COX2/PTGS2 Cancer Research Results

COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
5339- TFdiG,    Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line
- in-vitro, CRC, HCT116
eff↑, TumCCA↑, Inflam↓, COX2/PTGS2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, EP2↓, EP4/PTGER4↓,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, Synergy↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2/PTGS2↓, PGE1↓,
7938- TQ,    The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma
- in-vivo, Asthma, NA
*Dose↝, *Eos↓, *IFN-γ↑, *Inflam↓, *IL4↓, *antiOx↑, *NO↓, *COX2/PTGS2↓, *5LO↓, *antiAll↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑, *antiAll↑,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, Nor, NA
*COX2/PTGS2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
2136- TQ,    Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats
- in-vivo, Nor, NA
*COX2/PTGS2↓, *lipid-P↓, *SOD↑, *ROS↓, *Inflam↓, *NF-kB↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2088- TQ,    Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review
- Review, Nor, NA
*hepatoP↑, *lipid-P↓, *Thiols↑, *ROS↓, *Catalase↑, *SOD↑, *GSTs↑, *NF-kB↓, *COX2/PTGS2↓, *LOX1↓,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ChemoSen↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, Var, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2103- TQ,    Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
- in-vitro, PC, Hs766t - in-vitro, PC, MIA PaCa-2
MCP1/CCL2↓, TNF-α↓, IL1β↓, COX2/PTGS2↓, NF-kB↓, HDAC↓, P21↑,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
3405- TQ,  doxoR,    Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism
- vitro+vivo, CardioV, NA
*cardioP↑, *NRF2↑, *HO-1↑, *ROS↓, *NQO1↑, *COX2/PTGS2↓, *NOX4↓, *GPx4↑, *FTH1↑, *p‑mTOR↓, *TGF-β↓,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1/CCL2↓, *CXCc↓, *ROS↓, *antiAll↑,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, Var, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2/PTGS2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2/PTGS2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, CompStab↝, TumCG↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓, *antiAll↑, *Eos↓, *CD31/PECAM-1↓, *α-SMA↓,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
6452- TUR,    Turmeric Essential Oil Constituents as Potential Drug Candidates: A Comprehensive Overview of Their Individual Bioactivities
- Review, Nor, NA
Dose↝, Casp3↑, MMP9↓, COX2/PTGS2↓, NF-kB↓, PI3K↓, Akt↓, ERK↓, Inflam↓, TNF-α↓, IL6↓, IL17↓, IL22↓, IL23↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
4877- Uro,    Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *memory↑, *neuroP↑, *NRF2↑, *ROS↓, *Inflam↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
1218- VitC,  ASA,    Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
- in-vitro, GBM, SK-N-SH
PGE2↓, COX2/PTGS2↓,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2/PTGS2↓, ER Stress↑, IRE1↑, JNK↑, CHOP/DDIT3↑, Hif1a↓, Synergy↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, Synergy↑, TET1↑,
2277- VitK2,    Vitamin K2 suppresses rotenone-induced microglial activation in vitro
- in-vitro, Nor, BV2 - NA, AD, NA - NA, Park, NA
*p38↓, *ROS↓, *Casp1↓, *MMP↑, *NF-kB↓, *IL1β↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*ALB↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, *Learn↑, *memory↑, *AChE↓, *lipid-P↓, *TOS↓, *MDA↓, *ONOO↓, *NO↓, *NOS2↓, *TAC↑, *BDNF↑, *GDNF↑, *PSD95↑, *GFAP↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *neuroP↑, *NeuroI↓,
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
- Study, BC, NA
Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2/PTGS2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,
2427- Wog,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
NO↓, PGE2↓, COX2/PTGS2↓, Ca+2↑, mtDam↑, *toxicity↓, ChemoSen↑, eff↓,
5015- Xan,  PEITC,    Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
- in-vitro, HCC, HepG2
NRF2↓, ROS↑, NF-kB↓, COX2/PTGS2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2/PTGS2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,
9131- ZYF,    Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets
- vitro+vivo, PC, NA
TumCP↓, ChemoSen↑, Apoptosis↑, NF-kB↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, Bcl-2↓, IAP1↓, VEGF↓, survivin↓, ICAM-1↓, CXCR4↓, TumCG↓, Ki-67↓, MMP9↓,
9130- ZYF,    Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products
- in-vitro, Var, NA
NF-kB↓, Synergy↑, angioG↓, VEGF↓, COX2/PTGS2↓, MMP9↓, TumCI↓,
9129- ZYF,    Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation
- in-vitro, Pca, PC3
Inflam↓, COX1↓, COX2/PTGS2↓, 5LO↓, 5-HETE↓, TumCP↓, TumCCA↑, Apoptosis↑, 12LOX↓, p‑P21↑, pRB↓,
9128- ZYF,    Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression
- in-vitro, Pca, LNCaP
COX1?, COX2/PTGS2?, P21↑, TumCG↓, cl‑PARP↑, Casp3↑, Apoptosis↑, AR↓, STAT3↓, p‑PKCδ↓,

Showing Research Papers: 501 to 547 of 547
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 547

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 12,   Catalase↓, 5,   Catalase↑, 4,   Copper↓, 1,   GPx↓, 1,   GPx↑, 6,   GPx4↓, 5,   GSH↓, 21,   GSH↑, 10,   GSR↑, 2,   GSTs↓, 2,   GSTs↑, 3,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 16,   HO-2↓, 1,   Iron↑, 2,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 7,   lipid-P↑, 14,   MDA↓, 5,   MDA↑, 5,   MPO↓, 5,   NADH↓, 1,   NQO1↑, 3,   NRF2↓, 11,   NRF2↑, 31,   NRF2↝, 1,   Prx↑, 1,   Prx4↑, 1,   ROS↓, 36,   ROS↑, 162,   ROS⇅, 10,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 4,   SOD↓, 7,   SOD↑, 8,   SOD2↓, 4,   TBARS↑, 1,   Thiols↓, 2,   TrxR↓, 4,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 2,   Tf↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 5,   CDC25↓, 9,   EGF↓, 4,   ETC↓, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 3,   mitResp↑, 2,   MKK7↓, 2,   MKP5↑, 1,   mtDam?, 1,   mtDam↑, 11,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   SIRT3↓, 2,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5-HETE↓, 1,   5LO↓, 18,   AApath↓, 1,   ACC↑, 4,   p‑ACC↑, 1,   ACSL4↑, 1,   ALAT↓, 9,   ALAT↝, 1,   AMPK↓, 2,   AMPK↑, 26,   AMPK↝, 1,   p‑AMPK↑, 2,   ARG↓, 1,   ATP↓, 9,   ATP↑, 2,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 1,   ECAR↝, 1,   FASN↓, 4,   FASN↑, 1,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 9,   GlutMet↓, 1,   Glycolysis↓, 19,   GSK‐3β↓, 11,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 7,   HK2↓, 10,   HMG-CoA↓, 1,   lactateProd↓, 13,   lactateProd↑, 1,   LDHA↓, 5,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NADPH↓, 3,   NADPH↑, 3,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 9,   PDK3↑, 1,   PKM2↓, 9,   PLA2↓, 1,   SCD1↓, 1,   SHARP↑, 1,   SIRT1↓, 6,   SIRT1↑, 10,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 1,   TumCM/A↓, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 6,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 138,   Apoptosis↝, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 4,   Bak↓, 1,   Bak↑, 5,   BAX↓, 5,   BAX↑, 74,   BAX⇅, 1,   BAX↝, 2,   Bax:Bcl2↑, 26,   Bcl-2↓, 95,   Bcl-2↑, 3,   Bcl-2↝, 2,   Bcl-xL↓, 32,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 25,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 1,   Casp12↑, 2,   Casp3↓, 5,   Casp3↑, 106,   Casp3↝, 2,   cl‑Casp3↑, 17,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 15,   cl‑Casp7↑, 2,   Casp8↑, 31,   Casp8∅, 1,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 67,   cl‑Casp9↑, 9,   proCasp9↑, 1,   CellShr↑, 2,   cFLIP↓, 7,   Cyt‑c↓, 4,   Cyt‑c↑, 70,   Cyt‑c↝, 2,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 18,   Endon↑, 1,   FADD↑, 4,   Fap1↓, 1,   Fas?, 1,   Fas↑, 15,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 6,   GranB/GZMB↝, 1,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 18,   IAP2/BIRC3↓, 8,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 46,   JWA↑, 1,   Mcl-1↓, 21,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 8,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 2,   necrosis↑, 1,   NOXA↑, 2,   p38↓, 8,   p38↑, 19,   p‑p38↓, 2,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 5,   Pyro↑, 1,   RIP3↑, 1,   survivin↓, 57,   TNFR 1↑, 2,   TRAIL↑, 7,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 7,   TumCD∅, 1,   XIAP?, 1,   XIAP↓, 27,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 123,   Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 33,   AKT1↓, 1,   CK2↓, 4,   cMET↓, 3,   p‑cMET↑, 1,   CREB2↓, 1,   cSrc↓, 4,   EF-1α↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 51,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 14,   p‑ERK↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   GRB2↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 14,   HGF/c-Met↓, 1,   IGF-1R↓, 3,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 8,   p‑IKKα↓, 1,   IR↓, 1,   IκB↓, 3,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 6,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 12,   p‑JAK2↓, 1,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 18,   JNK↝, 1,   p‑JNK↓, 4,   MAP2K1/MEK1↓, 1,   MAPK↓, 28,   MAPK↑, 13,   MAPK↝, 3,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 7,   MKK4↓, 2,   MKP1↝, 1,   mTOR↓, 64,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 5,   mTORC2↓, 3,   p70S6↓, 2,   P70S6K↓, 2,   P90RSK↓, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 96,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 5,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PKA↓, 2,   PKCδ↓, 11,   p‑PKCδ↓, 1,   PTEN↑, 28,   PTEN↝, 1,   p‑PTEN↓, 1,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 15,   RAS↑, 1,   RIP1↑, 1,   RTK-RAS↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 6,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 5,   STAT3↓, 70,   STAT3↑, 3,   p‑STAT3↓, 14,   p‑STAT3↑, 1,   STAT4↓, 2,   STAT5↓, 2,   STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 2,   ATF4↑, 6,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 10,   cJun↑, 1,   p‑cJun↓, 1,   cMyc↓, 43,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 11,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 5,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 4,   FOXO3↑, 4,   FOXO3↝, 1,   H3↑, 2,   ac‑H3↓, 1,   ac‑H3↑, 3,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 3,   HATs↓, 9,   HATs↑, 2,   HDAC↓, 28,   HDAC1↓, 6,   HDAC2↓, 4,   HDAC3↓, 2,   HDAC6↓, 1,   HDAC8↓, 2,   HES1↓, 1,   Matr↓, 1,   miR-106b↓, 1,   miR-134↑, 1,   miR-145↑, 1,   miR-194↑, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-210↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   Myc↓, 7,   MYCN↓, 1,   n-MYC↓, 1,   NEAT1↓, 1,   OCT4↓, 8,   other↓, 6,   other↑, 3,   other⇅, 1,   other↝, 10,   other∅, 3,   PCAF↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 12,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 31,   GRP78/BiP↓, 2,   GRP78/BiP↑, 11,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 10,   HSP90↑, 1,   HSPs↓, 2,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 4,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 2,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 8,   p62↓, 3,   p62↑, 1,   TumAuto↑, 26,   TumAuto↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 2,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 2,   DNAdam↓, 3,   DNAdam↑, 47,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC1↓, 1,   hTERT/TERT↓, 7,   p16↑, 4,   P53?, 1,   P53↓, 4,   P53↑, 85,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 5,   PARP↑, 13,   PARP↝, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 55,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 28,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 5,   TOP2↓, 6,   TOP2↑, 2,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 2,   CDK1↓, 8,   CDK1↑, 4,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 44,   CDK2↑, 3,   CDK4↓, 48,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 18,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   Chk2↓, 2,   ChrCon↑, 1,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   CycB/CCNB1↓, 21,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 88,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 2,   cycE/CCNE↓, 23,   cycE/CCNE↑, 2,   cycE1↓, 1,   E2Fs↓, 6,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 22,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 5,   P21↑, 62,   P21↝, 2,   p‑P21↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 20,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 7,   Securin↓, 2,   TumCCA?, 3,   TumCCA↓, 5,   TumCCA↑, 146,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 2,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 6,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 8,   CSCs↓, 29,   Diff↓, 2,   Diff↑, 2,   EP2↓, 2,   EP4/PTGER4↓, 1,   FGF↓, 4,   Gli↓, 2,   Gli1↓, 5,   HH↓, 6,   Id1↓, 1,   IGF-1?, 1,   IGF-1↓, 8,   IGF-2↓, 1,   IGFBP3↑, 3,   Jun↓, 1,   Ki-67↓, 22,   Let-7↑, 3,   mTORC1↓, 5,   p‑mTORC1↓, 1,   Nanog↓, 9,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 13,   NOTCH1↓, 14,   NOTCH1↑, 2,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   SCF↓, 1,   Shh↓, 9,   Smo↓, 3,   STAT1↓, 2,   TAZ↓, 1,   TumCG↓, 43,   TumCG↑, 3,   TumCG∅, 1,   TumCP↓, 106,   tyrosinase↓, 1,   Wnt↓, 40,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 16,   AP-1↝, 1,   ARG1/2↑, 1,   ASAP2↓, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 6,   Ca+2↓, 2,   Ca+2↑, 23,   Ca+2↝, 2,   i-Ca+2?, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 3,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 39,   EFEMP↓, 1,   EMT↓, 62,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 15,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 7,   GIT1↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 3,   MMP2↓, 93,   MMP2↑, 1,   MMP2↝, 2,   MMP3↓, 5,   MMP7↓, 18,   MMP9↓, 134,   MMP9↑, 2,   MMP9↝, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 38,   MUC4↓, 4,   N-cadherin↓, 23,   p44↓, 1,   pax↓, 1,   PDGF↓, 8,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 5,   ROCK1↓, 6,   ROCK1↑, 1,   serineP↓, 1,   Slug?, 1,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD3↓, 2,   Snail?, 2,   Snail↓, 24,   SPARC↓, 1,   TET1↑, 3,   TGF-β↓, 20,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 9,   TIMP2↓, 2,   TIMP2↑, 12,   TIMP3↑, 1,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI↓, 57,   TumCMig↓, 57,   TumMeta↓, 62,   TumMeta↑, 4,   Twist↓, 20,   uPA↓, 27,   uPAR↓, 2,   Vim↓, 30,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 2,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 51,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 90,   angioG↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 6,   Hif1a↓, 60,   Hypoxia↓, 1,   LOX1↓, 4,   NO↓, 13,   NO↑, 3,   NO↝, 1,   PGI2↓, 1,   PHDs↓, 1,   VCAM-1↓, 4,   VEGF↓, 134,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 14,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   GLUT1↓, 11,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 71,   MMP↑, 3,   MPT↑, 3,   NHE1↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 1,   CD44↓, 9,   CD59↑, 1,   COX1?, 1,   COX1↓, 10,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 321,   COX2/PTGS2↑, 10,   COX2/PTGS2↝, 5,   COX2/PTGS2∅, 2,   CXCc↓, 2,   CXCL1↓, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 5,   Eos↑, 1,   FOXP3↓, 3,   FOXP3↑, 1,   FoxP3+↓, 1,   GM-CSF↓, 2,   HCAR2↑, 1,   HLA↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 7,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 11,   IL1↑, 1,   IL10↓, 10,   IL10↑, 2,   IL12↓, 4,   IL12↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 33,   IL1β↑, 2,   IL1β∅, 1,   IL2↓, 6,   IL2↑, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 3,   IL5↓, 1,   IL6↓, 71,   IL6↑, 2,   IL6↝, 1,   IL8↓, 18,   IL8↑, 2,   Imm↑, 10,   Imm↝, 1,   Inflam↓, 54,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 9,   MCT1↓, 2,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   mPGES-1↓, 2,   MyD88↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 207,   NF-kB↑, 6,   NF-kB↝, 1,   p‑NF-kB↓, 4,   p‑NF-kB↑, 2,   NK cell↑, 8,   NK cell⇅, 1,   NLRP3↓, 6,   p50↓, 2,   p65↓, 10,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 8,   PGD2↓, 1,   PGE1↓, 2,   PGE2↓, 56,   PGE2↑, 1,   PSA↓, 8,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 67,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TRADD↑, 1,   TRAF1↓, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ADRB2↓, 1,   AhR↓, 2,   AR↓, 14,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   CYP19↓, 1,   ER-α36↓, 2,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARα↓, 2,   PPARα↑, 3,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 13,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   AKR1B10↓, 1,   BioAv↓, 32,   BioAv↑, 28,   BioAv↝, 15,   BioEnh?, 1,   BioEnh↑, 4,   ChemoSen↓, 2,   ChemoSen↑, 124,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 5,   Dose↓, 1,   Dose↑, 11,   Dose⇅, 1,   Dose↝, 42,   Dose∅, 13,   eff↓, 18,   eff↑, 52,   eff↝, 11,   eff∅, 2,   GSTA1↑, 1,   GSTZ1↓, 1,   Half-Life↓, 12,   Half-Life↑, 2,   Half-Life↝, 11,   MDR1↓, 10,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 49,   selectivity?, 1,   selectivity↑, 53,   Synergy?, 1,   Synergy↓, 1,   Synergy↑, 94,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 9,   ALAT↝, 1,   ALP↓, 3,   ALP↝, 1,   AR↓, 14,   AR↝, 1,   ascitic↓, 2,   AST↓, 7,   AST↝, 1,   BloodF⇅, 1,   BMD↑, 1,   BP↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 7,   CYFRA21-1↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 5,   HER2/EBBR2↓, 14,   hTERT/TERT↓, 7,   IL6↓, 71,   IL6↑, 2,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 1,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 7,   NOS2↓, 3,   PD-L1↓, 8,   PSA↓, 8,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 2,   Tumccf↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↓, 3,   AntiCan↑, 41,   antiNeop↑, 3,   AntiTum↑, 12,   AntiTum⇅, 1,   BowelM↑, 1,   cachexia↓, 1,   cardioP↑, 12,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 36,   chemoPv↑, 22,   chemoPv⇅, 1,   ChemoSideEff↓, 5,   cognitive?, 1,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 13,   neuroP↑, 4,   NP/CIPN↓, 1,   Obesity↓, 1,   OS?, 1,   OS↑, 11,   Pain↓, 1,   QoL↑, 5,   radioP↑, 10,   RenoP↑, 9,   Risk↓, 18,   Symptoms∅, 1,   toxicity↓, 12,   toxicity↑, 1,   toxicity↝, 9,   toxicity∅, 1,   TumVol↓, 17,   TumW↓, 6,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 9,  
Total Targets: 1039

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 2,   antiOx↓, 9,   antiOx↑, 122,   ARE↑, 4,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 83,   Fenton↓, 2,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 59,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 73,   GSR↓, 1,   GSR↑, 11,   GSSG↓, 2,   GSTs↓, 3,   GSTs↑, 23,   H2O2↓, 6,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 61,   HO-1⇅, 1,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 66,   MDA↓, 60,   MDA↑, 1,   MPO↓, 13,   MPO↑, 1,   NADH↓, 1,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 11,   Nrf1↑, 1,   NRF2↓, 2,   NRF2↑, 92,   ONOO↓, 1,   Prx↑, 2,   RNS↓, 7,   ROS?, 1,   ROS↓, 206,   ROS↑, 2,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   SOD↓, 2,   SOD↑, 109,   SOD1↑, 3,   SOD2↑, 3,   TAC↑, 8,   TBARS↓, 4,   Thiols↑, 2,   TOS↓, 1,   TrxR↑, 2,   uricA↓, 2,   VitC↑, 3,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,   mitResp↑, 1,   mtDam↓, 3,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 3,   12LOX↑, 1,   15-LOX/ALOX15↓, 1,   5-HETE↓, 1,   5LO↓, 17,   5LO↝, 1,   Acetyl-CoA↓, 1,   ACSL4↓, 1,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 19,   AMPK↑, 11,   p‑AMPK↑, 1,   ATP↑, 6,   cAMP↑, 3,   cPLA2↓, 1,   cytoP450↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   Eic↓, 1,   FAO↑, 2,   FASN↓, 3,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK2↑, 1,   HMG-CoA↓, 2,   LDHA↓, 1,   LDL↓, 11,   lipidLev↓, 3,   LTC4↓, 1,   NAD↑, 2,   NADPH↓, 3,   NADPH↑, 3,   PGM1?, 1,   PKM2↓, 3,   SIRT1↑, 16,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 15,   ASC↓, 1,   BAX↓, 17,   Bcl-2↓, 3,   Bcl-2↑, 6,   Casp↓, 2,   Casp1↓, 3,   Casp3?, 1,   Casp3↓, 23,   Casp3∅, 1,   cl‑Casp3↓, 2,   Casp6↓, 1,   Casp8↓, 2,   Casp9↓, 12,   cl‑Casp9↓, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 1,   Fas↓, 3,   Ferroptosis↓, 3,   iNOS↓, 90,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 8,   p‑p38↓, 4,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 7,   p‑Akt↓, 1,   p‑Akt↑, 1,   AKT1↓, 1,   Akt2↓, 1,   CREB↑, 2,   p‑CREB↑, 1,   EGFR↓, 2,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 3,   p‑ERK↑, 2,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 6,   MAPK?, 1,   MAPK↓, 19,   MAPK↑, 3,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 2,   p‑MKK4↑, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 7,   PI3K↑, 4,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   MEF2D↑, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 13,   other↝, 10,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↑, 2,   LC3B↑, 1,   LC3II↑, 1,   MitoP↓, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 4,   p16↓, 1,   P53↓, 4,   P53↑, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 2,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 1,   EP2↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 4,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 22,   AP-1↓, 11,   BACH1↓, 1,   Ca+2↓, 8,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 3,   COL1↓, 1,   COL1↑, 1,   MLC2/MYL9↝, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 6,   MMP2↓, 6,   MMP3↓, 5,   MMP3↑, 1,   MMP9↓, 11,   MMP9↑, 1,   MMPs↓, 5,   MMPs↑, 1,   MUC1↑, 2,   p‑Rac1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β1↑, 1,   TIMP1↓, 2,   TIMP1↑, 2,   TumCI↓, 1,   TXNIP↓, 1,   α-SMA↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 2,   eNOS↓, 1,   Hif1a↓, 4,   LOX1↓, 2,   NO↓, 49,   NO↑, 2,   TXA2↓, 3,   VCAM-1↓, 7,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 23,   BBB↝, 3,   BBB∅, 2,   CLDN1↑, 3,   CLDN3↑, 1,   GastroP↑, 7,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 3,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MUC2↑, 1,   OCLN↑, 3,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 2,   TRPV3↑, 2,   VGSC↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   CB2 / CNR2↑, 3,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 15,   COX2/PTGS2?, 2,   COX2/PTGS2↓, 219,   COX2/PTGS2↑, 2,   COX2/PTGS2∅, 1,   CXCc↓, 1,   CXCR4↓, 2,   Eos↓, 2,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 8,   IFN-γ↑, 3,   IL1↓, 6,   IL10↓, 6,   IL10↑, 15,   IL12↓, 6,   IL17↓, 8,   IL18↓, 3,   IL1β↓, 89,   IL2↓, 7,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 96,   IL6↑, 2,   IL8↓, 19,   IL8↑, 1,   Imm↑, 13,   Imm⇅, 1,   INF-γ↓, 2,   Inflam?, 1,   Inflam↓, 201,   IRF3↓, 2,   LTA/TNF-β↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 7,   Neut↑, 1,   NF-kB↓, 128,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 3,   NLRP3↓, 20,   p65↓, 2,   PGD2↓, 2,   PGE2↓, 55,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 2,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 4,   TLR4↓, 20,   TLR4↑, 1,   TNF-α↓, 125,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,   β-HEX↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 4,   Ach↑, 5,   AChE↓, 30,   AChE↑, 1,   AChE∅, 1,   ADAM10↑, 1,   BChE↓, 7,   BChE∅, 1,   BDNF↑, 20,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 3,   EndoR↑, 1,   GABA↓, 1,   GABA↑, 1,   GDNF↑, 1,   MAOA↓, 3,   MAOA↑, 1,   monoA↑, 1,   NGF↑, 4,   PSD95↑, 3,   SNAP25↑, 2,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 1,   Aβ↓, 39,   Aβ42↓, 2,   BACE/β-secretase↓, 13,   tau↓, 10,   p‑tau↓, 6,   XO↓, 3,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   DHT↓, 1,   Estro↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 7,   testos↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 45,   BioAv↑, 59,   BioAv⇅, 1,   BioAv↝, 26,   BioEnh↑, 6,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP2E1↓, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 33,   eff↓, 2,   eff↑, 19,   eff↝, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 15,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 1,   P450↝, 1,   Synergy↑, 19,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 19,   ALB↑, 1,   ALP↓, 2,   AST↓, 24,   BG↓, 1,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 2,   BP↓, 10,   p‑BRCA1↑, 1,   Calcium↑, 1,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 4,   CRP↓, 9,   EGFR↓, 2,   hs-CRP↓, 1,   IL6↓, 96,   IL6↑, 2,   LDH↓, 11,   LDH↑, 1,   Mag↑, 1,   NOS2↓, 5,   PSA↓, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 25,   AntiArt↑, 6,   AntiCan↑, 19,   antiCG↑, 1,   AntiDiabetic↑, 18,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 65,   cardioP⇅, 1,   chemoP↑, 9,   chemoPv↑, 10,   cognitive↓, 2,   cognitive↑, 51,   cognitive↝, 1,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 51,   Learn↑, 5,   memory↑, 50,   Mood↑, 2,   motorD↓, 1,   motorD↑, 6,   Mucositis↓, 1,   neuroP↑, 131,   NP/CIPN↓, 2,   Obesity↓, 12,   OS↑, 5,   Pain↓, 14,   QoL↑, 1,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 20,   Risk↓, 1,   Sleep↑, 3,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 8,   toxicity↓, 38,   toxicity↑, 2,   toxicity↝, 11,   toxicity∅, 5,   Weight↓, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↓, 1,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 11,   Bacteria↑, 1,   Diar↓, 2,   GutMicro↑, 21,   GutMicro↝, 1,   Inf↓, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 1,   Ingr↝, 11,   Phen↑, 1,   QC↑, 1,  
Total Targets: 562

Scientific Paper Hit Count for: COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
29 Curcumin
25 Thymoquinone
19 Quercetin
18 Resveratrol
15 Fisetin
13 Lycopene
11 Celecoxib
11 Chrysin
11 Silymarin (Milk Thistle) silibinin
10 Apigenin (mainly Parsley)
10 Propolis -bee glue
10 Eugenol
9 Boswellia (frankincense)
9 Carvacrol
9 isoorientin
9 Sulforaphane (mainly Broccoli)
8 Berberine
8 Beta-Caryophyllene
8 Diclofenac
8 Honokiol
7 Artemisinin
7 EGCG (Epigallocatechin Gallate)
7 Kaempferol
7 Licorice
7 Luteolin
7 Rosmarinic acid
6 Chlorogenic acid
6 Ginger/6-Shogaol/Gingerol
5 Radiotherapy/Radiation
5 Baicalein
5 Echinacea
5 Ellagic acid
5 Ferulic acid
5 Garcinol
5 Magnetic Fields
5 Piperine
4 Aspirin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Cisplatin
4 lambertianic acid
4 Melatonin
4 Phycocyanin
4 Shikonin
4 Urolithin
4 Zyflamend
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Isovitexin
3 Betulinic acid
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cichoric acid / Chicoric acid
3 Chemotherapy
3 D-limonene
3 Dandelion Root
3 Formononetin
3 Gambogic Acid
3 Grapeseed extract
3 Isoliquiritigenin
3 Morin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Rutin
2 acetaminophen
2 Allicin (mainly Garlic)
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Baicalin
2 xanthohumol
2 Cannabidiol
2 Boron
2 buckwheat sprouts
2 Carnosic acid
2 Caffeic acid
2 Thymol-Thymus vulgaris
2 Chocolate
2 Crocetin
2 Ursolic acid
2 CUSP9
2 Docosahexaenoic Acid
2 Diindolylmethane
2 Emodin
2 Flaxseed/Linseed
2 Genistein (soy isoflavone)
2 Geraniol
2 Hydroxycinnamic-acid
2 Hyperoside
2 phytic acid, Inositol hexakisphosphate
2 Isorhamnetin
2 Vitexin
2 L-Theanine
2 Lemongrass Extract/Citral
2 Magnolol
2 Lemon Balm/Melissa officinalis
2 doxorubicin
2 Naringin
2 Nimbolide
2 Oleuropein
2 Oleocanthal
2 Piperlongumine
2 Sesamin
2 Vitamin C (Ascorbic Acid)
2 Vitamin K2
1 1,8-Cineole
1 3-bromopyruvate
1 Açaí, Euterpe oleracea
1 Auranofin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 Brucea javanica
1 brusatol
1 Beetroot
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 cannabidiolic acid
1 Celastrol
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Galantamine
1 Docetaxel
1 Oxygen, Hyperbaric
1 Lecithin
1 Dichloroacetate
1 Date Fruit Extract
1 eicosapentaenoic acid
1 Evodiamine
1 Exercise
1 flavonoids
1 Bortezomib
1 Shilajit/Fulvic Acid
1 Gamma-aminobutyric acid
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Proanthocyanidins
1 Siegesbeckia glabrescens
1 Hydrogen Gas
1 Hops (Humulus lupulus)
1 Inositol
1 iodine
1 Laetrile B17 Amygdalin
1 Lasiodin
1 Licochalcone A
1 Linalool
1 Lutein
1 5-fluorouracil
1 MBE, Maqui berry
1 mebendazole
1 Sulindac
1 Metformin
1 Magnetic Field Rotating
1 Moringa oleifera
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Neem
1 Marjoram (Origanum majorana)
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Protocatechuic acid
1 Mung Bean Sprouts
1 Polyphenols
1 Propranolol
1 Perilla
1 Germacranolide sesquiterpene lactone
1 Salvia officinalis
1 Sanguinarine
1 Lignans
1 Sesame seeds and Oil
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Whole Body Vibration
1 Wogonin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:66  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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