Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱

Source:

Type: type of cell death

Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.

Scientific Papers found: Click to Expand⟱

3832-

Cro,

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

-

Review,

AD,

NA

*neuroP↑, *memory↑, *Apoptosis↓, *cognitive↑, *ER Stress↓,

1602-

Cu,

A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†

-

in-vitro,

BC,

MCF-7

3.2uM

-

in-vitro,

BC,

4T1

3.3uM

-

in-vitro,

Lung,

A549

4uM

-

in-vitro,

Liver,

HepG2

3.5uM

eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,

1571-

Cu,

Copper in cancer: From pathogenesis to therapy

-

Review,

NA,

NA

*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,

1572-

Cu,

Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy

-

Review,

NA,

NA

eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,

1596-

Cu,

CDT,

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

-

Review,

NA,

NA

TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,

1410-

CUR,

Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway

-

vitro+vivo,

OS,

MG63

tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT↓, ROS↑, MDA↑, GSH↓,

1505-

CUR,

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

-

Review,

NA,

NA

25 μM @24hr

TumCCA↑, Apoptosis↑, DNMTs↓, HDAC↓, HATs↓, TumCP↓, p300↓, HDAC1↓, HDAC3↓, HDAC8↓, NF-kB↓,

990-

CUR,

Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro

-

in-vitro,

CRC,

HCT116

-

in-vitro,

CRC,

HT-29

HK2↓, Glycolysis↓, Apoptosis↑,

933-

CUR,

EP,

Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study

-

in-vitro,

BC,

NA

50uM, 1200v/c,100us

Apoptosis↑, ALDOA↓, ENO2↓, LDHA↓, LDHB↓, PFKP↓, PGK1↓, PGM1↓, PGAM1↓, OXPHOS↑, TCA↑,

141-

CUR,

Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer

-

in-vivo,

Pca,

PC3

 100 mg/kg, 50 mg/kg, and 25 mg/kg curcumin)

 nude mice

BAX↑, Bcl-2↓, TumCG↓, TumVol↓, TumW↓, Apoptosis↑, AR↓, Ca+2↑, MPT↑,

137-

CUR,

Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling

-

in-vitro,

Pca,

DU145

NOTCH1↓, cycD1/CCND1↓, CDK2↓, P21↑, p27↑, P53↑, Bcl-2↓, Casp3↑, Casp9↑, TumCCA↑, TumCP↓, Apoptosis↑,

161-

CUR,

MeSA,

Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

Pca,

DU145

Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,

117-

CUR,

Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells

-

in-vivo,

Pca,

RM-1

-

in-vivo,

Pca,

DU145

ROS↑, tumCV↓, Apoptosis↑, TumCCA↑, Ca+2↑, eff↓, ER Stress↑,

123-

CUR,

Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells

-

in-vitro,

Colon,

LoVo

 0.84–34.7 μg/mL

 curcumin analog

-

in-vitro,

Colon,

COLO205

 0.84–34.7 μg/mL

 curcumin analog

-

in-vitro,

Pca,

PC3

 17.1–22.9 μg/mL

 curcumin analog

-

in-vitro,

Pca,

22Rv1

 17.1–22.9 μg/mL

 curcumin analog

NF-kB↓, ATF3↑, HO-1↑, Wnt↓, Akt↓, mTOR↓, PTEN↑, Apoptosis↑, TGF-β↓, PPARγ↑,

124-

CUR,

Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

C4-2B

TGF-β↓, Wnt↓, PI3k/Akt/mTOR↓, NF-kB↓, PTEN↑, Apoptosis↑, TumCCA↑,

125-

CUR,

Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway

-

in-vitro,

adrenal,

H295R

 10 µg/mL

CYP17A1↓, CYP19↓, *Nrf1↑, *NF-kB↓, angioG↓, Apoptosis↑, AR↓, toxicity↓, BioAv↑,

134-

CUR,

RES,

MEL,

SIL,

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

PC3

Apoptosis↑, ROS↑, Trx1↓, TumCG↓, eff↓, TXNIP↑,

129-

CUR,

Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation

-

vitro+vivo,

Pca,

LNCaP

JNK↓, H3K4↓, TumCG↓, Apoptosis↑, eff↑,

131-

CUR,

Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer

-

vitro+vivo,

Pca,

LNCaP

 5, 25 and 50 μM, 24, 48 and 72 h; 200 mg/kg/day, 30days

 mice

-

vitro+vivo,

Pca,

22Rv1

AKR1C2↓, CYP11A1↓, HSD3B↓, DHT↓, testos↓, StAR↓, SRD5A1↑, AR↓, tumCV↓, TumCG↓, Apoptosis↑,

15-

CUR,

UA,

Effects of curcumin and ursolic acid in prostate cancer: A systematic review

-

Review,

Pca,

NA

NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,

14-

CUR,

Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway

-

vitro+vivo,

Pca,

PC3

 5-30 uM

PI3K/mTOR/ETS2↓, MDM2↓, P21↑, Apoptosis↑, TumCP↓, eff↑, RadioS↑,

12-

CUR,

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells

-

in-vitro,

MB,

DAOY

 20 uM

HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, eff↑,

9-

CUR,

Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo

-

vitro+vivo,

MG,

U87MG

 15uM

-

vitro+vivo,

MG,

T98G

 31uM
31 uM

HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,

167-

CUR,

Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria

-

in-vitro,

Pca,

PC3

MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,

476-

CUR,

The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer

-

in-vitro,

PC,

PATU-8988

5, 10, 15 and 20 μM, 48 and 72 h

-

in-vitro,

PC,

PANC1

TumCMig↓, TumCI↓, Apoptosis↑, NEDD9↓, p‑Akt↓, p‑mTOR↓, PTEN↑, p73↑, β-TRCP↑,

475-

CUR,

Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway

-

in-vitro,

PC,

PANC1

2.5, 5, 10 and 20 µM, 72 h

Apoptosis↑, cl‑Casp3↑, miR-340↑, cl‑PARP↑, XIAP↓,

474-

CUR,

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

-

in-vitro,

PC,

PANC1

6, 10 and 12 µM, 24 h

-

in-vitro,

PC,

MIA PaCa-2

TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,

472-

CUR,

Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis

-

vitro+vivo,

Ovarian,

SKOV3

10, 20 and 40 μM, 24, 48 and 72 h; 15 mg/kg/2days, 5 weeks

mice

-

vitro+vivo,

Ovarian,

A2780S

TumCP↓, Apoptosis↑, PCNA↓, miR-320a↓, BAX↑, cl‑Casp3↑, circ‑PLEKHM3↑, SMG1↑,

471-

CUR,

Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells

-

in-vitro,

Ovarian,

SKOV3

5, 10, 20, 40 and 80 μM, 24, 48 and 72 h

-

in-vitro,

Ovarian,

A2780S

Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↑,

468-

CUR,

5-FU,

Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability

-

vitro+vivo,

Liver,

HepG2

15 and 30 μM, 24, 48 and 72 h; 100 mg/kg/day, 14 days

-

vitro+vivo,

Liver,

402

-

vitro+vivo,

Liver,

Bel7

Apoptosis↑, TumCCA↑, PI3k/Akt/mTOR↓, p‑PI3K↓, Bacteria↑, cl‑Casp3↑,

467-

CUR,

Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling

-

in-vitro,

Liver,

HepG2

20, 50, 80 and 100 μM, 24, 48 and 72 h

TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, HSP70/HSPA5↓, e-HSP70/HSPA5↓, TLR4↓,

479-

CUR,

Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments

-

in-vitro,

Tong,

CAL27

10, 25, 50 and 100 µM, 16 and 24 h

TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, Bcl-2↓, BAX↑, cl‑Casp3↑,

461-

CUR,

Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis

-

in-vitro,

Pca,

PC3

10, 20, 30, 40 and 50 µM, 12, 24 and 48 h

-

in-vitro,

Pca,

DU145

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-30a-5p↑, PCLAF↓, Bcl-2↓, Casp3↓, BAX↑, cl‑Casp3↑,

460-

CUR,

Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer

-

in-vitro,

Bladder,

T24/HTB-9

1, 5, 10 and 20 µM, 24, 48 and 72 h

-

in-vitro,

Bladder,

TCCSUP

-

in-vitro,

Bladder,

J82

miR-7641↓, p16↑, Apoptosis↑, TumCI↓,

459-

CUR,

Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells

-

in-vitro,

Bladder,

T24/HTB-9

10, 15, 20 and 25 µM, 48 and 72 h

-

in-vitro,

Bladder,

RT4

Trop2↓, Apoptosis↑, cycE1↓, p27↑, TumCCA↑,

458-

CUR,

Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion

-

vitro+vivo,

GC,

SGC-7901

25 μM, 3, 5 and 7 days; 100 mg/kg, 2 weeks

Casp3↑, Apoptosis↑, TumCP↓,

405-

CUR,

5-FU,

Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis

-

vitro+vivo,

CRC,

HCT116

15uM

Apoptosis↑, TumCMig↓, NRF2↑, ROS↑, MET↑, miR-34a↑,

406-

CUR,

Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2

-

in-vitro,

BC,

MCF-7

50 μmol/L

-

in-vitro,

Hepat,

HepG2

GSH↓, Apoptosis↑, Bcl-2↓, cMyc↓,

407-

CUR,

Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress

-

in-vitro,

Melanoma,

A375

80uM

Apoptosis↑, ROS↑, GSH↓, MMP↓,

477-

CUR,

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

-

in-vitro,

Cerv,

SiHa

5, 15, 30 and 50 µM, 6, 12, 24 and 48 h

TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,

483-

CUR,

PDT,

Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin

-

in-vivo,

NA,

A431

0.2–1 μg/ml

mice

TumVol↓, TumCP↓, Apoptosis↑,

482-

CUR,

PDT,

The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro

-

in-vitro,

Bladder,

RT112

0.1 to 0.4 μg/ml

-

in-vitro,

Bladder,

UMUC3

Apoptosis↑, TumCG↓, TumCP↓,

480-

CUR,

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells

-

in-vitro,

GBM,

SNB19

10, 15, 20 and 25 µM, 48 and 72 h

TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, NEDD9↓, NOTCH1↓, p‑Akt↓,

435-

CUR,

Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

-

in-vitro,

Lung,

A549

5, 10, 20 and 40 μM, 24, 48, 72 and 96 h

Apoptosis↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1↑, p62↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, p‑mTOR↓,

457-

CUR,

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

-

in-vitro,

GC,

SGC-7901

10, 20 and 40 μM, 24 h

-

in-vitro,

GC,

BGC-823

TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,

455-

CUR,

Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin

-

in-vitro,

GC,

SGC-7901

10, 20, 40 and 80 µM, 48 h

Shh↓, Gli1↓, FOXM1↓, β-catenin/ZEB1↓, TumCMig↓, Apoptosis↑, TumCCA↑, Wnt↓, EMT↓, E-cadherin↑, Vim↓,

454-

CUR,

Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway

-

in-vitro,

GC,

MGC803

5, 10, 15, 20, 40 and 60 μM, 24, 48 and 72 h

TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,

448-

CUR,

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

-

in-vitro,

CRC,

HT-29

15, 20 and 25 μM, 48 h

Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,

444-

CUR,

Cisplatin,

LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells

-

vitro+vivo,

CRC,

HCT8

10 μM, 48 h; 1 g/kg/week, 42 days

TumVol↓, Apoptosis↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑PARP1↑, miR-497↑, KCNQ1OT1↓,

442-

CUR,

5-FU,

Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress

-

in-vitro,

CRC,

HCT116

0-40uM

Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,

Showing Research Papers: 501 to 550 of 1244
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1244

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ATF3↑, 1, Fenton↑, 4, GPx1↓, 1, GPx4↓, 2, GSH↓, 5, H2O2↑, 2, HNE↑, 1, HO-1↓, 1, HO-1↑, 2, lipid-P↓, 1, MDA↑, 1, NQO1↑, 1, NRF2↓, 1, NRF2↑, 1, NRF2↝, 1, OXPHOS↑, 1, ROS↑, 13, ROS↝, 1, mt-ROS↑, 1, Trx1↓, 1, xCT↓, 1,

Mitochondria & Bioenergetics ⓘ

AIF↑, 2, CDC25↓, 1, MMP↓, 2, MPT↑, 2, mtDam↑, 2, XIAP↓, 1,

Core Metabolism/Glycolysis ⓘ

ALDOA↓, 1, ATG7↑, 1, cMyc↓, 2, ENO2↓, 1, Glycolysis↓, 1, HK2↓, 1, LDHA↓, 1, LDHB↓, 1, PFKP↓, 1, PGAM1↓, 1, PGK1↓, 1, PGM1↓, 1, PI3k/Akt/mTOR↓, 2, PI3K/mTOR/ETS2↓, 1, PPARγ↑, 1, TCA↑, 1,

Cell Death ⓘ

Akt↓, 4, Akt↝, 1, p‑Akt↓, 6, Apoptosis↓, 1, Apoptosis↑, 47, Apoptosis↝, 1, BAD↑, 1, p‑BAD↓, 1, BAX↑, 7, BAX↝, 1, Bax:Bcl2↑, 1, Bcl-2↓, 11, Bcl-2↝, 1, Bcl-xL↓, 1, Bcl-xL↝, 1, Casp3↓, 1, Casp3↑, 5, Casp3↝, 1, cl‑Casp3↑, 8, Casp8↑, 1, Casp9↑, 3, Cupro↑, 2, Cyt‑c↑, 2, Cyt‑c↝, 1, JNK↓, 1, JNK↑, 2, JNK↝, 1, MAPK↑, 2, Mcl-1↓, 1, Mcl-1↑, 1, MDM2↓, 1, miR-497↑, 1, miR-7641↓, 1, p27↑, 2, Paraptosis↑, 2, Pyro↑, 1, survivin↓, 1, TumCD↑, 2, β-TRCP↑, 1,

Transcription & Epigenetics ⓘ

H3K4↓, 1, HATs↓, 1, KCNQ1OT1↓, 1, miR-30a-5p↑, 1, other↑, 1, tumCV↓, 3,

Protein Folding & ER Stress ⓘ

CHOP↑, 1, ER Stress↑, 2, HSP27↑, 1, HSP70/HSPA5↓, 1, e-HSP70/HSPA5↓, 1,

Autophagy & Lysosomes ⓘ

ATG3↑, 2, ATG5↑, 1, Beclin-1↑, 5, LC3‑Ⅱ/LC3‑Ⅰ↑, 3, LC3I↓, 1, LC3II↑, 1, p62↓, 2, p62↑, 2, TumAuto↑, 5,

DNA Damage & Repair ⓘ

ATR↑, 1, DNAdam↑, 4, DNMTs↓, 1, GADD45A↑, 1, p16↑, 1, P53↑, 3, P53↝, 1, p‑P53↑, 1, p73↑, 1, PARP↑, 1, cl‑PARP↑, 4, cl‑PARP1↑, 1, PCLAF↓, 1, PCNA↓, 1, SMG1↑, 1, γH2AX↑, 1, p‑γH2AX↑, 1,

Cell Cycle & Senescence ⓘ

CDK2↓, 1, Cyc↝, 1, CycB/CCNB1↓, 1, cycD1/CCND1↓, 3, cycD1/CCND1↝, 1, cycE1↓, 1, P21↑, 5, P21↝, 1, TumCCA↑, 15,

Proliferation, Differentiation & Cell State ⓘ

AXIN1↓, 1, EMT↓, 2, FOXM1↓, 2, Gli1↓, 3, HDAC↓, 1, HDAC1↓, 1, HDAC3↓, 1, HDAC8↓, 1, HH↓, 2, miR-34a↑, 1, mTOR↓, 2, mTOR↝, 1, p‑mTOR↓, 4, n-MYC↓, 1, NKD2↑, 1, NOTCH1↓, 2, p300↓, 1, p‑P70S6K↓, 1, PI3K↓, 2, PI3K↝, 1, p‑PI3K↓, 1, circ‑PLEKHM3↑, 1, PTCH1↓, 1, PTEN↑, 3, PTEN↝, 1, Shh↓, 3, STAT3↓, 1, TCF↓, 1, TumCG↓, 6, Wnt↓, 4,

Migration ⓘ

AKR1C2↓, 1, AP-1↑, 1, AP-1↝, 1, Ca+2↑, 2, E-cadherin↓, 1, E-cadherin↑, 1, FAK↓, 1, MET↑, 1, miR-320a↓, 1, miR-340↑, 1, MMP2↝, 1, NEDD9↓, 2, TET1↑, 1, TGF-β↓, 2, Trop2↓, 1, TumCI↓, 4, TumCMig↓, 8, TumCP↓, 16, TumMeta↓, 1, TXNIP↑, 1, Vim↓, 1, Vim↑, 1, β-catenin/ZEB1↓, 3, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, angioG↑, 1, EGFR↝, 1, VEGF↝, 1,

Immune & Inflammatory Signaling ⓘ

COX2↝, 1, IL6↝, 1, NF-kB↓, 5, NF-kB↝, 1, PSA↝, 1, TLR4↓, 1, TNF-α↝, 1,

Hormonal & Nuclear Receptors ⓘ

AR↓, 3, AR↝, 1, CYP11A1↓, 1, CYP19↓, 1, DHT↓, 1, HSD3B↓, 1, SRD5A1↑, 1, StAR↓, 1, testos↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↑, 1, ChemoSen↑, 3, CYP17A1↓, 1, eff↓, 4, eff↑, 18, RadioS↑, 3, selectivity↑, 3,

Clinical Biomarkers ⓘ

AR↓, 3, AR↝, 1, EGFR↝, 1, FOXM1↓, 2, IL6↝, 1, PSA↝, 1,

Functional Outcomes ⓘ

chemoPv↑, 1, OS↑, 1, toxicity↓, 1, TumVol↓, 3, TumVol↑, 1, TumW↓, 1,

Infection & Microbiome ⓘ

Bacteria↑, 1,
Total Targets: 222

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Cell Death ⓘ

Apoptosis↓, 1,

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Functional Outcomes ⓘ

cognitive↑, 1, memory↑, 1, neuroP↑, 1, toxicity?, 1, toxicity↝, 2,
Total Targets: 10

Scientific Paper Hit Count for: Apoptosis, Apoptosis

67 Silver-NanoParticles
61 Curcumin
43 Magnetic Fields
41 Quercetin
36 Thymoquinone
34 Berberine
31 Sulforaphane (mainly Broccoli)
30 EGCG (Epigallocatechin Gallate)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Shikonin
23 Betulinic acid
23 Phenethyl isothiocyanate
22 Resveratrol
19 Artemisinin
19 Radiotherapy/Radiation
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Honokiol
18 Lycopene
18 Urolithin
17 Garcinol
15 Chemotherapy
15 Carvacrol
14 Astaxanthin
14 chitosan
14 Luteolin
13 salinomycin
13 Magnolol
12 Cisplatin
12 Allicin (mainly Garlic)
12 Graviola
12 Selenium NanoParticles
11 Propolis -bee glue
11 Silymarin (Milk Thistle) silibinin
11 Gambogic Acid
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 Metformin
10 Chlorogenic acid
10 Phenylbutyrate
10 Piperlongumine
9 Fisetin
9 Juglone
9 Nimbolide
9 Rosmarinic acid
8 Photodynamic Therapy
8 Coenzyme Q10
8 Auranofin
8 Copper and Cu NanoParticles
8 Paclitaxel
8 Bufalin/Huachansu
8 Selenium
8 Citric Acid
8 Ursolic acid
8 Dichloroacetate
8 Magnetic Field Rotating
7 5-fluorouracil
7 Gemcitabine (Gemzar)
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Caffeic acid
7 Carnosic acid
7 Electrical Pulses
7 Emodin
7 HydroxyTyrosol
7 Vitamin K2
6 Astragalus
6 Andrographis
6 doxorubicin
6 Celecoxib
6 Ellagic acid
6 Hydrogen Gas
6 Piperine
6 Parthenolide
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Cinnamon
4 Disulfiram
4 Ferulic acid
4 Ginkgo biloba
4 γ-linolenic acid (Borage Oil)
4 Spermidine
3 2-DeoxyGlucose
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Cat’s Claw
3 Cannabidiol
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Galloflavin
3 Orlistat
3 Hyperthermia
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 Sorafenib (brand name Nexavar)
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 tamoxifen
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chocolate
2 irinotecan
2 Deguelin
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 cetuximab
1 5-Hydroxytryptophan
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Aspirin -acetylsalicylic acid
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 Hydroxycinnamic-acid
1 Vitamin E
1 Camptothecin
1 Crocetin
1 chemodynamic therapy
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Evodiamine
1 Exercise
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Grapeseed extract
1 hydrogen sulfide
1 Rapamycin
1 Huperzine A/Huperzia serrata
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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