Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
4997- Sal,    Salinomycin Treatment Specifically Inhibits Cell Proliferation of Cancer Stem Cells Revealed by Longitudinal Single Cell Tracking in Combination with Fluorescence Microscopy
- in-vitro, BC, NA
CD24↓, TumCP↓, CSCs↓,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,
4994- Sal,  Rad,    Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation
AntiCan↑, RadioS↓, Apoptosis↑, NRF2↓, ROS↑, DNAdam↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, eff↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
4907- Sal,    A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents
- Review, Var, NA
Apoptosis↑, MDR1↓, CSCs↓,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
4912- Sal,    Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157
CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP↑, AKT1↓, mTOR↓,
4998- Sal,    Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain
- in-vitro, NPC, NA
CSCs↓,
5128- Sal,    Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
- in-vitro, AML, NA
CSCs↓,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
5126- Sal,    Salinomycin induces calpain and cytochrome c-mediated neuronal cell death
CSCs↓, Ca+2↑, cal2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, MMP↓,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF-7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
5121- Sal,    Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, BC, NA
CSCs↓, Wnt↓, selectivity↑,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
3939- SAMe,  VitB12,  ALC,    Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
- Trial, NA, NA
*cognitive↑, *Mood↑,
3938- SAMe,    S-adenosyl-L-methionine in the treatment of Alzheimer's disease
- Human, AD, NA
*other↑,
4115- SAMe,    Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
- Review, AD, NA
*Mood↑, *BBB↑,
4114- SAMe,    S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
- Review, AD, NA
*Mood↑, *BBB↑, *5HT↑, *p‑tau↓, *Aβ↓, *other↑,
1210- SANG,    Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer
- in-vitro, BC, NA
EphB4↓, Hif1a↓, STAT3↓, MAPK↓, ERK↓,
1209- SANG,    Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration
- in-vitro, Lung, A549
VEGF↓, TumCMig↓, Akt↓, p38↓,
1208- SANG,    Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region
- in-vitro, OS, NA
SSBP1↑, mtDam↑, Apoptosis↑, JAK↓, STAT3↓, PI3k/Akt/mTOR↓, ROS↑, MMP↓,
1307- SANG,    Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway
- in-vitro, CRC, HT-29
Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑,
1090- SANG,    Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
- in-vitro, BC, MCF-7
MMP9↓, COX2↓, PGE2↓, NF-kB↓, AP-1↓, p‑Akt↓, p‑ERK↓, HO-1↑,
1134- SANG,    Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
Hif1a↓, EMT↓, Snail↓, PI3K↓, Akt↓, SMAD2↓, SMAD3↓,
6446- SAO,    Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway
- in-vitro, BC, NA
Wnt↓, β-catenin/ZEB1↓, TumCMig↓, Wound Healing↓,
6440- SAO,    Biological Properties of Sandalwood Oil and Microbial Synthesis of Its Major Sesquiterpenoids
- Review, Var, NA
AntiCan↑, *Bacteria↓, *antiOx↑, *Inflam↓, *ROS↓, AntiTum↑, TumCG↓, tumCV↓, β-catenin/ZEB1↓, TumCMig↓, chemoPv↑,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6443- SAO,    α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation
- in-vitro, Pca, PC3
tumCV↓, Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, TumCG↓,
6444- SAO,    Sandalwood oil by-product prevents prostate cancer development in mice
- in-vivo, Pca, PC12
TumVol↓, selectivity↑,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
6447- SAO,    Autophagy Induction by α-Santalol in Human Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
p‑Akt↓, p‑mTOR↓, TumAuto↑,
6448- SAO,    A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes
- in-vitro, Nor, HaCaT
*TumCCA↑, *AP-1↓, chemoPv↑,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,
6450- SAO,    Survivin Down-regulation by α-Santalol Is Not Mediated Through PI3K-AKT Pathway in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
survivin↓,
6451- SAO,    α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer
- vitro+vivo, BC, MDA-MB-231
TumCP↓, selectivity↑, Bcl-2↓, PLK1↓, BAD↑, Casp↑, BAX↑, Dose↝, TumCG↓,
3853- SAS,    Sulfur-containing therapeutics in the treatment of Alzheimer's disease
- Review, AD, NA
*antiOx↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT↓, GPx4↓, FTH1↓,
5045- SAS,    Sulfasalazine, a potent cystine-glutamate transporter inhibitor, enhances osteogenic differentiation of canine adipose-derived stem cells
- in-vivo, Var, NA
xCT↓, GSH↓, BMPs↑, Diff↑,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
5043- SAS,    Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects
- in-vivo, Nor, NA
*toxicity↝, *xCT↓, toxicity↓,
5042- SAS,    xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
- Review, Var, NA
xCT↓, GSH↓, TumCG↓, TumCI↓, ROS↑, RadioS↑, eff↓,

Showing Research Papers: 5501 to 5550 of 6658
Prev Page 111 of 134 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6658

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

PLK1↓, 1,  

Redox & Oxidative Stress ⓘ

Catalase↓, 2,   Ferroptosis↑, 3,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 5,   HO-1↓, 1,   HO-1↑, 1,   Iron↑, 3,   lipid-P↑, 3,   MDA↑, 2,   NRF2↓, 3,   OXPHOS↓, 2,   ROS↑, 12,   SOD↓, 3,   SOD1↓, 1,   xCT↓, 4,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   FTH1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   MMP↓, 6,   mtDam↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   Glycolysis↓, 1,   LDH↓, 1,   NADPH↓, 1,   PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↑, 14,   Apoptosis∅, 1,   BAD↑, 1,   BAX↑, 3,   Bcl-2↓, 3,   Casp↑, 3,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 7,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 1,   Casp8↓, 1,   Casp9↓, 1,   Casp9↑, 3,   Cyt‑c↑, 2,   Ferroptosis↑, 3,   lysoMP↑, 1,   MAPK↓, 1,   MOMP↑, 1,   necrosis↑, 1,   p38↓, 1,   survivin↓, 2,   TumCD↑, 3,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   ER Stress↑, 3,   ERStress↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes ⓘ

autoF↓, 2,   LC3II↑, 1,   lysosome↓, 1,   lysosome↝, 1,   MitoP↑, 1,   TumAuto↓, 1,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

DNAdam↑, 6,   P53↑, 1,   cl‑PARP↑, 3,   cl‑PARP↝, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 3,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   CD24↓, 3,   CD44↓, 3,   CSCs↓, 16,   CSCs↑, 1,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,   Diff↑, 3,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   GSK‐3β↑, 1,   LRP6↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   SOX2↓, 1,   STAT3↓, 2,   TumCG↓, 12,   Wnt↓, 8,  

Migration ⓘ

AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   cal2↑, 1,   E-cadherin↑, 1,   EphB4↓, 1,   Fibronectin↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PKCδ↑, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 5,   TumCP↓, 7,   Vim↓, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ATF4↑, 1,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CTSZ↓, 1,   IL1↓, 1,   IL2↓, 1,   JAK↓, 1,   NF-kB↓, 2,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 1,   ChemoSen↑, 3,   Dose↝, 2,   eff↓, 2,   eff↑, 2,   MDR1↓, 1,   RadioS↓, 1,   RadioS↑, 2,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

BMPs↑, 1,   Ferritin↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 3,   chemoPv↑, 2,   toxicity↓, 1,   toxicity⇅, 1,   TumVol↓, 2,   Wound Healing↓, 1,  
Total Targets: 151

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   DPPH↓, 1,   GSTs↑, 1,   ROS↓, 3,   xCT↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   tyrosinase↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   Snail↑, 1,   Twist↑, 1,   Vim↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

IL17↓, 1,   IL1β↓, 1,   Inflam↓, 4,   PGE2↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   Mood↑, 3,   PDE4↓, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 32

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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