TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
Type:
Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
6846- EVO,    Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116
TumCP↓, TumCI↓, TumCCA↑, PI3K↓, AKT1↓, P53↑, Bcl-2↓, BAX↑, Apoptosis↑, p‑Casp9↑, E-cadherin↑, N-cadherin↓, MMP9↓, CSCs↓, EGFR↓, PDGFRA↓, Dose↝, TumCG↓,
6848- EVO,    Evodiamine: A Extremely Potential Drug Development Candidate of Alkaloids from Evodia rutaecarpa
- Review, Nor, NA
AntiTum↑, cardioP↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, BioAv↓, toxicity↑, NF-kB↓, MAPK↓, NOD1↓, p‑Akt↓, BAX↑, cl‑Casp3↑, γH2AX↑, cl‑PARP↑, ROS↑, BBB↑, neuroP↑, BioAv↑,
6842- EVO,    Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma
- in-vitro, GBM, U251 - in-vitro, GBM, LN229
TumCP↓, ROS↑, MMP↓, PI3K↓, Akt↓, p‑MAPK↑, cl‑Casp3↑,
6841- EVO,    Evodiamine induces reactive oxygen species-dependent apoptosis and necroptosis in human melanoma A-375 cells
- in-vitro, Melanoma, A375
TumCP↓, TumCCA↑, Casp3↑, Casp9↑, PARP↑, MMP↓, RIP3↑, Necroptosis↑, ROS↑,
6838- EVO,    Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells
- in-vitro, AML, K562
TumCP↓, TOP1↓, TOP2↓,
1111- EVO,    Evodiamine exerts inhibitory roles in non‑small cell lung cancer cell A549 and its sub‑population of stem‑like cells
- in-vitro, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, EMT↓,
2150- Ex,    Roles and molecular mechanisms of physical exercise in cancer prevention and treatment
- Review, Var, NA
eff↓, Dose↝, TumCP↓, Apoptosis↓, ChemoSen↑, chemoP↑,
6865- FA,    Ferulic Acid Regulates GSDMD through the ROS/JNK/Bax Mitochondrial Apoptosis Pathway to Induce Pyroptosis in Lung Cancer
- in-vitro, Lung, NA
TumCP↓, MMP↓, LDH↑, Pyro↑, GSDMD↑, ROS↑, JNK↑, BAX↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1/CCNA1↑, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
7511- FA,    The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, CaSki
MMP9↓, TumCCA↑, P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, LC3II↓, Beclin-1/ATG6↓, ATG5↓, TumCP↓, TumCI↓, MMP9↓,
7510- FA,    Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability
- in-vitro, Lung, H1299
*antiOx↑, ROS↑, H2O2↑, TumCP↓, TumCMig↓, MMP2↓, MMP9↓,
7507- FA,    Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Dose↝, ATR↑, ATM↑, P21↑, p27/CDKN1B↑, E2F4↑, RB1↑, TP53↑, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, TumCP↓, Casp1↑, Casp2↑, Casp8↑, Fas↑, TRADD↑, Bcl-2↓, XIAP↓, TumCCA↑,
6862- FBZ,    Research: The Urgent Need for Clinical Studies to Evaluate the Anti-Tumor Efficacy of Fenbendazole
- Review, Var, NA
mitA↑, Apoptosis↑, GLUT4↓, HK2↓, Warburg↓, TumCCA↑, P53↑, Casp↑, TumCP↓, ROS↑, Ferroptosis↑, TumVol↓, Dose↝, BioAv↓, RadioS↝, ChemoSen↑,
6854- FBZ,    Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway
- in-vitro, Cerv, HeLa
eff↑, ROS↑, TumCP↓, Apoptosis↑, selectivity↑,
6855- FBZ,    Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study
- vitro+vivo, Ovarian, A2780S - vitro+vivo, Ovarian, SKOV3
TumCP↓, Apoptosis↑, TumCG↓, cl‑Casp3↑, Bax:Bcl2↑, CDK1↓,
2499- FBZ,  VitE,    Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells
- in-vitro, Pca, PC3
TumCP∅, TumCP↓, toxicity↓, eff↑,
6891- Fer,    Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
- vitro+vivo, lymphoma, NA
TumCG↓, Ferroptosis↑, i-Iron↑, lipid-P↑, GPx4↓, ROS↑, Fenton↑, TfR1/CD71↝, FPN↝, LIP↑, TumCP↓, Apoptosis↑, TumCG↓,
6904- FIS,    Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway
- in-vitro, Cerv, NA
TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, uPA↓,
6906- FIS,  Rad,    Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models
- in-vivo, CRC, CT26 - in-vivo, CRC, HCT116
antiOx↑, Inflam↓, angioG↓, TumCI↓, TumCP↓, TumCG↓, RadioS↑,
6910- FIS,    Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
- in-vitro, Lung, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, TumAuto↝, ChemoSen↑, RadioS↑, chemoP↑, BioAv↓, Half-Life↓,
6911- FIS,    New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
- vitro+vivo, BC, NA
MMP↓, mt-ROS↑, Apoptosis↑, p‑AMPK↑, Akt↓, HSP90↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, TumMeta↓, angioG↓, TumCD↑, selectivity↑, TumVol↓,
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, Synergy↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
6919- FIS,    Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells
- in-vitro, Var, NA
TumCP↓, Inflam↓, NO↓, iNOS↓, COX2/PTGS2↓, IL6↓, TNF-α↓, NF-kB↓, p‑cJun↓,
6902- FIS,    Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
P53↑, NF-kB↓, TumCP↓, Apoptosis↑, TumCCA↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK4↓, CDK2↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓,
2860- FIS,    Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3 - in-vitro, Nor, hTERT-HPNE - in-vivo, NA, NA
AMPK↑, mTOR↑, UPR↑, ER Stress↑, selectivity↑, TumCP↓, PERK↑, ATF4↑, ATF6↑,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2840- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
ROS↑, TumCMig↓, TumCP↓,
6990- Form,    Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo
- vitro+vivo, OS, U2OS
TumCP↓, Apoptosis↑, Bcl-2↓, miR-375↓, BAX↑,
6980- Form,    The potential role of formononetin in cancer treatment: An updated review
- Review, Var, NA
TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, TumCCA↑, p‑Akt↑, p38↑, P21↑, P53↑, NF-kB↓, ERK↓, LAMs↓, JAK↓, STAT↓, Akt↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6991- Form,    Formononetin-induced apoptosis of human prostate cancer cells through ERK1/2 mitogen-activated protein kinase inactivation
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
TumCCA↑, IGF-1↓, PI3K↓, Akt↓, TumCP↓, ERK↓, MAPK↓, BAX↑, Apoptosis↑,
6996- Form,  MET,    Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, Bcl-2↓, p‑ERK↓, Synergy↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
6963- Form,    Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
eff↝, TumCP↓, TumCP∅, MAPK↑, Bax:Bcl2↑, Apoptosis↑,
6964- Form,    Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo
- vitro+vivo, BC, MCF7
IGF-1↓, IGFR↓, PI3K↓, Akt↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, TumCG↓, Dose↝,
6965- Form,    Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways
- in-vitro, CRC, HCT116
TumCP↓, TumCI↓, cycD1/CCND1↓, TumCCA↑, MMP2↓, MMP9↓, miR-149↑, tumCV↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓,
6973- Form,    Formononetin enhances the chemosensitivity of triple negative breast cancer via BTB domain and CNC homolog 1-mediated mitophagy pathways
- Human, BC, NA
TumMeta↓, OS↑, TumCP↓, mtDam↑, Apoptosis↑, BACH1↑, eff↓, ChemoSen↑,
6975- Form,    Formononetin inhibits colorectal cancer via the miR-490-3p/ABCC2 axis and synergizes with 5-fluorouracil: mechanistic insights and therapeutic implications
- vitro+vivo, CRC, NA
TumCP↓, MRP↓, miR-490↑, eff⇅, ChemoSen↑, MRP2↓,
8313- FS,    Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?
- Review, BC, NA
TumCG↓, ChemoSen↑, Risk↓, OS↑, TumCP↓, Apoptosis↑,
8300- FS,    Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
- Trial, Pca, NA
Dose↝, TumCP↓, Ki-67↓, *toxicity↓, Ingr↑, testos↓, DHT↓, Risk↓, Dose↝,
8304- FS,    Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer
- Trial, Pca, NA
NF-kB↓, VEGF↓, Ki-67↓, TumCP↓,
8583- FS,    The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity
- in-vivo, BC, NA
TumCP↓, CD38↓, CD4+↑, CD8+↑, GutMicro↑,
8580- FS,    Anti-Cancer Properties of Flaxseed Proteome
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↑, *Inflam?, *ROS?, *TNF-α?, *IL6?, TumCCA↑, Imm↑, ChemoSen↑, Synergy↑,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,

Showing Research Papers: 501 to 550 of 1302
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1302

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 4,   NA↝, 1,   NA?, 1,   NA∅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 9,   Catalase↑, 7,   DJ-1↓, 1,   ENOX2↑, 1,   Fenton↑, 4,   GCLC↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 30,   GPx4↑, 2,   GSH↓, 60,   GSH↑, 12,   GSH/GSSG↓, 10,   GSR↓, 1,   GSR↑, 3,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↓, 3,   H2O2↑, 8,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 22,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 19,   i-Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 10,   lipid-P↑, 41,   lipid-P↝, 1,   MDA↓, 4,   MDA↑, 20,   i-MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   mt-NADH↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 6,   Nrf1↑, 1,   NRF2↓, 27,   NRF2↑, 33,   NRF2↝, 1,   Prx↓, 1,   Prx3↑, 1,   Prx6↑, 1,   PrxII↓, 2,   RNS↑, 1,   ROS?, 3,   ROS↓, 38,   ROS↑, 412,   ROS⇅, 9,   ROS↝, 6,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↓, 2,   mt-ROS↑, 15,   selenoP↓, 1,   SOD↓, 13,   SOD↑, 11,   SOD1↓, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   mt-SOD2↑, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 2,   i-Thiols↓, 1,   TKT↓, 1,   TKT↝, 1,   Trx↓, 3,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 9,   TrxR1↓, 5,   TrxR1↑, 1,   xCT/SLC7A11↓, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 5,   IronCh↑, 4,   LIP↑, 1,   NCOA4↑, 2,   SFXN2↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 6,   compII↓, 1,   compIII↓, 3,   compV↓, 1,   EGF↓, 4,   ETC↓, 6,   HSP60/HSPD1↓, 2,   Insulin↓, 3,   KIF2C↓, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 2,   Mortalin↓, 1,   mtDam?, 1,   mtDam↑, 40,   OCR↓, 13,   OCR↑, 7,   mt-OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 10,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 2,   PHB↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 4,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 3,   ACOX1↑, 1,   ACSL1↓, 1,   ACSL4↑, 6,   ALAT↓, 5,   ALAT↑, 1,   ALDOA↓, 2,   ALDOB↑, 1,   AMP↑, 3,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 42,   p‑AMPK↑, 6,   ATP↓, 47,   ATP↑, 3,   e-ATP↑, 1,   i-ATP↓, 1,   i-ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 5,   CAIX/CA9↑, 1,   CBS↑, 1,   CPT1A↓, 1,   CPT1A↑, 1,   DGAT1↓, 1,   ECAR↓, 8,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   ENO3↑, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 12,   FASN↑, 1,   FBI-1↓, 1,   FBP1↑, 1,   FBPase↑, 1,   FDG↓, 1,   G6PD↓, 2,   GALNT10↓, 1,   GLO-I↓, 1,   GLS↓, 3,   glucoNG↓, 1,   glucoNG↑, 1,   glucose↓, 6,   GlucoseCon↓, 34,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 3,   Glycolysis↓, 84,   Glycolysis↑, 1,   Glycolysis↝, 1,   GPI↓, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 7,   H2S↑, 1,   ac‑Histones↑, 1,   HK1↓, 2,   HK2↓, 39,   HK3↑, 1,   HMG-CoA↓, 6,   HSD17B4↓, 1,   IDH1↓, 1,   lactateProd↓, 40,   lactateProd↑, 1,   LDHA↓, 19,   LDHA∅, 1,   LDL↓, 4,   LDL↑, 1,   lipidLev↓, 2,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 6,   O-Glc↓, 1,   PCK1↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 15,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 10,   PFK1↓, 6,   PFK2↓, 1,   PFKFB3↓, 2,   PFKFB4?, 1,   PGC1A↑, 1,   PGK1↓, 2,   PGK2↑, 1,   PGM1↓, 1,   PGM1↑, 1,   PGM3↑, 1,   PIP3↑, 1,   PKLR↑, 1,   PKM1↑, 1,   PKM2↓, 37,   PKM2↑, 1,   PKM2∅, 2,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 3,   PYGL↓, 1,   Pyrim↓, 1,   R5P↝, 1,   p‑S6↓, 2,   SCD1↓, 4,   SCP2↓, 1,   SIRT1↓, 8,   SIRT1↑, 10,   SIRT2↓, 1,   SIRT2↑, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 6,   SREBP2↓, 2,   TCA↓, 2,   TCA↑, 2,   TPI↓, 1,   TS↓, 3,   TumCM/A↓, 1,   UGDH↓, 2,   Warburg↓, 25,  

Cell Death(tgid=5) ⓘ

AIF↑, 12,   APAF1↑, 9,   Apoptosis?, 6,   Apoptosis↓, 20,   Apoptosis↑, 647,   mt-Apoptosis↑, 4,   ASC↑, 1,   BAD?, 1,   BAD↓, 3,   BAD↑, 19,   p‑BAD↓, 1,   Bak↑, 10,   BAX↓, 6,   BAX↑, 210,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 41,   Bcl-2↓, 223,   Bcl-2↑, 6,   Bcl-2↝, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 46,   Bcl-xL↑, 2,   BID↓, 1,   BID↑, 6,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 3,   Casp↑, 53,   Casp↝, 2,   cl‑Casp↑, 3,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 2,   Casp10∅, 1,   Casp12↑, 3,   Casp12↝, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 3,   Casp3↓, 7,   Casp3↑, 205,   Casp3↝, 2,   cl‑Casp3↓, 1,   cl‑Casp3↑, 84,   proCasp3↓, 1,   proCasp3↑, 3,   CASP4↑, 1,   Casp6↑, 1,   Casp7↓, 1,   Casp7↑, 27,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 44,   Casp8∅, 1,   cl‑Casp8↑, 9,   proCasp8↓, 1,   proCasp8↑, 3,   Casp9↑, 106,   p‑Casp9↑, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 22,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↑, 104,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   DR5∅, 1,   Endon↑, 4,   FADD↑, 8,   FADD∅, 1,   Fas↓, 2,   Fas↑, 21,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 47,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDMD↑, 2,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 11,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   ICAD↑, 1,   ICD↑, 2,   iNOS↓, 16,   Mcl-1↓, 29,   MDM2↓, 15,   p‑MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 8,   necrosis↑, 4,   NOXA↑, 4,   p38↓, 4,   p38↑, 26,   p‑p38↓, 4,   p‑p38↑, 8,   Paraptosis↑, 1,   Perforin↑, 1,   PUMA↓, 1,   PUMA↑, 7,   Pyro↑, 4,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 72,   TNFR 1↓, 1,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 36,   TumCD∅, 2,   TUNEL↑, 2,   XIAP↓, 31,   YAP/TEAD↓, 12,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 239,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 85,   p‑Akt↑, 2,   AKT1↓, 7,   Akt2↓, 3,   AKT3↓, 1,   AMPKα↓, 1,   AMPKα↑, 1,   BCAP↓, 1,   BRAF↓, 1,   CaMKII ↓, 3,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 2,   CREB2↓, 1,   cSrc↓, 3,   DDIT4↑, 1,   EGFR↓, 42,   p‑EGFR↓, 4,   ERK↓, 71,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 28,   p‑ERK↑, 6,   FGFR1↓, 2,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↓, 1,   IGF-1R↓, 10,   IGF-2R↑, 1,   IGFR↓, 4,   IKKα↓, 10,   IKKα↑, 3,   p‑IKKα↓, 2,   ILK↓, 1,   IR↓, 2,   IκB↓, 1,   JAK↓, 11,   JAK1↓, 9,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 6,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 7,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 49,   MAPK↑, 23,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 3,   p‑MEK↑, 1,   MKK4↓, 1,   mTOR?, 1,   mTOR↓, 124,   mTOR↑, 6,   mTOR⇅, 1,   p‑mTOR↓, 20,   mTORC2↓, 1,   mTORC2↑, 1,   p42↑, 1,   p70S6↓, 2,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 3,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K?, 1,   PI3K↓, 168,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 23,   PI3K/Akt↓, 6,   PI3k/Akt/mTOR↓, 1,   PI3K/mTOR/ETS2↓, 1,   PKA↓, 4,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 3,   PTEN↑, 29,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 13,   RIP1↓, 2,   RIP1↑, 1,   S6K↓, 1,   p‑S6K↓, 1,   SGK1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 15,   Src↓, 3,   p‑Src↓, 2,   STAT↓, 8,   p‑STAT↓, 1,   STAT3↓, 94,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 23,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 3,   STAT6↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↓, 2,   ATF3↑, 2,   ATF4↑, 14,   p‑ATF4↝, 1,   BRD4↓, 1,   CBP↓, 2,   CBP↑, 1,   ChrMod↑, 1,   cJun↓, 5,   cJun↑, 2,   p‑cJun↓, 1,   p‑cJun↑, 2,   cMyc↓, 54,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMT3A↓, 1,   DNMT3B↓, 2,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 3,   FOXO1↑, 4,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   GATA2↑, 1,   GATA3↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   H3K18↓, 1,   H3K27ac∅, 1,   H3K9↓, 2,   H4↑, 2,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 25,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HMTs↓, 1,   HOXB-AS1↓, 1,   IGF2BP3/IMP3/KOC↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   miR-106b↓, 2,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-130a↓, 3,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-143↑, 1,   miR-145↑, 1,   miR-148a↓, 1,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-19b↓, 2,   miR-205↑, 1,   miR-21↓, 12,   miR-21↝, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 2,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 6,   miR-375↓, 1,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-486↑, 1,   miR-490↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 5,   Myc↑, 1,   MYCN↓, 1,   MYCN↑, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 11,   OLIG2↓, 1,   other?, 1,   other↓, 5,   other↑, 12,   other↝, 38,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   SD↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 5,   TBX15↑, 1,   TFAP2A↓, 1,   TFE3↑, 1,   TLE1↓, 1,   tumCV↓, 115,   tumCV↑, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 5,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 26,   p‑CHOP/DDIT3↝, 1,   CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 8,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 53,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 15,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 5,   e-HSP70/HSPA5↓, 1,   HSP90↓, 21,   HSP90↑, 2,   HTRA↓, 1,   IRE1↓, 1,   IRE1↑, 3,   IRE1∅, 1,   p‑IRE1↑, 1,   NQO2↑, 1,   OTUB2↓, 1,   PDI↑, 2,   PERK↑, 13,   p‑PERK↝, 1,   Proteasome↓, 3,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 10,   mt-UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↓, 1,   ATG5↑, 10,   ATG7↑, 5,   autolysosome↑, 1,   Beclin-1/ATG6↓, 8,   Beclin-1/ATG6↑, 30,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↓, 1,   LC3B-II↑, 7,   LC3I↓, 1,   LC3II↓, 2,   LC3II↑, 19,   LC3s↓, 1,   LC3s↑, 2,   lysoMP↑, 2,   MitoP↓, 1,   p62↓, 13,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto?, 1,   TumAuto↓, 4,   TumAuto↑, 99,   TumAuto⇅, 1,   TumAuto↝, 2,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 1,   ATR↑, 4,   BRCA1↓, 3,   BRCA2↓, 1,   DNAdam↓, 5,   DNAdam↑, 95,   DNArepair↓, 5,   DNArepair↑, 3,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   FEN1↓, 2,   hTERT/TERT↓, 13,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   NKX3.1↑, 1,   P53?, 2,   P53↓, 6,   P53↑, 128,   P53⇅, 1,   P53↝, 4,   p‑P53↓, 1,   p‑P53↑, 6,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 24,   PARP↝, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 111,   PARP1↑, 4,   cl‑PARP1↑, 3,   PCNA↓, 44,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 13,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 17,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 27,   CDK1↑, 5,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 53,   CDK2↑, 6,   CDK4↓, 61,   CDK4↑, 3,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 19,   CDK6↑, 3,   CDK6∅, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 3,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↓, 4,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 6,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 144,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 1,   cycD1/CCND1∅, 1,   CycD3↓, 4,   cycE/CCNE↓, 33,   cycE/CCNE↑, 3,   cycE/CCNE↝, 1,   cycE1↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↓, 1,   GADD45A↑, 5,   Ki-67↓, 65,   MAD↓, 1,   mitA↑, 4,   MKI67↑, 1,   p19↑, 1,   P21↓, 5,   P21↑, 113,   P21↝, 1,   p‑P21↑, 1,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 35,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 4,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   RRM2↓, 1,   TAp63α↑, 1,   TumCCA?, 3,   TumCCA↓, 13,   TumCCA↑, 418,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   ALDH1A3↓, 1,   AXIN1↓, 1,   AXIN1↑, 3,   BMI1↓, 2,   BMP7/OP1↓, 2,   CD133↓, 15,   CD24↓, 6,   CD34↓, 2,   cFos↓, 7,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 62,   CSCs↑, 3,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 11,   EIF4E↓, 1,   EP2↓, 1,   EP4/PTGER4↓, 2,   FGF↓, 3,   GH↓, 1,   Gli1↓, 14,   HH?, 1,   HH↓, 22,   HMGCR↓, 2,   IGF-1↓, 10,   IGF-1↑, 1,   IGF-2↓, 1,   IGF-2↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 65,   Let-7↑, 3,   LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 4,   Nanog↓, 11,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 2,   NOTCH↓, 14,   NOTCH↑, 2,   NOTCH1↓, 11,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGF↑, 1,   OGFr↑, 4,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   SCF↓, 1,   Shh↓, 10,   Smo↓, 6,   Smo∅, 1,   TAZ↓, 2,   TumCG?, 3,   TumCG↓, 213,   TumCG↑, 7,   TumCG↝, 1,   TumCG∅, 1,   TumCP?, 6,   TumCP↓, 1259,   TumCP↑, 26,   TumCP⇅, 6,   TumCP∅, 5,   p‑TumCP↓, 1,   tyrosinase↓, 2,   WDR72↓, 1,   Wnt↓, 57,   Wnt/(β-catenin)↓, 9,   ZFX↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 12,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2?, 1,   Ca+2↓, 3,   Ca+2↑, 36,   Ca+2↝, 2,   i-Ca+2↑, 3,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCAT1↓, 2,   CCN2/CTGF↓, 3,   CD11b↑, 1,   CD38↓, 1,   CD38↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1A1↓, 1,   COL3A1↓, 1,   COL4A3↓, 1,   E-cadherin↓, 10,   E-cadherin↑, 62,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 117,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 13,   FAK↑, 2,   p‑FAK↓, 5,   Fibronectin↓, 5,   Furin↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 2,   MET↓, 2,   MET↑, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 2,   MMP17↓, 1,   MMP2↓, 102,   proMMP2↓, 1,   MMP3↓, 8,   MMP7↓, 7,   MMP9↓, 139,   MMP9↑, 2,   MMPs↓, 31,   MMPs↝, 1,   MTA1↓, 1,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin↓, 42,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 1,   NEDD9↓, 1,   p44↓, 1,   p44↑, 1,   p‑p44↓, 1,   PAK1↓, 3,   pax↓, 2,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 16,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 2,   p‑SMAD2↓, 5,   SMAD3↓, 5,   SMAD3↑, 1,   p‑SMAD3↓, 3,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 32,   Snail↑, 1,   SPARC↑, 2,   STAC2↓, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 21,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 2,   TIMP1↑, 14,   TIMP2↓, 1,   TIMP2↑, 11,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 2,   TumCA↓, 6,   TumCA↑, 1,   TumCI↓, 258,   TumCI↑, 4,   TumCMig?, 1,   TumCMig↓, 293,   TumCMig↑, 6,   TumMeta↓, 139,   TumMeta↑, 9,   TumPF↓, 1,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 3,   uPA↓, 16,   uPAR↓, 3,   UroPA↓, 1,   Vim?, 1,   Vim↓, 52,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 7,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 4,   α-SMA↑, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 77,   β-catenin/ZEB1↑, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 162,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 4,   EGR1↓, 1,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 6,   Hif1a↓, 84,   Hif1a↑, 2,   Hif1a↝, 1,   Hypoxia↓, 2,   LOX1↓, 1,   NO↓, 7,   NO↑, 5,   PGI2↓, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 4,   VEGF↓, 120,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 15,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 2,   BBB↑, 6,   BBB∅, 1,   CellMemb↑, 3,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 9,   GLUT1↓, 25,   GLUT1↑, 2,   GLUT1∅, 1,   GLUT2↓, 3,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT3∅, 1,   GLUT4↓, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 173,   MMP↑, 4,   MMP↝, 2,   MMP∅, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   OATPs↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 3,   TRPV1↝, 1,   VGCC↑, 2,   VGSC↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 3,   CD155↓, 2,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 19,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 11,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 3,   COX1↑, 1,   COX2/PTGS2↓, 85,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR4↓, 14,   DCells↑, 1,   DR4↑, 11,   DR4∅, 1,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   Gal-3↓, 3,   Gal1↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 9,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 2,   IL1↓, 3,   IL1↑, 2,   IL10↓, 2,   IL10↑, 2,   IL12↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 2,   IL2↓, 1,   IL2↑, 2,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 49,   IL6↑, 2,   IL8↓, 12,   IL8↑, 1,   Imm↑, 25,   Imm↝, 2,   Inflam↓, 65,   IRAK1↓, 1,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   pol-M1↑, 2,   M2 MC↓, 4,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 204,   NF-kB↑, 7,   NF-kB↝, 2,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 7,   NLRP3↓, 6,   NLRP3↑, 3,   NOD1↓, 1,   p50↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 10,   PD-L1↑, 3,   PGE2↓, 13,   PSA↓, 17,   SOCS-3↑, 1,   T-Cell↑, 4,   TCF↓, 5,   Th1 response↑, 2,   TIGIT↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 6,   TLR4↑, 2,   TNF-α↓, 42,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   TRADD↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 2,   pH↑, 1,   e-pH↑, 2,   i-pH↓, 1,   TAMS↓, 2,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   ChE↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 2,   ADRB2↓, 1,   AhR↓, 1,   AhR↑, 2,   AR↓, 24,   AR-V7?, 1,   COMT↓, 1,   CYP19?, 1,   CYP19↓, 2,   DHT↓, 1,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   NR1H4↑, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 2,   SRC3↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   AKR1B10↓, 1,   BioAv↓, 49,   BioAv↑, 50,   BioAv↝, 16,   BioEnh?, 1,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 4,   ChemoSen↑, 235,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 4,   CYP1A1↓, 3,   CYP1A1↑, 4,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↓, 2,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 11,   Dose↓, 3,   Dose↑, 7,   Dose⇅, 3,   Dose↝, 108,   Dose∅, 9,   DrugR↓, 2,   eff?, 1,   eff↓, 104,   eff↑, 145,   eff⇅, 3,   eff↝, 14,   eff∅, 4,   GSTA1↓, 1,   GSTA1↑, 1,   GSTP1/GSTπ↑, 1,   GSTZ1↓, 1,   Half-Life↓, 12,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 11,   MRP↓, 1,   MRP1/ABCC1↓, 5,   MRP2↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS?, 1,   RadioS↑, 63,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 150,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 98,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 5,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 3,   ALP↑, 1,   AR↓, 24,   AST↓, 4,   AST↑, 1,   B2M↓, 1,   BloodF↓, 1,   BMD↑, 2,   BRAF↓, 1,   BRCA1↓, 3,   BUN↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 42,   p‑EGFR↓, 4,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 13,   IL6↓, 49,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 12,   LDH↑, 4,   LDH↝, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 5,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 10,   PD-L1↑, 3,   Polyps↓, 2,   PSA↓, 17,   TP53↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 9,   Tumccf↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 87,   AntiCan∅, 1,   antiD↑, 1,   antiNeop↑, 6,   AntiTum↓, 2,   AntiTum↑, 37,   cachexia↓, 3,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 48,   chemoPv↑, 32,   ChemoSideEff↓, 5,   ChemoSideEff∅, 1,   fatigue↓, 1,   FTO↓, 1,   FTO↑, 2,   hepatoP↓, 1,   hepatoP↑, 9,   kidSt↓, 1,   neuroP↓, 1,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↑, 30,   OS∅, 1,   Pain↓, 3,   PFS↑, 1,   PFS∅, 1,   Pin1↓, 2,   QoL↑, 11,   QoL∅, 1,   radioP↑, 15,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 39,   Risk↑, 1,   Strength↑, 1,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 42,   toxicity↑, 6,   toxicity⇅, 1,   toxicity↝, 14,   toxicity∅, 3,   TumNum?, 1,   TumNum↓, 2,   TumVol?, 1,   TumVol↓, 58,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 30,   TumW∅, 1,   Weight↑, 1,   Weight∅, 4,   Wound Healing↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 2,   Bacteria↓, 2,   GutMicro↑, 11,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 4,   Ingr↑, 1,   Ingr↝, 18,  
Total Targets: 1504

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 8,   antiOx↑, 101,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 33,   Fenton↓, 1,   GPx↑, 26,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 2,   GSH↑, 31,   GSR↑, 7,   GSTs↑, 8,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 21,   hyperG↓, 1,   hyperG↝, 1,   Keap1↓, 4,   Keap1↝, 1,   lipid-P↓, 26,   MDA↓, 20,   MDA↑, 1,   MPO↓, 4,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 4,   NRF2↓, 2,   NRF2↑, 40,   RNS↓, 5,   ROS?, 3,   ROS↓, 83,   ROS↑, 7,   ROS⇅, 1,   ROS∅, 1,   mt-ROS?, 1,   selenoP↑, 1,   SOD↑, 36,   SOD1↑, 6,   SOD2↑, 3,   TAC↑, 4,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ACSL4↓, 1,   ALAT↓, 9,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 6,   CRM↑, 1,   ECAR↓, 1,   ECAR∅, 1,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 4,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 2,   NADPH↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 5,   ASC↓, 1,   BAX↓, 3,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 8,   Casp3↑, 2,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Fas↓, 2,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 11,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 3,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 6,   Akt↝, 1,   p‑Akt↑, 2,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   p‑JNK↓, 4,   MAPK↓, 7,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 5,   PKCδ↓, 1,   PKCδ↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 4,   other↑, 3,   other↝, 8,   PhotoS↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   P53↑, 1,   PARP↑, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   Diff↑, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   HH↓, 1,   neuroG↑, 2,   NOTCH↓, 1,   TumCP↓, 10,   TumCP↑, 1,   Wnt↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   EMT↑, 1,   FAK↑, 1,   LAMs↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 2,   Smad1↑, 1,   TGF-β↓, 2,   TGF-β↑, 3,   TumCI↓, 2,   TumCMig↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 11,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 6,   BBB↝, 1,   GastroP↑, 3,   GLUT1↓, 1,   GLUT2↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 4,   MMP∅, 1,   SVCT-2↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX1↓, 4,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 6,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 22,   IL2↓, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IL8↓, 4,   Imm↑, 11,   Imm⇅, 1,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 106,   Inflam↑, 1,   IRF3↓, 2,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MCP1/CCL2↑, 1,   MyD88↓, 2,   NF-kB?, 1,   NF-kB↓, 28,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 6,   NLRP3↑, 2,   p65↓, 1,   PGE2↓, 6,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 6,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 29,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 7,   proBDNF↑, 1,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 10,   BACE/β-secretase↓, 3,   tau↓, 1,   p‑tau↓, 3,   XO↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   Estro↓, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 37,   BioAv↑, 49,   BioAv↝, 21,   BioEnh↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 15,   eff↓, 1,   eff↑, 9,   eff↝, 2,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 2,   AST↓, 10,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 7,   creat↓, 2,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IRes↝, 1,   LDH↓, 4,   NOS2↓, 2,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 7,   antiAll↑, 13,   AntiArt↑, 6,   AntiCan↓, 2,   AntiCan↑, 21,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 3,   AntiDiabetic↑, 22,   antiPs↑, 2,   AntiTum↑, 9,   ANXi↓, 1,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 34,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 5,   cognitive↓, 1,   cognitive↑, 16,   diuretic↑, 2,   hepatoP↓, 2,   hepatoP↑, 37,   Learn↑, 1,   memory↑, 14,   Mood↑, 1,   motorD↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 59,   Obesity↓, 15,   OS↑, 1,   Pain↓, 1,   QoL↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 14,   Risk↓, 2,   Sleep↑, 2,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 48,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 12,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 4,   AntiP↓, 1,   AntiP↑, 3,   AntiViral↑, 13,   Bacteria↓, 21,   GutMicro↑, 16,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   GA↑, 1,   Ingr↑, 2,   Ingr↝, 7,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 448

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
44 Curcumin
25 Quercetin
24 Luteolin
24 Thymoquinone
23 Magnetic Fields
23 Shikonin
19 EGCG (Epigallocatechin Gallate)
19 Sulforaphane (mainly Broccoli)
18 Berberine
18 Resveratrol
18 Matrine
17 Phenethyl isothiocyanate
17 Kaempferol
17 Licochalcone A
16 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Baicalein
14 Cisplatin
14 Apigenin (mainly Parsley)
14 Melatonin
14 Capsaicin
14 phytic acid, Inositol hexakisphosphate
13 Propolis -bee glue
13 Formononetin
13 Honokiol
13 Magnolol
12 Artemisinin
12 Fisetin
12 Garcinol
12 Lycopene
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Boron
11 Metformin
11 Crocetin
11 Emodin
11 Isorhamnetin
11 Juglone
11 Nimbolide
10 Chrysin
10 itraconazole
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Flaxseed/Linseed
9 Gallic acid
9 Hyperoside
9 Ivermectin
8 Citric Acid
8 5-fluorouracil
8 chitosan
8 Beta-Caryophyllene
8 chaetocin
8 Dandelion Root
8 HydroxyTyrosol
8 Isobavachalcone
8 Isoliquiritigenin
8 Licorice
7 Astragalus
7 Benzyl isothiocyanate
7 Anethole/trans-Anethole
7 Paclitaxel/Taxol
7 Bufalin/Huachansu
7 Centella asiatica / Gotu kola → asiaticoside
7 Eugenol
7 Evodiamine
7 Ferulic acid
7 Gambogic Acid
7 Ginkgetin
7 isoorientin
7 Linalool
7 mebendazole
7 Mangiferin
7 Piperlongumine
6 Boswellia (frankincense)
6 Chemotherapy
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Carvone
6 Cucurbitacin
6 Diclofenac
6 Diindolylmethane
6 Ellagic acid
6 isoquercitrin
6 Lemongrass Extract/Citral
6 Morin
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Phenylbutyrate
6 salinomycin
6 Zyflamend
5 Allyl isothiocyanate
5 DTS(dibenzyl trisulphide) from Anamu
5 Gemcitabine (Gemzar)
5 Betulinic acid
5 Carvacrol
5 Cinnamon
5 Copper and Cu NanoParticles
5 Deguelin
5 Indole-3-carbinol
5 D-limonene
5 Fucoidan
5 Galloflavin
5 Geraniol
5 Hydrogen Gas
5 Helleborus niger extracts – Christmas Rose
5 low dose naltrexone
5 Magnetic Field Rotating
5 Patchouli Oil (Pogostemon cablin)
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Atorvastatin
4 brusatol
4 Celecoxib
4 Chlorogenic acid
4 Chlorophyllin
4 Photodynamic Therapy
4 Date Fruit Extract
4 Disulfiram
4 Genistein (soy isoflavone)
4 Fenbendazole
4 Ginger/6-Shogaol/Gingerol
4 iodine
4 Inositol
4 Lutein
4 Marjoram (Origanum majorana)
4 Phycocyanin
4 Piperine
4 Ursolic acid
3 1,8-Cineole
3 Alpha-Lipoic-Acid
3 Andrographis
3 Isovitexin
3 Aspirin
3 immunotherapy
3 Docetaxel
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Cynaropicrin
3 Dichloroacetate
3 diet Methionine-Restricted Diet
3 Ginkgo biloba-EGb 761
3 Ginkgo biloba
3 Ginkgolide B
3 Vitamin C (Ascorbic Acid)
3 Lactoferrin/Talactoferrin
3 Methylene blue
3 Moringa oleifera
3 Mushroom Chaga, Inonotus obliquus
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Selenium
3 Sesamin
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Walnut
3 Zerumbone
2 Sorafenib (brand name Nexavar)
2 3-bromopyruvate
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Biochanin A
2 Isothiocyanates
2 Brucea javanica
2 Bacopa monnieri
2 Beetroot
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Carica papaya leaf extract
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dichloroacetophenone(2,2-)
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Echinacea
2 Eurycomanone
2 Flaxseed Oil
2 Arsenic trioxide
2 Ginkgolic acids
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Grapeseed extract
2 hydrogen sulfide
2 doxorubicin
2 Laetrile B17 Amygdalin
2 lambertianic acid
2 Lapachol
2 SDG/lignans
2 Mung Bean Sprouts
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Methylsulfonylmethane
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 EMF
2 Rutin
2 α-Santalol/Sandalwood oil
2 Sulfasalazine
2 Salvia miltiorrhiza
2 Vitamin D3
1 2-DeoxyGlucose
1 Açaí, Euterpe oleracea
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Bullatacin
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Camu camu
1 Camptothecin
1 irinotecan
1 Cranberry
1 CUSP9
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 Electrical Pulses
1 Exercise
1 Vitamin E
1 ferumoxytol
1 Trastuzumab
1 tamoxifen
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Ginseng
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Hyperthermia
1 Inoscavin A
1 Recombinant Methioninase
1 L-Theanine
1 Lactobacillus
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 methylseleninic acid
1 Caffeine
1 Magnesium
1 Methylglyoxal
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 magnetic nanoparticles
1 Mucuna pruriens/Velvet Bean
1 Mushroom Maitake
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin-A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Purple Corn / Purple Maize
1 xanthohumol
1 Pomi-T
1 Propranolol
1 Gold NanoParticles
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Oxaliplatin
1 Selenium NanoParticles
1 Lignans
1 diet Plant based
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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