| 1070- | IVM, | Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation |
| - | vitro+vivo, | GBM, | NA |
| 1175- | IVM, | PDT, | Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors |
| - | in-vitro, | Var, | NA |
| 1168- | IVM, | SRF, | Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways |
| - | in-vitro, | HCC, | NA |
| 1166- | IVM, | The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways |
| - | in-vitro, | NA, | NA |
| 1167- | IVM, | The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer |
| - | vitro+vivo, | NA, | NA |
| 7917- | IVT, | A review on the pharmacological effects of vitexin and isovitexin |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7918- | IVT, | Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices |
| - | in-vivo, | AD, | NA |
| 7894- | IVT, | Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression |
| - | in-vitro, | HCC, | SK-HEP-1 |
| - | in-vivo, | Nor, | NA |
| 7898- | IVT, | Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS |
| - | in-vivo, | Nor, | NA |
| 7897- | IVT, | VT, | Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathway |
| - | in-vitro, | Nor, | NA |
| 7896- | IVT, | VT, | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review |
| - | Review, | Var, | NA |
| 7895- | IVT, | Identification of Isovitexin as a novel CYP17A1 inhibitor through virtual screening and evaluation of its anti-cancer effects in MCF-7 breast cancer cells |
| - | in-vitro, | BC, | MCF7 |
| 7890- | IVT, | Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses |
| - | in-vivo, | Nor, | NA |
| 7900- | IVT, | Isovitexin: A Promising Active Compound Found in Nature's Bounty |
| - | in-vivo, | Nor, | NA |
| 7901- | IVT, | Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway |
| - | in-vivo, | Nor, | NA |
| 7903- | IVT, | Inhibition of advanced glycation end products by Isovitexin alleviates intestinal damage: Toward dietary strategies for gut health |
| - | in-vivo, | Nor, | NA |
| 7904- | IVT, | Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress |
| - | in-vivo, | Nor, | NA |
| 7906- | IVT, | Isovitexin accelerates diabetic wound repair via coordinated angiogenesis and collagen remodeling: Mechanistic insights from cellular and streptozotocin-induced SD rat models |
| - | in-vivo, | Nor, | NA |
| 7910- | IVT, | Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice |
| - | vitro+vivo, | Lung, | A549 | - | vitro+vivo, | Lung, | H1975 |
| 7911- | IVT, | Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study |
| - | in-vitro, | Arthritis, | NA |
| 7912- | IVT, | Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling |
| - | in-vivo, | AD, | NA |
| 7892- | IVT, | Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway |
| - | in-vitro, | Nor, | HCEC 1CT | - | in-vivo, | Colon, | NA |
| 7891- | IVT, | VT, | Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin |
| - | NA, | AD, | NA |
| 7893- | IVT, | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress |
| - | vitro+vivo, | Liver, | NA |
| 7889- | IVT, | Prevention of cellular ROS damage by isovitexin and related flavonoids |
| - | in-vitro, | Nor, | NA |
| 7888- | IVT, | Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways |
| - | vitro+vivo, | Nor, | NA |
| 7820- | JG, | Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription |
| 7819- | JG, | Evaluation of pharmacokinetic, biodistribution, pharmacodynamic, and toxicity profile of free juglone and its sterically stabilized liposomes |
| - | vitro+vivo, | Nor, | NA |
| 8008- | JG, | Juglone, isolated from Juglans mandshurica Maxim, induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells |
| - | in-vitro, | NA, | LNCaP |
| 7962- | JG, | Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide |
| - | in-vitro, | Var, | NA |
| 8007- | JG, | Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis |
| - | in-vitro, | GBM, | U251 |
| 8006- | JG, | VitC, | Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | Bxpc-3 |
| 8005- | JG, | Immunomodulation by juglone alleviates acute graft-versus-host disease without compromising the graft-versus-leukaemia activity in mice |
| - | in-vivo, | AML, | NA |
| 8004- | JG, | TP53 Is a Potential Target of Juglone Against Colorectal Cancer: Based on a Combination of Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments |
| 8003- | JG, | doxoR, | A juglone derivative that disrupts mitochondrial redox metabolism, inhibiting the breast fibroblast-cancer cell pro-migratory signaling induced by doxorubicin |
| - | in-vitro, | BC, | NA |
| 8002- | JG, | Identification and Biological Evaluation of Juglone-Derived STAT3 Inhibitors against Colorectal Cancer |
| - | in-vitro, | PC, | NA | - | in-vitro, | CRC, | NA |
| 7966- | JG, | Discovery of Juglone Derivatives as Novel STAT3 Inhibitors with Potent Suppression of Cancer Cell Stemness against Breast Cancer |
| - | in-vitro, | BC, | NA |
| 7965- | JG, | Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | HT-29 |
| 7964- | JG, | Juglone and KPT6566 Suppress the Tumorigenic Potential of CD44+CD133+ Tumor-Initiating Caco-2 Cells In Vitro and In Vivo |
| - | vitro+vivo, | Colon, | Caco-2 |
| 7963- | JG, | Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines |
| - | vitro+vivo, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
| 7961- | JG, | Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo |
| - | vitro+vivo, | BC, | MCF7 | - | in-vitro, | BC, | 4T1 | - | vitro+vivo, | CRC, | HCT116 |
| 8153- | JG, | Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes |
| - | in-vitro, | Nor, | HaCaT |
| 1920- | JG, | TQ, | PLB, | Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line |
| - | in-vitro, | PC, | PANC1 |
| 1918- | JG, | ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro |
| - | in-vitro, | Liver, | HepG2 | - | in-vivo, | NA, | NA |
| 1927- | JG, | Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway |
| - | in-vitro, | GC, | SGC-7901 |
| 1926- | JG, | Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway |
| - | in-vitro, | BC, | MCF7 |
| 1925- | JG, | Redox regulation of mitochondrial functional activity by quinones |
| - | in-vitro, | NA, | NA |
| 1924- | JG, | Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway |
| - | in-vitro, | Lung, | A549 |
| 1923- | JG, | Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells |
| - | in-vitro, | Endo, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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