toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, eff↑,
7633- Ins,    Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use
- Trial, Nor, NA
*BioAv↑, *toxicity↓,
7662- IP,    Digestive tolerance of inulin-type fructans: a double-blind, placebo-controlled, cross-over, dose-ranging, randomized study in healthy volunteers
- Trial, Nor, NA
Dose↝, toxicity↓,
7712- IP6,    Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice
- in-vivo, Pca, NA
toxicity↓, PCNA↓, TumCG↓, TumCP↓, Apoptosis↑, Risk↓,
7722- IP6,    Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
- Review, Var, NA
eff↑, TumCP↓, Diff↑, TumCCA↑, Imm↑, antiOx↑, BioAv↑, toxicity↓, ChemoSen↑, TumMeta↓, QoL↑,
7723- IP6,    Prostate cancer and inositol hexaphosphate: efficacy and mechanisms
- Review, Pca, NA
toxicity↓, AntiCan↑, TumCG↓, TumCCA↑, angioG↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, eff↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7756- ISL,    Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
AntiCan↑, VEGF↓, TumCI↓, TumCMig↓, Hif1a↓, TumCG↓, angioG↓, VEGFR2/KDR/Flk1↓, Apoptosis↑, toxicity↓, TumCCA↑, Inflam↓, ROS↑,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7739- isoFl,    Soy, red clover, and isoflavones and breast cancer: a systematic review
- Review, BC, NA
Dose↝, Risk↓, toxicity↓,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7881- isoO,    Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice
- in-vivo, Nor, NA
*Weight↑, *toxicity↓, *GutMicro↑, *SOD↑, *GPx↑, *MDA↓, *Inflam↓,
7880- isoO,    Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells
- in-vitro, Nor, PC12
*toxicity↓, *Apoptosis↓, *Casp3↓, *PARP↓, *ROS↓,
7846- ISQ,    Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rats
- in-vivo, Nor, NA
*BioAv↑, *toxicity↓,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
7984- itraC,    The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells
VEGFR2/KDR/Flk1↓, angioG↓, toxicity↓, mTOR↓,
8009- itraC,    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
- vitro+vivo, Melanoma, SK-MEL-28 - vitro+vivo, Melanoma, A375
OS↑, TumCP↓, Ki-67↓, TumCP↓, Gli1↓, GLI2↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, AXIN1↑, GLI3↑, AXIN1↑, HH↓, PI3K↓, Akt↓, *toxicity↓,
7996- itraC,    Itraconazole in the Treatment of Aberrantly Active Hedgehog and/or PI3K Recurrent Ovarian Cancer
- Trial, Ovarian, NA
HH↓, PI3K↓, toxicity↝, eff∅, CA125∅, other↝,
7991- itraC,    A Phase II Trial of Perioperative Oral Itraconazole for the Management of Low-Risk Basal Cell Carcinoma
- Trial, BCC, NA
Smo↓, Dose↓, TumVol↓, Endoglin↓, angioG↓, toxicity↝, GLI3↓, toxicity↓,
7990- itraC,    A Novel Approach to Reducing Chemoresistance in Advanced Ovarian Cancer: The Effect of Itraconazole-A Single-Institution Randomized Placebo-Controlled Trial
- Trial, Ovarian, NA
Dose↝, DCR↑, PFS↑, CA125↓, P-gp/ABCB1↓, VEGFR2/KDR/Flk1↑, toxicity↓, QoL↑, toxicity↝,
7988- itraC,    Itraconazole as a Noncastrating Treatment for Biochemically Recurrent Prostate Cancer: A Phase 2 Study
- Trial, Pca, NA
PSA↓, toxicity↝, testos∅, toxicity↝,
7987- itraC,    Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer
- Trial, Pca, NA
angioG↓, HH↓, Dose↝, PSA↓, CTC↓, other↝, toxicity↝,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8036- IVM,    Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway
- in-vitro, ESCC, KYSE-30
*AntiP↑, AntiTum↑, ER Stress↑, TumAuto↑, ATF4↑, CHOP/DDIT3↝, TumCG↓, PERK↑, ROS↑, *toxicity↓, Ca+2↑,
7889- IVT,    Prevention of cellular ROS damage by isovitexin and related flavonoids
- in-vitro, Nor, NA
*XO↓, *other↓, *Fenton↓, *ROS↓, *toxicity↓, *other↝,
1918- JG,    ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
- in-vitro, Liver, HepG2 - in-vivo, NA, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑, toxicity↝, p62↓, DR5↑, Casp8↑, PARP↑, cl‑Casp3↑,
8058- KAE,    A randomized, placebo‐controlled trial evaluating the safety of excessive administration of kaempferol aglycone
- Trial, Nor, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *Dose↝, *toxicity↓,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8064- KAE,    Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, SNU-213
AntiCan↑, tumCV↓, Apoptosis↑, TumCMig↓, *toxicity↓, Dose?,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, eff↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8108- L-Orn,    Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review
- Review, Nor, NA
*toxicity↓, *toxicity↓, *GH↑, *Obesity↓, *NH3↓, *hepatoP↑, *Sleep↑, *fatigue↓,
8146- Lae,    Laetrile treatment for cancer
- Review, Var, NA
AntiCan↝, toxicity↑,
865- Lae,    Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation
*toxicity↝, other↝,
8173- Lap,  Tras,    Efficacy and safety of lapatinib and trastuzumab for HER2-positive breast cancer: a systematic review and meta-analysis of randomised controlled trials
- Review, BC, NA
CR↑, EFS↑, OS↑, toxicity↝,
8169- Lap,    Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
- in-vitro, Liver, HepG2
toxicity↑, mtDam↑, ROS↑, NRF2↑, GSH↑, GSSG↑, SOD2↑,
8166- LapC,    Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model
- vitro+vivo, BC, NA
BioAv↓, *toxicity↑, eff↑,
8176- Las,    In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model
- vitro+vivo, BC, NA
TumCCA↑, Apoptosis↑, DNAdam↑, TumMeta↓, PI3K↓, Akt↓, mTOR↓, STAT3↓, TumVol↓, toxicity↓,
8219- LCA,    Licochalcone A Ameliorates Cognitive Dysfunction in an Alzheimer's Disease Model by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *Aβ↓, *ER Stress↓, *BioAv↑, *toxicity↓, *PERK↓, *eIF2α↓, *ATF4↓, *CHOP/DDIT3↓, *NRF2↑,
8232- LCA,    Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study
- vitro+vivo, ESCC, NA
TumCP↓, TumCMig↓, TumCI↓, MMPs↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK1↓, P53↑, TumCG↓, toxicity↓,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8127- LF,    Phase I trial of oral talactoferrin alfa in refractory solid tumors
- Trial, Var, NA
Imm↑, NK cell↑, Dose↝, toxicity↓, IL18↑, SD↑, TumCG↓, OS↑,
8128- LF,    Phase 2 trial of talactoferrin in previously treated patients with metastatic renal cell carcinoma
- Trial, RCC, NA
Imm↑, NK cell↑, Dose↝, toxicity↓, PFS↑,
8129- LF,    Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy
- Trial, CRC, NA
Dose↝, toxicity↓, INF-γ↝, other↑, *ROS↓, Imm↑, WBC↑, Neut↑, T-Cell↑, *antiOx↑, *GSH↑, *chemoP↑, *RenoP↑, *hepatoP↑, BUN↓, creat↓, ALAT↓, AST↓, RBC↑, PC↑, Mucositis↓, *AntiBio↑, *AntiViral↑, *AntiFungal↑, *Inflam↓,
8142- LF,    A Randomized, Double-Blind, Controlled Trial to Assess the Effects of Lactoferrin at Two Doses vs. Active Control on Immunological and Safety Parameters in Healthy Adults
- Trial, Nor, NA
*Dose↝, *toxicity↓,
8138- LF,    A review of the safety evidence on recombinant human lactoferrin for use as a food ingredient
- Review, Nor, NA
*toxicity↓,

Showing Research Papers: 451 to 500 of 698
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 698

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CR↑, 1,   DCR↑, 1,   EFS↑, 1,   FBXO5/EMI1↓, 1,   Mucositis↓, 1,   PC↑, 1,   PFS↑, 2,   PSEN1/PS1↓, 1,   RBC↑, 1,   WBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   Ferroptosis↑, 2,   GSH↑, 1,   GSSG↑, 1,   H2O2↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↑, 1,   NRF2↑, 1,   PARK2↑, 1,   ROS↓, 1,   ROS↑, 12,   SOD↑, 1,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   Insulin↓, 1,   MMP↓, 5,   MPT↑, 1,   mtDam↑, 4,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   BUN↓, 1,   glucose↝, 1,   Glycolysis↓, 3,   lipoGen↓, 1,   PKM2↓, 1,   PKM2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   p‑Akt↓, 2,   Apoptosis↑, 11,   BAX↑, 3,   Bax:Bcl2↑, 4,   Bcl-2↓, 2,   Casp3↑, 5,   cl‑Casp3↑, 2,   proCasp3↓, 1,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 2,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p27/CDKN1B↓, 2,   p38↓, 1,   p38↑, 1,   Pyro↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   other↑, 2,   other↝, 4,   pRB↓, 1,   p‑pRB↓, 2,   SD↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   CHOP/DDIT3↝, 1,   ER Stress↑, 4,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   DNMTs↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 3,   PARP1↑, 1,   PCNA↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↓, 2,   P21↑, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AXIN1↑, 2,   CD44↓, 1,   CSCs↓, 1,   Diff↑, 3,   EMT↓, 2,   ERK↓, 2,   ERK↑, 1,   p‑ERK↓, 1,   FOXO4↑, 1,   Gli1↓, 1,   HH↓, 5,   mTOR↓, 6,   mTOR↑, 1,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 8,   RAS↓, 1,   Smo↓, 1,   STAT↓, 1,   STAT3↓, 3,   TumCG↓, 8,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   Cofilin↓, 1,   E-cadherin↑, 1,   fascin↓, 1,   GLI2↓, 1,   GLI3↓, 1,   GLI3↑, 1,   Ki-67↓, 2,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 3,   N-cadherin↓, 1,   PKCδ↓, 1,   ROCK1↓, 1,   Snail↓, 1,   SOX4↓, 1,   TIMP2↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 11,   TumMeta↓, 6,   VEGFR1↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   ATF4↑, 1,   Endoglin↓, 1,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 2,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL18↑, 1,   Imm↑, 7,   Imm↝, 1,   INF-γ↝, 1,   Inflam↓, 3,   JAK↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB↓, 5,   NK cell↑, 4,   PGE2↓, 1,   PSA↓, 2,   T-Cell↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 6,   ChemoSen↑, 9,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 12,   eff↓, 2,   eff↑, 11,   eff∅, 1,   Half-Life↝, 1,   MDR1↓, 2,   RadioS↑, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   CA125↓, 1,   CA125∅, 1,   creat↓, 1,   CTC↓, 1,   Ki-67↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiCan↝, 1,   antiNeop↑, 1,   AntiTum↑, 1,   chemoP↑, 4,   neuroP↑, 1,   OS↑, 4,   QoL↑, 4,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 4,   toxicity↓, 20,   toxicity↑, 2,   toxicity↝, 10,   TumVol↓, 3,   TumW↓, 2,  
Total Targets: 218

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,   AntiP↑, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   ARE↑, 1,   Catalase↑, 1,   Fenton↓, 1,   Ferroptosis↓, 1,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 1,   HO-1↑, 2,   Iron∅, 1,   i-Iron↓, 1,   lipid-P↓, 1,   MDA↓, 3,   MPO↓, 1,   NQO1↑, 1,   NQO1↝, 1,   NRF2↑, 4,   ROS↓, 8,   SOD↑, 3,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↑, 1,   NH3↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Ferroptosis↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   eIF2α↓, 1,   ER Stress↓, 1,   PERK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GH↑, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 7,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,   XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   Dose↝, 3,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 4,   AntiTum↑, 2,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 3,   neuroP↑, 2,   Obesity↓, 1,   RenoP↑, 2,   Sleep↑, 1,   toxicity↓, 20,   toxicity↑, 2,   toxicity↝, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 3,  
Total Targets: 74

Scientific Paper Hit Count for: toxicity, toxicity
31 Silver-NanoParticles
21 Selenium NanoParticles
17 chitosan
16 Magnetic Fields
13 Chemotherapy
13 Dichloroacetate
12 Selenite (Sodium)
12 Sulforaphane (mainly Broccoli)
11 5-Hydroxytryptophan
11 Radiotherapy/Radiation
10 3-bromopyruvate
10 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Hydrogen Gas
9 Honokiol
9 Phenylbutyrate
8 Cisplatin
8 Copper and Cu NanoParticles
8 Ginkgo biloba-EGb 761
8 Fenbendazole
8 itraconazole
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Carvacrol
7 Dandelion Root
7 Graviola
6 Apigenin (mainly Parsley)
6 borneol
6 Boron
6 Metformin
6 D-limonene
6 Emodin
6 Eugenol
6 Germanium inorganic
6 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
6 Resveratrol
6 Magnetic Field Rotating
6 Piperlongumine
6 Pterostilbene
6 Selenium
5 Auranofin
5 Allicin (mainly Garlic)
5 HydroxyCitric Acid
5 Artemisinin
5 Capsaicin
5 Ellagic acid
5 Hyperthermia
5 Inositol
5 Lactoferrin/Talactoferrin
5 Shikonin
5 Urolithin
5 Vitamin K2
4 Gold NanoParticles
4 Alpha-Lipoic-Acid
4 beta-glucans
4 Betulinic acid
4 α-Bisabolol / Chamomile oil
4 Celastrol
4 Chlorogenic acid
4 chaetocin
4 Chrysin
4 Cucurbitacin
4 salinomycin
4 Deguelin
4 Disulfiram
4 Folic Acid, Vit B9
4 Fucoidan
4 Gambogic Acid
4 Garcinol
4 Ginkgolic acids
4 Ginkgo biloba
4 Germanium Organic/Ge-132 / propagermanium (organogermanium)
4 Ginger/6-Shogaol/Gingerol
4 isoorientin
4 Kaempferol
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Vitamin C (Ascorbic Acid)
3 SonoDynamic Therapy UltraSound
3 Anti-oxidants
3 doxorubicin
3 Atorvastatin
3 Baicalin
3 Beta-Caryophyllene
3 Bullatacin
3 Carnosine
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorophyllin
3 Cinnamon
3 Diclofenac
3 Docosahexaenoic Acid
3 diet FMD Fasting Mimicking Diet
3 Oxygen, Hyperbaric
3 Ivermectin
3 Gallic acid
3 Geldanamycin
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Indole-3-carbinol
3 Isoliquiritigenin
3 Licochalcone A
3 Magnolol
3 Melatonin
3 Bicarbonate(Sodium)
3 Niclosamide (Niclocide)
3 Quercetin
3 Rosmarinic acid
3 Sulfasalazine
2 Astragalus
2 Zinc
2 Ascorbyl Palmitate
2 Paclitaxel/Taxol
2 Arsenic trioxide
2 Aloe anthraquinones
2 Berbamine
2 brusatol
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 carboplatin
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Vitamin E
2 CUSP9
2 Docetaxel
2 Lemongrass Extract/Citral
2 immunotherapy
2 Echinacea
2 Estragole
2 Fennel Oil/Foeniculum vulgare
2 Evodiamine
2 Ferulic acid
2 Flickering Light Stimulation
2 Formononetin
2 Shilajit/Fulvic Acid
2 Gamma-aminobutyric acid
2 Germanium-Spirogermanium
2 Germacranolide sesquiterpene lactone
2 Hibiscus sabdariffa
2 Hyperoside
2 isoflavones
2 isoquercitrin
2 Laetrile B17 Amygdalin
2 Lapatinib
2 Luteolin
2 Lycopene
2 metronomic chemo
2 Propyl gallate
2 Piperine
2 Psoralidin
2 Ramucirumab (CYRAMZA)
2 EMF
2 Terpinen-4-ol / Tea Tree Oil
2 tetrathiomolybdate
2 Whole Body Vibration
1 1,8-Cineole
1 Resiquimod
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 5-Aminolevulinic acid
1 Aspirin
1 Astaxanthin
1 Dipyridamole
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 Bromelain
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 Catechins
1 Cat’s Claw
1 Celecoxib
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Black phosphorus
1 chemodynamic therapy
1 Cynaropicrin
1 Cysteamine
1 diet Fermented Foods
1 diet Ketogenic
1 diet Methionine-Restricted Diet
1 Protocatechuic acid
1 ferumoxytol
1 Fisetin
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
1 Vitamin D3
1 Ginkgolide B
1 Grapeseed extract
1 hydroxychloroquine
1 Isobavachalcone
1 imatinib
1 Inulin Prebiotic
1 Isovitexin
1 Juglone
1 L-ornithine
1 Trastuzumab
1 Lapachol
1 Lasiodin
1 Linalool
1 MCToil
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 magnetic nanoparticles
1 Moringa oleifera
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Oleuropein
1 Peppermint
1 5-fluorouracil
1 sericin
1 Sanguinarine
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 benzo(a)pyrene
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Date Fruit Extract
1 Taurine
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitexin
1 Wogonin
1 Xylitol
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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