neuroP Cancer Research Results

neuroP, neuroprotective: Click to Expand ⟱
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Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
4133- Silicon,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↓, *Dose↑, *neuroP↑,
4131- Silicon,    Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease
- Study, Nor, NA
*other↓, *BioAv↓, *neuroP↑,
4125- Silicon,    Oral silicon supplementation: an effective therapy for preventing oral aluminum absorption and retention in mammals
- Review, AD, NA
*neuroP↑, *BioAv↓,
4127- Silicon,    Interference of Parenteral Nutrition Components in Silicon-Mediated Protection Against Aluminum Bioaccumulation
- in-vivo, AD, NA
*other↓, *neuroP↑,
2214- SK,    Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *antiOx↑, *neuroP↑, *ROS↓, *MDA↓, *SOD↑, GSH↑,
2213- SK,    Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG1/2↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
3049- SK,    Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling
- in-vivo, Nor, NA - NA, Stroke, NA
*neuroP↑, *p‑PTEN↓, *p‑Akt↑, *Bcl-2↑, *BAX↓, *cognitive↑, *BDNF↑,
3050- SK,    Systemic administration of Shikonin ameliorates cognitive impairment and neuron damage in NPSLE mice
- in-vivo, Nor, NA
*Inflam↓, *neuroP↑, *cognitive↑,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,
4216- SSE,    Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways
- in-vitro, NA, NA
*BDNF↑, *TrkB↓, *PI3K↑, *Akt↑, *neuroP↑,
4748- SSE,  Chemo,  antiOx,    Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study
- Trial, GC, NA
toxicity↓, chemoP∅, *neuroP↑, *Dose↝,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4151- Taur,  Gins,    Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
- in-vitro, AD, NA
*BDNF↑, *antiOx↑, *neuroP↑, *eff↑,
3958- Taur,    Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging
- in-vivo, AD, NA
*neuroP↑, *Aβ∅, *cognitive↑, *toxicity↓, *Ca+2↓, *memory↑,
3957- Taur,    Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases
*UPR↑, *Inflam↓, *antiOx↑, *ROS↓, *Apoptosis↓, *Ca+2↓, *neuroP↑,
3949- Taur,    Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
- in-vivo, AD, NA
*neuroP↑, *GABA↑,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,
3953- Taur,    Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons
- in-vitro, AD, NA
*neuroP↑, *Ca+2↓, *LDH↓,
5338- TFdiG,    Isolation and antioxidant characterization of theaflavin for neuroprotective effect in mice model
- in-vivo, Nor, NA
*antiOx↑, *TOS↑, *TAC↑, *neuroP↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27↑, ROS↑, DNAdam↑, MUC4↓,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
2126- TQ,    Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway
- Review, Nor, NA
*antiOx↑, *Bacteria↓, *RenoP↑, *hepatoP↑, *neuroP↑, *Inflam↓, *Keap1↓, *NRF2↑, *other↝,
2089- TQ,    Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone-Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes
- in-vitro, Nor, SH-SY5Y
*neuroP↑, *ROS↓, *SOD1↑, *Catalase↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, NA, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1↓, *CXCc↓, *ROS↓,
3409- TQ,    Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
- in-vivo, Nor, NA
*MDA↓, *TGF-β↓, *CRP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *Casp3↓, *GSH↑, *NRF2↑, *IL10↑, *neuroP↑, *ROS↓, *Apoptosis↓, *Inflam↓,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1↓, *IP-10/CXCL-10↓, *PGE2↓,
3401- TQ,    Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review
- Review, Var, NA
TumCP↓, *antiOx↑, *ROS↓, NRF2↑, NF-kB↓, TumCCA↑, *GABA↑, P53↑, P21↑, AMPK↑, neuroP↑, cardioP↑, hepatoP↑,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3554- TQ,    Neuroprotective efficacy of thymoquinone against amyloid beta-induced neurotoxicity in human induced pluripotent stem cell-derived cholinergic neurons
- in-vitro, AD, NA
*GSH↑, *ROS↓, *neuroP↑, *Casp3↓, *Casp7↓, *antiOx↓, *H2O2↓,
3558- TQ,    Behavioral and histological study on the neuroprotective effect of thymoquinone on the cerebellum in AlCl3-induced neurotoxicity in rats through modulation of oxidative stress, apoptosis, and autophagy
- in-vivo, AD, NA
*MDA↓, *NO↓, *GSH↑, *neuroP↑, *cognitive↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3560- TQ,    Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *TAC↑, *AChE↓, *MDA↓, *NO↓, *TNF-α↓, *Bcl-2↑, *Ach↑, *neuroP↑,
3553- TQ,    Study Effectiveness and Stability Formulation Nanoemulsion of Black Cumin Seed (Nigella sativa L.) Essential Oil: A Review
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiAge↑, *hepatoP↑, *cardioP↑, *neuroP↑, *eff↑,
3563- TQ,    Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *IFN-γ↑, *neuroP↑, *Inflam↓, *cognitive↑,
3564- TQ,    The Potential Neuroprotective Effect of Thymoquinone on Scopolamine-Induced In Vivo Alzheimer's Disease-like Condition: Mechanistic Insights
- in-vivo, AD, NA
*Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *PPARγ↑, *NF-kB↓, *p‑tau↓, *MMP↑, *memory↑, *NF-kB↓, *ROS↓,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
3788- UA,  RosA,    Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer’s disease
- in-vivo, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *memory↑, *Inflam↓, *ROS↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4867- Uro,    Urolithin A exhibits a neuroprotective effect against Alzheimer’s disease by inhibiting DYRK1A activity
- in-vivo, AD, NA - in-vitro, AD, HEK293
*neuroP↑, *DYRK1A↓, *memory↑, *p‑tau↓, *Inflam↓,
4865- Uro,    Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis
- in-vitro, Diabetic, NA - in-vitro, AD, NA
*antiOx↑, *neuroP↑, *Ca+2↓, *Aβ↓, *BACE↓, *p‑tau↓, *cognitive↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1↑, *ROS↓, *GutMicro↑, *Risk↓,

Showing Research Papers: 501 to 550 of 583
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 583

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↓, 2,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 1,   NRF2↑, 1,   ROS↑, 4,   ROS⇅, 1,   mt-ROS↑, 1,   SOD1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   FAO↑, 1,   FASN↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↝, 1,   PKM2↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↑, 4,   Bcl-2↓, 2,   Bcl-xL↓, 2,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   IAP1↓, 1,   IAP2↓, 1,   JNK↑, 1,   Necroptosis↑, 1,   p27↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   LC3B-II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 2,   GADD45A↑, 2,   P53↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 4,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↓, 1,   GSK‐3β↑, 1,   HDAC↓, 2,   PI3K↓, 1,   STAT3↓, 2,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

CD31↓, 1,   Ki-67↓, 1,   MMP9↓, 1,   MUC4↓, 1,   TumCP↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 1,   NO↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   Inflam↓, 1,   NF-kB↓, 6,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 2,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   Ki-67↓, 1,   LDH↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   cardioP↑, 3,   chemoP↑, 1,   chemoP∅, 1,   chemoPv↑, 1,   hepatoP↑, 4,   neuroP↑, 5,   OS↑, 1,   RenoP↑, 2,   Risk↓, 2,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 93

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 19,   Catalase↑, 8,   Ferroptosis↓, 1,   GPx↓, 1,   GPx↑, 4,   GSH↑, 10,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 2,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 3,   MDA↓, 8,   MPO↓, 1,   MPO↑, 1,   NQO1↑, 1,   NRF2↑, 9,   PARK2↑, 2,   Prx↑, 1,   ROS↓, 22,   ROS↑, 1,   ROS∅, 1,   selenoP↑, 1,   SIRT3↑, 1,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 2,   Thiols↑, 1,   TOS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   mitResp↑, 1,   MMP↑, 8,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   cMyc↓, 1,   CREB↑, 1,   LDH↓, 2,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 5,   BAX↓, 3,   BAX↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 3,   Bcl-xL↓, 1,   Casp3↓, 5,   Casp3↑, 1,   Casp7↓, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   iNOS↑, 2,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 2,   other↓, 2,   other↑, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   UPR↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   DYRK1A↓, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   mTOR↓, 2,   PI3K↓, 1,   PI3K↑, 1,   p‑PTEN↓, 1,   STAT3↑, 1,   VGCC↓, 1,  

Migration(tgid=13) ⓘ

ARG1/2↑, 1,   Ca+2↓, 5,   Ca+2↝, 1,   cal2↓, 1,   Cartilage↑, 1,   MMP9↓, 1,   MMPs↓, 1,   PKCδ↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TumCI↓, 1,   TumCP↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   CRP↓, 4,   CXCc↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↑, 3,   IL12↓, 3,   IL1β↓, 6,   IL6↓, 6,   Imm↑, 1,   Inflam↓, 23,   IP-10/CXCL-10↓, 1,   MCP1↓, 3,   MyD88↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   PGE2↓, 2,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 8,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 5,   BDNF↑, 5,   BDNF∅, 1,   GABA↑, 3,   p‑tau↓, 5,   TrkB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 7,   Aβ∅, 1,   BACE↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 4,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 3,   Half-Life↓, 2,   Half-Life↝, 2,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 4,   GutMicro↑, 3,   IL6↓, 6,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 2,   cardioP↑, 5,   chemoP↑, 1,   cognitive↑, 12,   hepatoP↑, 5,   memory↑, 10,   motorD↑, 1,   neuroP↑, 45,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 2,   Risk↓, 4,   Strength↑, 2,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 2,   IRF3↓, 1,  
Total Targets: 163

Scientific Paper Hit Count for: neuroP, neuroprotective
22 Resveratrol
21 Thymoquinone
20 Alpha-Lipoic-Acid
18 Magnetic Fields
18 Quercetin
16 Silymarin (Milk Thistle) silibinin
15 Urolithin
14 Curcumin
14 Chlorogenic acid
14 Hydrogen Gas
12 Rosmarinic acid
11 Baicalein
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Carvacrol
10 Crocetin
9 Berberine
9 Bacopa monnieri
9 Chrysin
9 Ferulic acid
9 Honokiol
8 Moringa oleifera
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Centella asiatica / Gotu kola → asiaticoside
7 Piperine
7 EGCG (Epigallocatechin Gallate)
7 Huperzine A/Huperzia serrata
7 Taurine
6 Apigenin (mainly Parsley)
6 Selenium NanoParticles
6 Cysteamine
6 Eugenol
6 Fisetin
6 Ginseng
6 Mushroom Lion’s Mane
6 Phenylbutyrate
6 Silicic Acid
5 Astaxanthin
5 Beta-Caryophyllene
5 Vitamin C (Ascorbic Acid)
5 α-Bisabolol / Chamomile oil
5 Capsaicin
5 Luteolin
5 Piperlongumine
5 Shankhpushpi
5 Shikonin
5 Vitamin E
5 Vitamin B5,Pantothenic Acid
4 Boron
4 Boswellia (frankincense)
4 Carnosic acid
4 Carnosine
4 Propolis -bee glue
4 Folic Acid, Vit B9
4 Shilajit/Fulvic Acid
4 Melatonin
4 Magnetic Field Rotating
4 Pterostilbene
4 Vitamin B12
3 Anthocyanins
3 Artemisinin
3 Biochanin A
3 Betulinic acid
3 Vitamin B6,pyridoxine
3 Caffeic acid
3 Exercise
3 Celastrol
3 Cichoric acid / Chicoric acid
3 Cinnamon
3 Coenzyme Q10
3 diet Short Term Fasting
3 Methylene blue
3 Magnolol
3 nicotinamide adenine dinucleotide
3 Rutin
3 Selenite (Sodium)
3 Ursolic acid
2 1,8-Cineole
2 Anethole/trans-Anethole
2 Baicalin
2 beta-carotene(VitA)
2 borneol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Choline
2 Hydroxycinnamic-acid
2 Calorie Restriction Mimetics
2 Spermidine
2 Cucurbitacin
2 Metformin
2 D-limonene
2 Dandelion Root
2 Ellagic acid
2 Emodin
2 Ginkgo biloba
2 Geraniol
2 EMF
2 Naringin
2 Phosphatidylserine
2 Chemotherapy
2 Vitamin D3
2 Vitamin K2
1 Astragalus
1 alpha Linolenic acid
1 Aluminum
1 Fennel Oil/Foeniculum vulgare
1 doxorubicin
1 xanthohumol
1 Butyrate
1 Paclitaxel
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Selenium
1 Carica papaya leaf extract
1 Aspirin
1 Carvone
1 Silver-NanoParticles
1 Dichloroacetate
1 Bortezomib
1 Diclofenac
1 Date Fruit Extract
1 diet Methionine-Restricted Diet
1 diet FMD Fasting Mimicking Diet
1 Eurycomanone
1 Germacranolide
1 MCToil
1 Methylsulfonylmethane
1 Nimbolide
1 Psoralidin
1 Salvia officinalis
1 Aromatherapy
1 Sesame seeds and Oil
1 Anti-oxidants
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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