TumCI Cancer Research Results

TumCI, Tumor Cell invasion: Click to Expand ⟱
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Tumor cell invasion is a critical process in cancer progression and metastasis, where cancer cells spread from the primary tumor to surrounding tissues and distant organs. This process involves several key steps and mechanisms:

1.Epithelial-Mesenchymal Transition (EMT): Many tumors originate from epithelial cells, which are typically organized in layers. During EMT, these cells lose their epithelial characteristics (such as cell-cell adhesion) and gain mesenchymal traits (such as increased motility). This transition is crucial for invasion.

2.Degradation of Extracellular Matrix (ECM): Tumor cells secrete enzymes, such as matrix metalloproteinases (MMPs), that degrade the ECM, allowing cancer cells to invade surrounding tissues. This degradation facilitates the movement of cancer cells through the tissue.

3.Cell Migration: Once the ECM is degraded, cancer cells can migrate. They often use various mechanisms, including amoeboid movement and mesenchymal migration, to move through the tissue. This migration is influenced by various signaling pathways and the tumor microenvironment.

4.Angiogenesis: As tumors grow, they require a blood supply to provide nutrients and oxygen. Tumor cells can stimulate the formation of new blood vessels (angiogenesis) through the release of growth factors like vascular endothelial growth factor (VEGF). This not only supports tumor growth but also provides a route for cancer cells to enter the bloodstream.

5.Invasion into Blood Vessels (Intravasation): Cancer cells can invade nearby blood vessels, allowing them to enter the circulatory system. This step is crucial for metastasis, as it enables cancer cells to travel to distant sites in the body.

6.Survival in Circulation: Once in the bloodstream, cancer cells must survive the immune response and the shear stress of blood flow. They can form clusters with platelets or other cells to evade detection.

7.Extravasation and Colonization: After traveling through the bloodstream, cancer cells can exit the circulation (extravasation) and invade new tissues. They may then establish secondary tumors (metastases) in distant organs.

8.Tumor Microenvironment: The surrounding microenvironment plays a significant role in tumor invasion. Factors such as immune cells, fibroblasts, and signaling molecules can either promote or inhibit invasion and metastasis.
Scientific Papers found: Click to Expand⟱
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
3326- SIL,    Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B
*hepatoP↑, chemoPv↑, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓, angioG↓,
1127- SIL,    Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1
- in-vitro, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, EMT↓, RHBDD1↓,
2417- SK,    Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H446
TumCP↓, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, PFKFB2↓, Warburg↓, GLUT1∅, LDHA∅, PKM2∅, GLUT3∅, PDH∅,
2360- SK,    Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells through inactivating the phosphatidylinositol 3 kinase/AKT signal pathway
- in-vitro, NPC, HONE1 - in-vitro, NPC, SUNE-1
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, PI3K↓, Akt↓, MMP3↓, MMP9↓, TIMP1↑,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2234- SK,    Shikonin Suppresses Cell Tumorigenesis in Gastric Cancer Associated with the Inhibition of c-Myc and Yap-1
- in-vitro, GC, NA
TumCP↓, TumCI↓, TumCMig↓, cMyc↓, YAP/TEAD↓,
2190- SK,    Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway
- in-vitro, HCC, HCCLM3
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↓, ROS↑, OCR↓, ATP↓, PKM2↓,
2183- SK,    Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1
- in-vitro, Thyroid, TPC-1
TumCMig↓, TumCI↓, PTEN↑, DNMT1↓,
2182- SK,  Cisplatin,    Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway
- in-vitro, Lung, A549 - in-vitro, Lung, PC9 - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, PKM2↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, TumVol↓, TumW↓, GLUT1↓,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,
2210- SK,    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway
- in-vitro, BC, MGC803
TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
3046- SK,    Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway
- in-vitro, Lung, A549
TumCP↓, TumCI↓, TumCMig↓, p‑ERK↓, ITGB1↓,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
1191- SM,    Salvia miltiorrhiza extract inhibits TPA‑induced MMP‑9 expression and invasion through the MAPK/AP‑1 signaling pathw
- in-vitro, BC, MCF7
Inflam↓, MMP9↓, TumCI↓, AP-1↓, lipidLev↓,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1/SREBF1↓, toxicity↑,
962- TQ,    Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
- in-vitro, PC, PANC1 - in-vitro, Nor, hTERT-HPNE - in-vitro, PC, AsPC-1 - in-vitro, PC, Bxpc-3
TumCMig↓, TumCI↓, Apoptosis↑, Hif1a↓, PI3k/Akt/mTOR↓, TumCCA↑, *toxicity↓, *TumCI∅, *TumCMig∅,
1929- TQ,    Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells
- in-vitro, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,
1930- TQ,    Therapeutic implications and clinical manifestations of thymoquinone
- Review, Var, NA
AntiCan↑, antiOx↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, ROS↑, TumMeta↓, TumCI↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3403- TQ,    A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells
- in-vitro, RCC, 786-O
tumCV↓, ROS↑, TumCCA↑, eff↓, TumCI↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
4565- TQ,    Thymoquinone in the clinical treatment of cancer: Fact or fiction?
- Review, BC, NA
Dose↝, TumCCA↑, P21↑, cycD1/CCND1↓, TumCI↑, TumMeta↓, Bcl-2↓, Bcl-xL↓, survivin↓, PTEN↑, Akt↓, P53↑, NF-kB↓, cardioP↑, Dose↝,
5911- TV,    Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway
- vitro+vivo, CRC, NA
TumCP↓, Apoptosis↑, TumVol↓, Bax:Bcl2↑, EMT↓, TumCI↓, TumMeta↓, Wnt/(β-catenin)↓,
5019- UA,    Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions
- Review, Var, NA
TumCP↓, Diff↑, Apoptosis↑, TumCI↓, angioG↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4844- Uro,    Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H460
TumCMig↓, TumCI↓, EMT↓, Snail↓, MDM2↑, P53↑, E-cadherin↑, N-cadherin↓, Vim↓,
4849- Uro,    Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway
- vitro+vivo, GC, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, TumAuto↑, TumCG↓, chemoP↑, ChemoSen↑,
4851- Uro,    Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1
- in-vitro, OS, MG63
TumCMig↓, TumCI↓, TumCA↑, MMP2?, MMP9?,
8159- UsA,    Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity
- in-vitro, Cerv, HeLa
STAT3↓, RAS↓, mTOR↓, PD-L1↓, TumCP↓, angioG↓, TumCMig↓, TumCI↓, TumCG↓,
3143- VitC,  ATO,    Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
- in-vitro, OS, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,
3130- VitC,    Effect of high-dose vitamin C on MMP2 expression and invasive ability in human pancreatic cancer cell line PANC-1
- in-vitro, PC, PANC1
MMP2↓, TumCI↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,
7909- VT,    Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway
- vitro+vivo, GC, NA
tumCV↓, TumCMig↓, TumCI↓, EMT↓, PI3K↓, Akt↓, Hif1a↓, HMGB1↓, TumCG?,
1761- WBV,    Low Intensity Vibration Mitigates Tumor Progression and Protect Bone Quantity and Quality in a Murine Model of Myeloma
- in-vivo, Melanoma, NA
Dose∅, BMD↑, TumCI↓,
1751- WBV,    Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
- in-vitro, BC, MDA-MB-231 - in-vitro, AML, RAW264.7
BMD↑, YAP/TEAD↑, TumCG↓, Strength↑, TumCI↓, Fas↑, Ca+2↑,
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
- Study, BC, NA
Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2/PTGS2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,
1222- Z,    Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition
- in-vitro, Ovarian, NA
EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,
961- Z,    Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
- in-vitro, RCC, RCC4 - vitro+vivo, GBM, U373MG - in-vitro, Nor, HUVECs
Hif1a↓, HIF-1↓, VEGF↓, TumCI↓,
2414- β‐Ele,    Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumMeta↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, EGFR↓, GLUT1↓, LDHA↓, ECAR↓, OCR↓,

Showing Research Papers: 501 to 548 of 548
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 548

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 6,   ARE↓, 1,   Catalase↓, 3,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 13,   GSH↓, 27,   GSH↑, 2,   GSR↓, 1,   GSTs↑, 1,   H2O2↓, 2,   H2O2↑, 2,   HO-1↓, 5,   HO-1↑, 9,   Iron↑, 4,   i-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA?, 1,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 2,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 16,   NRF2↑, 15,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS↓, 19,   ROS↑, 147,   ROS⇅, 2,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 5,   SOD↑, 2,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   TAC↓, 1,   TAC↑, 1,   TKT↝, 1,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 3,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh∅, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 6,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   MFN2↓, 1,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 1,   PINK1↑, 3,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 3,   ACADS/SCAD↓, 1,   ACC↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 2,   AMPK↓, 1,   AMPK↑, 25,   AMPK↝, 1,   p‑AMPK↑, 5,   ATP↓, 19,   CAIX/CA9↓, 1,   citrate↓, 1,   ECAR↓, 3,   ENO1↓, 1,   FABP4↑, 1,   FABP5/E-FABP↓, 1,   FAM↓, 1,   FASN↓, 6,   FDG↓, 1,   G6PD↓, 5,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 11,   GlutMet↓, 1,   Glycolysis↓, 34,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 1,   Histones↑, 1,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 17,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDHA↓, 11,   LDHA∅, 1,   LDL↓, 3,   lipidLev↓, 2,   lipoGen↓, 2,   NADPH↓, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 2,   PGM1↓, 1,   PIP3↑, 1,   PKM2↓, 19,   PKM2∅, 1,   Pyruv↓, 1,   R5P↝, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 5,   SIRT1↑, 4,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,   SREBP2↓, 2,   TCA↓, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 6,   Apoptosis?, 3,   Apoptosis↓, 7,   Apoptosis↑, 234,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 2,   BAX↓, 1,   BAX↑, 84,   Bax:Bcl2↑, 14,   Bcl-2↓, 99,   Bcl-xL↓, 15,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 24,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   proCasp1↓, 1,   Casp10↓, 1,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 94,   cl‑Casp3↑, 24,   Casp7↑, 13,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 23,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 58,   p‑Casp9↑, 1,   cl‑Casp9↑, 8,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 47,   Cyt‑c↝, 1,   DR5↑, 11,   DR5∅, 1,   Endon↑, 1,   FADD↑, 3,   FADD∅, 1,   Fas↓, 2,   Fas↑, 11,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 22,   GSDMD↑, 2,   IAP1↓, 5,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 10,   Mcl-1↑, 1,   MDM2↓, 7,   MDM2↑, 1,   MOMP↓, 1,   MOMP↑, 3,   Necroptosis↑, 2,   necrosis↑, 2,   NOXA↑, 2,   P2X7↓, 1,   p38↓, 6,   p38↑, 9,   p‑p38↓, 4,   p‑p38↑, 3,   p‑p38↝, 1,   Paraptosis↑, 1,   PDCD4↑, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP1↓, 1,   survivin↓, 38,   TNFR 1↓, 1,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 9,   TUNEL↑, 1,   XIAP↓, 19,   YAP/TEAD↓, 6,   YAP/TEAD↑, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 122,   Akt↑, 5,   Akt↝, 1,   p‑Akt↓, 44,   p‑Akt↑, 1,   AKT1↓, 4,   AKT3↓, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 1,   p‑cMET↑, 2,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 34,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 7,   ERK↝, 2,   p‑ERK↓, 18,   p‑ERK↑, 1,   p‑ERK↝, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 2,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 10,   IKKα↝, 1,   p‑IKKα↓, 1,   IR↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 6,   JAK↝, 1,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 11,   p‑JAK2↓, 2,   p‑JAK3↓, 1,   JNK↓, 3,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 27,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MEK↓, 4,   p‑MEK↓, 2,   mTOR↓, 67,   mTOR↑, 4,   mTOR↝, 1,   p‑mTOR↓, 12,   mTORC2↓, 2,   mTORC2↑, 1,   NRAS↓, 1,   p42↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PFKFB2↓, 1,   PI3K↓, 83,   PI3K↝, 1,   p‑PI3K↓, 13,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 8,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 22,   PTK2B / PYK2↓, 1,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 1,   SGK1↓, 1,   Sp1/3/4↓, 19,   Src↓, 4,   p‑Src↓, 1,   STAT↓, 6,   p‑STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 57,   STAT3↑, 3,   p‑STAT3↓, 10,   p‑STAT3↑, 2,   STAT5↓, 1,   STAT6↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 6,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 6,   cJun↑, 2,   p‑cJun↓, 1,   cMyc↓, 26,   DNMT1↓, 4,   DNMT1↑, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 11,   HDAC1↓, 4,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 2,   HMTs↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   Matr↓, 1,   METTL7A↑, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 3,   miR-145↑, 1,   miR-149↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-194↑, 1,   miR-200b↑, 1,   miR-205↑, 2,   miR-206↑, 1,   miR-21↓, 8,   miR-223-3p↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-30a-5p↑, 1,   miR-340↓, 2,   miR-34a↓, 1,   miR-34a↑, 5,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-542↓, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-7641↓, 1,   miR-99↑, 1,   Myc↓, 1,   Myc↑, 1,   NDRG1↑, 1,   OCT4↓, 12,   other?, 1,   other↓, 2,   other↑, 3,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 2,   RASSF1A↑, 1,   sonoS↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 71,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 2,   ER Stress↑, 27,   Erlin1↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   e-HSP70/HSPA5↓, 1,   HSP90↓, 13,   HSPs↓, 1,   IRE1↑, 3,   OTUB2↓, 1,   PDI↑, 1,   PERK↑, 9,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↓, 1,   ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↓, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 4,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 42,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 33,   DNArepair↓, 5,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 50,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 3,   PARP↑, 9,   cl‑PARP↑, 42,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 22,   PCNA↑, 1,   POLD1↓, 1,   Telomerase↓, 5,   TOP1↓, 3,   TOP2↓, 2,   TOP2↑, 1,   TP53↑, 2,   XRCC1↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 2,   CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 20,   CDK2↑, 3,   CDK4↓, 25,   CDK4↑, 2,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 10,   CDK6↑, 2,   CDK6∅, 1,   CDK7↓, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 15,   cycD1/CCND1↓, 53,   cycD1/CCND1↑, 2,   cycD1/CCND1∅, 1,   CycD3↓, 3,   cycE/CCNE↓, 14,   E2Fs↓, 2,   Ki-67↓, 31,   MAD↓, 1,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 10,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TumCCA↓, 6,   TumCCA↑, 149,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 8,   ALDH1A1↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP2↓, 1,   BMPs↑, 2,   CD133↓, 11,   CD133↑, 1,   CD24↓, 4,   CD34↓, 1,   cFos↓, 7,   p‑cFos↓, 1,   cMYB↓, 1,   CSCs↓, 38,   Diff↑, 5,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 13,   HH?, 1,   HH↓, 12,   IGF-1↓, 4,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 31,   Let-7↑, 1,   LRP6↓, 2,   p‑LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 5,   Nanog↓, 10,   Nestin↓, 3,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 5,   NOTCH1↝, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 6,   STAT1↓, 1,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 2,   TumCG?, 2,   TumCG↓, 108,   TumCG↑, 3,   TumCG∅, 1,   TumCP?, 1,   TumCP↓, 242,   TumCP↑, 5,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   WDR72↓, 1,   Wnt↓, 30,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   Ca+2↑, 20,   CAFs/TAFs↓, 1,   CAFs/TAFs↝, 1,   cal2↑, 2,   Cav1↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   COL11A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 70,   EMT?, 1,   EMT↓, 124,   EMT↑, 4,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 14,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 7,   GLI2↓, 2,   ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 4,   ITGB3↓, 1,   ITGB4↓, 3,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 3,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP14↓, 2,   MMP16↓, 2,   MMP17↓, 1,   MMP2?, 1,   MMP2↓, 117,   MMP2↝, 1,   MMP3↓, 8,   MMP7↓, 11,   MMP9?, 1,   MMP9↓, 134,   MMP9↑, 1,   MMP9↝, 1,   MMPs↓, 32,   MTA1↓, 2,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 53,   NEDD9↓, 3,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   RECK↑, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 8,   Sharpin↓, 1,   Slug↓, 27,   Smad1↓, 2,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 9,   SMAD3↓, 8,   p‑SMAD3↓, 7,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail↓, 44,   Snail↑, 1,   T-cadherin↑, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 18,   TGF-β↑, 3,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 1,   TIMP1↑, 7,   TIMP2↓, 2,   TIMP2↑, 9,   TIMP3↑, 2,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 10,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 543,   TumCI↑, 7,   TumCMig?, 1,   TumCMig↓, 346,   TumCMig↑, 5,   TumMeta↓, 119,   TumMeta↑, 5,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 1,   uPA↓, 14,   uPAR↓, 2,   UroPA↓, 1,   Vim?, 1,   Vim↓, 58,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 17,   Zeb1↑, 1,   ZEB2↓, 3,   ZEB2↑, 1,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↑, 2,   β-catenin/ZEB1↓, 53,   β-catenin/ZEB1↑, 2,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 96,   angioG↑, 2,   EGR1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 6,   Hif1a↓, 53,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 69,   VEGF↑, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CLDN1↓, 1,   CLDN1↑, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 12,   GLUT1∅, 1,   GLUT3↓, 1,   GLUT3∅, 1,   MMP↓, 65,   MMP↑, 1,   MPT↑, 4,   OATPs↓, 1,   TRPM7↓, 2,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 13,   CD47↓, 1,   CD8+↑, 5,   p‑cDC2↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCR2↓, 1,   CXCR4↓, 11,   DR4↑, 7,   DR4∅, 1,   FOXP3↑, 1,   Gal-3↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL10↓, 1,   IL12↓, 1,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL6↓, 26,   IL6↑, 1,   IL8↓, 8,   Imm↑, 11,   Imm↝, 2,   Inflam↓, 34,   Inflam↝, 2,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   NF-kB↓, 115,   NF-kB↑, 6,   NF-kB↝, 2,   p‑NF-kB↓, 4,   p‑NF-kB↑, 1,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 3,   NLRP3↓, 5,   NLRP3↑, 2,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 2,   PGE2↓, 12,   PSA↓, 2,   T-Cell↑, 1,   TCF↓, 2,   Th1 response↑, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 20,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↑, 1,   e-pH↑, 3,   i-pH↓, 1,   TAMS↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 2,   AhR↓, 1,   AR↓, 10,   ER-α36↓, 2,   ERα/ESR1↓, 1,   Estro↝, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 22,   BioAv↑, 23,   BioAv↝, 11,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 107,   CompStab↓, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose↓, 5,   Dose↑, 3,   Dose↝, 42,   Dose∅, 4,   eff↓, 20,   eff↑, 55,   eff↝, 3,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 7,   Half-Life↑, 2,   Half-Life↝, 7,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 1,   RadioS?, 1,   RadioS↑, 31,   selectivity↑, 62,   Synergy↑, 75,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALB↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   BMD↑, 2,   BP↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   CRP↓, 1,   DBIL↓, 1,   EGFR↓, 34,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 1,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 26,   IL6↑, 1,   LDH↓, 7,   LDH↑, 2,   Myc↓, 1,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 8,   PD-L1↑, 2,   PSA↓, 2,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 32,   AntiCan⇅, 1,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 3,   AntiTum↓, 3,   AntiTum↑, 23,   cachexia↓, 1,   cardioP↑, 6,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 18,   chemoPv↑, 15,   ChemoSideEff↓, 3,   fatigue↓, 2,   FTO↓, 1,   FTO↑, 1,   hepatoP↓, 1,   hepatoP↑, 4,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 1,   OS↑, 11,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 5,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 2,   Risk↓, 8,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 1,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 19,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 25,   TumVol∅, 1,   TumW↓, 14,   TumW∅, 1,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 3,   Sepsis↓, 2,  
Total Targets: 1052

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 51,   Catalase↑, 18,   Fenton↓, 1,   GPx↑, 13,   GPx1↑, 1,   GSH↑, 13,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 11,   hyperG↝, 1,   Iron∅, 1,   Keap1↓, 2,   lipid-P↓, 17,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 23,   RNS↓, 4,   ROS↓, 44,   ROS↑, 1,   SOD↑, 16,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   HSP60/HSPD1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 2,   ATP↓, 1,   ATP↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 2,   HMG-CoA↓, 2,   LDL↓, 3,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 5,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 1,   Fas↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 9,   iNOS↑, 1,   p38↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 1,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↑, 1,   JAK2↑, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   mTOR↓, 2,   mTOR↑, 2,   PI3K↑, 4,   PKCδ↓, 1,   PKCδ↑, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other↓, 2,   other↑, 1,   other↝, 5,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   neuroG↑, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↝, 1,   EMT↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 2,   TumCI∅, 1,   TumCMig↓, 1,   TumCMig∅, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 5,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 2,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 3,   MMP↑, 2,   MUC5AC↓, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 12,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL1β↓, 8,   IL4↓, 1,   IL4↑, 1,   IL6↓, 15,   Imm↓, 1,   Imm↑, 4,   Inflam?, 1,   Inflam↓, 57,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   NLRP3↓, 3,   PGE2↓, 5,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 15,   Treg lymp↝, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 1,   AChE↓, 5,   AChE↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 2,   proBDNF↑, 1,   ChAT↑, 1,   MAOA↓, 1,   NGF↑, 2,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 20,   BioAv⇅, 1,   BioAv↝, 9,   BioEnh↑, 1,   CompStab↑, 1,   CompStab↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↑, 5,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   BMD↑, 2,   BP↓, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 3,   IL6↓, 15,   LDH↓, 2,   SpO2↑, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 7,   antiCG↑, 1,   antiD↓, 1,   antiD↑, 1,   AntiDiabetic↑, 9,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   ANXi↓, 1,   cardioP↑, 19,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 6,   diuretic↑, 1,   hepatoP↑, 17,   memory↑, 3,   Mood↑, 1,   neuroP?, 1,   neuroP↑, 34,   Obesity↓, 3,   OS↑, 1,   Pain↓, 2,   radioP↑, 3,   RenoP↑, 6,   Risk↓, 1,   Sleep↑, 1,   Stroke↓, 4,   toxicity↓, 23,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 7,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 11,   GutMicro↑, 10,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 271

Scientific Paper Hit Count for: TumCI, Tumor Cell invasion
21 Curcumin
15 Resveratrol
14 Quercetin
13 Matrine
12 Honokiol
12 Magnolol
12 Shikonin
11 Berberine
11 Fisetin
10 Apigenin (mainly Parsley)
10 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
9 Thymoquinone
8 Melatonin
8 Eugenol
8 Garcinol
8 Luteolin
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Chlorogenic acid
7 Chrysin
7 Licochalcone A
7 Magnetic Fields
6 Metformin
6 Cinnamon
6 Dandelion Root
6 Emodin
6 Formononetin
6 Ginkgetin
6 Piperlongumine
5 Astragalus
5 Gemcitabine (Gemzar)
5 Ferulic acid
5 Hyperoside
5 Lycopene
5 Morin
5 Pterostilbene
4 Artemisinin
4 Baicalein
4 Carvacrol
4 Celastrol
4 Cyclopamine
4 Radiotherapy/Radiation
4 Gambogic Acid
4 Isoliquiritigenin
4 Juglone
4 Nimbolide
4 Phenethyl isothiocyanate
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Berbamine
3 Brucea javanica
3 brusatol
3 Capsaicin
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Centella asiatica / Gotu kola → asiaticoside
3 chaetocin
3 Zinc
3 Propolis -bee glue
3 Crocetin
3 Copper and Cu NanoParticles
3 Diindolylmethane
3 Evodiamine
3 Gallic acid
3 Paclitaxel/Taxol
3 Genistein (soy isoflavone)
3 Hydrogen Gas
3 Indole-3-carbinol
3 iodine
3 Magnetic Field Rotating
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Bicarbonate(Sodium)
3 Piperine
3 Whole Body Vibration
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Aspirin
2 Astaxanthin
2 Beta-Caryophyllene
2 Boron
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Celecoxib
2 Hydroxycinnamic-acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dasatinib/Phyrago
2 Deguelin
2 Disulfiram
2 Ellagic acid
2 Ginkgolic acids
2 Ginkgolide B
2 5-fluorouracil
2 Graviola
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoflavones
2 isoorientin
2 isoquercitrin
2 itraconazole
2 Kaempferol
2 low dose naltrexone
2 Licorice
2 Linalool
2 Lutein
2 Modified Citrus Pectin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Cisplatin
2 salinomycin
2 Sulfasalazine
2 Selenite (Sodium)
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 Biochanin A
1 Atorvastatin
1 bempedoic acid
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Butyrate
1 Carnosic acid
1 chitosan
1 Selenium NanoParticles
1 Chlorophyllin
1 Carvone
1 CUSP9
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetate
1 Date Fruit Extract
1 Mistletoe/Viscum album Extracts
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Galloflavin
1 Ginkgo biloba
1 Geraniol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Ivermectin
1 Isovitexin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 mebendazole
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 doxorubicin
1 immunotherapy
1 Magnesium
1 Methylsulfonylmethane
1 Noscapine
1 Oroxylin A
1 Oleuropein
1 Orlistat
1 Psoralidin
1 Docetaxel
1 Germacranolide sesquiterpene lactone
1 Rauwolfia serpentina/Indian Snakeroot
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Usnic acid
1 Arsenic trioxide
1 Vitamin K2
1 VitK3,menadione
1 Vitexin
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:324  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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