tumCV Cancer Research Results

tumCV, Cell Viability: Click to Expand ⟱
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Cell Viability
Scientific Papers found: Click to Expand⟱
9021- Phyco,    C‑Phycocyanin induces apoptosis in oral squamous cell carcinoma KB cells via modulation of key molecular pathways
- in-vitro, Oral, KB
tumCV↓, selectivity↑, DNAdam↑, ChrCon↑, Apoptosis↑, NA↑, BAX↑, Bcl-2↓, Akt↓, PTEN↑, ERK↑,
9014- Phyco,    C-Phycocyanin Suppresses the In Vitro Proliferation and Migration of Non-Small-Cell Lung Cancer Cells through Reduction of RIPK1/NF-κB Activity
- in-vitro, Lung, H1650
tumCV↓, TumCP↓, Tumccf↓, TumCMig↓, Apoptosis↑, RIP1↓, NF-kB↓, Dose↝, MMP9↓,
9031- Phyco,    C-Phycocyanin induces apoptosis in oral squamous cell carcinoma KB cells via modulation of key molecular pathways
- in-vitro, Oral, NA
tumCV↓, selectivity↑, DNAdam↑, ChrCon↑, Apoptosis↑, P53↑, Bcl-2↓, Akt↓, PTEN↑, ERK↑,
9030- Phyco,    Enhancing the gastrointestinal stability of phycocyanin through modified PEGylation: Prospects for oral anticancer treatment
- in-vitro, Oral, NA
BioAv↓, Synergy↑, BioAv↑, tumCV↓, ROS↑, mtDam↑,
1131- PI,    Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
TumCG↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, Slug↓, N-cadherin↓, β-catenin/ZEB1↓, SMAD3↓, E-cadherin↑, EMT↓,
1163- PI,    The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line
- in-vitro, BC, MC38
tumCV↓, VEGF↓, MMP9↓, E-cadherin↓,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1939- PL,    Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP/DDIT3↑, Dose↝,
5159- PLB,    Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression
- in-vitro, AML, K562
tumCV↓, Apoptosis↑, ROS↑, eff↓, DR4↑, DR5↑, TRAIL↑,
2005- PLB,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,
2006- PLB,    Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,
5154- PTL,    Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro
- in-vitro, Melanoma, NA
tumCV↓, MMP↓, Casp3↑, Thiols↝,
1993- PTL,    Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer
- in-vitro, Cerv, HeLa
tumCV↓, TumAuto↑, Casp3↑, BAX↑, Beclin-1/ATG6↑, ATG3↑, ATG5↑, Bcl-2↓, mTOR↓, PI3K↓, Akt↓, PTEN↑, ROS↑, MMP↓,
1994- PTL,    Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells
- in-vitro, Melanoma, A2058 - in-vitro, Nor, L929
tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, Synergy↑,
4702- PTS,    Pterostilbene Inhibits Pancreatic Cancer In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCG↓, BioAv↑,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3339- QC,    Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas
- in-vitro, GBM, C6 - in-vitro, GBM, IMR32
BBB↑, tumCV↓, TumCMig↓, Rac1↓, p66Shc↓, ROS↓,
3362- QC,    The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action
- in-vitro, Cerv, HeLa
Apoptosis↑, cycD1/CCND1↓, Casp3↑, GRP78/BiP↑, CHOP/DDIT3↑, tumCV↓, IRE1↑, p‑PERK↑, c-ATF6↑, ER Stress↑,
3379- QC,    The Effect of Quercetin Nanosuspension on Prostate Cancer Cell Line LNCaP via Hedgehog Signaling Pathway
- in-vitro, Pca, LNCaP
tumCV↓, HH↓,
3376- QC,    Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
- in-vitro, BC, MCF7 - in-vitro, Lung, A549
CDK6↓, tumCV↓, Apoptosis↑, ROS↓, ChemoSen↑, *Synergy↑,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp/ABCB1↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP/DDIT3↑,
56- QC,    Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988
EMT↓, MMPs↓, MMP2↓, MMP7↓, STAT3↓, TumCI↓, TumMeta↓, tumCV↓,
62- QC,  GoldNP,    Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
EGFR↓, PI3k/Akt/mTOR↓, GSK‐3β↓, TumCP↓, Apoptosis↑, tumCV↓, mTOR↓, PTEN↑,
45- QC,    Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/β-Catenin Signaling Pathway
- in-vitro, Colon, CX-1 - in-vitro, Colon, SW480 - in-vitro, Colon, HT-29 - in-vitro, Colon, HCT116
cycD1/CCND1↓, survivin↓, Wnt/(β-catenin)↓, tumCV↓, TumCCA↑, Apoptosis↑,
90- QC,  HYP,    Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA‑21
- in-vitro, Pca, PC3
ROS↑, cl‑Casp3↑, cl‑PARP↑, miR-21↓, PDCD4↑, TAC↑, tumCV↓, TumCI↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB/CCNB1↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑, ROS⇅, TAC↑, tumCV↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2/PTGS2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
3072- RES,    Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
tumCV↓, TumCP↓, TumCMig↓, Apoptosis↑, NLRP3↓, JAK2↓, STAT3↓, IL1β↓, IL18↓, IL6↓, TNF-α↓, Inflam↓,
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
tumCV↓, Apoptosis↑, Sp1/3/4↓, p27/CDKN1B↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3016- RosA,    Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling
- in-vitro, HNSCC, UM-SCC-6 - in-vitro, HNSCC, UM-SCC-10B
chemoP↓, EGF↓, tumCV↓, TumCMig↓, ROS↓, PI3K↓, Akt↓, ERK↓, antiOx↑, p‑EGFR↓,
3017- RosA,  Per,    Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells
- in-vitro, Lung, A549
TumCD∅, ROS↓, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, SOD2↓, FOXO1↓, NF-kB↓, JNK↓, antiOx↑, tumCV∅,
3008- RosA,    Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells
- in-vitro, Melanoma, SK-MEL-28
tumCV↓, TumCMig↓, ROS↓, Casp3↑, selectivity↑, Casp8↑, NLRP3↓,
3029- RosA,    Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, tumCV↓, Apoptosis↑, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21↑, DNAdam↑, Casp3↑,
1132- RT,    Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
6440- SAO,    Biological Properties of Sandalwood Oil and Microbial Synthesis of Its Major Sesquiterpenoids
- Review, Var, NA
AntiCan↑, *Bacteria↓, *antiOx↑, *Inflam↓, *ROS↓, AntiTum↑, TumCG↓, tumCV↓, β-catenin/ZEB1↓, TumCMig↓, chemoPv↑,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6443- SAO,    α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation
- in-vitro, Pca, PC3
tumCV↓, Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, TumCG↓,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
1388- Sco,    Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells
- in-vitro, CRC, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, eff↓,
1403- SDT,  BBR,    From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Lung, LLC1
eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp/ABCB1↓, ER Stress↑, other↑,

Showing Research Papers: 501 to 550 of 622
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 622

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   ARE/EpRE↑, 1,   Catalase↓, 7,   Catalase↑, 5,   Fenton↑, 2,   GPx↓, 2,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 9,   GPx4↑, 1,   GPx4∅, 1,   GSH↓, 22,   GSH↑, 4,   GSH⇅, 1,   GSH∅, 1,   GSH/GSSG↓, 2,   GSR↓, 2,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   e-H2O2↓, 1,   i-H2O2∅, 1,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 7,   lipid-P↑, 10,   MDA?, 1,   MDA↑, 8,   NOX↓, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 9,   p‑NRF2↑, 2,   p66Shc↓, 1,   p66Shc↑, 1,   Prx↓, 1,   ROS?, 3,   ROS↓, 31,   ROS↑, 232,   ROS⇅, 1,   ROS↝, 1,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS↑, 13,   SOD↓, 8,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   TAC↓, 1,   TAC↑, 2,   TBARS↑, 2,   Thiols↓, 2,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 2,   Trx1↑, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   STEAP3↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 7,   compI↓, 3,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 2,   KIF2C↓, 1,   MFN2↓, 1,   mitResp↓, 3,   mitResp↑, 1,   mtDam↑, 28,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 3,   PDH↓, 1,   PDH↑, 1,   PINK1↑, 3,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 2,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 3,   AMP↑, 1,   AMPK↑, 18,   p‑AMPK↑, 4,   ATP↓, 17,   citrate↓, 1,   ECAR↓, 2,   ECAR↝, 1,   FAO↓, 1,   FASN↓, 3,   FASN↑, 1,   i-FASN↓, 1,   FBPase↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↑, 1,   glucoNG↑, 1,   glucose↓, 2,   GlucoseCon↓, 9,   GlucoseCon∅, 1,   GlutMet↓, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   Histones↑, 1,   HK2↓, 7,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 12,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 1,   O-Glc↓, 1,   PDHB↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PDKs↓, 1,   PFK↓, 2,   PGK1↓, 1,   PKM2↓, 11,   p‑S6↓, 1,   SIRT1↓, 1,   SIRT1↑, 3,   SIRT2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 13,   AIF↝, 1,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 8,   Apoptosis↑, 288,   Apoptosis∅, 1,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 7,   Bak↑, 3,   BAX↓, 2,   BAX↑, 107,   Bax:Bcl2↑, 26,   Bcl-2↓, 112,   Bcl-2↑, 2,   Bcl-xL↓, 20,   Bcl-xL↑, 2,   BID↑, 3,   BIM↑, 2,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 27,   cl‑Casp↑, 2,   proCasp↑, 1,   cl‑Casp1↑, 1,   Casp12↑, 6,   Casp3↓, 1,   Casp3↑, 155,   cl‑Casp3↓, 1,   cl‑Casp3↑, 40,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↓, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 22,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 30,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 2,   Casp9↑, 82,   cl‑Casp9↑, 17,   cFLIP↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 70,   Diablo↑, 1,   DR5↑, 3,   Endon↑, 2,   FADD↑, 2,   Fas↑, 7,   FasL↑, 9,   Ferroptosis↓, 1,   Ferroptosis↑, 16,   cl‑GSDMD↑, 1,   GSDME↑, 1,   GSDME-N↑, 1,   IAP1↓, 1,   iNOS↓, 4,   Mcl-1↓, 14,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 2,   p38↓, 4,   p38↑, 6,   p‑p38↓, 3,   p‑p38↑, 6,   PDCD4↑, 1,   proApCas↑, 1,   PUMA↑, 4,   Pyro↑, 4,   RIP3↑, 1,   p‑RIP3↑, 2,   survivin↓, 40,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 19,   TumCD∅, 1,   TUNEL↑, 1,   XIAP↓, 12,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 82,   Akt↑, 4,   p‑Akt↓, 37,   AKT1↓, 2,   Brk/PTK6↓, 1,   CaMKII ↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 19,   p‑EGFR↓, 2,   ERK↓, 23,   ERK↑, 6,   ERK↝, 1,   p‑ERK↓, 12,   p‑ERK↑, 3,   GRB2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   HRAS↓, 1,   IGF-1R↓, 5,   IKKα↓, 3,   IKKα↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 4,   JAK2↓, 9,   p‑JAK2↓, 1,   JNK↓, 4,   JNK↑, 12,   p‑JNK↓, 1,   p‑JNK↑, 6,   LIFR/CD118↓, 1,   MAPK↓, 10,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 5,   p‑MEK↑, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 47,   mTOR↑, 2,   p‑mTOR↓, 12,   mTORC2↓, 1,   mTORC2↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 2,   PI3K?, 1,   PI3K↓, 54,   PI3K↑, 1,   p‑PI3K↓, 13,   PI3k/Akt/mTOR↓, 2,   PKA↓, 2,   PKCδ↓, 3,   PKCδ↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↑, 8,   PTK2B / PYK2↓, 1,   e-Raf↓, 1,   RAS↓, 4,   RAS↑, 1,   RCC1↓, 1,   RIP1↓, 1,   Sp1/3/4↓, 6,   Src↓, 1,   STAT↓, 3,   STAT3↓, 40,   STAT3↑, 1,   p‑STAT3↓, 15,   STAT4↓, 1,   STAT4↑, 1,   STAT5↓, 4,   p‑STK11/LKB1↑, 2,   TK1↓, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 4,   ChrMod↝, 1,   cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 16,   cMyc↑, 2,   DNMT1↓, 6,   DNMT3A↓, 4,   DNMT3B↓, 2,   DNMTs↓, 2,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   ac‑H4↑, 3,   HATs↓, 1,   HDAC↓, 8,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 2,   HDAC6↓, 1,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-149↑, 1,   miR-155↓, 2,   miR-21↓, 2,   miR-22↑, 1,   miR-224↓, 1,   miR-27a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-542↓, 1,   Myc↓, 2,   OCT4↓, 6,   other↓, 1,   other↑, 3,   other↝, 9,   SALL4↓, 1,   SBF2-AS1↓, 1,   sonoS↑, 1,   SOX2↓, 6,   SOX4↓, 1,   SUV39H↓, 2,   TBX15↑, 1,   TET3↑, 1,   TLE1↓, 1,   tumCV?, 6,   tumCV↓, 593,   tumCV↑, 11,   tumCV∅, 7,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   c-ATF6↑, 1,   CHOP/DDIT3↑, 20,   eIF2α↑, 3,   p‑eIF2α↑, 5,   ER Stress↓, 1,   ER Stress↑, 32,   ERStress↑, 1,   GRP78/BiP↑, 16,   GRP94↑, 4,   HSF1↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 11,   CTSB↓, 2,   CTSD↓, 2,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↑, 2,   LC3I↑, 2,   LC3II↑, 11,   LC3s↑, 1,   MitoP↑, 3,   p62↓, 6,   p62↑, 4,   PARK2↑, 3,   SESN2↑, 1,   TumAuto↓, 4,   TumAuto↑, 41,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 65,   DNArepair↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   P53?, 1,   P53↓, 2,   P53↑, 57,   P53⇅, 1,   P53↝, 1,   p‑P53↑, 3,   p53 Wildtype↓, 1,   PARP↓, 5,   PARP↑, 15,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 54,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 14,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 5,   TOP1↓, 1,   TOP2↓, 3,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK1↑, 1,   p‑CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 16,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   cycA1/CCNA1↓, 6,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   CycD3↓, 3,   CycD3↑, 1,   cycE/CCNE↓, 14,   cycE1↓, 2,   E2Fs↓, 2,   Ki-67↓, 19,   mitA↑, 2,   MKI67↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 35,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 13,   PLK1↓, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 2,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA?, 3,   TumCCA↓, 2,   TumCCA↑, 157,   TumCCA⇅, 1,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 1,   Axin2↓, 1,   BMI1↓, 1,   BMPs↑, 1,   CD133↓, 5,   CD24↓, 2,   CEBPA↑, 1,   cFos↓, 2,   CSCs↓, 17,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   HH↓, 3,   HMGCR↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   Ki-67↓, 19,   LRP6↓, 1,   mTORC1↓, 4,   Nanog↓, 4,   Nestin↓, 2,   NOTCH↓, 3,   NOTCH1↓, 3,   NOTCH3↓, 1,   Piezo1↑, 1,   Shh↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 81,   TumCG↑, 2,   TumCG∅, 1,   TumCP↓, 116,   TumCP↑, 2,   Wnt↓, 14,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AKR1C2↓, 1,   Alix/AIP‑1↓, 1,   annexin II↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   APC↑, 1,   Ca+2↓, 2,   Ca+2↑, 20,   Ca+2↝, 5,   i-Ca+2↓, 1,   i-Ca+2↑, 4,   Cal1↑, 2,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   COL1↓, 1,   COL4↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 14,   EMT?, 1,   EMT↓, 31,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 2,   IQGAP3↓, 1,   KRAS↓, 4,   LEF1↓, 1,   MET↑, 1,   MMP1↓, 4,   MMP16↓, 1,   MMP2↓, 37,   MMP3↓, 3,   MMP7↓, 4,   MMP7∅, 1,   MMP9↓, 32,   MMP9:TIMP1↓, 1,   MMPs↓, 12,   N-cadherin↓, 8,   N-cadherin↑, 2,   PAK1↓, 2,   proline↓, 1,   Rac1↓, 2,   Rho↓, 1,   Rho↑, 1,   Slug?, 1,   Slug↓, 7,   SMAD2↓, 1,   SMAD3↓, 3,   Snail?, 1,   Snail↓, 9,   Snail↑, 1,   TET1↑, 3,   TGF-β↓, 3,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 78,   TumCMig↓, 98,   TumCMig↑, 1,   TumCMig⇅, 1,   TumMeta↓, 28,   TumMeta↑, 3,   Twist↓, 7,   TXNIP↑, 1,   uPA↓, 2,   Vim?, 1,   Vim↓, 12,   Vim↑, 2,   Zeb1↓, 2,   α-SMA↓, 1,   α-SMA↑, 2,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 1,   HIF-1↓, 4,   Hif1a↓, 17,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 34,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↑, 1,   BBB∅, 1,   CellMemb↓, 1,   EPR↑, 4,   GLUT1↓, 5,   MMP?, 1,   MMP↓, 105,   MMP↑, 2,   MMP∅, 1,   MPT↑, 5,   NHE1↓, 1,   SLC6A3?, 1,   sonoP↑, 2,   TRPM7↓, 3,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 1,   CD4+↑, 6,   CD44↓, 4,   CD8+↑, 7,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 2,   DR4↑, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL4↓, 1,   IL6↓, 21,   IL8↓, 4,   Imm↑, 10,   Inflam↓, 22,   MCP1/CCL2↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 66,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 2,   p50↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 5,   PSA↓, 2,   T-Cell↑, 1,   TCF↓, 2,   Th1 response↑, 1,   TLR4↓, 3,   TLR4↑, 1,   TNF-α↓, 16,   TNF-α↑, 5,   TRAF2↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   pH↓, 1,   pH↑, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 3,   CYP11A1↓, 1,   DHT↓, 1,   ER-α36↓, 2,   ER-α36↝, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   HSD3B↓, 1,   PPARγ↑, 6,   RANKL↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 13,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 85,   CompStab↓, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↓, 1,   Dose?, 2,   Dose↓, 3,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 60,   Dose∅, 6,   eff?, 2,   eff↓, 75,   eff↑, 52,   eff⇅, 1,   eff↝, 5,   eff∅, 2,   Half-Life↓, 4,   Half-Life↝, 1,   MDR1↓, 2,   MDR1↑, 1,   MRP1/ABCC1↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 8,   RadioS↑, 19,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 120,   selectivity∅, 1,   Synergy↑, 46,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AR↓, 3,   AST↓, 2,   BRCA1↓, 2,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 19,   p‑EGFR↓, 2,   EstroRS/ERS↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 21,   KRAS↓, 4,   LDH↓, 5,   LDH↑, 6,   Myc↓, 2,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 2,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 37,   AntiCan⇅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 3,   AntiTum↑, 14,   AntiTum⇅, 1,   cardioP↑, 5,   chemoP↓, 1,   chemoP↑, 10,   chemoPv↑, 13,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↓, 1,   hepatoP↑, 2,   Mucositis↓, 1,   neuroP↑, 5,   OS↑, 9,   Pain↓, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 3,   Sleep↑, 1,   TGFβR1↓, 1,   toxicity↓, 16,   toxicity↝, 3,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 34,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 17,   TumW∅, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 8,  
Total Targets: 843

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 46,   Bil↓, 1,   Catalase↑, 14,   Fenton↓, 1,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 15,   GSR↑, 1,   GSTs↑, 6,   HO-1↓, 1,   HO-1↑, 7,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 11,   MDA↓, 9,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 13,   RNS↓, 2,   ROS↓, 32,   ROS↑, 5,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 7,   AMPK↓, 1,   ATP↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   HK2↑, 1,   NAD↓, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKM↑, 1,   PKM2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   Apoptosis↑, 1,   BAX↓, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp3↓, 7,   Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 2,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 3,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   e-Akt↑, 1,   AMPKα↑, 1,   p‑CREB↑, 1,   ERK↑, 1,   e-ERK↑, 1,   IKKα↑, 1,   JAK2↑, 1,   PI3K↑, 1,   STAT↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 5,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   GADD34↓, 1,   P21↓, 1,   P21↑, 3,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   Ca+2↓, 1,   Cartilage↑, 1,   COL1↑, 1,   LRP1↑, 1,   MUC1↑, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCMig↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 7,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 6,   IL4↑, 1,   IL6↓, 8,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 39,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 8,   NK cell↑, 1,   NLRP3↓, 3,   PGE2↓, 5,   PSA∅, 1,   RAGE↓, 1,   TNF-α↓, 12,   Treg lymp↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 2,   testos↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 5,   BioAv↝, 3,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 6,   Half-Life↑, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 3,   AST↓, 6,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   CEA↓, 1,   creat↓, 1,   IL6↓, 8,   LDH↓, 1,   PSA∅, 1,   RAGE↓, 1,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 5,   AntiDiabetic↑, 11,   antiNeop↑, 1,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 11,   chemoP↑, 5,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 2,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 13,   memory↑, 3,   neuroP↑, 17,   Obesity↓, 3,   OS↑, 1,   Pain↓, 3,   RenoP↑, 2,   SoreThr?, 1,   Stress↓, 1,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 5,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 3,   AntiViral↑, 3,   Bacteria↓, 8,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 241

Scientific Paper Hit Count for: tumCV, Cell Viability
22 Silver-NanoParticles
17 Quercetin
14 Cisplatin
14 Sulforaphane (mainly Broccoli)
14 Thymoquinone
12 Curcumin
11 Honokiol
10 doxorubicin
10 Licochalcone A
9 Dandelion Root
9 Fisetin
9 Kaempferol
9 Magnetic Fields
9 Methylsulfonylmethane
9 Phenethyl isothiocyanate
8 Betulinic acid
8 Marjoram (Origanum majorana)
7 SonoDynamic Therapy UltraSound
7 Berberine
7 Capsaicin
7 Carvacrol
7 Eugenol
7 Cynaropicrin
7 Gallic acid
7 Luteolin
7 Shikonin
6 Cynara scolymus/Globe Artichoke/Artichoke Extract
6 Allicin (mainly Garlic)
6 Radiotherapy/Radiation
6 Chrysin
6 Resveratrol
6 Emodin
6 Hyperoside
6 Ivermectin
6 Morin
5 Allyl isothiocyanate
5 Melatonin
5 5-fluorouracil
5 chaetocin
5 Crocetin
5 Formononetin
5 Ginkgetin
5 isoquercitrin
5 Licorice
5 Linalool
5 Matrine
5 Magnetic Field Rotating
5 Phycocyanin
5 Rosmarinic acid
4 Apigenin (mainly Parsley)
4 Metformin
4 Artemisinin
4 Baicalein
4 Berbamine
4 Biochanin A
4 Gemcitabine (Gemzar)
4 Benzyl isothiocyanate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Carvone
4 Eurycomanone
4 Shilajit/Fulvic Acid
4 Graviola
4 Magnolol
4 iodine
4 Juglone
4 Lycopene
4 Terpinen-4-ol / Tea Tree Oil
4 Propolis -bee glue
4 α-Santalol/Sandalwood oil
4 Silymarin (Milk Thistle) silibinin
4 Vitamin C (Ascorbic Acid)
4 Vitexin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Beta-Caryophyllene
3 Carnosic acid
3 chitosan
3 Selenium
3 Citric Acid
3 CUSP9
3 Chlorella (Chlorella vulgaris)
3 Dichloroacetate
3 tamoxifen
3 Echinacea
3 eicosapentaenoic acid
3 Evodiamine
3 Fucoidan
3 Gambogic Acid
3 Hibiscus sabdariffa
3 Hyperthermia
3 HydroxyTyrosol
3 Methylene blue
3 mebendazole
3 Mushroom Chaga, Inonotus obliquus
3 Nimbolide
3 Piperlongumine
3 Plumbagin
3 Parthenolide
3 Selenite (Sodium)
3 Urolithin
2 3-bromopyruvate
2 Alpha-Lipoic-Acid
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Beetroot
2 brusatol
2 Caffeic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Polyphenols
2 Copper and Cu NanoParticles
2 Hydroxycinnamic-acid
2 Indole-3-carbinol
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Garcinol
2 Ginkgolic acids
2 Ginkgo biloba
2 Geraniol
2 Helleborus niger extracts – Christmas Rose
2 Rutin
2 Isoliquiritigenin
2 Isorhamnetin
2 isoorientin
2 Lasiodin
2 SDG/lignans
2 Lutein
2 Gold NanoParticles
2 Iron
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Mushroom Maitake
2 Naringin
2 Purple Corn / Purple Maize
2 Piperine
2 salinomycin
2 polyethylene glycol
2 Selenium NanoParticles
2 Chemotherapy
2 Photodynamic Therapy
2 Aflavin-3,3′-digallate
2 Ursolic acid
2 VitK3,menadione
2 Zerumbone
1 1,8-Cineole
1 Resiquimod
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Bevacizumab (brand Avastin)
1 borneol
1 Boron
1 α-Bisabolol / Chamomile oil
1 Bullatacin
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 hydroxychloroquine
1 Catechins
1 Cannabidiol
1 Selenate
1 Vitamin E
1 Cranberry
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Disulfiram
1 Ellagic acid
1 Cannabichromene
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Estrogen
1 Ferulic acid
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 olaparib/LYNPARZA
1 Genistein (soy isoflavone)
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Paclitaxel/Taxol
1 Isobavachalcone
1 Inositol
1 MCT, metronomic chemo
1 capecitabine
1 Isothiocyanates
1 itraconazole
1 L-Theanine
1 Lactobacillus
1 lambertianic acid
1 Lapachol
1 Lemongrass Extract/Citral
1 Folic Acid, Vit B9
1 MBE, Maqui berry
1 gefitinib, erlotinib
1 Modified Citrus Pectin
1 irinotecan
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 immunotherapy
1 Magnesium
1 Mangiferin
1 magnetic nanoparticles
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Bicarbonate(Sodium)
1 Niclosamide (Niclocide)
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Propyl gallate
1 Pterostilbene
1 Perilla
1 Scoulerine
1 Sesamin
1 acetazolamide
1 triptolide
1 Triphala
1 Turmerones
1 Vitamin D3
1 Vitamin K2
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:897  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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