PARP Cancer Research Results

PARP, poly ADP-ribose polymerase (PARP) cleavage: Click to Expand ⟱

Source:

Type:

Poly (ADP-ribose) polymerase (PARP) cleavage is a hallmark of caspase activation. PARP (Poly (ADP-ribose) polymerase) is a family of proteins involved in a variety of cellular processes, including DNA repair, genomic stability, and programmed cell death. PARP enzymes play a crucial role in repairing single-strand breaks in DNA.
PARP has gained significant attention, particularly in the treatment of certain types of tumors, such as those with BRCA1 or BRCA2 mutations. These mutations impair the cell's ability to repair double-strand breaks in DNA through homologous recombination. Cancer cells with these mutations can become reliant on PARP for survival, making them particularly sensitive to PARP inhibitors.
PARP inhibitors, such as olaparib, rucaparib, and niraparib, have been developed as targeted therapies for cancers associated with BRCA mutations.

PARP Family:
The poly (ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a number of cellular processes, including DNA repair, genomic stability, and programmed cell death.
PARP1 is the predominant family member responsible for detecting DNA strand breaks and initiating repair processes, especially through base excision repair (BER).

PARP1 Overexpression:
In several cancer types—including breast, ovarian, prostate, and lung cancers—elevated PARP1 expression and/or activity has been reported.
High PARP1 expression in certain cancers has been associated with aggressive tumor behavior and resistance to therapies (especially those that induce DNA damage).
Increased PARP1 activity may correlate with poorer overall survival in tumors that rely on DNA repair for survival.

Scientific Papers found: Click to Expand⟱

1310-

UA,

Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells

-

in-vitro,

BC,

MCF7

53 microM

GR↝, AP-1↝, cl‑PARP↑, Bcl-2↓,

1020-

UA,

Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway

-

in-vitro,

Melanoma,

RPMI-8226

β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,

4856-

Uro,

Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro

-

in-vitro,

NPC,

CNE1

20–60 μM UroA

34.72 μM and 44.91 μM

-

in-vitro,

NPC,

CNE2

Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,

4837-

Uro,

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

-

Review,

Var,

NA

AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,

4468-

VitC,

SSE,

Selenium modulates cancer cell response to pharmacologic ascorbate

-

in-vivo,

GBM,

U87MG

-

in-vitro,

CRC,

HCT116

eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,

627-

VitC,

High-Dose Vitamin C for Cancer Therapy

-

Review,

Var,

NA

ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,

633-

VitC,

Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment

-

Analysis,

Var,

NA

Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,

632-

VitC,

High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients

-

Review,

Var,

NA

SVCT-2∅, ROS↑, Hif1a↓, PARP∅, TET2↑,

3133-

VitC,

Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells

-

in-vitro,

Ovarian,

NA

*SVCT-2↑, *GLUT1↓, SVCT-2↓, GLUT1↑, TumCP↓, CDK2↓, PARP↓, selectivity↑,

3138-

VitC,

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

-

in-vitro,

RCC,

RCC4

-

in-vitro,

CRC,

HCT116

-

in-vitro,

BC,

MDA-MB-435

-

in-vitro,

Ovarian,

SKOV3

-

in-vitro,

Colon,

SW48

-

in-vitro,

GBM,

U251

eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,

Showing Research Papers: 451 to 460 of 460
Prev Page 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 460

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↓, 2, NA↑, 2, NA⇅, 1, NA?, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 2, ARE/EpRE↑, 1, Catalase↓, 5, Catalase↑, 2, Copper↑, 1, ENOX2↓, 1, Fenton↑, 3, GPx↓, 3, GPx↑, 2, GPx1↓, 1, GPx4↓, 3, GSH↓, 30, GSH↑, 5, i-GSH∅, 1, GSH/GSSG↓, 2, GSR↓, 2, GSR↑, 2, GSSG↑, 2, GSTs↓, 2, GSTs↑, 2, H2O2↑, 5, i-H2O2↑, 1, HO-1↓, 10, HO-1↑, 11, HO-2↓, 1, Iron↑, 2, i-Iron↑, 1, Keap1↓, 2, lipid-P?, 1, lipid-P↓, 1, lipid-P↑, 10, MDA↓, 2, MDA↑, 4, MPO↓, 1, NOX4↑, 1, NQO1↓, 3, NQO1↑, 1, NRF2↓, 18, NRF2↑, 18, p‑NRF2↑, 1, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, RNS↑, 2, ROS?, 3, ROS↓, 20, ROS↑, 231, ROS⇅, 10, ROS↝, 1, ROS∅, 2, i-ROS↑, 2, mt-ROS↑, 7, SOD↓, 6, SOD↑, 4, SOD1↓, 1, SOD1↑, 1, SOD2↓, 4, SOD2↑, 1, TAC↑, 2, Thiols↓, 1, Trx↓, 2, ox-Trx1↑, 1, TrxR↓, 7, TrxR1↓, 6, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, IronCh↑, 1, Tf↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1, CDC2↓, 7, CDC25↓, 15, EGF↓, 4, ETC↓, 3, MFN2↑, 1, mitResp↓, 2, MKK7↓, 1, mtDam↑, 20, OCR↓, 3, OCR↑, 1, OXPHOS↓, 5, mt-OXPHOS↓, 2, PDH↓, 2, PDH↝, 1, p‑PDH↑, 1, PINK1↑, 3, SDH↓, 1, SIRT3↓, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 1, ACC↑, 3, p‑ACC↑, 2, ALAT↓, 4, ALDOA↓, 2, AMP↑, 1, AMPK↓, 2, AMPK↑, 22, p‑AMPK↑, 2, p‑AMT/GCST/T-protein↑, 1, ATP↓, 15, ATP↑, 1, citrate↓, 1, CPT1A↓, 1, ECAR↝, 1, ENO1↓, 3, FASN↓, 4, FASN↑, 1, FBPase↑, 1, GAPDH↓, 2, glucoNG↓, 1, glucoNG↑, 1, glucose↓, 2, GlucoseCon↓, 8, GlutMet↓, 1, Glycolysis↓, 23, GSK‐3β↓, 9, GSK‐3β↑, 5, p‑GSK‐3β↓, 8, H2S↑, 1, HK1↓, 1, HK2↓, 13, HMG-CoA↓, 1, lactateProd↓, 12, LDHA↓, 6, LDL↓, 2, lipidLev↓, 1, MCT4↓, 1, NAD↓, 2, NADPH↓, 1, NADPH↑, 2, O-Glc↓, 1, PCK1↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 8, PDKs↓, 1, PFK↓, 3, PFK2?, 1, PGK1↓, 1, PKM2↓, 13, PKM2∅, 1, PLA2↓, 1, PPP↓, 1, SIRT1↓, 9, SIRT1↑, 2, TCA↓, 3, TS↓, 1, Warburg↓, 5, β-oxidation↓, 2,

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1, AIF↑, 13, APAF1↑, 11, Apoptosis↓, 9, Apoptosis↑, 253, mt-Apoptosis↑, 2, ASC↓, 1, BAD↓, 3, BAD↑, 21, p‑BAD↓, 2, Bak↓, 1, Bak↑, 14, BAX↓, 4, BAX↑, 146, BAX↝, 1, BAX∅, 1, Bax:Bcl2↑, 44, Bcl-2↓, 167, Bcl-2↑, 6, Bcl-2↝, 1, Bcl-2∅, 2, cl‑Bcl-2↓, 1, cl‑Bcl-2↑, 1, Bcl-xL↓, 53, Bcl-xL↑, 1, Bcl-xL∅, 1, BID↑, 11, cl‑BID↑, 2, BIM↑, 10, Casp↑, 38, Casp↝, 2, cl‑Casp↑, 2, Casp1↓, 1, Casp1↑, 2, Casp10↑, 3, Casp12?, 1, Casp12↑, 3, Casp2↑, 1, Casp3?, 1, Casp3↓, 3, Casp3↑, 215, Casp3↝, 1, Casp3∅, 1, cl‑Casp3↓, 1, cl‑Casp3↑, 94, cl‑Casp3⇅, 1, cl‑Casp3∅, 1, proCasp3↓, 4, proCasp3↑, 5, Casp6↓, 1, Casp6↑, 3, Casp7↑, 29, cl‑Casp7↑, 11, Casp8↓, 2, Casp8↑, 60, Casp8∅, 2, cl‑Casp8↑, 24, proCasp8↓, 1, proCasp8↑, 4, Casp9?, 1, Casp9↓, 2, Casp9↑, 127, Casp9∅, 1, cl‑Casp9↓, 1, cl‑Casp9↑, 38, proCasp9↓, 1, proCasp9↑, 4, cFLIP↓, 8, Cyt‑c↓, 3, Cyt‑c↑, 126, Cyt‑c↝, 2, Cyt‑c?, 1, Diablo↑, 12, DR5↑, 30, Endon↑, 1, FADD↑, 9, Fas↓, 1, Fas↑, 21, FasL↑, 10, Ferroptosis↓, 1, Ferroptosis↑, 5, GRP58↓, 1, GSDME↑, 1, cl‑GSDME↑, 1, HEY1↓, 2, IAP1↓, 11, IAP2/BIRC3↓, 5, IAP2/BIRC3↑, 1, cl‑IAP2/BIRC3↑, 1, ICAD↓, 2, ICD↑, 1, iNOS↓, 12, Mcl-1?, 1, Mcl-1↓, 35, Mcl-1↑, 1, cl‑Mcl-1↑, 1, MDM2↓, 11, MDM2↑, 1, p‑MDM2↓, 2, MLKL↑, 2, p‑MLKL↓, 1, MOMP↓, 1, MOMP↑, 1, Necroptosis↑, 4, necrosis↑, 7, NOXA↑, 5, p38↓, 2, p38↑, 18, p‑p38↓, 4, p‑p38↑, 10, PDCD4↑, 1, PUMA↑, 10, Pyro↑, 4, RIP1↓, 2, RIP3↓, 1, RIP3↑, 2, p‑RIP3↑, 2, survivin↓, 73, TNFR 1↑, 2, TRAIL↑, 3, TRAILR↑, 2, TumCD↓, 1, TumCD↑, 23, XIAP?, 1, XIAP↓, 35, XIAP↑, 1, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1, Akt↓, 118, Akt↑, 4, p‑Akt↓, 49, AKT1↓, 1, BRAF↓, 2, CaMKII ↓, 2, CIP2A↓, 1, CK2↓, 4, cMET↓, 1, p‑cMET↑, 1, p‑CREB↓, 1, cSrc↓, 6, DYRK1B↓, 1, EF-1α↓, 1, EGFR↓, 29, EGFR↑, 2, p‑EGFR↓, 1, ERK↓, 36, ERK↑, 12, p‑ERK↓, 21, p‑ERK↑, 5, FGFR1↓, 3, FGFR2↓, 1, HER2/EBBR2↓, 14, HGF/c-Met↓, 3, IGF-1R↓, 4, IGF-1R↑, 1, IGFR↓, 2, IKKα↓, 7, IKKα↑, 1, ILK↓, 1, IκB↓, 3, IκB↑, 1, p‑IκB↓, 1, JAK↓, 2, JAK1?, 1, JAK1↓, 8, JAK1↑, 1, p‑JAK1↓, 2, JAK2↓, 10, p‑JAK2↓, 5, JNK↓, 2, JNK↑, 23, p‑JNK↓, 2, p‑JNK↑, 10, cl‑JNK↑, 1, MAPK↓, 29, MAPK↑, 10, MAPK↝, 1, p‑MAPK↓, 1, p‑MAPK↑, 1, MEK↓, 4, p‑MEK↓, 1, p‑MEK↑, 1, MKK4↓, 1, mTOR↓, 56, mTOR↑, 4, mTOR↝, 1, p‑mTOR↓, 13, mTORC2↓, 4, p70S6↓, 2, p70S6↑, 1, P70S6K↓, 3, p‑P70S6K↓, 2, PDGFR-BB↓, 1, p‑PDGFR-BB↓, 1, PI3K↓, 84, PI3K↑, 1, p‑PI3K↓, 8, PI3K/Akt↓, 3, PI3k/Akt/mTOR↓, 1, PIAS-3↑, 1, PKA↓, 1, PKCδ↓, 8, cl‑PKCδ↑, 1, PP2A↑, 1, PRAS40↑, 1, PTEN↓, 2, PTEN↑, 21, p‑PTEN↓, 1, Raf↓, 4, c-Raf↓, 1, RAS↓, 11, RSK2/RPS6KA3/p90RSK2↓, 1, RTK-RAS↓, 1, SHP1↑, 4, Sp1/3/4↓, 7, Src↓, 3, p‑Src↓, 1, STAT↓, 2, p‑STAT↓, 1, STAT3↓, 58, STAT3↑, 2, p‑STAT3↓, 18, p‑STAT3↑, 1, STAT5↓, 2, STAT6↓, 2, p‑STAT6↓, 1, STK11/LKB1↑, 1, p‑STK11/LKB1↑, 2, THEM4/CTMP↑, 1, TK1↓, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1, ATF2↓, 1, ATF3↑, 2, ATF4↓, 1, ATF4↑, 15, ATF4↝, 1, CBP↓, 1, cJun↓, 6, cJun↑, 4, cMyc↓, 35, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 7, DNMT3A↓, 2, DNMTs↓, 3, EZH2↓, 2, FOXM1↓, 3, FOXO1↑, 2, FOXO3↓, 3, FOXO3↑, 4, FOXO3↝, 1, p‑FOXO3↓, 1, FOXO4↑, 2, H3↓, 4, H3↑, 2, p‑H3↓, 2, ac‑H3↑, 1, H4↓, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 4, HATs↑, 1, HDAC↓, 16, HDAC1↓, 4, HDAC2↓, 4, HDAC3↓, 3, HDAC8↓, 1, HES1↓, 2, miR-134↑, 1, miR-139-5p↑, 1, miR-200b↑, 1, miR-205↑, 1, miR-21↓, 5, miR-21↑, 1, miR-21↝, 1, miR-25-5p↓, 1, miR-27a-3p↓, 1, miR-29b↓, 1, miR-339-5p↝, 1, miR-340↑, 1, miR-34a↑, 1, miR-34b-5p↑, 1, miR-384↑, 1, Myc↓, 4, MYCN↓, 1, OCT4↓, 6, other↓, 1, other↑, 1, other⇅, 1, other↝, 7, PhotoS↑, 1, SOX2↓, 3, SOX4↓, 1, SOX4↑, 1, SOX9↓, 1, SUV39H↓, 2, TCF-4↓, 1, TFAP2A↓, 1, tumCV↓, 76, tumCV∅, 1, ZBTB10↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3, CHOP/DDIT3↑, 36, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 1, eIF2α↑, 6, p‑eIF2α↑, 9, ER Stress↓, 1, ER Stress↑, 53, GRP78/BiP↓, 1, GRP78/BiP↑, 18, HSF1↓, 1, HSP27↓, 5, HSP27↑, 1, HSP27↝, 1, HSP70/HSPA5↓, 9, HSP70/HSPA5↑, 2, HSP70/HSPA5↝, 1, HSP72↓, 1, HSP90↓, 11, HSPs↓, 1, IRE1↑, 6, PDI↑, 1, PERK↑, 9, Proteasome↓, 1, SERPINH1/HSP47↓, 1, UPR↑, 11, XBP-1↓, 2, XBP-1↑, 4, XBP-1↝, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↓, 1, ATG3↑, 4, ATG5↑, 12, ATG7↑, 3, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 20, CTSB↓, 1, CTSD↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 6, LC3A↑, 1, LC3B↑, 2, LC3B-II↑, 5, LC3I↓, 1, LC3I↑, 1, LC3II↓, 1, LC3II↑, 14, LC3s↑, 1, lysoMP↑, 1, MitoP↑, 1, p62↓, 10, p62↑, 5, PARK2↑, 3, RUBCN↓, 1, SESN2↑, 1, TumAuto↑, 44, TumAuto⇅, 1, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1, ATM↑, 1, p‑ATM↑, 1, BRCA1↓, 1, BRCA2↓, 1, DFF45↓, 2, DFF45↑, 3, DNA-PK↑, 1, DNAdam↓, 4, DNAdam↑, 71, DNArepair↓, 4, ERCC1↓, 1, ERCC4/XPF↓, 1, hTERT/TERT↓, 7, Ku70/XRCC6↓, 1, MGMT↓, 1, p16↑, 1, P53?, 1, P53↓, 6, P53↑, 81, p‑P53↓, 1, p‑P53↑, 7, ac‑P53↑, 1, p53 Wildtype↓, 1, PARP↓, 22, PARP↑, 85, PARP↝, 4, PARP∅, 1, p‑PARP↑, 6, cl‑PARP↓, 6, cl‑PARP↑, 324, cl‑PARP↝, 1, cl‑PARP∅, 2, proPARP↓, 1, PCNA↓, 21, SIRT6↑, 1, Telomerase↓, 13, TOP1↓, 4, TOP2↓, 3, TOP2↑, 1, TP53↓, 1, TP53↑, 1, TRF2↓, 1, γH2AX↓, 1, γH2AX↑, 12, p‑γH2AX↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 20, CDK1↑, 1, p‑CDK1↓, 2, p‑CDK1↑, 1, CDK1/2/5/9↓, 1, CDK2↓, 38, CDK2↑, 3, p‑CDK2↓, 2, CDK4↓, 42, CDK4↑, 1, CDK4/6↓, 1, CDK6↓, 21, CDK6↑, 2, CDK8↓, 1, CHK1↓, 2, CHK1↑, 1, Chk2↓, 3, Chk2↑, 1, ChrCon↑, 1, Cyc↓, 2, cycA1/CCNA1↓, 14, CycB/CCNB1↓, 31, CycB/CCNB1↑, 6, cycD1/CCND1↓, 82, cycD1/CCND1↑, 1, cycD1/CCND1↝, 1, CycD3↓, 4, CycD3↑, 1, cycE/CCNE↓, 26, cycE/CCNE↑, 1, E2Fs↓, 2, GADD45A↓, 1, GADD45A↑, 1, Ki-67↓, 21, MAD↓, 1, mitA↑, 3, p19↑, 1, P21?, 2, P21↓, 6, P21↑, 61, P21↝, 1, p27/CDKN1B↓, 3, p27/CDKN1B↑, 28, pRB↑, 1, p‑pRB↓, 2, p‑RB1↓, 7, cl‑RB1↓, 1, Securin↓, 1, TubPol↓, 1, TumCCA?, 1, TumCCA↓, 7, TumCCA↑, 188, WEE1↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, p‑4E-BP1↓, 1, ALDH↓, 4, Axin2↑, 1, BMI1↓, 1, CD133↓, 2, CD24↓, 2, CD34↓, 1, cFos↓, 6, cFos↑, 1, cMYB↓, 1, CSCs↓, 21, Diff↓, 1, Diff↑, 1, FGF↓, 5, Gli↓, 1, Gli1↓, 5, HH↓, 6, HMGCR↓, 1, IGF-1↓, 8, IGF-2↓, 1, IGFBP1↑, 1, IGFBP3↑, 3, JAG1↓, 1, Ki-67↓, 21, Let-7↑, 1, mTORC1↓, 4, Nanog↓, 3, Nestin↓, 1, NICD↓, 1, NOTCH↓, 10, NOTCH↑, 1, NOTCH1↓, 10, NOTCH1↑, 1, NOTCH2↑, 1, NOTCH3↓, 3, OGFr↑, 1, p300↓, 1, PTCH2↓, 1, SAL↑, 1, SCF↓, 2, Shh↓, 7, Smo↓, 2, STAT1↓, 1, Sufu↑, 1, TAZ↓, 1, TumCG?, 1, TumCG↓, 72, TumCG↑, 3, TumCP↓, 131, TumCP↑, 6, tyrosinase↓, 2, URGCP/URG4↓, 1, Wnt↓, 23, Wnt↑, 1, Wnt/(β-catenin)↓, 3,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg↑, 1, AP-1↓, 5, AP-1↝, 1, AXL↓, 3, BACH1↓, 1, Ca+2↓, 2, Ca+2↑, 27, Ca+2↝, 2, i-Ca+2↑, 1, CAFs/TAFs↓, 2, cal2↓, 1, cal2↑, 1, Cav1↓, 1, Cdc42↓, 2, COL1↓, 1, COL3A1↓, 1, E-cadherin↓, 6, E-cadherin↑, 28, EM↑, 1, EMT↓, 39, EMT↑, 1, EMT↝, 1, EpCAM↓, 3, F-actin↓, 1, FAK↓, 8, p‑FAK↓, 3, Fibronectin↓, 3, GLI2↓, 3, IQGAP3↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB3↓, 1, ITGB4↓, 1, KRAS↓, 2, LAMs↓, 1, LEF1↓, 1, MET↓, 3, p‑MET↓, 1, MMP-10↓, 2, MMP1↓, 7, MMP13↓, 1, MMP16↓, 1, MMP2↓, 60, MMP3↓, 7, MMP7↓, 6, MMP9↓, 67, MMPs↓, 24, MMPs↝, 1, MUC4↓, 1, N-cadherin↓, 21, p44↓, 1, PAK1↓, 2, pax↓, 1, p‑pax↓, 1, PDGF↓, 5, Rac1↓, 4, RECK↑, 1, Rho↓, 4, ROCK1↓, 2, Slug↓, 8, Smad1↓, 1, p‑SMAD2↓, 1, SMAD3↓, 3, SMAD3↑, 1, p‑SMAD3↓, 1, p‑SMAD4↓, 1, Snail?, 1, Snail↓, 22, TET1↓, 1, TET1↑, 2, TGF-β↓, 10, TGF-β↑, 1, TIMP1↑, 10, TIMP2↑, 10, TIMP3↑, 1, TRIB3↑, 1, TSC1↑, 1, TSP-1↑, 2, TumCA↑, 1, TumCI?, 1, TumCI↓, 53, TumCMig↓, 49, TumMeta?, 1, TumMeta↓, 42, TumMeta↑, 2, Twist↓, 14, Tyro3↓, 1, uPA↓, 14, uPAR↓, 1, Vim↓, 22, Vim↑, 1, Zeb1↓, 7, Zeb1↑, 1, ZEB2↓, 2, α-tubulin↓, 2, α-tubulin↑, 1, β-catenin/ZEB1↓, 32, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 70, angioG↑, 1, CD31/PECAM-1↓, 2, ECM/TCF↓, 1, Endoglin↑, 3, eNOS↓, 2, HIF-1↓, 3, Hif1a↓, 40, NO↓, 1, NO↑, 4, VCAM-1↓, 2, VEGF↓, 79, VEGF↑, 1, VEGF↝, 1, VEGFR1↓, 2, VEGFR2/KDR/Flk1↓, 16, p‑VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, BBB∅, 1, CLDN1↓, 2, CLDN1↑, 1, CLDN2↓, 1, EPR↑, 1, GLUT1↓, 9, GLUT1↑, 1, GLUT2↓, 1, GLUT4↓, 1, IBI↑, 1, MMP↓, 135, MMP↑, 2, MMP∅, 1, MPT↑, 8, NHE1↓, 1, OCLN↑, 1, SVCT-2↓, 1, SVCT-2∅, 1, TJ↑, 1, TRPM7↓, 1, TRPV1↑, 2, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD25+↑, 1, CD4+↑, 1, CD44↓, 9, cDC2↓, 4, p‑cDC2↓, 2, COX1↓, 1, COX2/PTGS2↓, 61, COX2/PTGS2↑, 2, COX2/PTGS2↝, 1, CXCR2↓, 1, CXCR4↓, 10, CXCR4↑, 1, DR4↑, 9, DR4∅, 1, FOXP3↑, 1, Gal-3↓, 1, HMGB1↓, 2, ICAM-1↓, 2, IFN-γ↓, 2, IFN-γ↑, 1, IL1↓, 1, IL1↑, 1, IL10↓, 2, IL12↓, 1, IL1α↓, 1, IL1β↓, 10, IL2↑, 3, IL4↓, 1, IL4↑, 1, IL6↓, 27, IL8↓, 4, Imm↑, 4, Imm↝, 2, Inflam↓, 21, LTA/TNF-β↑, 1, M2 MC↓, 1, MCP1/CCL2↓, 1, MCT1↓, 1, MIP2↓, 1, mPGES-1↓, 1, NF-kB↓, 101, NF-kB↑, 4, NF-kB↝, 1, p‑NF-kB↓, 2, p‑NF-kB↑, 2, NK cell↑, 1, NLRP3↓, 1, NLRP3↑, 1, NOD1↓, 1, p50↓, 1, p65↓, 6, p‑p65↓, 2, ac‑p65↓, 1, ac‑p65↑, 1, PD-1↓, 3, PD-1↝, 1, PD-L1↓, 4, PD-L1↑, 1, PGE2↓, 14, PSA↓, 6, RAGE↓, 1, SOCS-3↓, 1, T-Cell↑, 1, T-Cell↝, 1, TCF↓, 1, TCF↑, 1, TLR4↓, 4, TLR4↝, 1, TNF-α↓, 26, TNF-α↑, 4, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1, IM↓, 1, pH↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, SYN1↑, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 15, ER-α36↓, 2, ERα/ESR1↓, 1, GR↝, 1, PPARα↓, 2, PPARγ↓, 1, PPARγ↑, 3,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1, ABCG2↓, 3, BioAv↓, 27, BioAv↑, 31, BioAv↝, 9, BioEnh↑, 5, ChemoSen?, 1, ChemoSen↓, 1, ChemoSen↑, 101, CompStab↓, 1, CompStab↑, 2, CompStab↝, 2, CYP1A1↓, 1, CYP1A1↑, 1, CYP3A4↓, 2, Dose?, 2, Dose↓, 2, Dose↑, 4, Dose⇅, 1, Dose↝, 38, Dose∅, 10, eff↓, 83, eff↑, 66, eff↝, 6, eff∅, 1, GSTA1↑, 1, GSTP1/GSTπ↓, 1, Half-Life↓, 7, Half-Life↑, 1, Half-Life↝, 11, MDR1↓, 4, MRP1/ABCC1↓, 5, P-gp/ABCB1↓, 10, P-gp/ABCB1↑, 1, P450↓, 3, RadioS?, 1, RadioS↑, 30, selectivity↓, 1, selectivity↑, 93, Synergy↑, 73, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2, ALAT↓, 4, ALP↓, 2, AR↓, 15, ascitic↓, 1, AST↓, 3, BRAF↓, 2, BRCA1↓, 1, CEA↓, 2, CRP↓, 1, E6↓, 2, E7↓, 2, EGFR↓, 29, EGFR↑, 2, p‑EGFR↓, 1, ERα/ESR1↓, 1, EZH2↓, 2, Ferritin↓, 1, FOXM1↓, 3, HER2/EBBR2↓, 14, hTERT/TERT↓, 7, IL6↓, 27, KRAS↓, 2, LDH↓, 2, LDH↑, 4, LDH↝, 1, i-LDH↓, 1, Myc↓, 4, NSE↓, 1, PD-L1↓, 4, PD-L1↑, 1, PSA↓, 6, RAGE↓, 1, TP53↓, 1, TP53↑, 1, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1, AntiCan↑, 31, antiCG↓, 1, antiD↑, 1, antiNeop↑, 2, AntiTum↓, 2, AntiTum↑, 12, cachexia↓, 2, cardioP↑, 5, CardioT↑, 1, chemoP↑, 17, chemoPv↑, 14, ChemoSideEff↓, 2, hepatoP↓, 1, hepatoP↑, 7, neuroP↑, 5, NP/CIPN↓, 1, Obesity↓, 1, OS↑, 10, Pain↓, 2, QoL↑, 2, radioP↑, 3, Remission↑, 1, RenoP↑, 8, Risk↓, 10, toxicity?, 1, toxicity↓, 12, toxicity↑, 4, toxicity↝, 9, TumVol↓, 22, TumVol↑, 1, TumW↓, 9, Weight↑, 1, Weight∅, 1, Wound Healing↓, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, AntiP↑, 1, Bacteria↓, 3, GutMicro↑, 3, GutMicro↝, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1, Ingr↝, 2,
Total Targets: 1014

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1, antiOx↓, 3, antiOx↑, 41, i-antiOx↑, 1, Catalase↑, 22, GPx↑, 14, GPx1↑, 1, GSH↑, 15, GSR↑, 2, GSSG∅, 1, GSTs↑, 9, H2O2↓, 1, HDL↑, 1, HO-1↓, 1, HO-1↑, 11, Keap1↑, 1, Keap1↝, 1, lipid-P↓, 11, MDA↓, 9, MPO↓, 1, NADH↓, 1, NOX4↓, 1, Nrf1↑, 1, NRF2↓, 1, NRF2↑, 23, Prx↑, 1, RNS↓, 3, ROS↓, 44, ROS↑, 2, ROS∅, 4, mt-ROS?, 1, SOD↓, 1, SOD↑, 21, SOD1↑, 2, SOD2↑, 2, TAC↑, 2, TBARS↓, 1, uricA↓, 1, VitC↑, 1, VitE↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2, PGC-1α↑, 1, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 2, ALAT↓, 4, AMPK↑, 2, ATP↑, 3, GAPDH↑, 1, glucose↓, 4, glucose↝, 1, GSK‐3β↓, 2, LDL↓, 4, lipidLev↓, 1, NAD↑, 1, NADPH↑, 2, SIRT1↑, 2,

Cell Death(tgid=5) ⓘ

AIF↓, 1, Apoptosis↓, 5, Apoptosis∅, 1, mt-Apoptosis↓, 1, BAX↓, 5, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↑, 4, Casp↓, 1, Casp1↓, 1, Casp12↓, 1, Casp3?, 1, Casp3↓, 7, Casp3↑, 1, Casp3∅, 1, cl‑Casp3↓, 1, cl‑Casp3↑, 1, Casp8↑, 1, cl‑Casp8↑, 2, Casp9↓, 1, Casp9↑, 1, Casp9∅, 1, cl‑Casp9↓, 1, cl‑Casp9↑, 1, Cyt‑c↓, 4, Cyt‑c∅, 1, Fas↑, 2, iNOS↓, 9, iNOS↑, 1, p38↓, 3,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 1, p‑Akt↑, 1, Akt2↓, 1, ERK↓, 1, ERK↑, 1, IGF-1R↓, 1, IKKα↓, 1, IκB?, 1, JAK↓, 1, JNK↓, 3, JNK↑, 1, p‑JNK↓, 2, MAPK↓, 4, MAPK↑, 1, mTOR↓, 1, mTOR↑, 1, PDGFR-BB↓, 1, PI3K↓, 2, PI3K↑, 1, PKCδ↓, 1, STAT3↑, 1, p‑STAT3↑, 1, STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1, HOTAIR↑, 1, other↓, 2, other↑, 1, other↝, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, ER Stress↓, 1, GRP78/BiP↓, 1, HSP70/HSPA5↑, 1, IRE1↓, 1, PERK↓, 1, UPR↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3II↑, 1, p62↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1, p16↓, 1, P53↓, 3, P53↑, 2, PARP↓, 3, PARP↑, 1, PARP∅, 1, p‑PARP↓, 1, cl‑PARP↓, 2, cl‑PARP↑, 2, PARP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, E2Fs↑, 1, P21↓, 2, P21↑, 3, TumCCA↑, 3,

Migration(tgid=13) ⓘ

AntiAg↑, 5, AP-1↓, 1, Ca+2?, 1, Ca+2↓, 2, Ca+2↝, 1, MLC2/MYL9↝, 1, MMP13↓, 2, MMP2↓, 1, MMP3↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, E-sel↓, 1, Hif1a↓, 2, NO↓, 5, NO↑, 1, VCAM-1↓, 2, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5, GastroP↑, 2, GLUT1↓, 1, MMP↓, 3, MMP↑, 3, MMP∅, 1, MUC5AC↓, 1, OCLN↝, 1, SVCT-2↑, 1, TJ↑, 1, TRPA1↑, 1, TRPC1↓, 1, TRPV1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1, CD4+↑, 1, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 16, COX2/PTGS2↑, 1, IL10↓, 2, IL10↑, 1, IL17↓, 1, IL18↓, 1, IL1β↓, 9, IL6↓, 14, IL6↑, 1, IL8↓, 1, Imm↑, 4, Imm⇅, 1, Inflam↓, 49, pol-M2 MC↑, 1, MCP1/CCL2↓, 1, MyD88↓, 1, NeuroI↓, 1, NF-kB↓, 18, NLRP3↓, 1, PAF↓, 1, PGE2↓, 4, PGE2↑, 1, PSA∅, 1, Th1 response↓, 1, Th2↑, 2, TLR1↓, 1, TLR4↓, 1, TNF-α↓, 20, β-HEX↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, AChE↓, 5, BChE↓, 2, BDNF↑, 2, MAOA↓, 1, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 6, BACE/β-secretase↓, 2, tau↓, 2, p‑tau↓, 2,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1, PPARα↑, 1, PPARα↝, 1, PPARγ↓, 1, testos↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16, BioAv↑, 23, BioAv↝, 9, BioAv∅, 1, BioEnh↑, 1, CompStab↑, 1, Dose↝, 4, Dose∅, 1, eff↑, 6, GSTA1↑, 1, Half-Life↑, 1, Half-Life↝, 7, Half-Life∅, 2, P450↑, 1, Synergy↑, 4,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4, ALP↓, 2, AST↓, 5, BG↓, 1, BP↓, 4, creat↓, 1, CRP↓, 3, hs-CRP↓, 1, IL6↓, 14, IL6↑, 1, LDH↓, 4, LDH↑, 1, NOS2↓, 1, PSA∅, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2, AntiAge↑, 3, antiAll↑, 14, AntiArt↑, 7, AntiCan↑, 8, AntiDiabetic↑, 9, antiPs↑, 2, AntiTum↓, 1, AntiTum↑, 3, cardioP↑, 15, chemoP↑, 7, chemoPv↑, 2, cognitive↑, 3, hepatoP↓, 1, hepatoP↑, 9, memory↑, 3, motorD↓, 1, motorD↑, 1, neuroP↓, 1, neuroP↑, 27, Obesity↓, 6, Pain↓, 4, radioP↑, 3, RenoP↑, 1, Stress↓, 1, Stroke↓, 3, toxicity↓, 24, toxicity↑, 2, toxicity↝, 4, toxicity∅, 4,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9, AntiFungal↓, 1, AntiFungal↑, 2, AntiP↓, 1, AntiP↑, 2, AntiViral↑, 10, Bacteria↓, 12, GutMicro↑, 9,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1, Ingr↝, 4,
Total Targets: 292

Scientific Paper Hit Count for: PARP, poly ADP-ribose polymerase (PARP) cleavage

16 Apigenin (mainly Parsley)
16 Curcumin
15 Fisetin
14 Quercetin
14 Thymoquinone
12 Baicalein
10 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Shikonin
7 Ashwagandha(Withaferin A)
7 Berberine
7 Capsaicin
7 Emodin
7 Garcinol
7 Magnolol
6 Metformin
6 Boswellia (frankincense)
6 Carnosic acid
6 Chrysin
6 Gambogic Acid
6 isoorientin
6 lambertianic acid
6 Piperlongumine
6 Vitamin C (Ascorbic Acid)
5 doxorubicin
5 Betulinic acid
5 Eugenol
5 Licorice
5 Morin
5 Silymarin (Milk Thistle) silibinin
4 Cisplatin
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Carvacrol
4 chaetocin
4 Citric Acid
4 Docetaxel
4 Evodiamine
4 Formononetin
4 Fucoidan
4 Ginkgetin
4 Ivermectin
4 Nimbolide
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Resveratrol
3 Auranofin
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 5-fluorouracil
3 Brucea javanica
3 Thymol-Thymus vulgaris
3 Radiotherapy/Radiation
3 Ellagic acid
3 Ferulic acid
3 HydroxyTyrosol
3 Isobavachalcone
3 phytic acid, Inositol hexakisphosphate
3 Isoliquiritigenin
3 Luteolin
3 Lycopene
3 mebendazole
3 Magnetic Fields
3 Methylsulfonylmethane
3 Propyl gallate
3 α-Santalol/Sandalwood oil
2 1,8-Cineole
2 Artemisinin
2 Berbamine
2 Beta-Caryophyllene
2 temozolomide
2 brusatol
2 Boron
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Cichoric acid / Chicoric acid
2 Cinnamon
2 Cucurbitacin
2 Cynaropicrin
2 Dichloroacetate
2 D-limonene
2 Dandelion Root
2 Echinacea
2 Ginkgo biloba-EGb 761
2 Eurycomanone
2 Flaxseed/Linseed
2 Gallic acid
2 Photodynamic Therapy
2 Hyperoside
2 Rutin
2 Indole-3-carbinol
2 isoquercitrin
2 Juglone
2 methylseleninic acid
2 Phenylbutyrate
2 Paclitaxel/Taxol
2 Piperine
2 Rosmarinic acid
2 salinomycin
2 Selenite (Sodium)
2 Ursolic acid
2 Urolithin
1 3-bromopyruvate
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 immunotherapy
1 Atorvastatin
1 Aloe anthraquinones
1 Baicalin
1 almonertinib
1 Bromelain
1 Bullatacin
1 Butyrate
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Celastrol
1 Chlorogenic acid
1 Chlorophyllin
1 Coenzyme Q10
1 Carvone
1 Dichloroacetophenone(2,2-)
1 Date Fruit Extract
1 Diindolylmethane
1 Fenbendazole
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Gemcitabine (Gemzar)
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Graviola
1 Hydroxycinnamic-acid
1 hydroxychloroquine
1 isoflavones
1 Isovitexin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 low dose naltrexone
1 Linalool
1 Lutein
1 Methylene blue
1 Matrine
1 Dordaviprone; Modeyso
1 Modified Citrus Pectin
1 Chemotherapy
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 nelfinavir/Viracept
1 Oleuropein
1 Marjoram (Origanum majorana)
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Plumbagin
1 VitK3,menadione
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Selenium NanoParticles
1 chitosan
1 Folic Acid, Vit B9
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:239  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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