LC3II Cancer Research Results

LC3II, Microtubule-associated protein 1A/1B light chain 3: Click to Expand ⟱
Source:
Type:
LC3II (Microtubule-associated protein 1A/1B light chain 3, also known as LC3) is a protein that plays a crucial role in the process of autophagy. Autophagy is a cellular process in which cells recycle and remove damaged or dysfunctional components.
LC3II is often used as a marker for autophagy, as its levels increase during autophagic activity.
LC3II is overexpressed in certain types of cancer, including breast, lung, and colon cancer.
LC3II is also known by other names, including:
    MAP1LC3B (Microtubule-associated protein 1 light chain 3 beta)
    LC3B (Microtubule-associated protein 1 light chain 3 beta)
    ATG8F (Autophagy-related protein 8F)
: In many cancers, increased LC3-II expression indicates enhanced autophagy, which can support tumor cell survival, especially under stress conditions (e.g., nutrient deprivation, hypoxia). This is often associated with poor prognosis and treatment resistance.
Scientific Papers found: Click to Expand⟱
2287- AgNPs,    Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine
- in-vitro, Nor, HUVECs
*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
5376- ART/DHA,    Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, SW48 - in-vitro, BC, MDA-MB-453
Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1/ATG6↑,
2720- BetA,    Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo
- in-vitro, Cerv, HeLa
Keap1↝, ROS↑, Ca+2↑, Beclin-1/ATG6↓, GRP78/BiP↑, LC3II↑, p62↑, ERStress↑, TumAuto↑,
765- Bor,    High concentrations of boric acid induce autophagy in cancer cell lines
- in-vitro, Var, NA
p62↓, LC3II↑, TumAuto↑,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, Synergy↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, Synergy↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, Synergy↑, Synergy↑, Synergy↑,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
4772- CoQ10,    The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1/ATG6↑, TumAuto↑, ROS↑,
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
TumAuto↑, LC3II↑, Beclin-1/ATG6↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1 / PDPK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1/ATG6↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
143- CUR,    Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, ROS↑, LC3II↑, eff↓, tumCV↓,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, Synergy↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
1869- DCA,    Dichloroacetate induces autophagy in colorectal cancer cells and tumours
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29
LC3II↑, ROS↑, mTOR↓, MCT1↓, NADH:NAD↓, NAD↑, TumAuto↑, lactateProd↓, LDH↑,
2273- dietMet,    Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
ROS↑, GSH↓, TumCP↓, TumAuto↑, LC3II↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
655- EGCG,    A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells
- in-vitro, HCC, HepG2
AFP↓, TumAuto↑, LC3II↑, TumCG↓, MMP↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE/β-secretase↓, *LC3II↓, *Beclin-1/ATG6↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,
6843- EVO,    Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
- in-vivo, PC, PANC1 - in-vitro, PC, SW1990
Apoptosis↑, LC3II↓, p62↑, Akt↓, ERK↓, p38↓, TumW↓, TumCG↓, TumCMig↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
7511- FA,    The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, CaSki
MMP9↓, TumCCA↑, P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, LC3II↓, Beclin-1/ATG6↓, ATG5↓, TumCP↓, TumCI↓, MMP9↓,
6898- FIS,    Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
mTOR↓, Akt↓, AMPK↑, TumCG↓, mTORC1↓, mTORC2↓, 4E-BP1↑, LC3II↑, TumAuto↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
1962- GamB,  HCQ,    Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
- in-vitro, PC, NA
LC3II↑, Beclin-1/ATG6↑, p62↓, MMP↓, ROS↑, TumAuto⇅, Synergy↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
7553- HYP,    Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro
- in-vitro, NSCLC, A549 - in-vitro, Nor, BEAS-2B
LC3II↑, selectivity↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, p‑4E-BP1↓, p‑ERK↑, tumCV↓, Apoptosis↑,
8280- ISL,    ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
- vitro+vivo, HCC, SMMC-7721 cell
tumCV↓, TumCP↓, Apoptosis↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, TumCG↓, LC3II↑, cl‑Casp3↑, eff↑,
9245- ISO, IH,    Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells
- in-vitro, Lung, A549
TumCP↓, Tumccf↓, Apoptosis↑, MMP↓, Cyt‑c↑, LC3II↑, NA↑,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
7794- ISQ,    Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,
8011- itraC,    Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, SkBr3
MMP↓, Bcl-2↓, Casp3↑, TumAuto↑, LC3II↑, p62↓, HH↓, Shh↓, Gli1↓, Apoptosis↑, TumVol↓, eff↑, TumCCA↑,
8019- itraC,    Itraconazole Inhibits AKT/mTOR Signaling and Proliferation in Endometrial Cancer Cells
- in-vitro, Endo, AN3CA - in-vitro, Endo, HEC-1A - in-vitro, Endo, HEC-50B - in-vitro, Endo, SNG-II
*AntiFungal↑, TumCP↓, mTOR↓, LC3II↑, TumAuto↑, Akt↓,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
5118- JG,    Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1/ATG6↑,
1917- JG,    Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion
- in-vitro, AML, HL-60
selectivity↑, LC3I↑, LC3II↑, Beclin-1/ATG6↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
9062- L-THE,    Therapeutic Role of l‑Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose?, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,

Showing Research Papers: 1 to 50 of 72
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 72

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 2,   Catalase↑, 1,   GPx↓, 2,   GPx4↓, 2,   GSH↓, 7,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↓, 2,   HO-1↑, 1,   Iron↑, 1,   Keap1↝, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   PYCR1↓, 1,   ROS↓, 1,   ROS↑, 41,   ROS⇅, 1,   m-ROS↑, 1,   SOD↓, 4,   SOD↑, 1,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 7,   OCR↓, 2,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 9,   ATGL/PNPLA2↓, 1,   ATP↓, 3,   CAIX/CA9↓, 1,   FFA/NEFA↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 5,   GSK‐3β↓, 2,   GSK‐3β↑, 3,   HK1↓, 1,   HK2↓, 2,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 2,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 2,   Pyruv↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↑, 34,   ASC↓, 1,   BAD↑, 2,   Bak↑, 1,   BAX↓, 2,   BAX↑, 18,   Bax:Bcl2↑, 7,   Bcl-2↓, 21,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↓, 1,   BID↑, 1,   BIM↓, 1,   BNIP3?, 1,   BOK↑, 1,   Casp↑, 5,   Casp1↓, 1,   cl‑Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 22,   cl‑Casp3↑, 9,   proCasp3↓, 1,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 6,   Casp9↑, 8,   cl‑Casp9↑, 1,   Cyt‑c↑, 14,   DR5↑, 5,   FADD↑, 1,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 9,   FasL↑, 3,   Ferroptosis↑, 3,   IAP1↓, 2,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 3,   Mcl-1↑, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   NAIP↓, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 3,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 5,   TRAIL↑, 2,   TumCD↑, 2,   XIAP↓, 6,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 17,   Akt↑, 3,   p‑Akt↓, 9,   AKT1↓, 1,   Akt2↓, 1,   BCAP↓, 1,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 2,   EF-1α↓, 1,   EGFR↓, 1,   EGFR↑, 1,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 2,   p‑ERK↑, 2,   FGFR1↓, 3,   FGFR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↑, 1,   IKKα↓, 2,   JAK2↓, 4,   JNK↑, 5,   p‑JNK↑, 3,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 9,   MAPK↑, 4,   p‑MAPK↓, 1,   MEK↓, 2,   mTOR↓, 16,   mTOR↑, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PDE3B↓, 1,   PI3K↓, 16,   p‑PI3K↓, 2,   p‑PIK3R1↓, 1,   p‑PKA↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 2,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 1,   Rictor↓, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT3↓, 9,   STAT3↑, 1,   p‑STAT3↓, 2,   p‑STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   cJun↑, 2,   cMyc↓, 5,   DNMT1↓, 3,   DNMT3B↓, 1,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   H3↓, 1,   H3↑, 1,   H4↓, 1,   H4↑, 1,   HATs↑, 2,   HDAC↓, 4,   HDAC1↓, 1,   HDAC8↓, 1,   miR-107↑, 1,   miR-139-5p↑, 2,   miR-155↓, 1,   miR-21↓, 2,   miR-224↓, 1,   miR-27a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-384↑, 1,   miR-422a↑, 1,   miR-486↑, 1,   Myc↓, 2,   MYCN↓, 1,   NDRG1↑, 1,   OCT4↓, 2,   other↓, 2,   SOX2↓, 2,   SOX4↓, 1,   SOX9?, 1,   tumCV?, 1,   tumCV↓, 11,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 6,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 10,   ERStress↑, 1,   GRP78/BiP↑, 6,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 10,   ATG7↑, 3,   autoF↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 24,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,   CTSZ↓, 1,   LAMP1?, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B↑, 1,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 5,   LC3II↑, 58,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 14,   p62↑, 6,   PARK2↑, 2,   TFEB↑, 1,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 38,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   DNAdam↑, 5,   DNArepair↓, 1,   ERCC3↑, 1,   hTERT/TERT↓, 3,   p16↑, 3,   P53↓, 2,   P53↑, 16,   PARP↑, 5,   cl‑PARP↑, 11,   PCNA↓, 6,   Telomerase↓, 2,   TP53↓, 2,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 7,   CDK4↑, 1,   CDK6↓, 4,   CDK6↑, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 11,   cycE/CCNE↓, 1,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 4,   MAD↓, 1,   mitA↑, 1,   P21?, 1,   P21↓, 1,   P21↑, 7,   p27/CDKN1B↑, 1,   RB1↑, 2,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↑, 1,   p‑4E-BP1↓, 2,   BMI1↓, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 7,   FGF↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 4,   mTORC1↓, 2,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 4,   NOTCH1↓, 4,   NOTCH3↓, 2,   Shh↓, 1,   TumCG↓, 13,   TumCP?, 1,   TumCP↓, 22,   tyrosinase↓, 1,   Wnt↓, 4,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 1,   BACH1↓, 1,   Ca+2↑, 5,   i-Ca+2?, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 7,   EMT↓, 12,   EMT↑, 1,   FAK↓, 2,   ITGA5↓, 1,   ITGB1↓, 1,   LAMs↓, 2,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 10,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 12,   MMPs↓, 4,   N-cadherin↓, 6,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 2,   Snail↓, 4,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI?, 1,   TumCI↓, 8,   TumCMig↓, 6,   TumCMig↑, 1,   TumMeta↓, 10,   TumMeta↑, 2,   Twist↓, 1,   Tyro3↓, 1,   uPA↓, 4,   Vim↓, 8,   Vim↑, 1,   Zeb1↓, 2,   Zeb1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 10,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   angioG↑, 3,   CD31/PECAM-1↓, 2,   eNOS↑, 1,   Hif1a↓, 8,   VEGF↓, 16,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   CLDN1↓, 1,   GLUT1↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 19,   MMP↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   COX2/PTGS2↓, 9,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 1,   DR4↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 4,   IL12↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL2↑, 3,   IL4↓, 1,   IL6↓, 5,   IL8↓, 2,   Inflam↓, 5,   MCP1/CCL2↓, 1,   MCT1↓, 1,   MDSCs↓, 1,   MyD88↑, 1,   NF-kB↓, 19,   NF-kB↑, 2,   NLRP3↓, 2,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 3,   PGE2↓, 2,   RAGE↓, 1,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 4,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 7,   BioAv↑, 3,   BioAv↝, 3,   ChemoSen↓, 1,   ChemoSen↑, 21,   CYP1A1↓, 1,   CYP1B1↑, 1,   Dose↑, 1,   Dose↝, 2,   Dose∅, 4,   eff↓, 11,   eff↑, 18,   eff↝, 3,   Half-Life↓, 2,   Half-Life↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   RadioS↑, 4,   selectivity↑, 9,   Synergy↑, 19,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   AR↓, 1,   AST↓, 1,   BRCA1↓, 1,   CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   EZH2↓, 1,   Ferritin↓, 2,   hTERT/TERT↓, 3,   IL6↓, 5,   LDH↓, 5,   LDH↑, 2,   Myc↓, 2,   NSE↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 1,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 8,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 3,   hepatoP↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 2,   RenoP↑, 3,   Risk↓, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 513

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 11,   Catalase↑, 4,   GPx↑, 5,   GSH↓, 1,   GSH↑, 6,   GSTs↑, 1,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 1,   Keap1↝, 1,   lipid-P↓, 2,   MDA↓, 5,   MDA↑, 1,   MPO↓, 1,   NRF2↑, 3,   ROS↓, 17,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 5,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 2,   ATP↑, 1,   glucose↓, 2,   GSK‐3β↓, 1,   LDHA↑, 1,   LDL↓, 1,   NAD↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 1,   BAX↓, 3,   BAX↑, 1,   Bcl-2↓, 3,   Casp3↓, 6,   Casp3↑, 1,   Casp3∅, 1,   Casp9↓, 2,   cl‑Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 2,   CREB↑, 1,   JNK↓, 2,   MAPK↓, 2,   mTOR↑, 2,   p‑mTOR↓, 2,   PI3K↓, 1,   PKCδ↑, 1,   PP2A↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   LC3II↓, 2,   LC3II↑, 7,   p62↓, 1,   p62↑, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2?, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,   NO↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   MMP↓, 1,   MMP↑, 1,   MMP∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 3,   COX2/PTGS2↑, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 3,   Imm↓, 1,   Inflam?, 1,   Inflam↓, 16,   pol-M2 MC↑, 1,   NF-kB↓, 8,   NLRP3↓, 2,   PGE2↓, 3,   TLR3↓, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   BDNF↓, 1,   BDNF↑, 3,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 8,   BioAv↝, 3,   Dose?, 1,   Dose↝, 5,   eff↓, 1,   eff↑, 2,   Half-Life↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   colonLen↑, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 5,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 5,   cough?, 1,   hepatoP↑, 5,   Learn↑, 2,   memory↑, 7,   neuroP↑, 9,   Obesity↓, 2,   radioP↑, 1,   SoreThr?, 1,   Stroke↓, 1,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiP↑, 3,   AntiViral↑, 3,   Bacteria↓, 2,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 161

Scientific Paper Hit Count for: LC3II, Microtubule-associated protein 1A/1B light chain 3
4 Curcumin
3 Berberine
3 Propolis -bee glue
3 Ferulic acid
3 Licochalcone A
3 Luteolin
2 Artemisinin
2 Capsaicin
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Formononetin
2 Honokiol
2 itraconazole
2 Ivermectin
2 Juglone
2 L-Theanine
2 Silymarin (Milk Thistle) silibinin
1 Silver-NanoParticles
1 Betulinic acid
1 Boron
1 Butyrate
1 Caffeic acid
1 Coenzyme Q10
1 Dichloroacetate
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Evodiamine
1 Fisetin
1 Gambogic Acid
1 hydroxychloroquine
1 Genistein (soy isoflavone)
1 Hibiscus sabdariffa
1 Hyperoside
1 Isoliquiritigenin
1 Isorhamnetin
1 isoorientin
1 isoquercitrin
1 Isovitexin
1 Kaempferol
1 Licorice
1 Magnolol
1 Matrine
1 Magnetic Field Rotating
1 Magnetic Fields
1 Melatonin
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Ursolic acid
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:721  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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