Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

1428-

SFN,

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Review,

NA,

HDAC↓, NRF2↑,

1429-

SFN,

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast

in-vivo,

Nor,

Human,

Nor,

200 mumol

eight healthy women undergoing reduction mammoplasty were given a single dose of a broccoli sprout preparation containing 200 mumol of sulforaphane.

*NADPH↑, *NQO1↑, *HO-1↑, *Risk↑,

1315-

SFN,

Sulforaphane Induces Apoptosis of Acute Human Leukemia Cells Through Modulation of Bax, Bcl-2 and Caspase-3

in-vitro,

AML,

K562

TumCP↓, BAX↑, Casp3↑, Bcl-2↓,

1498-

SFN,

Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

NCM460

selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,

1459-

SFN,

AF,

Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway

in-vitro,

Liver,

Hep3B

 auranofin (0.5, 1, 1.5, and 2 μM) or sulforaphane (2.5, 5, 7.5, and 10 μM)

in-vitro,

Liver,

HepG2

eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,

1471-

SFN,

ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells

in-vitro,

GC,

AGS

TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,

1470-

SFN,

Rad,

Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

in-vitro,

Lung,

A549

in-vitro,

lymphoma,

U937

eff↓, ROS↑, NKG2D↑,

1469-

SFN,

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis

in-vitro,

Pca,

PC3

in-vitro,

Pca,

LNCaP

in-vivo,

Pca,

orthotopically implanted PC-3 tumors

eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,

1468-

SFN,

Cellular responses to dietary cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

PC3

ROS↑, DNAdam↑, MMP↓, Cyt‑c↑, TumCCA↑,

1467-

SFN,

Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells

in-vitro,

AML,

U937

Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,

1466-

SFN,

Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway

vitro+vivo,

Thyroid,

FTC-133

10.8 to 19.6 μM

mice

TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,

1465-

SFN,

TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells

NA,

Bladder,

eff↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,

1464-

SFN,

d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway

in-vitro,

GBM,

Apoptosis↑, Casp3↑, BAX↑, Bcl-2↓, ROS↑, p‑STAT3↓, JAK2↓, eff↓,

1463-

SFN,

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

in-vitro,

Bladder,

5637

tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,

1462-

SFN,

Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells

in-vitro,

Bladder,

T24/HTB-9

EMT↓, TumCI↓, TumCMig↓, E-cadherin↑, Zeb1↓, Snail↓, COX2↝, MMP2↝, MMP9↝,

1461-

SFN,

Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives

Review,

BC,

TumCP↓, Apoptosis↑, TumCCA↑, antiOx↑,

1460-

SFN,

High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells

in-vitro,

Lung,

ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,

1472-

SFN,

Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3

in-vitro,

ESCC,

TumCP↓, ROS↑, DNAdam↑,

1458-

SFN,

Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

Review,

Bladder,

HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,

1457-

SFN,

Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells

in-vitro,

CRC,

HT-29

 0–10 μM

IL6↓, ROS↓, TumCP↓, TumCI↓, p38↓, AP-1↓,

1456-

SFN,

Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells

in-vitro,

PC,

MIA PaCa-2

 0, 7.5, and 15 µM

in-vitro,

PC,

PANC1

tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,

1455-

SFN,

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

in-vitro,

Cerv,

HeLa

SFN (10 or 15 μM) for 9 h

in-vitro,

Nor,

1321N1

*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,

1454-

SFN,

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract

Human,

Nor,

Subjects consumed fresh broccoli sprouts or the BSE, each providing 200 μmol SFN daily, as a single dose and as two 100-μmol doses taken 12 h apart.

*HDAC↓, *eff↑, *eff↑, *eff↑, *BioAv↑, *BioAv↑,

1453-

SFN,

Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7

in-vitro,

Pca,

DU145

1–20 µM

14-32uM

Other investigators have calculated the IC50 value for SFN to be 14 µM for DU145 versus 32 µM for PC3

in-vitro,

Pca,

PC3

TumCG↓, TumCP↓, TumCCA↑, H3↑, H4↑, HDAC↓, CDK1↑, CDK2↑, p19↑, *BioAv↑,

1452-

SFN,

Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells

in-vitro,

GC,

AGS

MMP9↓, p38↓, ERK↓, AP-1↓, ROS↓, NF-kB↓, TumCI↓, MMP9↓, HDAC↓, Glycolysis↓, Hif1a↓, *memory↑, *cognitive↑,

1437-

SFN,

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

Review,

NA,

HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,

1436-

SFN,

PacT,

docx,

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells

in-vivo,

BC,

SUM159

mouse

NF-kB↓, ChemoSen↑, IL6↓, IL8↑,

1434-

SFN,

GEM,

Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity

in-vitro,

CCA,

HuCCT1

 SFN (0–80 μM) or GEM (0–10 μM) for 24 h

27.4uM(SFN),0.57 μM(GEM)

in-vitro,

CCA,

HuH28

34.2 μM(SFN), 0.71um(GEM)

in-vivo,

NA,

50 mg/kg/day

tumors of SFN- and GEM-treated mice

HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,

1432-

SFN,

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi

Human,

Melanoma,

50-200uM

Seventeen patients who each had at least 2 atypical nevi and a prior history of melanoma were randomly allocated to 50, 100, or 200 µmol oral BSE-SFN daily for 28 days.

other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1↓, CXCL9↓, MIP-1β↓, IFN-γ↓,

1431-

SFN,

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts

in-vivo,

Nor,

Topical application of an extract delivering 100 nmol sulforaphane/cm(2)

mice and human

*NADPH↑, *NQO1↑, *GSTA1↑, *HO-1↑,

1474-

SFN,

Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway

in-vitro,

Colon,

SW480

5, 10, 15 and 20 µM

TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,

1509-

SFN,

Combination therapy in combating cancer

Review,

NA,

NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX↓, chemoR↓, 5HT↓,

1508-

SFN,

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

Review,

Var,

*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,

1507-

SFN,

Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects

in-vivo,

Colon,

 7.5 mumol per animal for 21 days

Human,

Nor,

68 g BroccoSprouts

TumCG↓, HDAC↓, *BioAv↑, Dose∅, Half-Life∅,

1502-

SFN,

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

Review,

NA,

HDAC↓, AntiCan↑, DNMTs↓, hTERT/TERT↓, selectivity↑,

1501-

SFN,

The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation

in-vitro,

CRC,

T24/HTB-9

2.5 µM vs >10uM

Dose↝, NRF2↑, GSH↓, eff↑,

1500-

SFN,

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase

in-vitro,

Nor,

HEK293

in-vitro,

CRC,

HCT116

HDAC↓, P21↑, TOPflash↑,

1499-

SFN,

Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway

in-vitro,

BC,

TumCMig↓, TumCI↓, FAK↓, p‑MEK↓, p‑ERK↓,

1430-

SFN,

Sulforaphane bioavailability and chemopreventive activity in women scheduled for breast biopsy

Trial,

BC,

250 μM GFN glucoraphanin

*HDAC3↓, HDAC↓, *toxicity↓,

1497-

SFN,

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

in-vitro,

Nor,

PrEC

in-vitro,

Pca,

LNCaP

15 µM SFN

in-vitro,

Pca,

PC3

HDAC↓, selectivity↑, TumCCA↑, Apoptosis↑, selectivity↑, H3↑, P21↑, selectivity↑,

1496-

SFN,

VitD3,

Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells

in-vitro,

CRC,

Caco-2

24 h to vitamin D (100 nmol L-1 ) either alone or in combination with SFN and trichostatin A (20 and 1 μmol L-1 , respectively)

eff↑, VDR↑, CYP11A1↓, HDAC↓,

1495-

SFN,

doxoR,

Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation

in-vivo,

Nor,

Rats

*CardioT↓, *NRF2↑, *eff↓, *ROS↓,

1494-

SFN,

doxoR,

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

in-vivo,

BC,

rats

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, eff↑, ROS↑, selectivity?,

1484-

SFN,

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Review,

Var,

Review,

AD,

neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,

1483-

SFN,

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

in-vitro,

OS,

143B

0-10uM

in-vitro,

Nor,

HEK293

in-vivo,

OS,

25-50mg/kg

subcutaneous tumor-bearing nude mouse model

AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

1482-

SFN,

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,

1481-

SFN,

docx,

Combination of Low-Dose Sulforaphane and Docetaxel on Mitochondrial Function and Metabolic Reprogramming in Prostate Cancer Cell Lines

in-vitro,

Pca,

LNCaP

6.55 µM SFN and 0.0675 µM DCT

Prostate cancer cell lines LNCaP and PC-3 were treated with individual IC50 doses of SFN and DCT and half-reduced IC50 values for the SFN:DCT combination.

in-vitro,

Pca,

PC3

1.1 µM SFN and 0.0005 µM DCT

ChemoSen↑, Casp3↑, ROS↑, Casp8↑, Cyt‑c↑, Glycolysis↓, GSH↓, GSH/GSSG↓, *toxicity↓,

1480-

SFN,

Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells

in-vitro,

CRC,

HCT116

tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,

1479-

SFN,

Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway

in-vitro,

CRC,

HCT116

Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,

1478-

SFN,

acet,

Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells

in-vitro,

Nor,

eff↑, NO↓, iNOS↓, COX2↓, IL1β↓, ROS↓,

Showing Research Papers: 5751 to 5800 of 6658
Prev Page 116 of 134 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6658

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

GSH↑, 1, GSTA1↑, 1, HO-1↑, 2, NQO1↑, 2, NRF2↑, 2, ROS↓, 5,

Core Metabolism/Glycolysis ⓘ

NADPH↑, 2,

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1, HDAC↓, 1, HDAC3↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv?, 1, BioAv↑, 6, eff↓, 1, eff↑, 3, Half-Life∅, 1,

Functional Outcomes ⓘ

CardioT↓, 1, cognitive↑, 1, memory↑, 1, Risk↑, 1, toxicity↓, 6, toxicity∅, 3, Weight∅, 1,
Total Targets: 22

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Core Metabolism/Glycolysis ⓘ

Proliferation, Differentiation & Cell State ⓘ

Drug Metabolism & Resistance ⓘ

Functional Outcomes ⓘ

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