DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱

Source: HalifaxProj(prevent)

Type:

DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.

Scientific Papers found: Click to Expand⟱

7908-

VT,

Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway

-

in-vitro,

AML,

NA

MMP↓, DNAdam↑, BCR↓, ABL1↓, HRAS↓, NRAS↓, KRAS↓, Raf↓, p38↑, BAX↑, Casp9↑,

604-

ZO,

Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

-

Review,

Var,

NA

ROS↑, Apoptosis↑, DNAdam↑,

Showing Research Papers: 451 to 452 of 452
Prev Page 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 452

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↓, 1, NA↑, 3,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 2, antiOx↑, 10, Catalase↓, 7, Catalase↑, 3, Catalase∅, 1, cystine↓, 1, Fenton↑, 8, GPx↓, 2, GPx↑, 4, GPx4↓, 5, GSH↓, 30, GSH↑, 5, GSH∅, 1, mt-GSH↓, 1, GSH/GSSG↓, 5, GSR↓, 2, GSR↑, 2, GSSG↑, 1, ox-GSSG↑, 1, GSTs↓, 2, GSTs∅, 1, H2O2↓, 1, H2O2↑, 14, HO-1↓, 7, HO-1↑, 7, HO-2↓, 1, HO-2↑, 1, Iron↓, 1, Iron↑, 4, c-Iron↑, 1, lipid-P↓, 4, lipid-P↑, 19, lipid-P↝, 1, MDA↓, 2, MDA↑, 3, i-MDA↑, 1, mt-NADH↓, 1, NADPH/NADP+↓, 1, NOX↓, 1, NOX4↓, 1, NQO1↓, 1, NQO1↑, 1, NRF2↓, 12, NRF2↑, 12, Prx4↑, 1, PrxII↓, 1, ROS↓, 22, ROS↑, 253, ROS⇅, 4, ROS↝, 1, i-ROS↓, 1, i-ROS↑, 3, m-ROS↑, 1, mt-ROS↑, 6, SOD↓, 6, SOD↑, 5, SOD1↓, 1, SOD1↑, 1, SOD2↓, 1, SOD2↑, 1, TAC?, 1, TBARS↓, 1, TBARS↑, 1, Thiols↓, 1, Trx↓, 4, Trx↑, 1, Trx1↓, 1, Trx2↓, 1, TrxR↓, 10, TrxR1↓, 2, TrxR1⇅, 1, xCT/SLC7A11↓, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2, IronCh↑, 1, NCOA4↑, 1, Tf↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1, ADP:ATP↑, 1, BCR↓, 1, CDC2↓, 3, CDC25↓, 10, CDC25↝, 1, compI↓, 2, EGF↓, 3, ETC↓, 2, ETC↝, 1, Insulin↓, 2, mitResp↓, 2, MKK7↓, 1, mtDam↓, 1, mtDam↑, 19, OCR↓, 1, mt-OCR↓, 1, OXPHOS↓, 3, OXPHOS↑, 2, PDH↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 2, ACC↑, 2, ACLY↓, 1, ACSL4↑, 2, ALAT↓, 3, AMP↑, 1, AMPK↓, 1, AMPK↑, 17, p‑AMPK↑, 2, p‑AMT/GCST/T-protein↑, 1, ATP↓, 22, ATP↑, 1, CRM↑, 1, ECAR↓, 1, ECAR↝, 1, p‑ENO1↓, 1, FASN↓, 2, G6PD∅, 1, GAPDH↓, 1, glucoNG↓, 1, glucose↓, 1, GlucoseCon↓, 7, GlucoseCon∅, 1, Glycolysis↓, 21, GSK‐3β↓, 6, GSK‐3β↑, 1, p‑GSK‐3β↓, 4, H2S↑, 1, Histones↑, 2, HK2↓, 8, lactateProd↓, 9, lactateProd↑, 1, lactateProd∅, 1, LDHA↓, 6, LDL↓, 2, MCT4↓, 1, NAD↓, 5, NADPH↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 6, p‑PDK1 / PDPK1↓, 1, PKM2↓, 7, PPP↓, 1, Pyruv↓, 2, Pyruv↑, 1, p‑S6↓, 1, SIRT1↓, 4, SIRT1↑, 6, SIRT2↓, 1, SREBP2↓, 1, TCA?, 1, TCA↓, 1, TCA↑, 1, Warburg↓, 3,

Cell Death(tgid=5) ⓘ

AIF↑, 17, APAF1↑, 6, Apoptosis↓, 6, Apoptosis↑, 208, mt-Apoptosis↑, 4, BAD↓, 1, BAD↑, 8, Bak↑, 4, BAX?, 1, BAX↓, 2, BAX↑, 74, Bax:Bcl2↑, 26, Bcl-2↓, 74, Bcl-2↑, 2, Bcl-xL↓, 13, Bcl-xL↑, 1, BID↑, 3, p‑BID↓, 1, cl‑BID↑, 2, BIM↑, 5, Casp↓, 2, Casp↑, 33, Casp3↓, 3, Casp3↑, 129, cl‑Casp3↑, 19, proCasp3↑, 1, pro‑Casp3↑, 2, Casp6↑, 1, Casp7↑, 20, cl‑Casp7↑, 2, Casp8↑, 28, cl‑Casp8↑, 3, proCasp8↑, 1, Casp9?, 1, Casp9↑, 71, cl‑Casp9↑, 11, proCasp9↑, 1, pro‑Casp9↑, 1, Cupro↑, 1, Cyt‑c↓, 2, Cyt‑c↑, 64, Diablo↑, 8, DR5↑, 6, Endon↑, 2, FADD↑, 2, Fap1↓, 1, Fas↓, 2, Fas↑, 13, FasL↑, 5, Ferroptosis↑, 8, IAP1↓, 1, IAP2/BIRC3↓, 1, ICAD↓, 1, iNOS↓, 8, JWA↑, 1, Mcl-1↓, 8, p‑Mcl-1↓, 1, cl‑Mcl-1↑, 1, MDM2↓, 4, MLKL↑, 2, p‑MLKL↓, 1, MOMP↓, 1, MOMP↑, 4, Necroptosis↑, 5, necrosis↑, 6, NOXA↑, 2, oncosis↑, 1, p38↓, 4, p38↑, 13, p‑p38↑, 2, Paraptosis↑, 2, PUMA↑, 4, RIP3↑, 2, p‑RIP3↑, 2, survivin↓, 23, TRAIL↑, 2, TRAILR↑, 1, TumCD↑, 32, XIAP↓, 11, YAP/TEAD↓, 1, β-TRCP↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1, Akt↓, 81, Akt↑, 2, p‑Akt↓, 17, p‑Akt↑, 2, Akt2↓, 1, CK2↓, 2, cMET↓, 1, cSrc↓, 1, DDIT4↑, 1, EGFR↓, 18, p‑EGFR↓, 1, ERK↓, 31, ERK↑, 4, p‑ERK↓, 5, p‑ERK↑, 2, FGFR1↓, 2, FGFR2↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 7, HRAS↓, 1, IKKα↓, 2, p‑IKKα↓, 1, JAK↓, 5, p‑JAK↓, 1, JAK1↓, 4, JAK1↑, 1, JAK2↓, 7, JNK↓, 4, JNK↑, 13, p‑JNK↑, 2, MAPK↓, 23, MAPK↑, 10, MAPK↝, 1, MARK4↓, 1, MEK↓, 3, MKK4↓, 1, mTOR↓, 41, mTOR↑, 2, mTOR⇅, 1, p‑mTOR↓, 1, mTORC2↓, 2, NRAS↓, 1, p70S6↓, 2, p‑p70S6↑, 1, p‑P70S6K↓, 1, p‑P90RSK↑, 1, PI3K↓, 47, PI3K↑, 4, p‑PI3K↓, 1, PI3K/Akt↓, 1, PIK3CA↓, 1, PKCδ↓, 9, cl‑PKCδ↑, 1, PTEN↓, 1, PTEN↑, 13, Raf↓, 4, RAS↓, 6, RIP1↑, 1, p‑S6K↓, 2, Sp1/3/4↓, 6, STAT↓, 3, p‑STAT↓, 1, STAT3↓, 34, STAT3↑, 2, p‑STAT3↓, 6, p‑STAT3↑, 1, STAT5↓, 4, STAT6↓, 1, p‑STK11/LKB1↑, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1, ATF4↑, 5, ATF4↝, 1, ATFs↑, 1, CBP↓, 1, ChrMod↑, 1, cJun↓, 7, cJun↑, 1, cMyc↓, 23, p‑cMyc↑, 1, DNMT1↓, 3, DNMT3A↓, 1, DNMTs↓, 1, EZH2↓, 1, FOXM1↓, 3, FOXO↓, 1, FOXO↑, 1, FOXO3↑, 1, FOXO3↝, 1, FOXO4↑, 2, ac‑H3↑, 3, H3K18↓, 1, ac‑H4↑, 2, HATs↓, 2, HDAC↓, 7, HDAC1↓, 3, HDAC2↓, 2, HDAC3↓, 1, HDAC8↓, 1, miR-21↓, 2, miR-210↓, 1, miR-218↑, 1, miR-27a-3p↓, 1, miR-590-3p↑, 1, Myc↓, 4, n-MYC↓, 1, OCT4↓, 7, other↓, 1, other↑, 9, other↝, 9, OV6↓, 1, PhotoS↑, 2, SOX2↓, 5, SOX4↑, 1, SOX9?, 1, SOX9↓, 1, TCF-4↓, 2, tumCV?, 1, tumCV↓, 58, tumCV∅, 1, ZBTB10↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2, cl‑ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 12, eIF2α↑, 2, p‑eIF2α↓, 1, p‑eIF2α↑, 2, ER Stress↓, 2, ER Stress↑, 35, GRP78/BiP?, 1, GRP78/BiP↓, 1, GRP78/BiP↑, 12, HSF1↓, 1, HSP27↓, 3, HSP70/HSPA5↓, 4, HSP70/HSPA5↑, 1, HSP90↓, 2, IRE1↑, 4, NPL4↓, 1, PERK↑, 3, Proteasome↓, 1, UPR↑, 10, XBP-1↓, 1, XBP-1↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2, ATG5↑, 2, ATG7↑, 1, autoF↓, 1, AVOs↑, 1, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 8, CTSB↓, 1, CTSD↓, 1, LAMP2↑, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 2, LC3B↑, 2, LC3B-II↑, 1, LC3I↑, 1, LC3II↓, 2, LC3II↑, 3, LC3s↝, 1, lysoMP↑, 2, lysosome↝, 1, MitoP↑, 1, p62↓, 5, p62↑, 3, SESN2↑, 2, TumAuto↓, 1, TumAuto↑, 28, TumAuto↝, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6, p‑ATM↑, 1, ATR↑, 3, p‑ATR↑, 1, BRCA1↓, 2, BRCA1↑, 1, p‑BRCA1↑, 1, DFF45↓, 1, DNAdam↓, 14, DNAdam↑, 377, mt-DNAdam↑, 2, DNArepair↓, 3, FEN1↓, 2, HR↓, 1, hTERT/TERT↓, 6, Ku70/XRCC6↓, 1, MGMT↓, 1, NHEJ↓, 1, p16↑, 2, P53↓, 3, P53↑, 67, P53↝, 3, p‑P53↑, 5, p53 Wildtype↓, 1, PARP↓, 3, PARP↑, 13, p‑PARP↑, 1, cl‑PARP↓, 3, cl‑PARP↑, 56, cl‑PARP↝, 1, PARP1↑, 3, PCNA↓, 21, RAD51↓, 1, SIRT6↑, 1, Telomerase↓, 10, TOP1↓, 6, TOP1∅, 1, TOP2↓, 8, TP53↑, 2, TRF2↓, 1, XRCC1↓, 1, γH2AX↓, 1, γH2AX↑, 25, p‑γH2AX↑, 6,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6, CDK1↑, 3, CDK1↝, 1, p‑CDK1↓, 1, CDK2↓, 24, CDK2↑, 1, CDK4↓, 26, CDK4↑, 1, p‑CDK4↓, 1, CDK4/6↓, 1, CDK6↓, 11, CDK6↑, 2, CDK8↓, 1, CHK1↓, 4, CHK1↑, 2, CHK1↝, 1, p‑CHK1↑, 1, Chk2↓, 2, Chk2↑, 5, p‑Chk2↑, 1, ChrCon↑, 3, Cyc↓, 1, cycA1/CCNA1↓, 6, CycB/CCNB1↓, 10, CycB/CCNB1↑, 2, CycB/CCNB1↝, 1, cycD1/CCND1↓, 54, cycD1/CCND1↑, 1, p‑cycD1/CCND1↓, 1, cycE/CCNE↓, 19, cycE1↓, 2, E2Fs↓, 2, E2Fs↑, 1, GADD45A↑, 2, Ki-67↓, 12, mitA↑, 3, P21↓, 3, P21↑, 55, p27/CDKN1B↓, 1, p27/CDKN1B↑, 20, RB1↓, 1, p‑RB1↓, 4, Securin↓, 1, TumCCA?, 1, TumCCA↓, 3, TumCCA↑, 166, TumCCA∅, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7, ALDH1A1↓, 2, ALDH1A3↓, 1, CD133↓, 7, CD133↑, 1, cFos↓, 7, CSCs↓, 34, CSCsMark↓, 1, Diff↓, 1, Diff↑, 4, FGF↓, 1, Gli1↓, 4, HH↓, 2, IGF-1↓, 5, IGF-2↓, 1, IGFBP3↑, 1, IGFBP7↑, 1, Ki-67↓, 12, mTORC1↓, 3, p‑mTORC1↓, 1, Nanog↓, 7, Nestin↓, 2, NICD↓, 1, NOTCH↓, 5, NOTCH⇅, 1, NOTCH1↓, 7, NOTCH1↑, 2, NOTCH2↓, 1, p300↓, 1, PTCH1↓, 3, SCF↓, 1, Shh↓, 2, Smo↓, 3, STAT1↓, 1, TAZ↓, 1, TumCG↓, 63, TumCG↑, 1, TumCP↓, 97, TumCP↑, 2, tyrosinase↓, 1, Wnt↓, 20, Wnt/(β-catenin)↓, 5,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg?, 1, AntiAg↑, 1, AP-1↓, 6, APC↑, 1, AXL↓, 1, Ca+2↓, 2, Ca+2↑, 26, Ca+2↝, 1, i-Ca+2↑, 1, cal2↓, 1, CCN2/CTGF↓, 1, CD11b↑, 1, Cdc42↑, 1, E-cadherin↓, 3, E-cadherin↑, 17, EMT↓, 33, EMT↑, 1, EpCAM↓, 3, F-actin↓, 1, FAK↓, 4, p‑FAK↓, 1, fascin↓, 1, Fibronectin↓, 3, GLI2↓, 2, ITGB1↑, 1, KRAS↓, 1, LAMs↓, 1, MALAT1↓, 1, MET↓, 1, MMP-10↓, 1, MMP1↓, 2, MMP13↓, 1, MMP2↓, 42, MMP3↓, 4, MMP7↓, 6, MMP9↓, 43, MMPs↓, 10, MUC4↓, 1, N-cadherin↓, 11, NCAM↑, 1, NEDD9↓, 1, PDGF↓, 1, RECK↑, 1, Slug?, 1, Slug↓, 4, p‑SMAD2↓, 1, SMAD3↓, 3, p‑SMAD3↓, 1, p‑SMAD4↓, 1, Snail?, 1, Snail↓, 7, STAC2↓, 1, TET1↓, 1, TET1↑, 4, TGF-β↓, 11, TGF-β↑, 1, TIMP1↑, 4, TIMP2↓, 1, TIMP2↑, 7, TRIB3↑, 1, TSC1↑, 1, TumCA↓, 2, TumCI↓, 34, TumCMig↓, 37, TumMeta↓, 42, TumMeta↑, 1, Twist↓, 5, TXNIP↑, 1, uPA↓, 8, Vim↓, 14, Zeb1↓, 2, α-SMA↓, 1, β-catenin/ZEB1↓, 21, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54, angioG↑, 2, CD31/PECAM-1↓, 1, Endoglin↑, 2, eNOS↓, 2, HIF-1↓, 4, Hif1a↓, 29, Hif1a↑, 1, Hypoxia↓, 2, LOX1↓, 2, NO↓, 4, NO↑, 5, VCAM-1↓, 3, VEGF↓, 51, VEGFR1↓, 2, VEGFR2/KDR/Flk1↓, 5,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, CellMemb↑, 4, CLDN1↓, 1, CTR1↑, 2, EPR↑, 11, GLUT1↓, 5, GLUT2↓, 1, MMP↓, 115, MMP↑, 2, MMP↝, 1, MPT↓, 1, MPT↑, 4, NHE1↓, 1, SVCT-2↝, 1, SVCT-2∅, 1, TRPM7↓, 2, TRPV1↓, 1, TRPV1↑, 1, TRPV1↝, 1, VGCC↑, 1, VGSC↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD44↓, 8, CD47↓, 1, CD8+↑, 1, COX1↓, 2, COX2/PTGS2↓, 34, COX2/PTGS2↑, 2, CXCL12↓, 1, CXCR4↓, 7, DR4↑, 1, FOXP3↑, 1, HMGB1↓, 3, ICAM-1↓, 3, IFN-γ↓, 2, IFN-γ↑, 1, Igs↑, 1, IL1↓, 3, IL1↑, 1, IL10↓, 1, IL12↓, 1, IL12↑, 2, IL1α↓, 1, IL1β↓, 8, IL1β↑, 1, IL2↓, 3, IL2↑, 2, IL4↓, 2, IL4↑, 1, IL6↓, 22, IL8↓, 3, Imm↑, 13, Inflam↓, 19, M2 MC↓, 1, MCP1/CCL2↓, 2, MIP2↓, 1, Neut↓, 1, NF-kB↓, 65, NF-kB↑, 7, NF-kB↝, 1, p‑NF-kB↑, 1, NK cell↑, 3, NLRP3↓, 1, NLRP3↑, 1, p65↓, 3, PD-L1↓, 2, PD-L1↑, 1, PGE2↓, 14, PSA↓, 2, TCF↓, 1, TCF↑, 1, TLR4↓, 3, TNF-α↓, 17, TNF-α↑, 4, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1, pH↑, 1, pH↝, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1, BChE↓, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7, AR-V7?, 1, CYP19?, 1, ER-α36↓, 1, ER(estro)↓, 1, PPARα↓, 1, PPARγ↓, 1, PPARγ↑, 2, PRL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1, BioAv↓, 20, BioAv↑, 24, BioAv↝, 5, BioEnh↑, 3, CBR1↓, 1, chemoR↓, 2, ChemoSen↓, 2, ChemoSen↑, 114, ChemoSen⇅, 1, ChemoSen↝, 1, ChemoSen∅, 1, CompStab↓, 1, CompStab↑, 2, CompStab↝, 1, CYP1A1↓, 2, CYP1A1↑, 1, DDS↑, 1, Dose?, 6, Dose↓, 5, Dose↑, 7, Dose↝, 34, Dose∅, 10, DrugR↓, 1, eff↓, 48, eff↑, 88, eff⇅, 1, eff↝, 12, GSTA1↑, 2, Half-Life↓, 5, Half-Life↝, 5, MDR1↓, 8, MRP1/ABCC1↓, 2, P-gp/ABCB1↓, 13, P450↓, 2, RadioS↓, 1, RadioS↑, 59, selectivity?, 2, selectivity↓, 2, selectivity↑, 99, selectivity↝, 1, Synergy↑, 62,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 3, ALP↓, 1, AR↓, 7, AST↓, 1, BG↓, 2, BloodF↑, 1, BRCA1↓, 2, BRCA1↑, 1, p‑BRCA1↑, 1, E6↓, 1, E7↓, 1, EGFR↓, 18, p‑EGFR↓, 1, EZH2↓, 1, Ferritin↓, 2, FOXM1↓, 3, HER2/EBBR2↓, 7, hTERT/TERT↓, 6, IL6↓, 22, KRAS↓, 1, LDH↓, 6, LDH↑, 2, LDH↝, 1, Myc↓, 4, PD-L1↓, 2, PD-L1↑, 1, PSA↓, 2, TP53↑, 2, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2, AntiCan↑, 42, AntiCan∅, 1, antiNeop↑, 1, AntiTum↓, 1, AntiTum↑, 11, cachexia↓, 1, cardioP↑, 4, chemoP↑, 17, chemoPv↑, 6, ChemoSideEff↓, 5, hepatoP↑, 4, K17↓, 1, LC↑, 1, neuroP↑, 3, NKG2D↑, 1, NP/CIPN↓, 1, NP/CIPN↝, 1, OS↑, 13, Pain↓, 1, PFS↑, 1, Pin1↓, 2, QoL↑, 4, radioP↑, 7, RenoP↑, 4, Risk↓, 10, Strength↑, 1, toxicity↓, 11, toxicity↝, 5, toxicity∅, 1, TumVol↓, 13, TumW↓, 4, Weight↑, 2, Weight∅, 1, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5, Sepsis↓, 2,
Total Targets: 831

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5, antiOx↑, 57, Bil↓, 1, Catalase↑, 28, DPPH↓, 1, Fenton↓, 1, GPx↑, 21, GPx1↑, 2, GPx4↑, 1, GSH↓, 1, GSH↑, 24, GSR↑, 2, GSTs↑, 9, H2O2↓, 1, H2O2↑, 1, HDL↓, 1, HDL↑, 4, HO-1↑, 17, Keap1↓, 1, lipid-P↓, 22, lipid-P↑, 1, MDA↓, 20, MPO↓, 3, NADH↓, 1, NOX↓, 1, NOX4↓, 1, NQO1↑, 1, NRF2↑, 20, p‑NRF2↑, 1, Prx↑, 1, RNS↓, 3, ROS?, 1, ROS↓, 75, ROS↑, 3, ROS∅, 4, selenoP↑, 5, SOD↓, 2, SOD↑, 31, SOD1↑, 1, SOD2↑, 1, TAC↑, 1, TBARS↓, 2, Trx1↑, 1, uricA↓, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1, FIS1↓, 1, mtDam↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4, ACC↓, 1, ALAT↓, 7, AMPK↑, 2, Buty↑, 1, DGAT1↓, 1, FASN↓, 2, glucose↓, 2, GlucoseCon↑, 1, GSK‐3β↓, 2, HMG-CoA↓, 1, LDL↓, 6, lipidLev↓, 1, NADPH↓, 1, SCFAs↑, 1, SIRT1↓, 1, SIRT1↑, 5, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6, BAX↓, 7, Bax:Bcl2↓, 1, Bcl-2↑, 5, Bcl-xL↑, 1, Casp↓, 1, Casp3↓, 7, cl‑Casp3↓, 1, Casp9↓, 2, Cyt‑c↓, 2, iNOS↓, 10, iNOS↑, 1, necrosis↓, 1, p38↓, 2, p38↑, 1, p‑p38↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 1, ERK↓, 2, ERK↑, 3, IκB?, 1, JAK2↓, 1, JAK2↑, 1, JNK↓, 2, JNK↑, 1, p‑JNK↓, 1, MAPK↓, 2, PI3K↓, 1, PI3K↑, 1, PKCδ↑, 1, STAT3↓, 2, STAT3↑, 2,

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2, p‑cJun↓, 1, p‑cMyc↑, 1, HDAC↓, 2, HDAC3↓, 1, other↓, 4, other↑, 4, other↝, 3, RUNX2↑, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1, cl‑eIF2α↑, 1, ER Stress↓, 2, GRP78/BiP↑, 1, HSP70/HSPA5↓, 1, p‑PERK↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1, p62↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 63, DNAdam↑, 3, DNAdam∅, 1, DNArepair↑, 2, SIRT6↑, 2, γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↓, 1, Ki-67↓, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, cFos↓, 1, FGF↑, 1, Ki-67↓, 2, TumCG↓, 1, TumCP↓, 1, tyrosinase↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 1, Ca+2↓, 3, Ca+2↝, 1, COL1↓, 1, COL1↑, 1, EMT↓, 1, Fibrosis↓, 1, LRP1↑, 1, MMP1↓, 1, MMP2↓, 1, MMP2↑, 2, MMP3↓, 1, MMP9↓, 1, MUC1↑, 1, ROCK1↓, 2, Snail↑, 1, TGF-β↓, 3, TGF-β↑, 1, TGF-β1↓, 1, TIMP1↓, 1, TumCI↓, 1, TumCMig↓, 1, TumMeta↓, 1, Twist↑, 1, Vim↑, 1, α-SMA↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, HIF-1↓, 1, Hif1a↓, 1, Hif1a↑, 1, NO↓, 5, NO↑, 2, VCAM-1↓, 2, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7, GastroP↑, 3, GLUT2↑, 1, GLUT3↑, 1, GLUT4↑, 1, IBI↑, 2, MMP↑, 3, MUC19↓, 1, MUC2↓, 1, TJ↑, 1, VGCC↝, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1, CD25+↑, 1, CD4+↑, 2, cGAS–STING↓, 2, COX1↓, 2, COX2/PTGS2↓, 16, FOXP3↑, 1, HMGB1↓, 2, ICAM-1↓, 2, IFN-γ↓, 2, IL1↓, 1, IL10↓, 2, IL10↑, 5, IL17↓, 3, IL1α↓, 1, IL1β↓, 9, IL2↓, 1, IL22↓, 2, IL23↓, 1, IL4↓, 1, IL4↑, 1, IL6↓, 19, IL6↑, 1, IL8↓, 1, Imm↑, 4, Inflam↓, 70, Inflam↑, 1, IRF3↓, 1, M2 MC↑, 1, MCP1/CCL2↓, 4, MCP1/CCL2↑, 1, MIP‑1α/CCL3↓, 1, MyD88↓, 1, NeuroI↓, 1, NF-kB↓, 19, NF-kB↑, 1, NK cell↑, 2, NLRP3↓, 4, PGE2↓, 8, PGE2↑, 1, RAGE↓, 2, RANTES↓, 1, Th1 response↓, 1, Th2↑, 2, TLR1↓, 1, TLR2↓, 1, TLR4↓, 2, TNF-α↓, 23, TNF-α↑, 1, Treg lymp↝, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, AChE↓, 6, AChE↑, 1, AChE↝, 1, BChE↓, 2, BDNF↑, 6, GABA↑, 1, MAOA↓, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3, Aβ↓, 7, BACE/β-secretase↓, 2, tau↓, 2, p‑tau↓, 3,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17, BioAv↑, 25, BioAv↝, 3, BioEnh↑, 1, ChemoSen↑, 2, CompStab↑, 1, CompStab↝, 1, CYP2E1↓, 1, Dose?, 2, Dose↓, 2, Dose↑, 2, Dose↝, 19, Dose∅, 1, eff↓, 1, eff↑, 16, eff↝, 1, Half-Life↓, 2, Half-Life↝, 2, Half-Life∅, 1, P450↓, 1, P450↑, 1, RadioS↑, 1, selectivity↑, 1, Synergy↑, 7,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7, ALB↑, 1, ALB↝, 1, ALP↓, 3, AST↓, 8, BG↓, 1, Bil↓, 1, BloodF↑, 1, BMD↑, 3, BP↓, 5, BUN↓, 2, creat↓, 3, CRP↓, 4, HOMA↓, 1, hs-CRP↓, 1, IL6↓, 19, IL6↑, 1, LDH↓, 2, NOS2↓, 1, RAGE↓, 2, SpO2↑, 1, TC↓, 1, TG/TAG↓, 2,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3, antiAll↑, 6, AntiArt↑, 4, AntiCan↑, 13, AntiDiabetic↑, 16, AntiTum↑, 1, Bone Healing↑, 1, cardioP↑, 19, CardioT↓, 1, chemoP↑, 4, chemoPv↑, 2, cognitive↓, 1, cognitive↑, 10, diuretic↑, 2, hepatoP↑, 20, memory↑, 11, Mood↑, 1, motorD↑, 2, neuroP↓, 1, neuroP↑, 27, Obesity↓, 4, OS↑, 3, Pain↓, 3, PDE4↓, 1, QoL↑, 1, radioP↑, 11, RenoP↑, 7, Sleep↑, 1, Strength↑, 1, Stress↓, 1, Stroke↓, 1, toxicity?, 2, toxicity↓, 27, toxicity↝, 6, toxicity∅, 6, Weight↓, 1, Weight↑, 1, Wound Healing↑, 6,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2, AntiFungal↑, 4, AntiViral↑, 5, Bacteria↓, 15, Diar↓, 1, GutMicro↑, 8, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1, Ingr↝, 4,
Total Targets: 339

Scientific Paper Hit Count for: DNAdam, DNA damage

33 Silver-NanoParticles
19 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
14 Magnetic Fields
12 Curcumin
11 Fisetin
9 Cisplatin
8 Quercetin
8 Lycopene
7 Chemotherapy
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Chrysin
7 salinomycin
7 Selenium NanoParticles
7 Sulforaphane (mainly Broccoli)
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 Kaempferol
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Licorice
4 Magnolol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Moringa oleifera
3 Anethole/trans-Anethole
3 Melatonin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Juglone
3 Lemongrass Extract/Citral
3 Lutein
3 mebendazole
3 Nimbolide
3 Marjoram (Origanum majorana)
3 Phenethyl isothiocyanate
3 Phycocyanin
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 methylseleninic acid
2 Morin
2 Mucuna pruriens/Velvet Bean
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 buckwheat sprouts
1 Rutin
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Lapachol
1 Lasiodin
1 Linalool
1 Luteolin
1 MCT, metronomic chemo
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Aromatherapy
1 5-fluorouracil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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