| 1197- | MAG, | Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells |
| - | in-vivo, | MS, | NA |
| 1198- | MAG, | Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells |
| - | in-vivo, | Melanoma, | NA |
| 8525- | MAG, | Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells |
| - | in-vitro, | Thyroid, | NA |
| 8524- | MAG, | Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | CRC, | HCT116 |
| 8523- | MAG, | Anticancer potential of magnolol for lung cancer treatment |
| - | in-vitro, | Lung, | A549 |
| 8522- | MAG, | Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice |
| - | in-vivo, | AD, | NA |
| 8521- | MAG, | Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H520 | - | in-vitro, | Lung, | NCI-H441 |
| 8520- | MAG, | The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy |
| - | in-vitro, | BC, | MDA-MB-231 |
| 8518- | MAG, | Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway |
| - | in-vitro, | CCA, | NA |
| 8519- | MAG, | Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway |
| - | vitro+vivo, | Gall, | NA |
| 8516- | MAG, | Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma |
| - | in-vitro, | Melanoma, | NA |
| 8515- | MAG, | Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism |
| - | in-vitro, | Liver, | HepG2 |
| 8514- | MAG, | Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ |
| - | in-vivo, | AD, | NA |
| 8512- | MAG, | Enhanced Oral Bioavailability of the Pharmacologically Active Lignin Magnolol via Zr-Based Metal Organic Framework Impregnation |
| - | in-vivo, | Nor, | NA |
| 8492- | MAG, | Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway |
| - | in-vivo, | AD, | NA |
| 8493- | MAG, | Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway |
| - | in-vitro, | AD, | SH-SY5Y |
| 8494- | MAG, | Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease |
| - | in-vivo, | AD, | NA |
| 8495- | MAG, | Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats |
| - | in-vivo, | Nor, | NA |
| 8496- | MAG, | Metabolic interactions of magnolol with cytochrome P450 enzymes: uncompetitive inhibition of CYP1A and competitive inhibition of CYP2C |
| - | in-vitro, | Nor, | NA |
| 8497- | MAG, | Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway |
| - | in-vitro, | BC, | MCF7 |
| 8498- | MAG, | Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells |
| - | in-vitro, | Kidney, | 786-O | - | in-vitro, | RCC, | OS-RC-2 | - | in-vitro, | Nor, | HK-2 |
| 8499- | MAG, | Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells |
| - | vitro+vivo, | CRC, | SW480 | - | in-vitro, | CRC, | HCT116 |
| 8500- | MAG, | Magnolol Induces Apoptosis Through Extrinsic/intrinsic Pathways and Attenuates NF-κB/STAT3 Signaling in Non-small-cell Lung Cancer Cells |
| - | in-vitro, | NSCLC, | A549 |
| 8501- | MAG, | Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy |
| - | vitro+vivo, | neuroblastoma, | NA |
| 8503- | MAG, | Magnolol mitigates neuroinflammation via NF-κB/IL-6/IL-1β pathways in AlCl₃-induced Alzheimer's disease: insights from in-vivo and in-silico investigations |
| - | in-vivo, | AD, | NA |
| 8513- | MAG, | Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I |
| - | vitro+vivo, | Oral, | SCC4 | - | in-vitro, | Tong, | SCC9 | - | in-vitro, | SCC, | CAL27 |
| - | vitro+vivo, | CRC, | HT-29 | - | in-vitro, | Colon, | CT26 |
| 8510- | MAG, | Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma |
| - | in-vitro, | Oral, | CAL27 | - | in-vitro, | Tong, | SCC9 | - | in-vitro, | SCC, | SCC4 |
| 8509- | MAG, | Rad, | The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma |
| - | in-vivo, | HCC, | NA |
| 8507- | MAG, | Magnolol acts as a neurorestorative agent in an Aβ1‑42‑induced mouse model of Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 8502- | MAG, | Magnolol as a promising multitarget agent for Alzheimer's disease: Evidence from a systematic evidence synthesis, network pharmacology, and molecular dynamics simulations |
| - | Review, | AD, | NA |
| 8506- | MAG, | Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells |
| - | in-vitro, | PC, | Panc02 | - | in-vitro, | PC, | MIA PaCa-2 |
| 8505- | MAG, | Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives |
| - | Review, | GC, | NA |
| 8504- | MAG, | Magnolol nanoparticles combat MRSA by disrupting TCA cycle and arginine metabolism to induce oxidative stress |
| - | in-vitro, | Var, | NA |
| 5252- | MAG, | Insights on the Multifunctional Activities of Magnolol |
| - | Review, | Var, | NA |
| 1089- | MAG, | Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways |
| - | in-vitro, | AML, | RAW264.7 |
| 972- | MAG, | Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells |
| - | vitro+vivo, | Bladder, | T24/HTB-9 |
| 2450- | Matr, | The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors |
| - | Review, | Var, | NA |
| 8556- | Matr, | Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway |
| - | in-vivo, | AD, | NA | - | in-vivo, | Diabetic, | NA |
| 8557- | Matr, | Effects of matrine in combination with cisplatin on liver cancer |
| - | in-vivo, | Liver, | HepG2 |
| 8558- | Matr, | Matrine exerts anti‑breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF‑7 cells |
| - | in-vitro, | BC, | MCF7 |
| 8559- | Matr, | Matrine induces toxicity in mouse liver cells through an ROS-dependent mechanism |
| - | vitro+vivo, | Nor, | NA |
| 8560- | Matr, | Matrine: A Promising Natural Product With Various Pharmacological Activities |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA | - | Review, | Var, | NA |
| 8561- | Matr, | Matrine triggers colon cancer cell apoptosis and G0/G1 cell cycle arrest via mediation of microRNA-22 |
| - | in-vitro, | Colon, | SW480 | - | in-vitro, | CRC, | SW-620 |
| 8563- | Matr, | Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition |
| - | in-vitro, | BC, | MDA-MB-231 |
| 8564- | Matr, | Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway |
| - | in-vitro, | Lung, | A549 |
| 8565- | Matr, | Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway |
| - | in-vitro, | AML, | THP1 |
| 8566- | Matr, | Matrine suppresses lung metastasis of human hepatocellular carcinoma by directly targeting matrix metalloproteinase-9 |
| - | vitro+vivo, | HCC, | MHCC-97H |
| 8567- | Matr, | Matrine induces apoptosis in multiple colorectal cancer cell lines in vitro and inhibits tumour growth with minimum side effects in vivo via Bcl-2 and caspase-3 |
| - | vitro+vivo, | CRC, | NA |
| 8568- | Matr, | Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro |
| - | in-vitro, | NSCLC, | A549 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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