TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
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Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
6902- FIS,    Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
P53↑, NF-kB↓, TumCP↓, Apoptosis↑, TumCCA↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK4↓, CDK2↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓,
6994- FIS,    Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells
- in-vitro, Colon, HT29
TumCG↓, TumCCA↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑,
6923- Flav,    Flavonoids: an overview
- Review, Nor, NA
*antiOx↑, AntiCan↑, *cardioP↑, *XO↓, *COX2/PTGS2↓, *5LO↓, *PI3K↓, *AChE↓, *Imm⇅, *BP↓, TumCCA↑, *Aβ↓, *BACE/β-secretase↓, *NF-kB↓, *ROS↓, *neuroP↑, *AntiAg↑, *AntiThr↑,
6980- Form,    The potential role of formononetin in cancer treatment: An updated review
- Review, Var, NA
TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, TumCCA↑, p‑Akt↑, p38↑, P21↑, P53↑, NF-kB↓, ERK↓, LAMs↓, JAK↓, STAT↓, Akt↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, eff↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, eff↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6991- Form,    Formononetin-induced apoptosis of human prostate cancer cells through ERK1/2 mitogen-activated protein kinase inactivation
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
TumCCA↑, IGF-1↓, PI3K↓, Akt↓, TumCP↓, ERK↓, MAPK↓, BAX↑, Apoptosis↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
6964- Form,    Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo
- vitro+vivo, BC, MCF7
IGF-1↓, IGFR↓, PI3K↓, Akt↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, TumCG↓, Dose↝,
6965- Form,    Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways
- in-vitro, CRC, HCT116
TumCP↓, TumCI↓, cycD1/CCND1↓, TumCCA↑, MMP2↓, MMP9↓, miR-149↑, tumCV↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓,
6971- Form,    In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa
- vitro+vivo, Cerv, HeLa
p‑Akt↓, Apoptosis↑, TumCG↓, Dose↝, PI3K↓, eff↑, ATP↓, OCR↓, TumCCA↑, IGF-1↓, angioG↓, TumCI↓,
6972- Form,  PacT,    Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy
- in-vivo, BC, MDA-MB-231
AntiCan↑, miR-199↓, ChemoSen↑, TumVol↓, Dose↝, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↓, eff↓,
7011- Fuc,  ATO,  VitA,RetA,    Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo
- NA, APL, APL NB4 - vitro+vivo, NA, NA
TumCCA↑, DNAdam↑, TumCP↓, Apoptosis↑, Diff↑, CD11b↑, eff↑, Dose↝,
7014- Fuc,  5-FU,    Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
tumCV↓, ChemoSen↑, TumCCA↑, cl‑PARP↑, KRAS↓, p‑ERK↓, PI3K↓, p‑Akt↓, TumCMig↓, MMP2↓, Dose↝,
7022- Fuc,    Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling
- in-vitro, Colon, HT29
TumCG↓, TumCCA↑, Cyc↓, Akt↑, eff↓, Apoptosis↑, angioG↓,
7009- Fuc,    Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
selectivity↑, TumCCA↑, Casp3↑, Casp7↑, Casp9↑, ChemoSen↑, chemoP↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
7007- Fuc,    The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
- Review, Var, NA
TumCCA↑, Apoptosis↑, NK cell↑, chemoP↑, TumCG↓, *Inflam↓, *antiOx↑, *AntiThr↑, *AntiViral↑, angioG↓, ChemoSen↑, ROS↑, GSH↓, mtDam↓, MMP↓, DNMT3B↓, TumCG↓, Dose↝, Dose↝, QoL∅, fatigue∅, Dose↝,
4025- FulvicA,    Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment
- in-vitro, Bladder, T24/HTB-9 - Review, AD, NA
tumCV↓, selectivity↑, TumCCA↑, other↝, *neuroP↑, *memory↑, *tau↓, *other↝, *lipid-P↓, *VitC↑, *antiOx↑,
1115- GA,    Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway
- in-vivo, GC, GES-1
TumCP↓, TumCCA↑, Wnt/(β-catenin)↓, EMT↓,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
7041- GA,    Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
- vitro+vivo, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, Nor, HK-2
selectivity↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumVol↓, TumW↓, Ki-67↓, MMP9↓, TumAuto↑, LC3B-II↓, Beclin-1↓, p62↑,
7046- GA,    Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, Ferroptosis↑, THBS1↓, EGR1↓, TGF-β1↓, SMAD2↓, SMAD3↓, GPx4↓, ROS↑, i-MDA↑, i-Iron↑,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↑,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
1300- GA,  PacT,  carbop,    Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, P53↑, BAX↑, Casp3↑, Bcl-2↓,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
7058- GamB,  docx,    Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells
- in-vitro, GC, BGC-823
ChemoSen↑, TumCCA↑, survivin↓,
1957- GamB,    Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
- in-vitro, ESCC, EC9706
AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,
1966- GamB,  Cisplatin,    Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling
- in-vitro, Lung, A549 - in-vitro, Lung, NCIH1299
TumCCA↑, PARP↑, eff↑, ROS↑, ChemoSen↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
7088- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC4
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, selectivity↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7091- GAR,    Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
antiOx↑, Inflam↓, HATs↓, p300↓, CBP↓, PCAF↓, cycD1/CCND1↓, STAT↓, PI3K↓, Akt↓, TumCP↓, TumCI↓, TumMeta↓, TumCCA↑, CDK2↓, CDK4↓,
807- GAR,    Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Apoptosis↑, TumCCA↑,
806- GAR,    Garcinol exerts anti-cancer effect in human cervical cancer cells through upregulation of T-cadherin
- vitro+vivo, Pca, HeLa - vitro+vivo, Cerv, SiHa
TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑, T-cadherin↑,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, NA, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27/CDKN1B↑, ERK↓, MAPK↓,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
814- GAR,  PacT,    Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model
- in-vivo, BC, NA
Apoptosis↑, TumCCA↑, EMT↓, TumCI↓,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,

Showing Research Papers: 501 to 550 of 982
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 982

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DDIT4↑, 1,   miR-149↑, 1,   miR-199↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 2,   GPx4↓, 2,   GSH↓, 3,   i-Iron↑, 1,   lipid-P↑, 1,   i-MDA↑, 1,   ROS↑, 16,   ROS⇅, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   CDC25↓, 1,   CDC25↝, 1,   MMP↓, 10,   mtDam↓, 1,   mtDam↑, 1,   OCR↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   Histones↑, 1,   LDH↓, 1,   LDHA↓, 1,   PDH↑, 1,   PI3K/Akt↓, 1,   Pyruv↑, 1,   SIRT1↓, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   Akt↑, 1,   p‑Akt↓, 4,   p‑Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 27,   mt-Apoptosis↑, 1,   Bak↑, 2,   BAX↑, 7,   Bax:Bcl2↑, 3,   Bcl-2↓, 12,   Bcl-xL↓, 4,   Casp↑, 1,   Casp3↑, 14,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 4,   Casp9↑, 10,   CBP↓, 3,   Chk2↑, 1,   Cyt‑c↑, 6,   Diablo↑, 1,   DR5↑, 1,   FADD↑, 1,   Fas↓, 1,   FasL↑, 1,   Ferroptosis↑, 2,   GSDME↑, 1,   IAP1↓, 1,   JNK↑, 3,   MAPK↓, 5,   MAPK↑, 1,   Mcl-1↓, 5,   MDM2↓, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 5,   p38↑, 1,   Pyro↑, 1,   survivin↓, 5,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   ac‑H3↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   miR-21↓, 1,   miR-218↑, 1,   other↝, 3,   PCAF↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3B-II↓, 1,   p62↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   CHK1↑, 1,   CHK1↝, 1,   DNAdam↑, 7,   mt-DNAdam↑, 1,   DNArepair↓, 1,   DNMT3B↓, 1,   P53↓, 2,   P53↑, 9,   PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   PCNA↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK1↝, 1,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 8,   CDK4↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 17,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   mitA↑, 1,   P21↓, 1,   P21↑, 10,   TumCCA↑, 51,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 2,   Diff↑, 1,   EMT↓, 3,   ERK↓, 7,   p‑ERK↓, 2,   FGF↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↓, 3,   IGFR↓, 1,   Let-7↑, 1,   mTOR↓, 2,   Nanog↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   p300↓, 3,   PI3K↓, 11,   p‑PI3K↓, 1,   PTEN↑, 1,   Shh↓, 1,   SOX2↓, 1,   STAT↓, 2,   STAT3↓, 6,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT5↓, 1,   TumCG↓, 15,   Wnt↓, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   i-Ca+2↑, 2,   CD11b↑, 1,   CLDN1↑, 1,   E-cadherin↑, 2,   Ki-67↓, 4,   KRAS↓, 1,   LAMs↓, 2,   MMP2↓, 5,   MMP9↓, 6,   MMPs↓, 4,   Slug↓, 1,   SMAD2↓, 2,   SMAD3↓, 2,   T-cadherin↑, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TJ↑, 1,   TRIB3↑, 1,   TumCI↓, 12,   TumCMig↓, 7,   TumCP↓, 22,   TumMeta↓, 8,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   EGFR↓, 4,   EGR1↓, 1,   Hif1a↓, 3,   VEGF↓, 9,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,   OCLN↑, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   IL6↓, 1,   Inflam↓, 2,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 11,   NK cell↑, 2,   ac‑p65↑, 1,   PD-1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 13,   Dose↝, 11,   eff↓, 4,   eff↑, 10,   eff↝, 1,   Half-Life↓, 2,   RadioS↑, 2,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↑, 1,   EGFR↓, 4,   GutMicro↑, 1,   IL6↓, 1,   Ki-67↓, 4,   KRAS↓, 1,   LDH↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   antiNeop↑, 2,   AntiTum↑, 3,   chemoP↑, 2,   chemoPv↑, 1,   fatigue∅, 1,   NP/CIPN↓, 1,   QoL∅, 1,   toxicity↓, 1,   TumVol↓, 5,   TumW↓, 2,  
Total Targets: 237

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 2,   GSTs↑, 1,   HO-1↓, 1,   Keap1↝, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 4,   mt-ROS?, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 1,   Insulin↑, 1,   MMP↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   COX2/PTGS2↑, 1,   IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm⇅, 2,   Inflam↓, 3,   pol-M2 MC↑, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↑, 1,   NGF↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 5,   BioAv↝, 1,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   BP↓, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 3,   Obesity↓, 1,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 2,  
Total Targets: 79

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
29 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Radiotherapy/Radiation
14 Shikonin
13 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
11 Graviola
11 Magnolol
11 Lycopene
10 Propolis -bee glue
9 Cisplatin
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 5-fluorouracil
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Ferulic acid
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
8 Luteolin
7 Chemotherapy
7 chitosan
7 Evodiamine
7 Fucoidan
7 Indole-3-carbinol
7 Phenylbutyrate
7 Pterostilbene
6 doxorubicin
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Paclitaxel/Taxol
6 Gambogic Acid
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Juglone
4 Laetrile B17 Amygdalin
4 Linalool
4 Magnetic Field Rotating
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 Piperine
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Inositol
3 Isoliquiritigenin
3 Metformin
3 Propyl gallate
3 Parthenolide
2 Glucose
2 Gold NanoParticles
2 Photodynamic Therapy
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Melatonin
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 diet Methionine-Restricted Diet
2 Echinacea
2 Electrical Pulses
2 carboplatin
2 Geraniol
2 Hyperthermia
2 isoflavones
2 isoquercitrin
2 itraconazole
2 Vitexin
2 Licorice
2 Methylene blue
2 Magnesium
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Sanguinarine
1 Psoralidin
1 Kaempferol
1 Rhein
1 Rutin
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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