BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱
Source:
Type: Proapototic protein
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
Scientific Papers found: Click to Expand⟱
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
7894- IVT,    Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression
- in-vitro, HCC, SK-HEP-1
CD44↓, CSCs↓, ABCG2↓, ALDH1A1↓, Nanog↓, miR-34a↑, BAX↑, Bcl-2↓, Mcl-1↓, Apoptosis↑,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
8006- JG,  VitC,    Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCP↓, ROS↑, antiOx⇅, Bcl-2↓, survivin↓, BAX↑, Trx2↓, Synergy↑,
7961- JG,    Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, 4T1 - vitro+vivo, CRC, HCT116
EMT↓, CSCs↓, TumMeta↓, Pin1↓, TumCCA↑, angioG↓, Apoptosis↑, BAX↑, Bcl-2↓,
5113- JG,    Juglone in Oxidative Stress and Cell Signaling
- Review, Var, NA - Review, AD, NA
ROS↑, Pin1↓, antiOx⇅, *ROS↓, SMAD2↓, GSH↓, lipid-P↑, TumCCA↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Ca+2↑, Cyt‑c↑, AntiFungal↑, Bacteria↓, Akt↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
1927- JG,    Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway
- in-vitro, GC, SGC-7901
Apoptosis↑, ROS↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Casp3?, Bax:Bcl2↑,
1926- JG,    Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway
- in-vitro, BC, MCF7
TumCG↓, ROS↑, MMP↓, i-Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp3?,
1924- JG,    Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,
1923- JG,    Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
- in-vitro, Endo, NA
TumCP↓, TumCCA↑, cycA1/CCNA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8096- KAE,  5-FU,    Synergistic effect of kaempferol and 5‑fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT8
ChemoSen↑, TumCP↓, Apoptosis↓, BAX↑, Bcl-2↓, TS↓, PI3K↓, Akt↓,
8102- KAE,    Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
- vitro+vivo, GC, MKN-28 - vitro+vivo, GC, SGC-7901 - in-vitro, GC, GES-1
TumCP↓, TumCCA↑, Apoptosis↑, selectivity↑, TumVol↓, CycB/CCNB1↓, CDK1↓, CDC25↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, p‑Akt↓, p‑ERK↓, COX2/PTGS2↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8063- KAE,    Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways
- in-vitro, Ovarian, NA
Dose↓, selectivity↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, TumCCA↑, MEK↓, ERK↓, STAT3↓,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
9064- L-THE,    L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
- in-vivo, Stroke, NA
*Stroke↓, *Bcl-2↑, *BAX↓, *Casp3↓, *ROS?, *MDA?, *NO?, *TAC↑, *GSH↑, *SOD↑, *cardioP↑, *JAK2↑, *STAT3↑,
9067- L-THE,    l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways
- in-vivo, AD, NA
*AGEs↓, *Aβ42↓, *Ach↑, *AChE↓, *NF-kB↓, *SIRT1↑, *Inflam↓, *RAGE↓, *SOD2↑, *Catalase↑, *ROS↓, *PGC-1α↓, *BAX↓, *cl‑Casp3↓, *Bcl-2↑, *BDNF↑,
9007- L-THE,    L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model
- in-vivo, CRC, NA
CRP↓, AFP↓, CEA↓, CA19-9↓, Ki-67↓, Apoptosis↑, Casp3↑, cl‑Casp3↑, BAX↑, Bcl-2↓, *ROS↓, *Inflam↓, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *IL1β↓, *TNF-α↓, *IL6↓, *IL10↓, *COX2/PTGS2↓, *NF-kB↓, *NLRP3↓, *GutMicro↑, *chemoPv↑, *Dose↝, Ki-67↓,
8121- LA,    Exploring Anticancer Potential of Lactobacillus Strains: Insights into Cytotoxicity and Apoptotic Mechanisms on HCT 115 Cancer Cells
- in-vitro, CRC, NA
tumCV↓, BAX↑, Bcl-2↓,
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,
866- Lae,    Amygdalin from Apricot Kernels Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review
- Review, Var, NA
BAX↑, Casp3↑, Bcl-2↓, TumCCA↑,
862- Lae,    Molecular mechanism of amygdalin action in vitro: review of the latest research
- Review, Var, NA
BAX↑, Casp3↑, Bcl-2↓, Akt↓, mTOR↓, p19↑, TumCCA↑, other↓,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8207- LCA,    Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, Apoptosis↑, eff↓, TrxR1↓, cDC2↓, Bcl-2↓, BAX↑, NRF2↓, p‑ASK1↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8232- LCA,    Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study
- vitro+vivo, ESCC, NA
TumCP↓, TumCMig↓, TumCI↓, MMPs↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK1↓, P53↑, TumCG↓, toxicity↓,
8222- LCA,    Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-κB Signaling Pathways
- in-vitro, CCA, KKU-100 - in-vitro, CCA, KKU-213 - in-vitro, CCA, KKU-214 - in-vitro, CCA, KKU-156 - in-vitro, 0-Reserved, KKU-452
TumCP?, TumCD?, ROS↑, NRF2↓, BAX↑, Cyt‑c↑, TumCMig↓, TumCCA↑, NF-kB↓, STAT3↓, cycD1/CCND1↓, VEGF↓, ICAM-1↓,
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
8337- LDN,    Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway
- in-vitro, CRC, NA
OGFr↑, BAX↑, Casp9↑, Casp3↑, PARP↑, Bcl-2↓, survivin↓, Ki-67↓, Apoptosis↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8262- LE,    Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of Glycyrrhiza glabra ethanolic extract
- in-vitro, Liver, HepG2
*Dose↝, *AntiBio↑, Dose↝, P53↑, BAX↑, Bcl-2↓, Apoptosis↑,
8263- LE,    Glycyrrhiza glabra L. suppress the proliferation of non-small cell lung cancer by inducing necrosis rather than apoptosis despite increasing bax level
- in-vitro, Lung, A549
BAX↑, necrosis↑, Dose↝,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
1306- LE,    Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell
- in-vitro, BC, MCF7
Bcl-2↓, BAX↑, Apoptosis↑, TumCCA↑,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8294- lign,    Secoisolariciresinol diglucoside induces pyroptosis by activating caspase-1 to cleave GSDMD in colorectal cancer cells
- vitro+vivo, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, NA, SW480 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
tumCV↓, Pyro↑, cl‑GSDMD↑, cl‑Casp1↑, ROS↑, p‑PI3K↓, TumCG↓, BAX↑, Cyt‑c↑, PI3K↓, Akt↓,
8330- LIN,    SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
- in-vitro, GBM, U87MG
tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,

Showing Research Papers: 451 to 500 of 755
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 755

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 5,   antiOx↑, 10,   antiOx⇅, 3,   ARE↑, 1,   Catalase↓, 15,   Catalase↑, 10,   Copper↑, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 4,   GPx↑, 7,   GPx4↓, 11,   GPx4↑, 1,   GSH↓, 53,   GSH↑, 8,   GSH/GSSG↓, 3,   GSR↑, 2,   GSS↑, 1,   GSSG↓, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↑, 8,   HO-1↓, 6,   HO-1↑, 11,   HO-1↝, 1,   Iron↑, 4,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 10,   lipid-P↑, 16,   lipid-P↝, 1,   MDA↓, 6,   MDA↑, 14,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↓, 18,   NRF2↑, 23,   NRF2⇅, 1,   NRF2↝, 3,   p‑NRF2↓, 1,   Prx↓, 1,   Prx6↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 25,   ROS↑, 347,   ROS⇅, 7,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↑, 7,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 19,   SOD↑, 11,   SOD1↓, 1,   SOD1↑, 2,   SOD2↓, 3,   SOD2↑, 5,   TAC?, 1,   TAC↓, 1,   TAC↑, 1,   TBARS↑, 2,   Thiols↓, 3,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 5,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   IronCh↑, 2,   NCOA4↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR↓, 1,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 17,   CDC25↑, 1,   p‑CDC25↑, 1,   compI↓, 2,   compIII↓, 1,   compIII↑, 1,   compV↓, 1,   EGF↓, 6,   ETC↓, 4,   HSP60/HSPD1↓, 1,   HSP60/HSPD1↑, 1,   MFN2↑, 1,   mitResp↓, 2,   mitResp↑, 2,   MKK7↓, 1,   mtDam↑, 33,   OCR↓, 6,   OXPHOS↓, 4,   OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PHB↓, 1,   PINK1↑, 3,   SIRT3↓, 3,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 5,   5LO↓, 2,   ACC↑, 3,   Acetyl-CoA↓, 1,   ACLY↓, 3,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↝, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 21,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 17,   ATP∅, 1,   e-ATP↑, 1,   CAIX/CA9↓, 3,   CAIX/CA9↑, 1,   i-Cer↑, 1,   ENO1↓, 1,   FASN↓, 5,   FBI-1↓, 1,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 7,   GlutMet↓, 1,   Glycolysis↓, 25,   GSK‐3β↓, 9,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 5,   H2S↑, 1,   HK1↓, 1,   HK2↓, 16,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 9,   lactateProd↑, 1,   LDHA↓, 7,   LDL↓, 3,   MCT4↓, 1,   NAD↝, 1,   NADPH↓, 3,   PCK1↓, 1,   PDK1 / PDPK1↓, 8,   PDKs↓, 1,   PFK↓, 4,   PFKFB4?, 1,   PFKP↓, 1,   PKM2↓, 10,   Pyruv↓, 1,   p‑S6↓, 1,   SIRT1↓, 3,   SIRT1↑, 7,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 4,   TS↓, 1,   TumCM/A↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 24,   AIF↝, 1,   APAF1↑, 14,   Apoptosis?, 4,   Apoptosis↓, 10,   Apoptosis↑, 369,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASK1↑, 2,   p‑ASK1↑, 1,   BAD?, 1,   BAD↓, 5,   BAD↑, 29,   BAD↝, 1,   Bak↓, 1,   Bak↑, 27,   BAX?, 1,   BAX↓, 17,   BAX↑, 664,   BAX⇅, 2,   BAX↝, 5,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 20,   Bcl-2↓, 504,   Bcl-2↑, 10,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 66,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 17,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↓, 1,   BIM↑, 13,   BNIP3?, 1,   BNIP3↓, 1,   BNIP3↑, 5,   BOK↑, 2,   Casp↓, 2,   Casp↑, 40,   Casp↝, 1,   cl‑Casp↑, 1,   cl‑Casp1↑, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12↑, 6,   Casp12↝, 1,   cl‑Casp12↑, 2,   Casp2↑, 2,   Casp3?, 2,   Casp3↓, 8,   Casp3↑, 313,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 99,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   proCasp3↑, 4,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↑, 2,   Casp7↑, 30,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 67,   cl‑Casp8↑, 17,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 195,   Casp9∅, 1,   p‑Casp9↑, 1,   cl‑Casp9↑, 36,   proCasp9↓, 1,   proCasp9↑, 4,   pro‑Casp9↑, 1,   CellShr↑, 2,   cFLIP↓, 7,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 204,   Cyt‑c↝, 3,   Cyt‑c?, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 8,   DR5↑, 37,   Endon↑, 1,   FADD↑, 11,   Fas↓, 2,   Fas↑, 41,   FasL↓, 1,   FasL↑, 21,   FasL⇅, 1,   Ferroptosis↑, 10,   GranB/GZMB↝, 1,   GSDMD↑, 2,   cl‑GSDMD↑, 1,   GSDME↑, 1,   GSDME-N↑, 2,   HEY1↓, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 3,   ICAD↓, 1,   ICD↑, 3,   iNOS↓, 15,   iNOS↑, 1,   Mcl-1↓, 37,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 15,   MDM2↑, 2,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 6,   NAIP↓, 2,   Necroptosis↑, 4,   necrosis↑, 4,   NOXA↑, 6,   p38↓, 5,   p38↑, 32,   p‑p38↓, 5,   p‑p38↑, 10,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 12,   PUMA⇅, 1,   Pyro↑, 8,   RIP3↑, 3,   p‑RIP3↑, 2,   survivin↓, 71,   survivin↝, 1,   TNFR 1↑, 3,   TRAIL↑, 10,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 25,   TUNEL↑, 2,   XIAP↓, 26,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 167,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 66,   AKT1↓, 4,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 2,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 2,   p‑CREB↓, 1,   cSrc↓, 1,   EGFR↓, 34,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 65,   ERK↑, 15,   p‑ERK↓, 19,   p‑ERK↑, 6,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 1,   Hippo↑, 1,   HRAS↓, 3,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFR↓, 2,   IKKα↓, 7,   IKKα↑, 2,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 5,   JAK1↓, 5,   JAK1↑, 1,   JAK2↓, 10,   p‑JAK2↓, 2,   JNK↓, 7,   JNK↑, 32,   JNK↝, 1,   p‑JNK↑, 7,   cl‑JNK↑, 1,   LATS1↓, 1,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 40,   MAPK↑, 26,   MAPK↝, 2,   p‑MAPK↓, 3,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 7,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 77,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 25,   mTORC2↓, 3,   NRAS↓, 1,   p‑p42↑, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 3,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFRA↓, 1,   PI3K↓, 130,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 17,   p‑PI3K↑, 1,   PI3K/Akt↓, 9,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↝, 1,   PIK3CA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 12,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 29,   PTEN↝, 2,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 11,   RAS↑, 1,   RET↓, 1,   Rictor↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   RTK-RAS↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 9,   Src↓, 1,   Src↑, 1,   STAT↓, 4,   STAT3↓, 71,   STAT3↑, 4,   p‑STAT3↓, 15,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT5↓, 1,   STAT6↓, 2,   THEM4/CTMP↑, 1,   TSC2↑, 4,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF1↓, 1,   ATF4↓, 1,   ATF4↑, 13,   ATFs↑, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 1,   cMyc↓, 37,   cMyc↑, 3,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT3A↓, 5,   DNMTs↓, 6,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 3,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↓, 1,   H3↓, 3,   p‑H3↓, 1,   ac‑H3↑, 3,   ac‑H4↑, 2,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 22,   HDAC1↓, 7,   HDAC10↑, 1,   HDAC2↓, 4,   HDAC3↓, 4,   HDAC4↓, 1,   HDAC8↓, 2,   HMTs↓, 1,   IRF1↑, 1,   KCNQ1OT1↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 4,   miR-21↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 2,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 8,   miR-375↓, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-590-3p↑, 1,   Myc↓, 5,   MYCN↓, 1,   NDRG1↑, 1,   NR1D2↓, 1,   OCT4↓, 9,   OCT4↑, 1,   other?, 1,   other↓, 4,   other↑, 2,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 2,   SALL4↓, 1,   Shc↓, 1,   sonoS↑, 2,   SOX2↓, 7,   SOX4↑, 1,   TCF-4↓, 1,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 108,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 35,   CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 8,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 52,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 14,   GRP94↑, 2,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 4,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 8,   HSP90↑, 2,   IRE1↑, 4,   PERK↑, 10,   p‑PERK↑, 2,   Proteasome↓, 2,   UPR↑, 9,   XBP-1↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 10,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 26,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 1,   LC3B↑, 2,   LC3B-II↑, 3,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 20,   LC3s↑, 3,   MitoP↑, 1,   p62↓, 9,   p62↑, 4,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 48,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↑, 4,   p‑ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 81,   DNArepair↓, 7,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 12,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 4,   P53↑, 187,   P53⇅, 1,   P53↝, 3,   p‑P53↑, 9,   p53 Wildtype↓, 1,   PARP↓, 5,   PARP↑, 34,   PARP↝, 1,   p‑PARP↑, 4,   cl‑PARP↓, 3,   cl‑PARP↑, 115,   cl‑PARP∅, 1,   PARP1↓, 1,   PARP1↑, 4,   cl‑PARP1↑, 5,   PCNA↓, 45,   PCNA↑, 1,   RAD51↓, 1,   RAD51↑, 1,   SIRT6↓, 1,   SMG1↑, 1,   Telomerase↓, 12,   TOP1↓, 3,   TOP1↝, 1,   TOP2↓, 7,   TP53↓, 3,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CDK1↓, 30,   CDK1↑, 3,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 39,   CDK2↑, 4,   p‑CDK2↓, 2,   CDK4↓, 48,   CDK4↑, 2,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK6↓, 21,   CDK6↑, 3,   CHK1↓, 2,   CHK1↑, 2,   p‑CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   Cyc↓, 4,   Cyc↝, 1,   cycA1/CCNA1↓, 13,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 41,   CycB/CCNB1↑, 4,   cycD1/CCND1↓, 107,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 22,   cycE/CCNE↑, 2,   cycE1↓, 3,   cycF↓, 1,   cycF↑, 1,   E2Fs↓, 3,   FBXO5/EMI1↓, 1,   GADD45A↑, 3,   Ki-67↓, 39,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 8,   P21↑, 104,   P21↝, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 39,   PLK1↓, 1,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 2,   RB1↑, 3,   cl‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 267,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 4,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 5,   CD133↑, 1,   CD24↓, 2,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 8,   CSCs↓, 28,   Diff↑, 2,   EIF4E↓, 2,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 10,   HH↓, 7,   HMGCR↓, 1,   IGF-1↓, 10,   p‑IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   Jun↓, 1,   Ki-67↓, 39,   Let-7↑, 3,   MCM2↓, 1,   mTORC1↓, 8,   Nanog↓, 9,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 11,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGFr↑, 2,   PCLAF↓, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 3,   SAL↑, 1,   Shh↓, 8,   Smo↓, 6,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 116,   TumCG↑, 4,   TumCP?, 2,   TumCP↓, 216,   TumCP↑, 5,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 36,   Wnt↑, 1,   Wnt/(β-catenin)↓, 4,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 11,   AP-1↝, 1,   AXL↓, 1,   Ca+2↓, 3,   Ca+2↑, 42,   Ca+2↝, 3,   i-Ca+2↑, 3,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 4,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↑, 1,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 9,   E-cadherin↑, 51,   EMT?, 1,   EMT↓, 64,   EMT↑, 3,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   Fibronectin↓, 4,   GLI2↓, 3,   hnRNPA1↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 2,   KRAS↓, 3,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 2,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 4,   MMP16↓, 1,   MMP2↓, 89,   MMP2↝, 1,   MMP3↓, 8,   MMP7↓, 9,   MMP9↓, 109,   MMPs↓, 28,   MRGPRF↓, 1,   MTA1↓, 2,   N-cadherin↓, 33,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 1,   p‑p44↑, 1,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   PAK1↑, 1,   PDGF↓, 5,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 7,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   SMAD4↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 23,   TET1↑, 3,   TGF-β↓, 16,   TGF-β↑, 2,   TIMP1↓, 5,   TIMP1↑, 12,   TIMP2↓, 4,   TIMP2↑, 16,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 4,   TumCA↓, 2,   TumCI?, 2,   TumCI↓, 89,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 93,   TumCMig↑, 1,   TumMeta↓, 57,   TumMeta↑, 5,   TumPF↓, 2,   Twist↓, 17,   uPA↓, 23,   uPAR↓, 2,   Vim↓, 39,   Zeb1↓, 8,   Zeb1↑, 1,   ZEB2↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 39,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   Endoglin↑, 2,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 52,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 4,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 98,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 15,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 1,   CellMemb↓, 1,   CLDN2↓, 2,   EPR↑, 3,   GLUT1↓, 9,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 192,   MMP↑, 1,   MMP↝, 1,   MPT↑, 4,   TRPM7↓, 2,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 9,   CD8+↑, 3,   cDC2↓, 3,   p‑cDC2↑, 1,   COX2/PTGS2↓, 65,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR3↓, 1,   CXCR4↓, 11,   DR4↑, 11,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 1,   HLA↑, 1,   HMGB1↓, 3,   HMGB1↑, 1,   ICAM-1↓, 5,   IFN-γ↓, 4,   IFN-γ↑, 3,   IL1↓, 5,   IL1↑, 1,   IL10↓, 6,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 13,   IL1β↑, 3,   IL2↓, 2,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 40,   IL6↑, 1,   IL6↝, 1,   IL7↓, 1,   IL8↓, 10,   Imm↑, 14,   Imm↝, 2,   Inflam↓, 27,   Inflam↝, 1,   LTA/TNF-β↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MDSCs↓, 1,   MIP-1β↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 151,   NF-kB↑, 7,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 1,   NOD1↓, 1,   p65↓, 9,   p‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 9,   PSA↓, 8,   PSA↝, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 5,   TNF-α↓, 41,   TNF-α↑, 10,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 5,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 15,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   AKR1B10↓, 1,   BioAv↓, 33,   BioAv↑, 33,   BioAv↝, 6,   BioEnh↑, 1,   ChemoSen?, 2,   ChemoSen↓, 3,   ChemoSen↑, 136,   ChemoSen↝, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 5,   CYP1A1↑, 2,   CYP1A2↓, 2,   CYP1B1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 5,   Dose↝, 52,   Dose∅, 9,   eff↓, 79,   eff↑, 93,   eff↝, 10,   eff∅, 1,   GSTA1↑, 2,   Half-Life↓, 8,   Half-Life↝, 5,   Half-Life∅, 2,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P-gp/ABCB1⇅, 1,   P450↓, 4,   RadioS?, 1,   RadioS↑, 37,   selectivity?, 2,   selectivity↓, 1,   selectivity↑, 100,   selectivity∅, 2,   Synergy?, 1,   Synergy↑, 107,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 4,   ALAT↓, 2,   ALAT↝, 1,   ALAT∅, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 15,   AR↝, 1,   AST↓, 2,   AST↝, 1,   AST∅, 1,   B2M↓, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 2,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 34,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 12,   IL6↓, 40,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 3,   LDH?, 1,   LDH↓, 14,   LDH↑, 8,   LDH↝, 2,   i-LDH↓, 1,   Maspin↑, 2,   Myc↓, 5,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 8,   PSA↝, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 1,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 61,   AntiCan∅, 1,   antiCG↓, 1,   antiNeop↑, 3,   AntiTum↓, 2,   AntiTum↑, 25,   cachexia↓, 1,   cardioP↑, 9,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 30,   chemoPv↑, 15,   ChemoSideEff↓, 6,   ChemoSideEff∅, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 14,   Mucositis↓, 1,   neuroP↑, 6,   NKG2D↑, 1,   OS↑, 10,   Pain↓, 2,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 2,   QoL∅, 1,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 11,   Risk↓, 12,   Sleep↑, 1,   toxicity?, 1,   toxicity↓, 22,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 30,   TumVol↑, 1,   TumW↓, 17,   Weight↑, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   Bacteria↓, 3,   GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 7,  
Total Targets: 1201

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 91,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 2,   Catalase↑, 54,   GPx↓, 1,   GPx↑, 42,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 49,   GSH/GSSG↑, 1,   GSR↑, 7,   GSTs↓, 2,   GSTs↑, 9,   H2O2↓, 5,   HDL↑, 3,   HO-1?, 2,   HO-1↓, 2,   HO-1↑, 26,   Iron↓, 2,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 39,   MDA?, 1,   MDA↓, 35,   MDA↑, 2,   MPO↓, 4,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 56,   RNS↓, 4,   ROS?, 1,   ROS↓, 113,   ROS↑, 6,   ROS∅, 1,   SOD↓, 3,   SOD↑, 72,   SOD1↑, 2,   SOD2↑, 3,   TAC↑, 5,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mtDam↓, 4,   PGC-1α↓, 2,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↝, 1,   ACSL4↓, 1,   ALAT↓, 14,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 1,   ATP↓, 2,   ATP↑, 3,   DGAT1↓, 1,   FASN↓, 1,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HMG-CoA↓, 2,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PLA2↓, 1,   SIRT1↑, 9,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 2,   Apoptosis↓, 27,   Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 3,   BAX↓, 67,   BAX↑, 8,   Bax:Bcl2↓, 1,   Bcl-2↓, 9,   Bcl-2↑, 40,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   Casp1↓, 2,   Casp12↓, 2,   Casp3↓, 41,   Casp3↑, 2,   cl‑Casp3↓, 10,   Casp8↓, 3,   Casp9↓, 12,   cl‑Casp9↓, 4,   Cyt‑c↓, 12,   Cyt‑c↑, 3,   Fas↓, 3,   FasL↓, 1,   Ferroptosis↓, 4,   iNOS↓, 21,   iNOS↑, 1,   MLKL↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 7,   p‑Akt↓, 2,   p‑Akt↑, 8,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↑, 1,   JNK↓, 7,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   Mst1↓, 2,   mTOR↓, 1,   mTOR↑, 4,   p‑mTOR↑, 2,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 2,   PI3K↑, 6,   PKA↑, 1,   PKCδ↑, 1,   PP2A↑, 1,   p‑PTEN↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 1,   STAT3↑, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF4↓, 2,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 3,   other↑, 3,   other↝, 5,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 4,   IRE1↓, 2,   PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 3,   p62↑, 3,   PARK2↑, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 7,   p16↓, 1,   P53↓, 6,   P53↑, 1,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 1,   IGF-1↑, 1,   Ki-67↓, 1,   neuroG↑, 2,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 2,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 1,   Ca+2↝, 1,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 1,   COL1↑, 1,   E-cadherin↓, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 5,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   Zeb1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   HIF-1↓, 1,   Hif1a↓, 1,   NO?, 1,   NO↓, 16,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 8,   BBB↝, 2,   BBB∅, 2,   CLDN1↓, 1,   CLDN4↑, 1,   GastroP↑, 5,   GLUT1↑, 1,   GLUT2↑, 2,   GLUT3↑, 2,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 4,   TRPA1↑, 1,   TRPV1↑, 1,   ZO-1↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 32,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 8,   IL10↑, 3,   IL12↓, 1,   IL13↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 28,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↓, 1,   Imm↑, 5,   Inflam↓, 99,   Inflam↑, 1,   IRF3↓, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 3,   NF-kB?, 1,   NF-kB↓, 40,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 6,   p65↓, 1,   PGE2↓, 12,   PGE2↑, 1,   PSA∅, 1,   RAGE↓, 4,   RANTES↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 50,   TNF-α↑, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 3,   AChE↓, 20,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 13,   BDNF⇅, 1,   ChAT↑, 2,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 3,   PSD95↑, 2,   SNAP25↑, 2,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 18,   Aβ42↓, 4,   BACE/β-secretase↓, 9,   IDE↑, 1,   tau↓, 4,   p‑tau↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 4,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 35,   BioAv↝, 13,   BioAv∅, 1,   BioEnh↑, 3,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↑, 1,   Dose↝, 14,   Dose∅, 1,   eff↓, 5,   eff↑, 9,   GSTA1↑, 2,   Half-Life↑, 2,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 2,   P450↓, 3,   P450↝, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 14,   ALP↓, 5,   AST↓, 15,   Bil↓, 1,   BMD↑, 1,   BP↓, 4,   BUN?, 1,   BUN↓, 1,   CEA↓, 1,   colonLen↑, 1,   creat↓, 3,   CRP↓, 6,   hs-CRP↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 5,   NOS2↓, 1,   PSA∅, 1,   RAGE↓, 4,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 13,   AntiArt↑, 7,   AntiCan↑, 15,   antiCG↑, 2,   antiD↓, 1,   AntiDiabetic↑, 20,   AntiTum↓, 1,   AntiTum↑, 4,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 4,   cognitive↑, 20,   diuretic↑, 2,   hepatoP↓, 2,   hepatoP↑, 37,   Learn↑, 4,   memory↑, 22,   motorD↑, 6,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 67,   Obesity↓, 4,   Pain↓, 4,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 14,   Risk↓, 2,   Strength↑, 1,   Stroke↓, 8,   toxicity?, 1,   toxicity↓, 22,   toxicity↑, 4,   toxicity↝, 4,   toxicity∅, 7,   Weight∅, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 3,   AntiViral↑, 10,   Bacteria↓, 15,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 10,   Inf↓, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 475

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
33 Silver-NanoParticles
27 Quercetin
25 Curcumin
20 Thymoquinone
19 Luteolin
17 Baicalein
15 Apigenin (mainly Parsley)
12 Allicin (mainly Garlic)
12 Propolis -bee glue
12 EGCG (Epigallocatechin Gallate)
11 Emodin
11 Lycopene
10 Sulforaphane (mainly Broccoli)
10 Betulinic acid
10 Fisetin
9 Ashwagandha(Withaferin A)
9 Berberine
9 Kaempferol
9 Matrine
9 Resveratrol
8 Eugenol
8 Ferulic acid
8 Magnetic Fields
8 Graviola
8 Isobavachalcone
8 Juglone
8 Licochalcone A
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
7 Cisplatin
7 Melatonin
7 Carvacrol
7 D-limonene
7 Garcinol
7 Hyperoside
7 Magnolol
7 Phenethyl isothiocyanate
6 Artemisinin
6 Radiotherapy/Radiation
6 Capsaicin
6 Chrysin
6 Ellagic acid
6 Gallic acid
6 Honokiol
6 isoorientin
6 Licorice
6 Morin
6 Nimbolide
5 5-fluorouracil
5 Alpha-Lipoic-Acid
5 Beta-Caryophyllene
5 Benzyl isothiocyanate
5 Cinnamon
5 Formononetin
5 Gambogic Acid
5 Geraniol
5 Hibiscus sabdariffa
5 Isorhamnetin
5 Ivermectin
5 Rosmarinic acid
4 Astragalus
4 Andrographis
4 Isovitexin
4 Astaxanthin
4 Bufalin/Huachansu
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Carnosic acid
4 chitosan
4 Crocetin
4 Paclitaxel/Taxol
4 Evodiamine
4 Ginkgolide B
4 Indole-3-carbinol
4 Isoliquiritigenin
4 Moringa oleifera
4 Urolithin
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Photodynamic Therapy
3 Gemcitabine (Gemzar)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Chemotherapy
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Chlorogenic acid
3 Docetaxel
3 Ursolic acid
3 Dandelion Root
3 Eurycomanone
3 Ginkgetin
3 HydroxyTyrosol
3 isoquercitrin
3 L-Theanine
3 methylseleninic acid
3 Oleuropein
3 Patchouli Oil (Pogostemon cablin)
3 Phycocyanin
3 Piperlongumine
3 Parthenolide
3 Aflavin-3,3′-digallate
2 tamoxifen
2 Allyl isothiocyanate
2 Metformin
2 immunotherapy
2 beta-glucans
2 Berbamine
2 Biochanin A
2 borneol
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Hydroxycinnamic-acid
2 Carvone
2 Polyphenols
2 Chlorella (Chlorella vulgaris)
2 Cynaropicrin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Rutin
2 doxorubicin
2 Vitamin C (Ascorbic Acid)
2 Lactobacillus
2 Laetrile B17 Amygdalin
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 Linalool
2 Lutein
2 Mangiferin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Propyl gallate
2 Piperine
2 Plumbagin
2 Pterostilbene
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Spirulina(Arthrospira/Limnospira)
2 Selenite (Sodium)
2 Vitamin K2
2 Vitexin
1 1,8-Cineole
1 Coenzyme Q10
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Brucea javanica
1 Bromelain
1 Black turtle bean
1 Bullatacin
1 Butyrate
1 Cat’s Claw
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Prebiotic
1 Chlorophyllin
1 Citicoline, CDP-Choline
1 Citric Acid
1 Cranberry
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Date Fruit Extract
1 Disulfiram
1 Electrical Pulses
1 Fenbendazole
1 Flaxseed/Linseed
1 carboplatin
1 olaparib/LYNPARZA
1 Ginkgo biloba
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 iodine
1 Isothiocyanates
1 itraconazole
1 lambertianic acid
1 Lapachol
1 SDG/lignans
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Methyl Jasmonate
1 Magnetic Field Rotating
1 Moringin
1 Methylglyoxal
1 Zeolite
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Neem
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 sericin
1 Purple Corn / Purple Maize
1 Psoralidin
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Auranofin
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Vitamin D3
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:26  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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