| 7734- | isoFl, | Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis |
| - | Review, | BC, | NA |
| 7733- | isoFl, | Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy |
| - | Review, | Var, | NA |
| 7732- | isoFl, | Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity |
| 7731- | isoFl, | Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial |
| - | Trial, | AD, | NA |
| 7730- | isoFl, | Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years |
| - | Review, | Var, | NA |
| 7866- | isoO, | Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects |
| - | Review, | Var, | NA |
| 7865- | isoO, | Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis |
| - | in-vivo, | Diabetic, | NA |
| 7864- | isoO, | Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | AD, | BV2 |
| 7863- | isoO, | Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa |
| - | in-vitro, | Nor, | NA |
| 7869- | isoO, | Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology |
| - | in-vitro, | GC, | HGC27 |
| 7862- | isoO, | Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia |
| - | in-vitro, | Nor, | BV2 |
| 7851- | isoO, | Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice |
| - | in-vivo, | AD, | NA |
| 7861- | isoO, | Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7852- | isoO, | Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways |
| - | in-vitro, | AD, | NA |
| 7853- | isoO, | Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review |
| - | Review, | Var, | NA |
| 7860- | isoO, | Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration |
| 7859- | isoO, | Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells |
| - | in-vitro, | PC, | PANC1 |
| 7858- | isoO, | Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis |
| - | in-vitro, | Oral, | SCC25 |
| 7854- | isoO, | Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells |
| - | in-vitro, | Liver, | HepG2 |
| 7855- | isoO, | Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Nor, | HL7702 |
| 7856- | isoO, | Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways |
| - | in-vitro, | Lung, | A549 |
| 7868- | isoO, | Isoorientin Suppresses Invasion of Breast and Colon Cancer Cells by Inhibition of CXC Chemokine Receptor 4 Expression |
| 7886- | isoO, | Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo |
| - | vitro+vivo, | Nor, | NA |
| 7885- | isoO, | Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway |
| 7884- | isoO, | Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome |
| - | in-vitro, | Nor, | RAW264.7 |
| 7883- | isoO, | Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7882- | isoO, | Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair |
| - | in-vitro, | Liver, | NA |
| 7881- | isoO, | Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice |
| - | in-vivo, | Nor, | NA |
| 7880- | isoO, | Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells |
| - | in-vitro, | Nor, | PC12 |
| 7879- | isoO, | Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex |
| - | in-vivo, | AD, | NA |
| 7878- | isoO, | Cisplatin, | Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway |
| - | in-vivo, | Nor, | NA |
| 7877- | isoO, | Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications |
| - | Review, | Nor, | NA |
| 7876- | isoO, | Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway |
| - | in-vitro, | Nor, | NA |
| 7875- | isoO, | Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | Nor, | BV2 |
| 7874- | isoO, | Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways |
| - | in-vivo, | Nor, | NA |
| 7873- | isoO, | Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | CRC, | HT-29 | - | in-vitro, | Lung, | A549 |
| 7872- | isoO, | Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways |
| - | in-vivo, | Arthritis, | NA |
| 7871- | isoO, | Cisplatin, | Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway |
| - | vitro+vivo, | Lung, | NA |
| - | vitro+vivo, | AD, | PC12 |
| 7822- | isoO, | Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice |
| - | in-vivo, | AD, | NA |
| 7867- | isoO, | Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine |
| - | Review, | AD, | NA |
| 7795- | ISQ, | The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway |
| - | in-vitro, | Melanoma, | SK-MEL-28 | - | in-vitro, | Nor, | HaCaT |
| 7850- | ISQ, | Effect of quercetin glycosides on cognitive functions and cerebral blood flow: a randomized, double-blind, and placebo-controlled study |
| - | Trial, | Nor, | NA |
| - | in-vivo, | Nor, | NA |
| 7791- | ISQ, | Isoquercitrin: pharmacology, toxicology, and metabolism |
| - | Review, | Nor, | NA |
| 7823- | ISQ, | Isoquercitrin Upregulates Aldolase C Through Nrf2 to Ameliorate OGD/R-Induced Damage in SH-SY5Y Cells |
| - | in-vitro, | Stroke, | SH-SY5Y |
| 7821- | ISQ, | Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer's disease mice |
| - | in-vivo, | AD, | NA |
| 7817- | ISQ, | MOR, | Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis |
| - | in-vitro, | AD, | NA |
| 7816- | ISQ, | Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells |
| - | in-vitro, | GC, | AGS | - | in-vitro, | GC, | HGC27 |
| 7814- | ISQ, | Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90 |
| - | in-vivo, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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