Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
2011- SK,    Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling
- in-vitro, Nor, HL7702 - in-vivo, Nor, NA
*NRF2↑, *hepatoP↑, *ALAT↓, *AST↓, *MPO↓, *ROS↓, *GSH↑,
1280- SK,    Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells
- in-vitro, GC, AGS
ROS↑, Casp3↑, P53↑, NRF2↓,
1281- SK,    Enhancement of NK cells proliferation and function by Shikonin
- in-vivo, Colon, Caco-2
Perforin↑, GranB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
977- SK,    A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, HMEC
TumCG↓, ERα/ESR1↓, selectivity↑, *toxicity↓,
965- SK,    Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620
Hif1a↓, ROS↓, mTOR↓, p70S6↓, 4E-BP1↓, eIF2α↓, TumCCA↑, TumCP↓, Half-Life↝,
1050- SK,    Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation
- in-vitro, Colon, CT26
HSP70/HSPA5↑, ROS↑, PKM2↓,
1073- SK,  Chemo,    Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
PAK1↓, TumCP↓, Apoptosis↑, ChemoSen↑, ROS↑,
1049- SK,    Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2
- in-vivo, NA, NA
TNF-α↓, IL6↓, IFN-γ↓, IL1β↓, PD-L1↓, p‑PKM2↓,
5102- SK,  GEM,    Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway
TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,
5103- SK,    Attenuation of PI3K-Akt-mTOR Pathway to Reduce Cancer Stemness on Chemoresistant Lung Cancer Cells by Shikonin and Synergy with BEZ235 Inhibitor
- in-vitro, NSCLC, A549
CSCs↓, TumCP↓, Nanog↓, OCT4↓, p‑Akt↓, P70S6K↓, PI3K↓, mTOR↓, eff↑,
5101- SK,    Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
- vitro+vivo, CRC, SW-620 - vitro+vivo, CRC, HCT116
Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,
5100- SK,    Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression
- vitro+vivo, NPC, NA
TumCP↓, RIP1↑, ROS↑, Necroptosis↑, Casp3↑, Casp8↑, eff↓, TumCG↓,
5104- SK,    Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression.
- in-vitro, GC, AGS
TumCP↓, TumCCA↑, P21↑,
1133- SM,    Salvianolic Acid A, a Component of Salvia miltiorrhiza, Attenuates Endothelial-Mesenchymal Transition of HPAECs Induced by Hypoxia
- in-vitro, Nor, HPAECs
*ROS↓, *p‑Smad1↑, *p‑SMAD5↑, *SMAD2↓, *SMAD3↓, *p‑ERK↓, *p‑Cofilin↓,
1068- SM,    Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA - Human, BC, NA
TumCG↓, Ferroptosis↑, GPx4↓, TumVol↓, OS↑, GSH/GSSG↓,
1193- SM,    Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- in-vivo, Alcohol, NA - in-vitro, Liver, HepG2
*p‑AMPK↑, *SIRT1↑, *NRF2↑, *CYP2E1↓, *lipoGen↓, *ROS↓, *Inflam↓,
1192- SM,    Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1
- in-vitro, GC, AGS - in-vitro, Liver, HepG3
Hif1a↓, VEGF↓,
1191- SM,    Salvia miltiorrhiza extract inhibits TPA‑induced MMP‑9 expression and invasion through the MAPK/AP‑1 signaling pathw
- in-vitro, BC, MCF-7
Inflam↓, MMP9↓, TumCI↓, AP-1↓, lipidLev↓,
1194- SM,    Salvia miltiorrhiza protects against diabetic nephropathy through metabolome regulation and wnt/β-catenin and TGF-β signaling inhibition
- in-vivo, Diabetic, NA
β-catenin/ZEB1↓, TGF-β↓,
1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,
1291- SM,    Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCCA↑, BAX↑, Bcl-2↓,
5790- Sper,    The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
- Trial, Nor, NA
*memory↑,
5789- Sper,    Long-term oral polyamine intake increases blood polyamine concentrations
- Human, Nor, NA
*Dose↝, *BioAv↑,
5794- Sper,    Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- in-vitro, Nor, U2OS
*EP300↓, *mTORC1↓, *CRM↑, *HATs↓, *p62↓, *AntiAge↑, AntiCan↑,
5806- Sper,    Spermidine – an old molecule with a new age-defying immune function
GutMicro↝, GutMicro↝,
5805- Sper,    The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review
- Review, AD, NA
*cognitive↝, *Dose↝,
5802- Sper,    Spermidine reduces cancer-related mortality in humans
- Review, Var, NA
EP300↓, Risk↓,
5782- Sper,    Cardioprotection and lifespan extension by the natural polyamine spermidine
- in-vivo, Nor, NA
cardioP↑, eff↓, AntiAge↑, BioAv↑, CRM↝,
5799- Sper,    The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
- Trial, AD, NA
*cognitive↑, memory↑, *Dose↑, *Dose↑, *Dose↝, *Dose↝, BioAv↓, eff↑,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, eff↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
4893- Sper,  immuno,    Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators
- in-vitro, Var, NA
*mt-FAO↑, eff↑,
4894- Sper,    Application of Spermidine in Cancer Research Models: Notes and Protocols
- Review, Var, NA
TumAuto↑, AntiTum↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,
4896- Sper,  immuno,    Spermidine potentiates anti-tumor immune responses and immunotherapy sensitivity in breast cancer
- vitro+vivo, BC, NA
eff↑, AntiTum↑,
4897- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA
Inflam↓, TumAuto↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Bcl-2↓,
1512- Squ,    Combination therapy in combating cancer
- Review, NA, NA
ChemoSideEff↓, *ROS↓, *GSH↑, eff↑, chemoP↑,
107- SS,    Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway
- vitro+vivo, MB, LS174T
HH↓, Smo↓, Gli↓, Gli1↓, PTCH1↓, TumCG↓,
1017- SSE,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
Akt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, survivin↓, Apoptosis↑, ROS↑,
1062- SSE,    Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells
- in-vitro, GBM, LN229 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HDAC↓, TumCP↓, TumCCA↑, Apoptosis↑, Casp3↝, MMP2↓, *BioAv↝,
1018- SSE,    Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, HCT116 - vitro+vivo, CRC, SW480
TumAuto↑, LC3s↑, TumW↓, Weight∅, Beclin-1↑, p62↓, ROS↑,
984- SSE,    Effects of selenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
ERα/ESR1↓, PR↑, pS2/TFF1↑, Catalase↑,
1002- SSE,  Osi,  Adag,    Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
- in-vitro, Lung, H1975 - in-vitro, Lung, H385
Apoptosis↑, Ferroptosis↑, DNMT1↓, TET1↑, TumCCA↑, cl‑PARP↑, cl‑Casp3↑, Cyt‑c↑, BIM↑, NOXA↑, Apoptosis↑, ROS↑, ER Stress↑, UPR↑,
1003- SSE,    Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression
- vitro+vivo, Lung, NA
NF-kB↓, PDK1↓, p‑p65↑, p‑IκB↑, BAX↑, lactateProd↓, MMP↓, Cyt‑c↑, mitResp↑, Apoptosis↑,
4216- SSE,    Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways
- in-vitro, NA, NA
*BDNF↑, *TrkB↓, *PI3K↑, *Akt↑, *neuroP↑,
4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
4748- SSE,  Chemo,  antiOx,    Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study
- Trial, GC, NA
toxicity↓, chemoP∅, *neuroP↑, *Dose↝,
4727- SSE,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,
4743- SSE,    Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients
- Review, Var, NA
eff↝, chemoP↝, radioP↝,

Showing Research Papers: 5301 to 5350 of 5929
Prev Page 107 of 119 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5929

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 4,   GPx4↓, 2,   GSH↓, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 2,   lipid-P↑, 2,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 15,   mt-ROS↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↑, 1,   MMP↓, 4,  

Core Metabolism/Glycolysis ⓘ

CRM↑, 1,   CRM↝, 1,   lactateProd↓, 1,   LDH↓, 1,   lipidLev↓, 1,   PDK1↓, 1,   PKM2↓, 1,   p‑PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 12,   BAX↑, 2,   Bcl-2↓, 2,   BIM↑, 1,   Casp3↑, 2,   Casp3↝, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   Cyt‑c↑, 5,   Ferroptosis↑, 4,   GranB↑, 1,   JNK↑, 1,   p‑JNK↑, 1,   Necroptosis↑, 1,   NOXA↑, 1,   Perforin↑, 1,   pS2/TFF1↑, 1,   RIP1↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,   ER Stress↑, 1,   HSP70/HSPA5↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   LC3B-II↑, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↑, 6,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   P53↑, 2,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

4E-BP1↓, 1,   CSCs↓, 2,   EP300↓, 1,   p‑ERK↑, 2,   Gli↓, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   mTOR↓, 2,   Nanog↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   PR↑, 1,   PTCH1↓, 1,   Smo↓, 1,   TumCG↓, 6,   TumCG⇅, 1,  

Migration ⓘ

AP-1↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PAK1↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 10,   TumCP∅, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   p‑EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

Gal1↑, 1,   HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 1,   IL6↑, 1,   Inflam↓, 3,   p‑IκB↑, 1,   NF-kB↓, 2,   NK cell↑, 1,   p‑p65↑, 1,   PD-L1↓, 1,   T-Cell↑, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 5,   Dose⇅, 1,   eff↓, 3,   eff↑, 8,   eff↝, 2,   eff∅, 1,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

p‑EGFR↓, 1,   ERα/ESR1↓, 2,   GutMicro↝, 2,   IL6↓, 1,   IL6↑, 1,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiTum↑, 4,   cardioP↑, 2,   chemoP↑, 1,   chemoP↝, 1,   chemoP∅, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   memory↑, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 1,   radioP↝, 1,   Risk↓, 3,   toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 159

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   CYP2E1↓, 1,   Ferroptosis↓, 1,   GPx4↑, 1,   GSH↑, 2,   MPO↓, 1,   NRF2↑, 3,   ROS↓, 4,   ROS↑, 1,   selenoP↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   p‑AMPK↑, 1,   CRM↑, 1,   mt-FAO↑, 1,   lipoGen↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Ferroptosis↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   other↓, 1,  

Autophagy & Lysosomes ⓘ

p62↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 1,   p‑ERK↓, 1,   mTORC1↓, 1,   PI3K↑, 1,  

Migration ⓘ

p‑Cofilin↓, 1,   p‑Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD5↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 3,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   TrkB↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 5,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 2,   cognitive↑, 2,   cognitive↝, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   toxicity↓, 1,  
Total Targets: 50

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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