑, P53↑, Bcl-2↓, Casp3↑, Casp9↑, TumCCA↑, TumCP↓, Apoptosis↑,
8857- DIM,    Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
Dose↝, TumCCA↑, CDK2↓, E2Fs↓, cycA1/CCNA1↓, cycD1/CCND1↓, CDK4↓, P21↑, p27/CDKN1B↑, CDC2↓, CDC25↓,
8839- DIM,    3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression
- in-vitro, BC, MDA-MB-231
TumCCA↑, CDK2↓, P21↑,
8838- DIM,    3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, p27/CDKN1B↑, other↝,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, Cerv, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27/CDKN1B↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
7507- FA,    Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Dose↝, ATR↑, ATM↑, P21↑, p27/CDKN1B↑, E2F4↑, RB1↑, TP53↑, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, TumCP↓, Casp1↑, Casp2↑, Casp8↑, Fas↑, TRADD↑, Bcl-2↓, XIAP↓, TumCCA↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6922- FIS,    Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin
- Review, Var, NA
*memory↑, *Inflam↓, *5LO↓, *lipid-P↓, *NF-kB↓, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, *ROS↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumCMig↓, MMPs↓, PSA↓,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
6902- FIS,    Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
P53↑, NF-kB↓, TumCP↓, Apoptosis↑, TumCCA↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK4↓, CDK2↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓,
6994- FIS,    Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells
- in-vitro, Colon, HT29
TumCG↓, TumCCA↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,

Showing Research Papers: 1 to 50 of 125
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 125

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 3,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 2,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx1↓, 1,   GSH↓, 6,   GSH↑, 4,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 5,   HO-1↑, 7,   HO-2↓, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 2,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 9,   NRF2↑, 13,   ROS↓, 13,   ROS↑, 61,   ROS⇅, 2,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 4,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   TBARS↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 8,   CDC25↓, 13,   compI↓, 2,   EGF↓, 3,   ETC↓, 1,   mitResp↓, 3,   MKK7↓, 1,   mtDam↑, 7,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 2,   ALAT↓, 2,   ALDOA↓, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 8,   ATP↓, 5,   mt-ATP↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 2,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 8,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   HK2↓, 3,   lactateProd↓, 4,   LDHA↓, 2,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 5,   Apoptosis↓, 1,   Apoptosis↑, 45,   mt-Apoptosis↑, 2,   BAD↑, 5,   Bak↑, 4,   BAX↓, 2,   BAX↑, 41,   BAX⇅, 1,   Bax:Bcl2↑, 9,   Bcl-2↓, 47,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 4,   BIM↑, 5,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 9,   Casp↝, 1,   Casp1↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 47,   cl‑Casp3↑, 9,   Casp7↑, 3,   cl‑Casp7↑, 5,   Casp8↑, 15,   cl‑Casp8↑, 4,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 33,   cl‑Casp9↑, 7,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 15,   FADD↑, 3,   Fas↑, 13,   FasL↑, 1,   Ferroptosis↑, 2,   HEY1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 7,   Mcl-1↓, 14,   Mcl-1↑, 1,   MDM2↓, 7,   MDM2↑, 1,   p‑MDM2↓, 1,   NAIP↓, 1,   NOXA↑, 2,   p38↓, 2,   p38↑, 9,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 3,   survivin↓, 20,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 7,   XIAP↓, 13,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 45,   Akt↑, 2,   p‑Akt↓, 11,   AKT1↓, 3,   Akt2↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 2,   CREB↓, 1,   p‑CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 16,   p‑EGFR↓, 2,   ERK↓, 15,   ERK↑, 1,   p‑ERK↓, 4,   p‑ERK↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGFR↓, 1,   IKKα↓, 4,   IκB↑, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 2,   JNK↑, 11,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 13,   MAPK↑, 6,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 28,   mTOR↑, 1,   p‑mTOR↓, 2,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 41,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 6,   PTEN↓, 1,   PTEN↑, 6,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 5,   RSK2/RPS6KA3/p90RSK2↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 4,   STAT↓, 2,   STAT3↓, 21,   STAT3↑, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT6↓, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 6,   ATFs↑, 1,   CBP↓, 2,   CBP↑, 1,   cJun↓, 7,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 16,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMTs↓, 3,   EZH2↓, 2,   FOXM1↓, 2,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↑, 2,   p‑FOXO3↓, 1,   H3↓, 1,   H3↑, 3,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 9,   HDAC1↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   miR-200b↑, 1,   miR-21↑, 1,   Myc↓, 3,   n-MYC↓, 1,   OCT4↓, 3,   other↝, 1,   PCAF↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   SOX4↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 8,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 17,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 3,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 4,   LC3s↑, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 6,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 22,   hTERT/TERT↓, 6,   MSH2↑, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 42,   p‑P53↑, 2,   PARP↓, 3,   PARP↑, 7,   cl‑PARP↑, 33,   PARP1↑, 1,   PCNA↓, 17,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 5,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 12,   CDK1↑, 2,   CDK1/2/5/9↓, 1,   CDK2↓, 114,   CDK2↑, 8,   p‑CDK2↓, 2,   CDK4↓, 74,   CDK4↑, 3,   CDK4/6↓, 4,   CDK6↓, 27,   CDK6↑, 4,   CDK8↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 15,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 22,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 79,   cycD1/CCND1↑, 1,   CycD3↓, 5,   cycE/CCNE↓, 45,   cycE/CCNE↑, 2,   cycE1↓, 1,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   Ki-67↓, 10,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 1,   P21↑, 57,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 37,   pRB↑, 2,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 6,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 95,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   BMPs↑, 1,   CD133↓, 3,   cFos↓, 7,   CSCs↓, 9,   Diff↓, 1,   Diff↑, 1,   EP300↑, 1,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 5,   IGFBP3↑, 1,   Ki-67↓, 10,   Let-7↑, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 10,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH3↓, 2,   p300↓, 2,   SCF↓, 1,   Shh↓, 2,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 19,   TumCP↓, 54,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 12,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AP-1↓, 7,   AXL↓, 1,   Ca+2↑, 14,   Ca+2↝, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 19,   EMT↓, 25,   EMT↝, 1,   FAK↓, 6,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 1,   ITGA5↓, 1,   KRAS↓, 1,   MET↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP2↓, 35,   MMP3↓, 4,   MMP7↓, 9,   MMP9↓, 40,   MMP9↑, 3,   MMPs↓, 10,   N-cadherin↓, 14,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 7,   Smad1↑, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 14,   TET1↓, 1,   TGF-β↓, 5,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↑, 4,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 23,   TumCMig↓, 21,   TumMeta↓, 21,   TumMeta↑, 2,   Twist↓, 12,   uPA↓, 16,   uPAR↓, 1,   Vim↓, 14,   Zeb1↓, 6,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 10,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 19,   LOX1↓, 1,   NO↓, 1,   NO↑, 2,   VEGF↓, 37,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT4↓, 1,   MMP↓, 38,   NHE1↓, 1,   SVCT-2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 1,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 3,   CXCL1↓, 1,   CXCR4↓, 5,   DR4↑, 4,   ICAM-1↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 3,   IL10↓, 2,   IL10↑, 1,   IL12↓, 1,   IL1α↓, 1,   IL1β↓, 3,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 11,   IL8↓, 5,   Imm↑, 2,   Inflam↓, 8,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 52,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 4,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 11,   PSA↓, 4,   PSA∅, 1,   TCF↑, 1,   TCF↝, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 1,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 2,   AR↓, 8,   ER-α36↓, 2,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 13,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 43,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 5,   Dose↝, 12,   Dose∅, 1,   eff↓, 9,   eff↑, 14,   eff↝, 2,   GSTA1↓, 1,   Half-Life↓, 7,   Half-Life↝, 3,   MDR1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 1,   P450↝, 1,   RadioS↑, 16,   selectivity↑, 32,   Synergy↑, 38,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 8,   ascitic↓, 1,   AST↓, 2,   BRCA1↓, 2,   BRCA1↑, 2,   CRP↓, 1,   E6↓, 3,   E7↓, 3,   EGFR↓, 16,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 6,   IL6↓, 11,   KRAS↓, 1,   LDH↓, 2,   LDH↑, 1,   Myc↓, 3,   PD-L1↓, 3,   PSA↓, 4,   PSA∅, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12,   AntiTum↑, 3,   cardioP↑, 5,   chemoP↑, 5,   chemoPv↑, 6,   ChemoSideEff↓, 1,   hepatoP↑, 3,   neuroP↑, 2,   NP/CIPN↓, 1,   OS↑, 4,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 4,   TGFβR1↑, 1,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 666

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 24,   Catalase↑, 10,   GPx↑, 5,   GSH↑, 11,   GSR↑, 3,   GSTs↑, 5,   H2O2↓, 1,   HDL↑, 2,   HO-1↑, 7,   Keap1↑, 1,   lipid-P↓, 5,   MDA↓, 6,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 12,   Prx↑, 1,   RNS↓, 1,   ROS↓, 23,   ROS↑, 1,   SOD↓, 1,   SOD↑, 11,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ALAT↓, 1,   AMPK↑, 2,   FASN↓, 2,   glucose↓, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↑, 1,   Casp↓, 1,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   Fas↑, 1,   IAP1↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 2,   IκB?, 1,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   mTOR↑, 1,   PI3K↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   p‑cMyc↑, 1,   other↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   Ca+2↓, 2,   Ca+2↝, 1,   MMP2↑, 1,   Rho↓, 1,   ROCK1↓, 1,   TregCell↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 2,   VCAM-1↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↓, 1,   MMP↓, 1,   MMP↑, 1,   SVCT-2↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   ICAM-1↓, 1,   IL10↓, 2,   IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL4↑, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 24,   MCP1/CCL2↓, 1,   NF-kB↓, 11,   NLRP3↓, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   AChE↑, 1,   BDNF↑, 3,   GABA↑, 2,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↝, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 5,   BioAv↝, 2,   CompStab↝, 1,   Dose↑, 1,   Dose↝, 2,   GSTA1↑, 1,   Half-Life↑, 1,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 4,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 3,   LDH↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 5,   AntiTum↓, 1,   cardioP↑, 9,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 6,   memory↑, 6,   Mucositis↓, 1,   neuroP↑, 18,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 177

Scientific Paper Hit Count for: CDK2, Cyclin-dependent kinase 2
16 Fisetin
5 Lycopene
5 Quercetin
4 Chrysin
4 Ellagic acid
4 Garcinol
4 Honokiol
4 Luteolin
3 Apigenin (mainly Parsley)
3 Artemisinin
3 Propolis -bee glue
3 Diindolylmethane
3 Ferulic acid
3 Sulforaphane (mainly Broccoli)
3 Magnolol
2 Silver-NanoParticles
2 Berberine
2 Boswellia (frankincense)
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Flaxseed/Linseed
2 HydroxyTyrosol
2 Indole-3-carbinol
2 Juglone
2 Thymoquinone
1 Allicin (mainly Garlic)
1 Cisplatin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Biochanin A
1 Betulinic acid
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Crocetin
1 Cucurbitacin
1 Emodin
1 Eugenol
1 Gallic acid
1 Ginseng
1 5-fluorouracil
1 Inulin Prebiotic
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Lactobacillus
1 Lapachol
1 Licochalcone A
1 Licorice
1 Metformin
1 Magnetic Fields
1 Chemotherapy
1 Lemon Balm/Melissa officinalis
1 Morin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Plumbagin
1 Pterostilbene
1 Resveratrol
1 Rosmarinic acid
1 Sesame seeds and Oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:467  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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