NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
7088- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC4
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, selectivity↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓,
7084- GAR,    A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry
- in-vivo, Nor, NA
*BioAv↝, *Dose↝, *Inflam↓, *antiOx↑, *chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ERK↓, PI3K↓, Akt↓, NF-kB↓, STAT3↓, TumCP↓, antiNeop↑, ChemoSen↑, chemoP↑,
7089- GAR,    Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, PC, NA
STAT3↓, TumCI↓, NF-kB↓, uPA↓, VEGF↓, MMP9↓,
7090- GAR,    Garcinol
AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, eff↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
810- GAR,  GEM,    Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures
- in-vitro, PC, NA
TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, NA, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
799- GAR,    Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, NMSC, MCF10
TumCG↓, Apoptosis↑, NF-kB↓,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
822- GAR,    Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
- vitro+vivo, HNSCC, NA
ROS↑, STAT3↓, cSrc↓, JAK1↓, JAK2↓, NF-kB↓, TGF-β↓, TumCG↓,
825- GAR,    Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, Bxpc-3 - in-vitro, Pca, PC3 - in-vitro, Pca, C4-2B
TumCG↓, Apoptosis↑, NF-kB↓,
828- GAR,  Cisplatin,    Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells
- in-vitro, Ovarian, OVCAR-3
tumCV↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, p‑PI3K↓, p‑Akt↓, NF-kB↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7224- GAs,    Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Wound Healing↓, uPA↓, PAI-1/SERPINE1↓, CXCR4↓, MMP9↓, TumCMig↓, NF-kB↓,
7238- GBE,    Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells
- in-vitro, Nor, RAW264.7
*NO↓, *PGE2↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓,
7223- GBE,    Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3K/Akt/NF- κ B/MMP-9 Signaling Pathway
- vitro+vivo, Melanoma, B16-F10
TumCP↓, TumCMig↓, p‑PI3K↓, p‑Akt↓, NF-kB↓, MMP9↓, TumMeta↓, Dose↝,
7108- GEN,    Genistein: A Review on its Anti-Inflammatory Properties
- Review, Nor, NA
*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, eff↑, ChemoSen↑,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1↓,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
7221- GGB,  GEM,    Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway
- in-vitro, PC, NA
eff↑, NF-kB↓,
7141- GI,    Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Study, Nor, BV2
*eff↑, *eff↓, *NRF2↑, *Inflam↓, *eff↑, *antiOx↑, *neuroP↑, *COX2/PTGS2↓, *NF-kB↓, *eff↓, *BioAv↝, *BioAv↑,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, eff↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7296- Gins,    Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1
- vitro+vivo, AD, SH-SY5Y
*MAPK↓, *NF-kB↓, *STAT3↓, *ROS↓, *NRF2↑, *HO-1↑, *HNE↑, *LPAR1/EDG2↑, *cognitive↑,
4003- Gins,    Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences
- Review, adrenal, NA
*neuroP↑, *Inflam↓, *ROS↓, *BACE/β-secretase↓, *PPARγ↑, *Aβ↓, *p‑tau↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓, *CREB↓, *BDNF↑, *memory↑,
4511- GLA,    Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study
- vitro+vivo, Nor, RAW264.7
*radioP↑, *ROS↓, *DNAdam↓, *IL6↓, *TNF-α↓, *IL10↓, *NF-kB↓, *SOD↑, *Catalase↑, *GSH↑,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, NA, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
834- Gra,    Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
- Review, NA, NA
EGFR↓, PI3K/Akt↓, NF-kB↓, JAK↓, STAT↓, Hif1a↓, GLUT1↓, GLUT4↓, ROS↑, Catalase↑, SOD↑, HO-1↑,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, NA, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,

Showing Research Papers: 501 to 550 of 966
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 966

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   DDIT4↑, 1,   HLA-I/II↑, 1,   IL7↓, 1,   IRF1↑, 1,   PLA2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↓, 1,   Catalase↑, 1,   HO-1↑, 1,   HO-1↝, 1,   NRF2↓, 1,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 13,   SOD↑, 1,   TrxR↓, 2,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 4,   MEK↓, 1,   MMP↓, 8,   mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 2,   Glycolysis↓, 1,   HK2↓, 4,   LDHA↓, 4,   PI3K/Akt↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   Akt↑, 1,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↑, 18,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 4,   Bcl-2↓, 14,   Bcl-xL↓, 4,   BID↓, 1,   BID↑, 1,   Casp↑, 3,   Casp↝, 2,   Casp∅, 1,   Casp3↑, 10,   cl‑Casp3↑, 1,   Casp8↑, 3,   Casp9↑, 8,   CBP↓, 2,   cFLIP↓, 1,   Cyt‑c↑, 3,   FADD↑, 1,   Fas↓, 1,   FasL↑, 1,   GSDME↑, 1,   hTERT/TERT↓, 3,   IAP1↓, 4,   IAP2/BIRC3↓, 1,   iNOS↓, 4,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 4,   Mcl-1↓, 3,   MDM2↓, 2,   MOMP↑, 1,   Myc↓, 1,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 1,   Pyro↑, 1,   survivin↓, 8,   Telomerase↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   FOXD3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4∅, 1,   HATs↓, 6,   miR-21↓, 1,   miR-21↝, 1,   miR-218↑, 1,   other↝, 1,   PCAF↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   ER Stress↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   SESN2↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 1,   DNAdam↑, 3,   DNMT3B↓, 1,   P53↑, 5,   P53↝, 1,   PARP↑, 1,   PARP↝, 1,   cl‑PARP↑, 4,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 9,   P21↑, 2,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 3,   EMT↓, 4,   ERK↓, 5,   HDAC↓, 1,   HDAC1↓, 1,   HRAS↓, 1,   Let-7↑, 2,   mTOR↓, 4,   NOTCH↓, 1,   NOTCH1↓, 2,   p300↓, 3,   PI3K↓, 8,   p‑PI3K↓, 2,   PTEN↑, 1,   Shh↓, 1,   SHP1↑, 1,   Src↓, 1,   STAT↓, 2,   STAT3↓, 14,   STAT5↓, 1,   TumCG↓, 8,   TumCG↑, 1,   Wnt↓, 2,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   CDK4/6↓, 1,   E-cadherin↑, 3,   FAK↓, 4,   p‑FAK↓, 1,   Fibronectin↓, 1,   MET↑, 1,   miR-200c↑, 2,   MMP2↓, 7,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 12,   MMPs↓, 2,   MMPs↝, 1,   MUC4↓, 2,   N-cadherin↓, 3,   PAI-1/SERPINE1↓, 1,   PDGF↓, 1,   PKA↓, 1,   Snail↓, 1,   TGF-β↓, 2,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 5,   TumCMig↓, 6,   TumCP↓, 11,   TumMeta↓, 9,   Twist↓, 1,   uPA↓, 3,   Vim↓, 3,   Zeb1↓, 2,   ZEB2↓, 1,   ZEB2↑, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 4,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   angioG↑, 1,   EGFR↓, 3,   HIF-1↓, 1,   Hif1a↓, 8,   VEGF↓, 14,   VEGF↝, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 5,   GLUT4↓, 5,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 12,   CXCR4↓, 2,   CXCR4↑, 1,   ICAM-1↓, 1,   IKKα↓, 2,   IL1↓, 1,   IL6↓, 5,   Imm↑, 1,   Inflam↓, 3,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   M2 MC↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   NF-kB↓, 37,   NF-kB↝, 1,   p‑NF-kB↓, 1,   ac‑p65↑, 1,   PGE2↓, 3,   RANTES↓, 1,   SOCS1↑, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 4,   TRAF1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   ChemoSen↑, 9,   Dose↝, 2,   eff↓, 2,   eff↑, 7,   Half-Life↓, 2,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 3,   EZH2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 5,   Myc↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   antiNeop↑, 3,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 3,   hepatoP↑, 1,   Risk↓, 1,   toxicity↓, 2,   TumVol↓, 2,   TumW↓, 2,   Wound Healing↓, 1,  
Total Targets: 248

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 2,   LPAR1/EDG2↑, 1,   PAF↓, 1,   Stroke↓, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 3,   GSTs↑, 2,   HNE↑, 1,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 1,   MDA↓, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 4,   ROS↓, 9,   SOD↑, 2,   TBARS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CREB↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Cyt‑c↓, 1,   iNOS↓, 4,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 3,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PARP↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   E-sel↓, 1,   TumCP↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 3,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL1β↓, 3,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 13,   MCP1/CCL2↓, 1,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 12,   p65↓, 1,   PGE2↓, 4,   RANTES↓, 1,   TLR1↓, 1,   TLR4∅, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 2,   BrainVol↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 3,   Dose↝, 3,   eff↓, 2,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 2,   neuroP↑, 8,   radioP↑, 1,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiViral↑, 1,   Bacteria↓, 3,  
Total Targets: 90

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
71 Curcumin
43 Thymoquinone
28 Resveratrol
27 Fisetin
24 Propolis -bee glue
22 Quercetin
22 Lycopene
21 EGCG (Epigallocatechin Gallate)
20 Betulinic acid
19 Baicalein
19 Sulforaphane (mainly Broccoli)
19 Silymarin (Milk Thistle) silibinin
16 Apigenin (mainly Parsley)
16 Ashwagandha(Withaferin A)
16 Garcinol
15 Alpha-Lipoic-Acid
14 Eugenol
14 Shikonin
13 Boswellia (frankincense)
13 Hydrogen Gas
13 isoorientin
12 Silver-NanoParticles
12 Artemisinin
12 Chrysin
12 Emodin
12 Honokiol
11 Cisplatin
11 Berberine
11 Caffeic Acid Phenethyl Ester (CAPE)
11 Rosmarinic acid
10 Beta-Caryophyllene
10 Luteolin
9 Magnetic Fields
9 Radiotherapy/Radiation
8 Capsaicin
8 Chlorogenic acid
8 Crocetin
8 Disulfiram
8 Isoliquiritigenin
8 Phenethyl isothiocyanate
7 Selenite (Sodium)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Hyperoside
7 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
7 Nimbolide
7 Parthenolide
7 Pterostilbene
7 Vitamin K2
6 Isovitexin
6 Ginger/6-Shogaol/Gingerol
6 Deguelin
6 Dandelion Root
6 Copper and Cu NanoParticles
6 Gambogic Acid
6 Magnolol
5 Anethole/trans-Anethole
5 Boron
5 Celastrol
5 Cinnamon
5 Hydroxycinnamic-acid
5 Ellagic acid
5 Piperine
5 Ferulic acid
5 Graviola
5 HydroxyTyrosol
5 Indole-3-carbinol
5 Piperlongumine
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Gemcitabine (Gemzar)
4 Astaxanthin
4 Docetaxel
4 Berbamine
4 borneol
4 Chemotherapy
4 Ursolic acid
4 Cynaropicrin
4 Formononetin
4 Paclitaxel/Taxol
4 Hibiscus sabdariffa
4 Inositol
3 1,8-Cineole
3 Auranofin
3 Astragalus
3 Citric Acid
3 beta-glucans
3 xanthohumol
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Carnosic acid
3 Carvacrol
3 Cat’s Claw
3 Celecoxib
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cucurbitacin
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 Gallic acid
3 Genistein (soy isoflavone)
3 Geraniol
3 Orlistat
3 Oleuropein
3 Rutin
3 Sulfasalazine
2 Ajoene (compound of Garlic)
2 5-fluorouracil
2 immunotherapy
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 brusatol
2 Zinc
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorophyllin
2 Echinacea
2 Photodynamic Therapy
2 CUSP9
2 D-limonene
2 Ginkgo biloba-EGb 761
2 Eurycomanone
2 Evodiamine
2 Ginkgo biloba
2 Ginkgolide B
2 Ginkgetin
2 Ginseng
2 Grapeseed extract
2 Proanthocyanidins
2 Inulin Prebiotic
2 Melatonin
2 Methyl salicylate / Sweet Birch oil
2 Methylsulfonylmethane
2 Naringin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Plumbagin
2 Psoralidin
2 salinomycin
2 Selenium NanoParticles
2 Aflavin-3,3′-digallate
2 Vitexin
1 2-DeoxyGlucose
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Arctigenin
1 Aloe anthraquinones
1 Cannabidiol
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosine
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Galantamine
1 Lecithin
1 Oxygen, Hyperbaric
1 methylseleninic acid
1 Cyclopamine
1 Diclofenac
1 Dipyridamole
1 methotrexate
1 Ascorbyl Palmitate
1 flavonoids
1 Bortezomib
1 Fucoidan
1 Ginkgolic acids
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 isoflavones
1 isoquercitrin
1 Juglone
1 Magnetic Field Rotating
1 Moringa oleifera
1 Mushroom Chaga
1 Neem
1 Oroxylin A
1 Propyl gallate
1 temozolomide
1 Phenolic Acids
1 Polyphenols
1 Kaempferol
1 Perilla
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Taurine
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin D3
1 probiotics
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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