Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
7605- I3C,    Indole-3-carbinol and prostate cancer
- Review, Pca, NA
Risk↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, ChemoSen↑,
7608- I3C,    Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells
- in-vitro, Pca, PC3
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, Akt↓, EGF↓, PI3K↓, Bcl-xL↓, BAD↓,
7609- I3C,    Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives
- Review, Var, NA
AntiCan↑, tumCV↓, HIF-1↓, NF-kB↓, IGF-1↓, PI3K↓, Akt↓, Wnt↓, EstroRS/ERS↓,
7610- I3C,    Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line
- in-vitro, BC, MDA-MB-468 - in-vitro, Nor, HBL-100 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
Akt↓, selectivity↑, Apoptosis↑,
7585- I3C,    Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells
- in-vitro, BC, NA
Apoptosis↑, selectivity↑, Akt↓, NF-kB↓,
7589- I3C,    Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells
- vitro+vivo, Laryn, HEp2
TumCP↓, Apoptosis↑, PI3K↓, Akt↓, GSK‐3β↓, TumVol↓, *toxicity↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, AntiCan↑, Apoptosis↑, Akt↓, ERK↓, *antiOx↑, *Inflam↓, *neuroP↑, *toxicity↓, selectivity↑,
7802- IBC,    Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression
- in-vitro, NA, HepG2
TumCD↑, Apoptosis↑, ROS↑, mtDam↑, p‑Akt↓, eff↓,
7806- IBC,    Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway
- in-vitro, PC, NA
TumCP↓, EGF↓, PI3K↓, Akt↓, Casp3↑, BAX↑,
7808- IBC,    Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells
- in-vitro, Tong, Tca8113
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, Casp↑, p‑Akt↓, ERK↓, MMP2↓, MMP9↓,
7809- IBC,    Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways
- in-vitro, GC, MGC803
TumCMig↓, TumCI↓, Akt↓, ERK↓, BAX↑, Bcl-2↓, Casp3↑,
7775- IBC,    Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells
- vitro+vivo, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Necroptosis↑, TumAuto↑, Akt↓, BAX↑, cl‑Casp3↑, RIP3↑, p‑RIP3↑, MLKL↑, LC3‑Ⅱ/LC3‑Ⅰ↑, mtDam↑, ATP↓, ROS↑, TumCG↓,
7774- IBC,    Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, BAX↑, XIAP↓, survivin↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, GSK‐3β↓,
7773- IBC,    Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells
- in-vitro, Var, NA
Akt↓,
7628- Ins,    Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line
- in-vitro, Pca, DU145
tumCV↓, annexin II↓, Cofilin↓, Rho↑, APAF1↑, TRAF2↑, Apoptosis↑, PI3K↓, Akt↓,
7617- Ins,    miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting
- in-vitro, BC, NA
PI3K↓, Akt↓, TumMeta↓, miR-125b↝, IP6K1↓,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, VEGF↓, Imm↑, NK cell↑, eff↑, PI3K↓, Akt↓, EMT↓, MAPK↓, Wnt↓, NF-kB↓, IRes↓, *ROS↓, TumVol↓, *TSHR↓,
7641- Ins,    Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
- Review, CRC, NA
AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, eff↑,
7632- Ins,    The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor
- Review, Var, NA
AMPK↑, AntiCan⇅, p‑Akt↓, PI3K↓,
7654- IP,    Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations
- in-vivo, BC, NA
TumCG↓, GutMicro↑, PA↑, HDAC2↓, HDAC8↓, DNMT3B↓, Akt↓, PI3K↓, NF-kB↓, Dose↝, Dose↝,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7724- IP6,    Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway
- in-vitro, Cerv, HeLa
NF-kB↓, Akt↓, MMP↓, Cyt‑c↑, Apoptosis↑, Casp3↑, Casp9↑, PARP↑, eff↑,
7726- IP6,    Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation
- in-vitro, BC, MCF7
AntiCan↑, PKCδ↑, ERK↓, Akt↓, p27/CDKN1B↑, p‑pRB↓,
7645- IP6,  Ins,    Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview
AntiCan↑, TumCP↓, Apoptosis↑, Diff↑, p27/CDKN1B↓, pRB↓, PI3K↓, RAS↓, ERK↓, Akt↓, NF-kB↓, Inflam↓, AntiTum↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, eff↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7704- IP6,    Inositol hexaphosphate hydrolysate competitively binds to AKT to inhibit the proliferation of colon carcinoma
- in-vitro, CRC, SW-620
TumCG↓, Akt↓, other↝,
7763- ISL,    Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer
AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,
7745- ISL,    Isoliquiritigenin inhibits colorectal cancer progression by targeting the FGFR4/FASN mediated lipid metabolism pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, TumCMig↓, FASN↓, FGFR4/CD334↓, PI3K↓, Akt↓,
7746- ISL,    Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HCT116
AntiCan↑, tumCV↓, Apoptosis↑, TumCCA↑, TumCG↓, PI3K↓, Akt↓, p‑Akt↓, p‑GSK‐3β↓, CDK1↓, NF-kB↓, Bcl-2↓, ERβ/ESR2↑, BAX↑, Bax:Bcl2↑, ROS↑,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7730- isoFl,    Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years
- Review, Var, NA
Apoptosis↑, ROS↓, TumCCA↓, TumCMig↓, TumCI↓, MMP↓, angioG↓, ChemoSen↑, p‑Akt↓, p‑mTOR↓, cl‑PARP↑, cycA1/CCNA1↓, CycB/CCNB1↓, STAT3↓,
7869- isoO,    Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology
- in-vitro, GC, HGC27
TumCP↓, TumCMig↓, TumCI↓, BAX↑, Casp3↑, p‑PI3K↓, p‑Akt↓, Bcl-2↓, TumCCA↑, ROS↑,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7855- isoO,    Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, HL7702
TumAuto↑, Beclin-1↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
7872- isoO,    Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
- in-vivo, Arthritis, NA
*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7793- ISQ,    Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, ROS↑, AMPK↑, Glycolysis↓, p‑PI3K↓, p‑Akt↓, Casp↑, mTOR↓, ACC↓, FASN↓,
7797- ISQ,    Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway
- vitro+vivo, ESCC, KYSE-510 - in-vitro, ESCC, KYSE450
TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,

Showing Research Papers: 501 to 550 of 810
Prev Page 11 of 17 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 810

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   CTSK↓, 1,   DHODH↓, 1,   FGFR4/CD334↓, 1,   ILK↓, 1,   IP6K1↓, 1,   IRes↓, 1,   PA↑, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   TF-Ag↓, 1,   TRAF2↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   i-Iron↑, 1,   OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 12,   SOD1↓, 1,   SOD2↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   EGF↓, 2,   Insulin↓, 1,   MMP↓, 4,   MPT↑, 1,   mtDam↑, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALDOA↓, 1,   AMPK?, 1,   AMPK↑, 2,   ENO1↓, 1,   FASN↓, 2,   glucose↝, 1,   Glycolysis↓, 3,   lactateProd↓, 1,   LDHA↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   PPARγ↑, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 37,   p‑Akt↓, 10,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 22,   BAD↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-xL↓, 1,   Casp↑, 5,   Casp3↑, 7,   cl‑Casp3↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 5,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   JNK↑, 2,   MAPK?, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MLKL↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 3,   p38↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 2,   pRB↓, 2,   p‑pRB↓, 3,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA1↝, 1,   BRCA2↑, 1,   DNAdam↑, 2,   DNMT3B↓, 1,   DNMTs↓, 1,   P53↓, 1,   PARP↑, 1,   cl‑PARP↑, 8,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 3,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 2,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   P21↓, 2,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 1,   Diff↑, 4,   EMT↓, 4,   ERK↓, 7,   FOXO4↑, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 2,   HDAC↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   IGF-1↓, 2,   miR-125b↝, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 26,   p‑PI3K↓, 2,   RAS↓, 2,   STAT3↓, 2,   STAT3↑, 1,   TOP2↑, 1,   TumCG↓, 8,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   Ca+2↑, 1,   CD31/PECAM-1↓, 1,   Cofilin↓, 2,   E-cadherin↑, 1,   ER-α36↓, 1,   fascin↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   PKCδ↑, 1,   Rho↑, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 1,   Snail↓, 1,   TIMP1↓, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 14,   TumMeta↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 3,   IκB↑, 1,   NF-kB?, 1,   NF-kB↓, 18,   NK cell↑, 3,   PGE2↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   ERβ/ESR2↑, 1,   EstroRS/ERS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   ChemoSen↑, 8,   Dose↑, 1,   Dose↝, 6,   eff↓, 4,   eff↑, 5,   Half-Life↓, 2,   RadioS↑, 2,   selectivity↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↑, 1,   BRCA1↝, 1,   EstroRS/ERS↓, 1,   GutMicro↑, 3,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12,   AntiCan⇅, 1,   AntiTum↓, 1,   AntiTum↑, 1,   chemoP↑, 3,   neuroP↑, 1,   OS↑, 1,   QoL↑, 2,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 3,   TumVol↓, 3,   TumW↓, 3,  
Total Targets: 218

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,   FFA/NEFA↓, 1,   IRes↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 1,   HO-1↑, 2,   Iron∅, 1,   Keap1↓, 1,   lipid-P↓, 1,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 4,   ROS↓, 7,   SOD↑, 2,   Trx1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 2,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   p‑AMPK↑, 1,   p‑CREB↑, 1,   FASN↓, 1,   glucose↝, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Akt↝, 1,   p‑Akt↑, 2,   Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↝, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↑, 2,   PI3K↓, 1,   PI3K↑, 1,   p‑PI3K↑, 1,   STAT3↝, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   TGF-β↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,   PGE2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF⇅, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   neuroP↑, 4,   toxicity↓, 3,  
Total Targets: 64

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
39 Curcumin
28 Quercetin
25 Thymoquinone
25 Apigenin (mainly Parsley)
22 Fisetin
21 Baicalein
20 Resveratrol
16 Berberine
16 Chrysin
14 Shikonin
13 Alpha-Lipoic-Acid
12 Emodin
12 Sulforaphane (mainly Broccoli)
11 Magnetic Fields
11 Formononetin
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 HydroxyTyrosol
9 Isobavachalcone
9 Inositol
9 Magnolol
8 5-fluorouracil
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Garcinol
8 Hyperoside
8 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 isoorientin
8 Piperlongumine
8 Urolithin
7 Isovitexin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 Radiotherapy/Radiation
7 Gambogic Acid
7 Indole-3-carbinol
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 Celastrol
6 Dandelion Root
6 Ferulic acid
6 Fucoidan
6 Gallic acid
6 Isoliquiritigenin
6 Vitexin
6 Luteolin
5 Allicin (mainly Garlic)
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Ginkgolide B
5 Ginseng
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Caffeic acid
4 Celecoxib
4 Ginkgetin
4 Hydrogen Gas
4 Hibiscus sabdariffa
4 Juglone
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 3-bromopyruvate
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Paclitaxel/Taxol
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Thymol-Thymus vulgaris
3 chaetocin
3 Hydroxycinnamic-acid
3 Cucurbitacin
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Evodiamine
3 Ginger/6-Shogaol/Gingerol
3 Grapeseed extract
3 isoquercitrin
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geldanamycin
2 Genistein (soy isoflavone)
2 Geraniol
2 Huperzine A/Huperzia serrata
2 Inulin Prebiotic
2 Melatonin
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 chemodynamic therapy
1 Camptothecin
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 Trastuzumab
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Cynaropicrin
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Bortezomib
1 chitosan
1 Ginkgolic acids
1 Ginkgo biloba
1 Gossypol/AT-101
1 Graviola
1 hydrogen sulfide
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 isoflavones
1 itraconazole
1 Laetrile B17 Amygdalin
1 Licorice
1 Mung Bean Sprouts
1 MCToil
1 Metformin
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Phenolic Acids
1 Psoralidin
1 Rhein
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 acetazolamide
1 statins
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page