Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
4741- SSE,    Selenium in Oncological Intervention
- Review, Var, NA
Risk↓, *other↝, Risk↓, AntiTum↑, chemoR↓, chemoP↑,
4740- SSE,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,
4728- SSE,    Selective Impact of Selenium Compounds on Two Cytokine Storm Players
- NA, Covid, NA
*IL6↓, *TNF-α↓, *NRF2↑, *other↑, *eff↑,
4716- SSE,    Selenium Substitution During Radiotherapy of Solid Tumours – Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients
- in-vivo, HNSCC, NA
Dose↝, *GPx↑, *ROS↓,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
4733- SSE,    Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
- NA, Nor, NA
*selenoP↑, *Trx↑, *GPx↑, *NRF2↑,
4732- SSE,    Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
- in-vivo, Autism, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *other↝,
4731- SSE,    Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *H2O2↓, *Catalase↑, *GSH↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *other↝,
4718- SSE,    High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer
- in-vitro, Ovarian, NA
TumCP↑, ROS↑, GPx↓, lipid-P↑, Ferroptosis↑, Dose↑,
4750- SSE,  Rad,    Selenium in Radiation Oncology—15 Years of Experiences in Germany
- Review, Var, NA
RadioS∅, radioP↑, eff↑,
4753- SSE,  Chemo,    Selenium and Lung Cancer: A Systematic Review and Meta Analysis
- Review, Lung, NA
Risk⇅, chemoP↑, radioP↑,
5081- SSE,    Application Notes and Protocols: Selenite as a Selenium Source in Cell Culture Media Supplementation
- Review, Var, NA
Dose↝, ROS↑, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
5079- SSE,  Rad,    The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B
chemoP↑, eff↝, ROS↑, MMP↓, Cyt‑c↑, TumCG↓, RadioS↝, other↝,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5077- SSE,    Antitumor effects of sodium selenite on acute lymphocytic leukemia
- in-vitro, AML, NA
TumCD↑, Apoptosis↑,
5076- SSE,    Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway
- in-vivo, Cerv, HeLa - in-vivo, Cerv, SiHa
TumCG↓, toxicity↓, tumCV↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, eff↑,
5075- SSE,    Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
- vitro+vivo, RCC, 786-O
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5073- SSE,    Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
- Trial, Var, NA
AntiTum↑, ChemoSen↑, Dose↑, Half-Life↝, toxicity↝, toxicity↝,
5091- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, BC, MCF-7 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29 - in-vitro, Nor, SVGp12
Ferroptosis↑, xCT↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,
5093- SSE,    Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice
- in-vivo, Var, NA
AntiCan↑, eff↑, selectivity↑, ROS↑, Dose↝, Trx↓, GSH↓,
5111- SSE,    Sodium selenite induces apoptosis via ROS-mediated NF-κB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells
- in-vitro, BC, 4T1
ROS↑, NF-kB↓, p65↓, mtDam↑, Casp9↑, Casp3↑, Apoptosis↑, eff↓,
5110- SSE,    Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells
- in-vitro, AML, APL NB4
Apoptosis↑, selectivity↑, TumAuto↓, PI3K↓, Akt↓,
5109- SSE,    Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells
- in-vitro, CRC, HCT116
ROS↑, DNAdam↓, ATM↑, eff↓, TumCCA↑,
5108- SSE,    Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis
- in-vitro, AML, U937
p‑P53↑, Beclin-1↓, LC3I↓, Apoptosis↑, Casp↑,
5107- SSE,    Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells
- vitro+vivo, AML, APL NB4
PERK↑, eIF2α↑, ATF4↑, Apoptosis↑, AntiTum↑, ER Stress↑, p38↑,
5106- SSE,  GSH,    Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells
- in-vitro, Liver, HepG2
ROS↑, Apoptosis↑, eff↑, GSH↓,
5105- SSE,    Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells
- in-vitro, Pca, LNCaP
TumCD↑, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, necrosis↑, chemoPv↑,
5097- SSE,    Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells
- in-vitro, Var, NA
other↝,
5096- SSE,    Selenium Toxicity Accelerated by Out-of-Control Response of Nrf2-xCT Pathway
- in-vitro, BC, MCF-7
xCT↑, ROS↑, NRF2↑,
5095- SSE,    Extracellular thiol-assisted selenium uptake dependent on the xc− cystine transporter explains the cancer-specific cytotoxicity of selenite
- in-vitro, Lung, H157
toxicity↝, eff↓, other↝, ROS↑, mtDam↑,
5094- SSE,    Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
- vitro+vivo, Nor, NRK52E
*GPx4↑, *xCT↑, *GSH↑, *RenoP↑,
5082- SSE,    Rationale for the treatment of cancer with sodium selenite
- Review, Var, NA
Risk↑, antiOx↑, ROS↑, Imm↑, NK cell↑, angioG↓, toxicity↓,
5092- SSE,    Redox-Active Selenium Compounds—From Toxicity and Cell Death to Cancer Treatment
- Review, Var, NA
*antiOx↑, ROS↑, GSH↓, BioAv↓,
5112- SSE,    https://pubmed.ncbi.nlm.nih.gov/19811770/
- in-vitro, Pca, PC3
VEGF↓, IL6↓, NF-kB↓, p65↓,
5090- SSE,    Sodium Selenite Induces Ferroptosis in Non-small Cell Lung Cancer A549 Cells Via Reactive Oxygen Species (ROS)/Glutathione (GSH)/Glutathione Peroxidase4 (GPx4) Axis
- NA, Lung, A549
TumCP↓, ROS↑, GSH↓, MMP↓, GPx4↓, Iron↑,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF-7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
5087- SSE,    Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System
- Trial, BC, NA
eff↑, Inflam↓, Imm↑, ROS↑, *NK cell↑,
5086- SSE,    Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, T98G - in-vitro, GBM, A172
TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,
5084- SSE,  GEM,    The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
- in-vitro, PC, PANC1 - vitro+vivo, PC, Panc02
tumCV↓, ChemoSen↑, TumCG↓, OS↑, MMP↓, AIF↑, GSH↓, Trx↓, ROS↑, AntiTum↑,
5083- SSE,    Sodium Selenite as an Anticancer Agent
- Review, Var, NA
AntiCan↑, ROS↑,
4500- SSE,    Dietary selenium affects host selenoproteome expression by influencing the gut microbiota
- in-vivo, Nor, NA
*GutMicro↑, Risk↓, *GPx↑,
4610- SSE,  Rad,    Protection during radiotherapy: selenium
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓, *DNAdam↓, *lipid-P↓, *selenoP↑, *GPx1↑, *BUN↓,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4497- SSE,    Selenium and inflammatory bowel disease
- Review, Var, NA - Review, IBD, NA
*GutMicro↑, *selenoP↑, *Inflam↓, Risk↓, *NF-kB↓, *ROS↓,
4494- SSE,    Advances in the study of selenium and human intestinal bacteria
- Review, IBD, NA - Review, Var, NA
*Risk↓, OS↑, *CRP↓, *GPx↑, *Inflam↓, *ROS↓, *GutMicro↑, *selenoP↑, *other↓,

Showing Research Papers: 5351 to 5400 of 5929
Prev Page 108 of 119 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5929

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 4,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 4,   GSH↓, 8,   GSH⇅, 1,   Iron↑, 4,   lipid-P↑, 3,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 28,   Thiols↓, 1,   Trx↓, 3,   xCT↓, 2,   xCT↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 8,   mtDam↑, 4,  

Core Metabolism/Glycolysis ⓘ

NADPH↓, 2,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↑, 13,   BAD↓, 1,   BAX↑, 1,   Bcl-2↓, 2,   Casp↑, 2,   Casp3↑, 2,   cl‑Casp3↑, 2,   Casp9↑, 2,   Cyt‑c↑, 2,   Ferroptosis↑, 4,   necrosis↑, 2,   p38↑, 1,   TumCD↑, 5,  

Transcription & Epigenetics ⓘ

other↝, 4,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 3,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   LC3I↓, 1,   MitoP↑, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↓, 1,   DNAdam↑, 1,   DNArepair↑, 1,   p‑P53↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   HOXB-AS1↓, 1,   mTOR↓, 1,   PI3K↓, 1,   p‑PI3K↓, 1,   TumCG↓, 4,  

Migration ⓘ

E-cadherin↑, 2,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 6,   TumCP↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   angioG↑, 1,   ATF4↑, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Imm↑, 3,   Inflam↓, 1,   NF-kB↓, 4,   NK cell↑, 2,   p65↓, 2,   PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   chemoR↓, 1,   ChemoSen↑, 3,   Dose↑, 6,   Dose↝, 3,   eff↓, 7,   eff↑, 5,   eff↝, 1,   Half-Life↝, 3,   RadioS↑, 1,   RadioS↝, 1,   RadioS∅, 1,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   IL6↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 5,   chemoP↑, 5,   chemoPv↑, 1,   OS↑, 3,   Pain↓, 1,   radioP↑, 4,   Risk↓, 8,   Risk↑, 1,   Risk⇅, 1,   toxicity↓, 2,   toxicity↝, 6,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 108

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 1,   Ferroptosis↓, 1,   GPx↓, 1,   GPx↑, 5,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 2,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 2,   NRF2↑, 4,   ROS↓, 5,   selenoP↑, 6,   SOD↑, 1,   Trx↑, 1,   xCT↑, 1,  

Core Metabolism/Glycolysis ⓘ

BUN↓, 1,  

Cell Death ⓘ

Bcl-2↑, 1,   Ferroptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 1,   other↝, 3,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 2,   IL1↓, 1,   IL6↓, 2,   Imm↑, 2,   Inflam↓, 5,   MCP1↓, 1,   NF-kB↓, 1,   NK cell↑, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   Dose↓, 1,   Dose↝, 2,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

CRP↓, 2,   GutMicro↑, 4,   IL6↓, 2,  

Functional Outcomes ⓘ

memory↑, 1,   neuroP↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↝, 1,  
Total Targets: 50

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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