Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3029- RosA,    Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, tumCV↓, Apoptosis↑, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21↑, DNAdam↑, Casp3↑,
3028- RosA,    Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer’s disease
- in-vitro, AD, HT22 - in-vivo, NA, NA
*Aβ↓, *Apoptosis↓, *antiOx↑, *neuroP↑, *eff↑, *IGF-1↑, *MMP9↑, *Src↓, *MAPK↓, *MMP↑,
3937- RT,    Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
- in-vivo, AD, NA
*p‑tau↓, *Inflam↓, *NF-kB↓, *cognitive↑, *Aβ↓, *memory↑, *neuroP↑, *BioAv↓, *BBB↑,
3936- RT,    Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *Aβ↓, *SOD↑, *GSH↑, *GSSG↓, *MDA↓, *IL1β↓, *IL6↓, *antiOx↑, *Inflam↓,
3935- RT,    Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance
- in-vivo, AD, NA
*Aβ↓, *Glycolysis↓, *OXPHOS↑, *memory↑, *BioAv↓, *BioAv↑, *cognitive↑, *Inflam↓,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2↓, *NF-kB↓, *iNOS↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
3932- RT,    Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action
- Review, AD, NA
*cognitive↑, *BBB↑, *Aβ↓, *ROS↓, *Inflam↓,
4575- RT,  AgNPs,    Rutin-Loaded Silver Nanoparticles With Antithrombotic Function
- in-vivo, NA, NA
*AntiThr↑, *AntiAg↑, *antiOx↑, *Inflam↓,
1132- RT,    Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,
106- RT,    Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
- in-vivo, BC, MCF-7
P-gp↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
966- RT,    Antioxidant Mechanism of Rutin on Hypoxia-Induced Pulmonary Arterial Cell Proliferation
- vitro+vivo, Nor, NA
*ROS↓, *NOX4↓, *Hif1a↓, *α-tubulin↓,
1251- RT,  OLST,    Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions
- in-vitro, BC, MCF-7 - in-vitro, PC, PANC1 - in-vivo, NA, NA
TumVol↓, *CEA↓, *FASN↓, *ROS↓, *MDA↓, *GSH↑, Apoptosis↑,
3638- Sage,    Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial
- Trial, AD, NA
*cognitive↑,
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2↓, angioG↓, *AST↓, *ALAT?,
3640- Sage,    Evaluation of Traditional Herb Extract Salvia officinalis in Treatment of Alzheimers Disease
- in-vivo, AD, NA
*antiOx↑, *memory↑,
3641- Sage,    Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer's Disease
- Review, AD, NA
*cognitive↑, *memory↑, *AChE↓,
3642- Sage,    Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice
- in-vivo, AD, NA
*memory↑, *cognitive↑,
3643- Sage,    Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery
- Human, Nor, NA
*cognitive↑, *AChE↓,
3644- Sage,    Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers
- Human, AD, NA
*memory↑, *cognitive↑,
3645- Sage,  RosA,    Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family
- Study, AD, NA
*AChE↓, *AChE↓,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
2040- SAHA,    The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
- in-vitro, Pca, LNCaP - in-vitro, CRC, T24/HTB-9 - in-vitro, BC, MCF-7
HDAC↓, TumCG↓, Diff↑, Apoptosis↑, TXNIP↑,
4911- Sal,    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
- in-vitro, Var, DU145
MUC1-C↓, Ferroptosis↑, CSCs↓, NF-kB↓, GSR↓, GSH↑, Iron↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4899- Sal,    Anticancer activity of salinomycin quaternary phosphonium salts
- in-vitro, Var, NA
eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
5005- Sal,    Salinomycin Derivatives Kill Breast Cancer Stem Cells by Lysosomal Iron Targeting
- Review, Var, NA
CSCs↑,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
5002- Sal,  SFN,    Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo
- in-vivo, CRC, Caco-2 - vitro+vivo, CRC, CX-1
Apoptosis↑, PI3K↓, Akt↓, P53↑, BAX↑, Bax:Bcl2↑, p‑PARP↑, TumCMig↓,
5001- Sal,    Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complex
- in-vitro, CRC, NA
CSCs↓, β-catenin/ZEB1↓, Wnt↓,
5000- Sal,    Salinomycin kills cancer stem cells by sequestering iron in lysosomes
- vitro+vivo, BC, NA
CSCsMark↓, eff↑, Ferroptosis↑, ROS↑,
4999- Sal,    Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells
- in-vitro, Pca, PC3
Bacteria↓, CSCs↓, ER Stress↑,
4997- Sal,    Salinomycin Treatment Specifically Inhibits Cell Proliferation of Cancer Stem Cells Revealed by Longitudinal Single Cell Tracking in Combination with Fluorescence Microscopy
- in-vitro, BC, NA
CD24↓, TumCP↓, CSCs↓,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,
4994- Sal,  Rad,    Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation
AntiCan↑, RadioS↓, Apoptosis↑, NRF2↓, ROS↑, DNAdam↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, eff↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
4907- Sal,    A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents
- Review, Var, NA
Apoptosis↑, MDR1↓, CSCs↓,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
4912- Sal,    Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157
CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP↑, AKT1↓, mTOR↓,
4998- Sal,    Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain
- in-vitro, NPC, NA
CSCs↓,
5128- Sal,    Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
- in-vitro, AML, NA
CSCs↓,

Showing Research Papers: 4951 to 5000 of 6108
Prev Page 100 of 123 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6108

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Ferroptosis↑, 3,   GPx↓, 1,   GPx4↓, 1,   GSH↑, 1,   GSR↓, 1,   HO-1↓, 1,   Iron↑, 4,   lipid-P↑, 2,   NRF2↓, 2,   OXPHOS↓, 3,   ROS↓, 1,   ROS↑, 14,   SOD↓, 1,   SOD1↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   mitResp↑, 1,   MMP↓, 4,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   AMPK↑, 1,   cMyc↓, 1,   Glycolysis↓, 1,   NADPH↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 13,   Apoptosis∅, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 3,   Ferroptosis↑, 3,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   Myc↓, 1,   necrosis↑, 1,   p27↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 3,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↑, 5,   ERStress↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 6,  

DNA Damage & Repair ⓘ

DNAdam↑, 7,   P53↑, 2,   p‑P53↑, 1,   p‑PARP↑, 1,   cl‑PARP↝, 1,   PCNA↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↑, 3,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 3,   CD24↓, 2,   CD44↓, 2,   CSCs↓, 19,   CSCs↑, 3,   CSCsMark↓, 2,   Diff↑, 3,   EMT↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   mTOR↓, 2,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PTCH1↓, 1,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 1,   TumCG↓, 7,   Wnt↓, 9,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↑, 1,   E-cadherin↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   MUC1-C↓, 1,   N-cadherin↑, 1,   PKCδ↑, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 6,   TumCP↑, 1,   TumMeta↓, 1,   TXNIP↑, 1,   Vim↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ATF4↑, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 3,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 1,   ChemoSen↑, 8,   Dose↝, 1,   eff↓, 3,   eff↑, 7,   MDR1↓, 1,   RadioS↓, 1,   RadioS↑, 4,   selectivity↑, 6,   selectivity↝, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ferritin↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   MKI67↑, 1,   toxicity⇅, 1,   toxicity↝, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 131

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 7,   GSH↑, 3,   GSSG↓, 1,   lipid-P↓, 2,   MDA↓, 3,   NOX4↓, 1,   OXPHOS↑, 1,   ROS↓, 5,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT?, 1,   ALAT↓, 1,   CREB↑, 1,   FASN↓, 1,   Glycolysis↓, 1,   LDL↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   iNOS↓, 2,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

AntiThr↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   IGF-1↑, 1,   Src↓, 1,  

Migration ⓘ

AntiAg↑, 2,   Cartilage↑, 1,   CEA↓, 1,   MMP9↑, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

BBB↑, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1β↓, 3,   IL6↓, 2,   IL8↓, 2,   Inflam↓, 8,   NF-kB↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 5,   BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 6,   Aβ↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT?, 1,   ALAT↓, 1,   AST↓, 2,   CEA↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 12,   hepatoP↑, 1,   memory↑, 10,   neuroP↑, 5,   RenoP↑, 1,   toxicity↝, 1,  
Total Targets: 58

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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