| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 5938- | Cela, | Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application |
| - | Review, | Var, | NA |
| 5942- | Cela, | Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer |
| - | vitro+vivo, | NSCLC, | H460 | - | in-vitro, | NSCLC, | PC9 |
| 5943- | Cela, | Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases |
| - | Review, | Arthritis, | NA | - | Review, | IBD, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 5948- | Cela, | Recent Trends in anti-tumor mechanisms and molecular targets of celastrol |
| - | Review, | Var, | NA |
| 6615- | Cen, | Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer |
| - | vitro+vivo, | CRC, | HCT116 | - | in-vitro, | CRC, | SW480 | - | in-vitro, | CRC, | LoVo |
| 6640- | Cen, | Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells |
| - | in-vitro, | HCC, | Bel-7402 | - | in-vitro, | HCC, | QGY-7703 |
| 6651- | Cen, | Study of the cytotoxicity of asiaticoside on rats and tumour cells |
| - | vitro+vivo, | BC, | MCF7 |
| 6652- | Cen, | AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells |
| - | in-vitro, | GC, | SGC-7901 | - | in-vitro, | GC, | HGC27 |
| 6021- | CGA, | Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action |
| - | in-vitro, | Var, | NA |
| 6020- | CGA, | BetaL, | Chlorogenic Acid Enhances Beta‐Lapachone‐Induced Cell Death by Suppressing Autophagy in NQO1‐Positive Cancer Cells |
| - | in-vitro, | BC, | MDA-MB-231 |
| 6017- | CGA, | Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment |
| - | Review, | Var, | NA |
| 6006- | CGA, | Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF-κB signaling pathway |
| - | in-vitro, | BC, | NA |
| 6007- | CGA, | A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer |
| - | Review, | CRC, | NA |
| 6009- | CGA, | Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment |
| - | Review, | Var, | NA |
| 6014- | CGA, | Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research |
| - | Review, | Var, | NA |
| 6012- | CGA, | Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma |
| - | in-vitro, | CCA, | HCC9810 |
| 6030- | CGA, | Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway |
| - | vitro+vivo, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MDA-MB-453 | - | in-vitro, | Nor, | MCF10 |
| 6026- | CGA, | Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression |
| - | Review, | Var, | NA |
| - | in-vitro, | GBM, | U343 | - | in-vitro, | GBM, | U87MG | - | in-vitro, | GBM, | U251 | - | in-vitro, | GBM, | T98G | - | in-vitro, | Nor, | HEK293 |
| - | in-vitro, | GBM, | U343 | - | in-vitro, | GBM, | U87MG | - | in-vitro, | GBM, | U251 | - | in-vitro, | GBM, | T98G | - | in-vitro, | Nor, | HEK293 |
| 7177- | CHA, | Chaetocin inhibits the progression of neuroblastoma by targeting JAK2/STAT3 signaling pathway in SH-SY5Y cells |
| - | in-vitro, | neuroblastoma, | SH-SY5Y |
| 7180- | CHA, | Chaetocin: A review of its anticancer potentials and mechanisms |
| - | Review, | Var, | NA |
| 7171- | CHA, | Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201 |
| - | vitro+vivo, | GBM, | DIPG |
| 7168- | CHA, | The anticancer effect of chaetocin is enhanced by inhibition of autophagy |
| - | vitro+vivo, | Liver, | HepG2 | - | in-vitro, | Liver, | HepG3 | - | in-vitro, | Liver, | HUH7 |
| 7167- | CHA, | Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism |
| - | vitro+vivo, | GBM, | A172 | - | in-vitro, | GBM, | T98G | - | in-vitro, | GBM, | U87MG |
| 7166- | CHA, | Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1 |
| - | vitro+vivo, | AML, | U937 |
| 7164- | CHA, | Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo |
| - | vitro+vivo, | Melanoma, | A375 |
| 7163- | CHA, | The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | OS, | U2OS | - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | HeLa | - | in-vivo, | Ovarian, | SKOV3 |
| 7160- | CHA, | Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress |
| - | in-vitro, | Lung, | A549 |
| 7159- | CHA, | ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin |
| - | vitro+vivo, | GC, | HGC27 | - | in-vitro, | GC, | AGS | - | in-vitro, | GC, | BGC-823 | - | in-vitro, | GC, | SGC-7901 | - | in-vitro, | Nor, | HEK293 |
| 5984- | Chit, | Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system |
| - | Review, | Var, | NA |
| 5991- | Chit, | Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies |
| - | Review, | BC, | NA |
| 5990- | Chit, | Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies |
| - | Review, | Var, | NA |
| 4493- | Chit, | Selenate, | Se, | A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway |
| - | in-vitro, | Lung, | A549 |
| 4487- | Chit, | PreB, | Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review |
| - | Review, | Var, | NA |
| 4482- | Chit, | Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44 |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Liver, | HepG2 |
| 4478- | Chit, | Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | T47D |
| 6066- | CHL, | The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion |
| - | in-vitro, | BC, | MCF7 |
| 6070- | CHL, | Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity |
| - | in-vitro, | BC, | 4T1 |
| 6073- | CHL, | GEM, | Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis |
| - | in-vitro, | PC, | NA |
| 6067- | CHL, | Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells |
| - | in-vitro, | BC, | MCF7 |
| 6068- | CHL, | Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis |
| - | in-vivo, | Oral, | NA |
| 6082- | CHOC, | Potential for preventive effects of cocoa and cocoa polyphenols in cancer |
| - | Review, | Var, | NA |
| 6083- | CHOC, | Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer |
| - | Review, | Colon, | NA |
| 6119- | Chol, | Is Citicoline Effective in Preventing and Slowing Down Dementia?—A Systematic Review and a Meta-Analysis |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 3258- | CHr, | PBG, | Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells |
| - | in-vitro, | GC, | MKN45 |
| 6133- | CHr, | Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells. |
| - | Review, | Var, | NA |
| 6132- | CHr, | MET, | Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression |
| - | in-vitro, | BC, | T47D |
| 6130- | CHr, | Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4 |
| - | vitro+vivo, | Colon, | CT26 |
| 6135- | CHr, | Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:14 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid