Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
2282- VitK2,    Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes
- in-vitro, Nor, NA
*ROS↓, *12LOX↓,
4090- VitK2,  ProBio,    Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment
- Review, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *memory↑, *NF-kB↓, *ROS↓, *GSH↑, *ATP↑, *p‑tau↓, *cardioP↑, *other↝, *cognitive↑,
4091- VitK2,    The possible role of vitamin K deficiency in the pathogenesis of Alzheimer's disease and in augmenting brain damage associated with cardiovascular disease
- Review, AD, NA
*cognitive↑, *other↓, *cardioP↑,
4188- VitK2,    Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
- in-vivo, NA, NA
*BDNF↑, *Aβ↓, *cognitive↑, *Ach↑, *Inflam↓,
1827- VitK3,    A biophysical approach to menadione membrane interactions: relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects
- Analysis, Var, NA
ROS↑, ChemoSen↑,
1828- VitK3,  VitC,    Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C
- in-vivo, GBM, NA
eff↑, ROS↑, Dose∅,
1831- VitK3,  VitK2,    The anticancer effects of vitamin K
- Review, Var, NA
AntiCan↑, Dose∅,
1826- VitK3,    PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549
eff↑, ROS↑,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,
1834- VitK3,  PDT,    Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells
- in-vitro, Melanoma, A431
eff↑, TumCG↓, TumCP↓, ROS↑, MMP↓,
1821- VitK3,    Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
- in-vitro, Oral, NA - in-vitro, Nor, HEK293 - in-vitro, Nor, HaCaT
selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,
1815- VitK3,  VitK2,    Vitamin K
- Review, Nor, NA
*Dose↝, BMD↑,
1835- VitK3,  VitC,    Potential therapeutic application of the association of vitamins C and K3 in cancer treatment
- Review, Var, NA
ROS↑, TumCD↑, TumCG↓, OS↑,
1837- VitK3,  VitC,    Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death
- in-vivo, Pca, NA
eff↑, ROS↑, TumAuto↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,
1839- VitK3,    Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, Apoptosis↑, TumCCA↑, ROS↑, eff↓, AR↓, Trx↓, Bcl-2↓,
2428- VitK3,    Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
- Study, Var, NA
PKM2↓, ChemoSen↑,
2372- VitK3,    The role of pyruvate kinase M2 in anticancer therapeutic treatments
- Review, Var, NA
PKM2↓, eff↑, AntiCan↑,
1760- WBV,    Molecular jackhammers eradicate cancer cells by vibronic-driven action
- in-vitro, Melanoma, NA
TumCD↑,
1761- WBV,    Low Intensity Vibration Mitigates Tumor Progression and Protect Bone Quantity and Quality in a Murine Model of Myeloma
- in-vivo, Melanoma, NA
Dose∅, BMD↑, TumCI↓,
1759- WBV,    Prostate cancer and occupational exposure to whole-body vibration in a national population-based cohort study
- Study, Pca, NA
Risk↓,
1750- WBV,    Whole body vibration exercise in the management of cancer therapy-related morbidities: A systematic review
- Review, Var, NA
Wmax↑, UrinaryC↑, other↓, other↓, Dose?,
1758- WBV,    Whole-body vibration in breast cancer survivors: a pilot study exploring its effects on muscle activity and subjectively perceived exertion
- Human, BC, NA
eff↑,
1757- WBV,    The Impact of Vibration Therapy Interventions on Skin Condition and Skin Temperature Changes in Young Women with Lipodystrophy: A Pilot Study
- Human, Nor, NA
Dose∅, other↑,
1756- WBV,    Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
- in-vitro, MB, A431
Apoptosis↑, GlucoseCon↝, other↓,
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,
1754- WBV,    Vibration Therapy for Cancer-Related Bone Diseases
- Review, Var, NA
*BMD↑, *toxicity∅, other↓, Dose↝, Dose↑, eff↑, eff↑, eff↑,
1753- WBV,  Ex,    Physical Exercise with or without Whole-Body Vibration in Breast Cancer Patients Suffering from Aromatase Inhibitor—Induced Musculoskeletal Symptoms: A Pilot Randomized Clinical Study
- Trial, BC, NA
Pain↓, Strength↑, QoL↑, Dose∅,
1752- WBV,  Chemo,    Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study
- Trial, Var, NA
*BP∅, eff↑, Dose∅, other↑, *toxicity∅, eff↑,
1751- WBV,    Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
- in-vitro, BC, MDA-MB-231 - in-vitro, AML, RAW264.7
BMD↑, YAP/TEAD↑, TumCG↓, Strength↑, TumCI↓, Fas↑, Ca+2↑,
2427- Wog,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
NO↓, PGE2↓, COX2↓, Ca+2↑, mtDam↑, *toxicity↓, eff↑, eff↓,
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,
2621- Wog,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, Var, NA
Hif1a↓, MCT4↓, LDH↓, lactateProd↓, ECAR↓, TumCP↓, Glycolysis↓,
2397- Wor,    Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
- Review, Var, NA
lactateProd↓, GlucoseCon↓, GLUT3↓, HK2↓, PKM2↓, LDHA↓,
5015- Xan,  PEITC,    Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
- in-vitro, HCC, HepG2
NRF2↓, ROS↑, NF-kB↓, COX2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,
1913- Xyl,    Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer
- in-vivo, Oral, NA
TumVol↓, OS↑, PFK↓, toxicity↓, Dose∅, Ki-67↓,
1221- Z,    Unexpected zinc dependency of ferroptosis: what is in a name?
- Analysis, Nor, NA
*Ferroptosis↑, *ROS↑, *lipid-P↑,
1222- Z,    Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition
- in-vitro, Ovarian, NA
EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,
961- Z,    Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
- in-vitro, RCC, RCC4 - vitro+vivo, GBM, U373MG - in-vitro, Nor, HUVECs
Hif1a↓, HIF-1↓, VEGF↓, TumCI↓,
4196- Z,    The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis
- Review, NA, NA
*BDNF∅,
4197- Z,    The Effect of Zinc Supplementation on Circulating Levels of Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, NA, NA
*BDNF↑, *other↓, *eff↑, *Inflam↓, *antiOx↑,
4084- Z,    Role of micronutrients in Alzheimer's disease: Review of available evidence
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *memory↑,
4166- Z,    Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: a double-blind, randomized, placebo-controlled trial
- Trial, Obesity, NA
*BDNF↑, *Mood↑,
4165- Z,    Antidepressant-like activity of zinc: further behavioral and molecular evidence
- in-vivo, AD, NA
*BDNF↑,
4164- Z,    Zinc treatment induces cortical brain-derived neurotrophic factor gene expression
- Review, AD, NA
*BDNF↑,
4191- Zeax,  Lut,    Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance
- Trial, AD, NA
*BDNF↑, *IL1β↓, *cognitive↑, *memory↑,
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,
4889- ZER,    Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
- in-vitro, CRC, HCT116
TumCP↓, TNF-α↓, *toxicity↝,
4888- ZER,  5-FU,    Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts
- in-vitro, CRC, CT26
TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,

Showing Research Papers: 5901 to 5950 of 5957
Prev Page 119 of 120 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5957

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

H2O2↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 10,   SOD↑, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   GlucoseCon↓, 1,   GlucoseCon↝, 1,   Glycolysis↓, 2,   HK2↓, 2,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 2,   MCT4↓, 1,   PDK1↓, 1,   PFK↓, 1,   PKM2↓, 3,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↑, 5,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-xL↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   survivin↓, 1,   TumCD↓, 1,   TumCD↑, 2,   YAP/TEAD↑, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   other↓, 4,   other↑, 2,   tumCV↓, 1,   tumCV∅, 1,   UrinaryC↑, 1,   Wmax↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 3,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   EMT↑, 1,   ERK↑, 1,   p300↓, 1,   PI3K↓, 1,   Piezo1↑, 1,   TOPflash↓, 1,   TumCG↓, 5,   TumCG∅, 1,  

Migration ⓘ

Ca+2↑, 2,   E-cadherin↑, 2,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCI↓, 5,   TumCI↑, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 5,   TumMeta↑, 1,   Vim↓, 3,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

HIF-1↓, 1,   Hif1a↓, 3,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   COX2↑, 1,   NF-kB↓, 1,   NF-kB↑, 1,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose?, 2,   Dose↑, 1,   Dose↝, 1,   Dose∅, 8,   eff↓, 2,   eff↑, 13,   eff∅, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   BMD↑, 3,   Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   Risk↓, 1,   Strength↑, 2,   toxicity↓, 1,   TumVol↓, 2,  
Total Targets: 110

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Ferroptosis↑, 1,   GSH↑, 1,   lipid-P↑, 1,   ROS↓, 2,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 2,   other↝, 1,   tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   Inflam↓, 4,   NF-kB↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 6,   BDNF∅, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BP∅, 1,  

Functional Outcomes ⓘ

cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 5,   memory↑, 3,   Mood↑, 1,   neuroP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 2,  
Total Targets: 37

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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