selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
1948- PL,  BNL,    Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy
- in-vitro, GBM, NA
selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, eff↑,
1949- PL,    Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor
- in-vitro, CRC, HCT116 - in-vitro, Cerv, HeLa
TrxR↓, selectivity↑, ROS↑, IDO1↓,
1950- PL,    Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Lung, A549
selectivity↑, ROS↑, SETBP1↓, cl‑Casp9↑, eff↓, FOSB↑,
1953- PL,    Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation
- in-vitro, Lung, A549 - in-vitro, Nor, WI38
ROS↑, selectivity↑, TrxR↓, TumCCA↑, GSH?, H2O2↑,
1944- PL,    Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress
- in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
ER Stress↑, TrxR1↓, ROS↑, eff↓, Bcl-2↓, proCasp3↓, BAX↓, cl‑Casp3↑, TumCCA↑, p‑PERK↑, ATF4↑, TumCG↓, lipid-P↑, selectivity↑,
1943- PL,    Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells
- in-vitro, GBM, NA - in-vivo, NA, NA
selectivity↑, ROS↑, selectivity↑, Prx4↓, *Prx4∅, ER Stress↑, CHOP/DDIT3↑, UPR↑,
1941- PL,    Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
- in-vitro, HNSCC, NA
selectivity↑, eff↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,
1939- PL,    Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP/DDIT3↑, Dose↝,
2973- PL,    The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1
MMP2↓, MMP9↓, IL6↓, E-cadherin↑, ROS↑, EMT↓, Zeb1↓, Slug↓, TumMeta↓, selectivity↑, MMP2↓, GSH↓,
3000- PL,    Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
- in-vitro, Nor, HUVECs - in-vitro, Laryn, HEp2
Inflam↓, AntiTum↑, *α-tubulin↓, selectivity↑, HIF2a↓, MCP1/CCL2↓,
2941- PL,    Selective killing of cancer cells by a small molecule targeting the stress response to ROS
- in-vivo, BC, MDA-MB-231 - in-vitro, OS, U2OS - in-vitro, BC, MDA-MB-453
ROS↑, Apoptosis↑, selectivity↑, *ROS∅, GSH↓, GSSG↑, H2O2↑, NO↑, Half-Life?,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2949- PL,    Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
selectivity↑, ROS↑, JNK↑, p38↑, GSH↓, eff↓,
2955- PL,    Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,
2954- PL,    The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
- Review, Var, NA
NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP/DDIT3↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,
2006- PLB,    Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,
2005- PLB,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,
4969- PSO,    The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
- in-vitro, Cerv, HeLa
AntiCan↑, chemoPv↑, TRAIL↑, selectivity↑, toxicity↓, MMP↓, Apoptosis↑,
5157- PTL,    An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
- vitro+vivo, AML, NA
CSCs↓, selectivity↑, BioAv↓, BioAv↑, ROS↑, NF-kB↓, P53↑,
5156- PTL,    Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells
- in-vitro, AML, NA
NADPH↑, PPP↑, NRF2↑, ROS↑, CSCs↓, selectivity↑, other↝,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
1994- PTL,    Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells
- in-vitro, Melanoma, A2058 - in-vitro, Nor, L929
tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, eff↑,
2409- PTS,    Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway
- in-vitro, BC, EMT6 - in-vitro, BC, 4T1 - in-vitro, Nor, HC11
Pyro↑, Glycolysis↓, *toxicity∅, selectivity↑, GSDMC↑, PKM2↓, PKM1↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCG↓,
2303- QC,  doxoR,    Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- in-vitro, BC, 4T1 - in-vivo, NA, NA
cardioP↑, hepatoP↑, TumCG↓, OS↑, ChemoSen↑, chemoP↑, Hif1a↓, *Hif1a↑, selectivity↑, TumVol↓, OS↑,
3344- QC,    Quercetin induced ROS production triggers mitochondrial cell death of human embryonic stem cells
- in-vitro, Nor, hESC
mt-ROS↑, selectivity↑, P53↑, ROS⇅,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
JAK↓, STAT↓, Inflam↓, NO↓, COX2/PTGS2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *eff↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp/ABCB1↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
71- QC,    Role of Bax in quercetin-induced apoptosis in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PrEC - in-vitro, Pca, YPEN-1 - in-vitro, Pca, HCT116
Casp8↑, Casp9↑, PARP↑, BAD↓, BAX↑, PI3K/Akt↓, Cyt‑c↑, selectivity↑,
73- QC,    The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
HSP90↓, Casp3↑, Casp9↑, TumCG↓, TumCD↑, selectivity↑, toxicity↓,
2991- RES,  Chemo,    Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells
- in-vitro, Melanoma, MSTO-211H - in-vitro, Nor, MeT5A
eff↑, selectivity↑, Sp1/3/4↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
3011- RosA,    Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition
- in-vitro, GBM, SH-SY5Y - in-vitro, Lung, A549 - in-vitro, Nor, HEK293 - in-vitro, Nor, MCF10
MARK4↓, p‑tau↓, selectivity↑, *toxicity∅,
3008- RosA,    Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells
- in-vitro, Melanoma, SK-MEL-28
tumCV↓, TumCMig↓, ROS↓, Casp3↑, selectivity↑, Casp8↑, NLRP3↓,
3033- RosA,    Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP - vitro+vivo, NA, NA
ER Stress↑, selectivity↑, AR↓, TumCG↓, TumCCA↑, CHOP/DDIT3↑, PERK↓, GRP78/BiP↑, PSA↓,
4899- Sal,    Anticancer activity of salinomycin quaternary phosphonium salts
- in-vitro, Var, NA
eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP/DDIT3↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
5121- Sal,    Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, BC, NA
CSCs↓, Wnt↓, selectivity↑,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6444- SAO,    Sandalwood oil by-product prevents prostate cancer development in mice
- in-vivo, Pca, PC12
TumVol↓, selectivity↑,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
6451- SAO,    α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer
- vitro+vivo, BC, MDA-MB-231
TumCP↓, selectivity↑, Bcl-2↓, PLK1↓, BAD↑, Casp↑, BAX↑, Dose↝, TumCG↓,

Showing Research Papers: 451 to 500 of 589
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 589

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Fenton↑, 1,   Ferroptosis↑, 1,   GSH?, 1,   GSH↓, 7,   GSH/GSSG↓, 1,   GSSG↑, 3,   GSTP1/GSTπ↓, 1,   H2O2↑, 2,   HO-1↑, 3,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↑, 1,   NRF2↑, 4,   OXPHOS↓, 2,   Prx4↓, 1,   Prx4↑, 1,   ROS?, 2,   ROS↓, 3,   ROS↑, 28,   ROS⇅, 2,   mt-ROS↑, 2,   SOD2↓, 1,   Trx↓, 1,   TrxR↓, 3,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   EGF↓, 1,   mitResp↑, 1,   MMP↓, 5,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   IDO1↓, 1,   lactateProd↓, 1,   NADPH↑, 2,   PI3K/Akt↓, 1,   PKM1↑, 1,   PKM2↓, 1,   PPP↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 2,   Apoptosis↑, 11,   BAD↓, 1,   BAD↑, 1,   BAX↓, 2,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Casp↑, 3,   Casp3↓, 1,   Casp3↑, 10,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 2,   Casp9↓, 1,   Casp9↑, 6,   cl‑Casp9↑, 1,   Cyt‑c↑, 6,   DR5↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   GSDMC↑, 1,   JNK↑, 4,   MAPK↓, 2,   MAPK↑, 2,   MDM2↓, 1,   MKP1↓, 1,   MKP2↓, 1,   p38↓, 1,   p38↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 1,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   other⇅, 1,   other↝, 1,   SETBP1↓, 1,   tumCV↓, 9,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   ER Stress↑, 8,   ERStress↑, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   PERK↓, 1,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↑, 4,   PARP↑, 3,   cl‑PARP↑, 6,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   P21↓, 1,   P21↑, 2,   PLK1↓, 1,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD24↓, 3,   CD44↓, 3,   CSCs↓, 11,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 3,   EMT↓, 2,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   GSK‐3β↓, 1,   HH↓, 1,   mTOR↓, 4,   PI3K↓, 1,   PI3K↑, 1,   PTEN↑, 1,   RAS↓, 2,   Shh↓, 2,   STAT↓, 1,   STAT1↓, 1,   STAT3↓, 3,   STAT4↓, 1,   STAT6↓, 1,   TOP2↓, 1,   TumCG↓, 9,   Wnt↓, 6,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 2,   E-cadherin↑, 1,   Fibronectin↓, 1,   FOSB↑, 1,   KRAS↓, 1,   MARK4↓, 1,   MMP2↓, 5,   MMP9↓, 4,   MMPs↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   PKCδ↑, 1,   Slug↓, 1,   SOX4↑, 1,   TIMP1↑, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 4,   TumMeta↓, 3,   Twist↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 1,   Hif1a↓, 2,   HIF2a↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   CRP↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IL6↓, 2,   Inflam↓, 3,   JAK↓, 1,   JAK2↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   PSA↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↑, 8,   Dose↝, 3,   eff↓, 8,   eff↑, 17,   Half-Life?, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   RadioS↑, 5,   selectivity?, 1,   selectivity↑, 49,   selectivity↝, 1,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CRP↓, 1,   EGFR↓, 1,   IL6↓, 2,   KRAS↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 2,   radioP↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 1,  
Total Targets: 239

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GSH↑, 3,   GSH/GSSG↑, 1,   GSSG∅, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↑, 3,   MDA↓, 1,   Nrf1↑, 1,   NRF2↑, 2,   Prx4∅, 1,   ROS↓, 3,   ROS↑, 2,   ROS∅, 3,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH∅, 1,  

Cell Death(tgid=5) ⓘ

JNK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 1,  

Migration(tgid=13) ⓘ

α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 3,   MCP1/CCL2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↑, 2,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 2,   CardioT↓, 1,   neuroP↑, 3,   Pain↓, 1,   toxicity↓, 1,   toxicity∅, 2,  
Total Targets: 44

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
27 Magnetic Fields
17 Piperlongumine
16 Radiotherapy/Radiation
14 Selenium NanoParticles
13 Thymoquinone
12 Chemotherapy
12 Betulinic acid
12 Dandelion Root
10 Vitamin C (Ascorbic Acid)
10 chitosan
10 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 salinomycin
10 Fisetin
10 Phenethyl isothiocyanate
10 Shikonin
9 Capsaicin
9 Propolis -bee glue
8 doxorubicin
8 Carvacrol
8 Copper and Cu NanoParticles
8 Hydrogen Gas
8 Honokiol
8 Magnetic Field Rotating
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
7 Curcumin
6 3-bromopyruvate
6 Fenbendazole
6 Apigenin (mainly Parsley)
6 Baicalein
6 Cisplatin
6 Chrysin
6 EGCG (Epigallocatechin Gallate)
6 Gallic acid
6 HydroxyTyrosol
5 Rosmarinic acid
5 Metformin
5 Ashwagandha(Withaferin A)
5 Melatonin
5 Selenium
5 Ellagic acid
5 Hibiscus sabdariffa
5 Indole-3-carbinol
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Gold NanoParticles
4 Boron
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 diet FMD Fasting Mimicking Diet
4 Eurycomanone
4 Eugenol
4 Graviola
4 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
4 Lycopene
4 Magnolol
4 Parthenolide
4 α-Santalol/Sandalwood oil
4 Terpinen-4-ol / Tea Tree Oil
4 VitK3,menadione
3 1,8-Cineole
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Centella asiatica / Gotu kola → asiaticoside
3 Citric Acid
3 Coenzyme Q10
3 Cynaropicrin
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Helleborus niger extracts – Christmas Rose
3 Isobavachalcone
3 Isoliquiritigenin
3 isoorientin
3 isoquercitrin
3 Nimbolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Hydroxycinnamic-acid
2 Dihydrocaffeic Acid
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 D-limonene
2 Disulfiram
2 Electrical Pulses
2 Evodiamine
2 Fucoidan
2 Gambogic Acid
2 Ginkgo biloba
2 Geldanamycin
2 Gossypol/AT-101
2 Hyperthermia
2 Hyperoside
2 Inositol
2 iodine
2 Linalool
2 Luteolin
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Vitexin
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Boswellia (frankincense)
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Polyphenols
1 Cucurbitacin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Lemongrass Extract/Citral
1 Echinacea
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 PXD, phenoxodiol
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 ferumoxytol
1 Formononetin
1 olaparib/LYNPARZA
1 Garcinol
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Ginseng
1 Grapeseed extract
1 High-Ozonide Oil
1 Paclitaxel/Taxol
1 Gemcitabine (Gemzar)
1 isoflavones
1 Isovitexin
1 Juglone
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Bicarbonate(Sodium)
1 Oleuropein
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 triptolide
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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