lactateProd Cancer Research Results

lactateProd, lactate production: Click to Expand ⟱
Source:
Type:
Lactate production has been linked to cancer development and progression. In normal conditions, lactate is produced in cells through a process called glycolysis, which breaks down glucose to generate energy. However, in cancer cells, this process is often upregulated, leading to increased lactate production, even in the presence of oxygen. This phenomenon is known as the Warburg effect.

-Lactate is the end product of glycolysis and induces TGFβ1 upregulation and the acidic microenvironment.
Scientific Papers found: Click to Expand⟱
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
944- AG,    Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model
- vitro+vivo, CRC, NA
Glycolysis↓, lactateProd↓, TumCG↓,
2646- AL,    Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
- in-vitro, Pca, DU145 - in-vitro, Melanoma, RPMI-8226
AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
6596- Anamu,    Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells
- in-vitro, AML, K562
TumCP↓, OCR↓, ATP↓, TumCCA↑, ECAR↑, Glycolysis↓, lactateProd↓, mitResp↓,
206- Api,    Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, Melanoma, A375 - in-vitro, Lung, H2030 - in-vitro, CRC, SW480
Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
2323- ART/DHA,    Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706
PKM2↓, lactateProd↓, GlucoseCon↓, cycD1/CCND1↓, Bcl-2↓, MMP2↓, VEGF↓, Casp3↑, cl‑PARP↑, BAX↑, DNAdam↑, ROS↑,
2320- ART/DHA,    Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis
- in-vitro, AML, K562 - in-vitro, Liver, HepG2
Glycolysis↓, GlucoseCon↓, lactateProd↓, GLUT1↓, PKM2↓, ECAR↓, LDHA↓, cMyc↓, other↝,
566- ART/DHA,  2DG,    Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,
2388- Ash,    Withaferin A decreases glycolytic reprogramming in breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-453
GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, GLUT1↓, HK2↓, PKM2↓, cMyc↓, Warburg↓, cMyc↓,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
996- Ba,  Tam,    Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α
Hif1a↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, lact/pyru↓, ROS↑, Apoptosis↑,
2620- Ba,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, GC, NA
Hif1a↓, HK2↓, LDHA↓, PDK1↓, p‑Akt↓, PTEN↑, GlucoseCon↓, lactateProd↓, Glycolysis↓,
940- BBR,    Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
- vitro+vivo, PC, PANC1 - in-vivo, PC, MIA PaCa-2
LDHA↓, lactateProd↓, AMPKα↓, TumVol↓, Ki-67↓,
2335- BBR,    Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116 - in-vivo, NA, NA
PKM2↓, Glycolysis↓, p‑STAT3↓, Bcl-2↓, cycD1/CCND1↓, TumCG↓, Ki-67↓, lactateProd↓, glucose↓,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
2740- BetA,    Effects and mechanisms of fatty acid metabolism-mediated glycolysis regulated by betulinic acid-loaded nanoliposomes in colorectal cancer
- in-vitro, CRC, HCT116
TumCP↓, Glycolysis↓, HK2↓, PFK1↓, PKM2↓, ACSL1↓, CPT1A↓, FASN↓, FAO↓, GlucoseCon↓, lactateProd↓,
943- BetA,    Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
Glycolysis↓, lactateProd↓, GlucoseCon↓, ECAR↓, cMyc↓, LDHA↓, p‑PDK1↓, PDK1↓, Cav1↑, *Glycolysis↑, selectivity↑, OCR↓, OXPHOS↓,
1261- CAP,    Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression
- in-vitro, ESCC, KYSE150
GlucoseCon↓, lactateProd↓, HK2↓, Glycolysis↓, PTEN↑, AKT1↓,
939- Catechins,  5-FU,    Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil
- vitro+vivo, GC, SNU620
lactateProd↓, ROS↑, tumCV↓, LDHA↓, mt-ROS↑, proApCas↑,
7185- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, p‑ATM↑, YAP/TEAD↑, p‑JNK↑, TumPF↓, SUV39H↓, TrxR↓, Casp3↑, Trx1↓, H3↓, lactateProd↓, ATP↓, GlucoseCon↓, TumCG↓, Dose↝,
7167- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, YAP/TEAD↑, ATM↑, JNK↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCP↓, TrxR↓, Trx1↓, H3K9↓, p‑ATM↑, γH2AX↑, ALDOB↑, ENO3↑, FBP1↑, GSK‐3β↑, HK3↑, PCK1↑, PGK2↑, PGM1↑, PGM3↑, PHKG1↑, PKLR↑, HK2↓, PCNA↓,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
1143- CHr,    Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2
- in-vitro, HCC, HepG2 - in-vivo, NA, NA - in-vitro, HCC, HepG3 - in-vitro, HCC, HUH7
HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, Apoptosis↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
7039- Cic,    Chicoric acid targets PYGL to normalize glycogenolysis-driven glycolysis to suppress non-small cell lung cancer
- in-vitro, NSCLC, H1975 - in-vitro, NSCLC, H460
PYGL↓, Glycolysis↓, LDHA↓, lactateProd↓, GlucoseCon↓, TumCP↓,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
GlucoseCon↓, lactateProd↓, pH↑, NO↑, LAR↓, Hif1a↓, LDHA↓, MCT1↓, MDR1↓, STAT3↓, HCAR1↓,
6685- DAP,    Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
- in-vitro, Lung, H1975
PDKs↓, selectivity∅, MMP↓, Apoptosis↑, lactateProd↓, ROS↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6682- DCA,  QC,    Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer
- in-vivo, HNSCC, MEER
PDK1↓, lactateProd↓, GlucoseCon↓, tumCV↓, mTOR↓, Apoptosis↑, ROS↑, TumCG↓, pH↑, cl‑PARP↑, Casp3↑, DNAdam↑, p‑γH2AX↑, eff↓, OS↑,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
PDK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
6678- DCA,  Cisplatin,    Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma
- Trial, HNSCC, NA
PDK1↓, OS∅, lactateProd↓, toxicity↝, FAO↑,
5195- DCA,  Rad,    Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
- in-vitro, BC, 4T1 - in-vitro, BC, EMT6
PDKs↑, ROS↑, p‑PDH↓, ECAR↓, lactateProd↓, selectivity↓, RadioS↑,
1878- DCA,  5-FU,    Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
- in-vitro, CRC, LS174T - in-vitro, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1882- DCA,    Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
- Analysis, NA, NA
PDKs↓, PDH↑, lactateProd↓, Half-Life∅,
1869- DCA,    Dichloroacetate induces autophagy in colorectal cancer cells and tumours
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29
LC3II↑, ROS↑, mTOR↓, MCT1↓, NADH:NAD↓, NAD↑, TumAuto↑, lactateProd↓, LDH↑,
1866- DCA,  MET,  BTZ,    Targeting metabolic pathways alleviates bortezomib-induced neuropathic pain without compromising anticancer efficacy in a sex-specific manner
- in-vivo, NA, NA
eff↑, TumCG↓, Hif1a↓, PDH↑, lactateProd↓, TumVol↓, TumW↓, Glycolysis↑, neuroP↑,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
6700- DFC,    Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments
- in-vitro, BC, MDA-MB-231
MCT1↓, MCT4↓, lactateProd↓,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6706- DFC,  MET,    Frontiers | Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells
- in-vitro, AML, U937
lactateProd↓, TumCP↓, eff↑, Glycolysis↓,
6708- DFC,    Repurposing Drugs as Expanding Cancer Treatment Palette: Diclofenac
lactateProd↓, LDHA↓, TumCCA↑, TumCG↓, eff↑,
6688- DFC,    New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- in-vivo, lymphoma, U937
AntiCan↑, COX2↓, Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, lactateProd↓, TumCP↓, other∅, toxicity↝,
6696- DFC,  MET,    Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma
- in-vitro, GBM, GBM
compI↓, Glycolysis↓, OCR↓, Glycolysis↑, lactateProd↓, eff↑, TumCP↓, TumCMig↓, TumCD∅,

Showing Research Papers: 1 to 50 of 141
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 141

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDOB↑, 1,   ENO3↑, 1,   H3K9↓, 1,   HK3↑, 1,   miR-375↑, 1,   PGK2↑, 1,   PGM3↑, 1,   PHKG1↑, 1,   PKLR↑, 1,   PYGL↓, 1,   SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   Ferroptosis↑, 3,   GPx↓, 1,   GPx4↓, 3,   GSH↓, 3,   GSH∅, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   H2O2↑, 1,   HK1↓, 1,   HO-1↑, 2,   HO-2↑, 1,   Iron↑, 3,   lipid-P↑, 2,   MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NRF2↓, 1,   NRF2↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   ROS↑, 29,   mt-ROS↑, 1,   SOD2↓, 1,   Trx1↓, 2,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 11,   ETC↓, 1,   mitResp↓, 2,   mitResp↑, 1,   MMP↓, 4,   MPT↑, 1,   mtDam↑, 2,   OCR↓, 5,   OCR↑, 2,   SDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL1↓, 1,   AKT1↓, 1,   ALDOA↓, 1,   AMPK↑, 2,   p‑AMPK↑, 1,   Cav1↑, 1,   cMyc↓, 5,   CPT1A↓, 1,   ECAR↓, 6,   ECAR↑, 1,   ENO1↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 3,   FBP1↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 24,   GlucoseCon∅, 1,   Glycolysis↓, 29,   Glycolysis↑, 2,   HK2↓, 14,   HMG-CoA↓, 1,   lact/pyru↓, 1,   lactateProd↓, 48,   lactateProd↑, 1,   lactateProd∅, 1,   LAR↓, 1,   LDH↑, 1,   LDHA↓, 13,   lipoGen↓, 1,   MCT4↓, 2,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 2,   PCK1↑, 1,   PDH↑, 2,   p‑PDH↓, 1,   p‑PDH↑, 1,   PDK1↓, 9,   p‑PDK1↓, 2,   PDKs↓, 5,   PDKs↑, 1,   PFK↓, 1,   PFK1↓, 2,   PFKP↓, 1,   PGK1↓, 1,   PGM1↑, 1,   PI3K/Akt↓, 1,   PKM2↓, 9,   PPARγ↑, 1,   PPP↓, 1,   Pyruv↓, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 6,   p‑Akt↓, 2,   Apoptosis↑, 15,   BAX↑, 5,   Bcl-2↓, 6,   BIM↑, 1,   Casp↑, 4,   Casp3↑, 10,   Casp8↑, 1,   Casp9↑, 4,   Cyt‑c↑, 6,   DR5↑, 2,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 3,   hTERT/TERT↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MCT1↓, 6,   Myc↓, 2,   p38↑, 2,   proApCas↑, 1,   survivin↓, 1,   TumCD∅, 1,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↓, 1,   CaMKII ↓, 1,   HER2/EBBR2↓, 1,   RET↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   other↝, 3,   other∅, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 2,   HSP90↓, 1,   PERK↑, 3,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↑, 1,   LC3s↓, 1,   p62↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 2,   DNA-PK↑, 1,   DNAdam↑, 5,   DNMTs↓, 1,   P53↑, 2,   p73↑, 1,   cl‑PARP↑, 5,   PCNA↓, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 2,   cMET↓, 1,   CSCs↓, 5,   EMT↓, 5,   GSK‐3β↑, 1,   HDAC↓, 1,   HH↓, 1,   HMTs↓, 2,   Let-7↑, 1,   mTOR↓, 10,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   PI3K↓, 4,   PTEN↑, 2,   SHP1↑, 1,   SOX2↓, 1,   STAT3↓, 4,   p‑STAT3↓, 3,   TOP1↓, 1,   TumCG↓, 10,   TumCG↑, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   CAFs/TAFs↓, 1,   E-cadherin↑, 2,   Ki-67↓, 3,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 2,   Slug↓, 1,   Snail?, 1,   TET1↑, 2,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 12,   TumMeta↓, 4,   TumPF↓, 1,   Twist↓, 2,   uPA↓, 2,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   ATF4↑, 2,   Hif1a↓, 11,   NO↓, 1,   NO↑, 1,   VEGF↓, 4,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   COX2↑, 1,   HCAR1↓, 2,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   M2 MC↓, 1,   NF-kB↓, 5,   NK cell↑, 1,   TLR4↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 3,   e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 6,   Dose↝, 7,   Dose∅, 1,   eff↓, 8,   eff↑, 25,   eff↝, 1,   Half-Life↓, 1,   Half-Life∅, 1,   MDR1↓, 1,   RadioS↑, 5,   selectivity↓, 1,   selectivity↑, 7,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   Ferritin↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 3,   LDH↑, 1,   Myc↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   chemoP↑, 1,   fatigue↓, 1,   neuroP↑, 1,   NP/CIPN↑, 1,   OS↑, 2,   OS∅, 1,   Remission↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 4,   TumVol↓, 3,   TumW↓, 2,  
Total Targets: 298

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSR↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↑, 1,   lipidLev↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 2,   IL1β↓, 1,   IL2↓, 1,   Inflam↓, 4,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   Half-Life↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 2,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 4,   Pain↓, 1,   RenoP↑, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 38

Scientific Paper Hit Count for: lactateProd, lactate production
18 Shikonin
12 Dichloroacetate
8 Quercetin
8 Diclofenac
7 Resveratrol
5 EGCG (Epigallocatechin Gallate)
4 Artemisinin
4 Curcumin
4 Metformin
4 Rosmarinic acid
3 Betulinic acid
3 Chrysin
3 Methylene blue
3 Ursolic acid
3 Vitamin K2
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 5-fluorouracil
2 chaetocin
2 Citric Acid
2 Cisplatin
2 Radiotherapy/Radiation
2 Fenbendazole
2 Glabrescione B
2 Magnetic Fields
2 Propolis -bee glue
2 Pterostilbene
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
1 3-bromopyruvate
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Apigenin (mainly Parsley)
1 2-DeoxyGlucose
1 tamoxifen
1 Capsaicin
1 Catechins
1 Cichoric acid / Chicoric acid
1 Dichloroacetophenone(2,2-)
1 Bortezomib
1 salinomycin
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ellagic acid
1 Gossypol
1 Hydrogen Gas
1 Honokiol
1 Kaempferol
1 lambertianic acid
1 Melatonin
1 Magnetic Field Rotating
1 Oroxylin-A
1 Pachymic acid
1 Proanthocyanidins
1 Phenylbutyrate
1 Sulforaphane (mainly Broccoli)
1 Selenite (Sodium)
1 triptolide
1 Vitamin B1/Thiamine
1 Arsenic trioxide
1 Wogonin
1 Worenine
1 β‐Elemene
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:739  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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