Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
264- ALA,    α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells
- in-vitro, HCC, FaO
ROS↑, P53↑, ER Stress↑, UPR↑, CHOP↑, PDI↑, GRP78/BiP↑, GRP58↓,
265- ALA,    Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↓, SOD↓, GSTP1/GSTπ↓, NRF2↓, p62↓, p62↑, SOD↑, p‑mTOR↑, Beclin-1↓, ROS↑, SOD1↑,
267- ALA,    α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
Apoptosis↑, ROS↑, PDK1↓, NRF2↓, PDK1↓, Bcl-2↓, Casp9↑, Dose∅,
271- ALA,  VitC,  LDN,    The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol
OS↑, Weight↑, TumVol↓,
276- ALA,    Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B
P53↑, EMT↓, AMPK↑, cycD1/CCND1↓, TumCMig↓,
274- ALA,  LDN,    Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases
- Human, PC, NA
OS↑,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
1235- ALA,  Cisplatin,    α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- in-vitro, Nor, HEI-OC1 - ex-vivo, NA, NA
ROS↑, HO-1↓, *toxicity↓, chemoP↑, *ROS↓, *HO-1↑, *SOD1↑, *NRF2↑,
4283- ALC,    Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice
- in-vivo, NA, NA
*BDNF↑, *p‑Akt↑, *PI3K↑,
5320- ALC,    l-Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer
- in-vivo, Var, NA
Strength↑, *Casp3↓, cachexia↓, *Dose↝,
5323- ALC,    Preventive Effect of Acetyl-L-carnitine on Oxaliplatin-induced Peripheral Neuropathy
- Trial, Var, NA
Pain↓, NP/CIPN↓,
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,
5325- ALC,    L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial
- Trial, PC, NA
Weight↑, QoL↑, OS↑,
5326- ALC,    L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro
- vitro+vivo, Liver, HepG2
TumCG↓, P21↑, ac‑H3↑, HDAC↓, *ATP↑, selectivity↑, ac‑H4↑,
5322- ALC,    Comparison of pharmacokinetics of L-carnitine, Acetyl-L-carnitine and Propionyl-Lcarnitine after single oral administration of L-carnitine in healthy volunteers
- Human, Nor, NA
*Half-Life↝,
5321- ALC,    L-Carnitine
- Review, Var, NA
fatigue↝, *Dose↝, NP/CIPN↓,
5315- ALC,    Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy
- Trial, BC, NA
other↑, NP/CIPN↑,
5316- ALC,    Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L-Carnitine
- Trial, BC, NA
NP/CIPN↑,
5317- ALC,    Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2
- in-vivo, Nor, NA
*BBB↝,
5318- ALC,    Efficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis
- Review, Var, NA
fatigue↝,
5319- ALC,    l-carnitine and cancer cachexia: Clinical and experimental aspects
- Review, Var, NA
fatigue↓, QoL↑, *GSH↑, Dose↝,
3974- ALC,    Carnitine
- Review, AD, NA
*Dose↝, *cognitive↑,
3975- ALC,    Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
- Trial, AD, NA
*cognitive↑,
3976- ALC,    Acetyl-L-carnitine for dementia
- Review, AD, NA
*cognitive↝, *Mood↝,
3859- ALC,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*ROS↓, *ADAM10↑,
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
4512- aLinA,  GLA,    Evening primrose oil: a comprehensive review of its bioactives, extraction, analysis, oil quality, therapeutic merits, and safety
- in-vivo, Nor, NA
*other↝,
1252- aLinA,    α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase
- in-vitro, BC, NA
FASN↓, Apoptosis↑, TumCI↓, TumMeta↓, TumCCA↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
5262- aLinA,    The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review
- Review, AD, NA
*neuroP↑, *Risk↓, *cognitive↑, *Inflam↓, *antiOx↑, *BDNF↑,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
5361- almon,    Abstract CT190: A multicenter, open-label, single-arm, phase II study: The third generation EGFR tyrosine kinase inhibitor almonertinib for pretreated EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer (APOLLO)
- Trial, NSCLC, NA
EGFR↓, OS↑, Dose↝,
5360- almon,  BEV,    Case report: Almonertinib in combination with bevacizumab for leptomeningeal metastases from epidermal growth factor receptor-mutation non-small cell lung cancer: Case series
- Case Report, NSCLC, NA
BBB↑, Dose↝, eff↓, OS↑,
5359- almon,    Aumolertinib as adjuvant therapy in resected EGFR-mutated non-small-cell lung cancer (ARTS): a double-blind, multicentre, randomised, controlled, phase 3 trial
- Trial, NSCLC, NA
eff↑, EGFR↓,
5358- almon,    Experimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models
- vitro+vivo, NSCLC, NA
TumMeta↓, BBB↑, EGFR↓,
5357- almon,    AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
- Trial, NSCLC, NA
EGFR↓, eff↝, OS↑,
4124- Alum,    The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders
- Review, AD, NA
*cognitive↓,
4130- Alum,    Silica and aluminum in drinking water and cognitive impairment in the elderly
- Study, AD, NA
*cognitive↓,
4132- Alum,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↑, *cognitive↓, *BioAv↑,
4135- Alum,    Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer's Disease
- Review, AD, NA
*Risk↑, *cognitive↓, *neuroP↓, *other↑, *other↝,
1440- AMQ,    Lysosomotropism depends on glucose: a chloroquine resistance mechanism
- in-vitro, BC, 4T1
eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,
552- Anamu,    A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu)
- Review, NA, NA
p‑MAPK↑, Th1 response↓, Th2↑,
553- Anamu,    The anti-inflammatory and analgesic effects of a crude extract of Petiveria alliacea L. (Phytolaccaceae)
- in-vivo, NA, NA
TumCMig↓,
554- Anamu,    Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
- in-vitro, NA, 769-P
TumCCA↑, HSP70/HSPA5↓, HSP90↓,
931- And,    Effect of Andrographis Paniculata Aqueous Extract on Hyperammonemia Induced Alteration of Oxidative and Nitrosative Stress Factors in the Liver, Spleen and Kidney of Rats
- in-vivo, NA, NA
*SOD↝, *Catalase↝, *ROS↓, *MDA↓, *NO↓,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,
1007- And,    In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on fatty acid synthase expression on breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, EMT6
tumCV↓, i-FASN↓,
1279- And,    Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
Apoptosis↑, Bcl-2↓, BAX↑, ERα/ESR1↓, PI3K↓, mTOR↓,

Showing Research Papers: 551 to 600 of 5743
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5743

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GCLC↑, 1,   GCLM↑, 1,   GSTP1/GSTπ↓, 1,   HO-1↓, 1,   lipid-P↑, 1,   NOX4↓, 1,   NRF2↓, 2,   ROS↓, 2,   ROS↑, 4,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   MPT↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2,   AMPK↑, 2,   FASN↓, 2,   i-FASN↓, 1,   PDK1↓, 2,   PPARγ↑, 1,   RARβ↑, 1,   SAT1↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Apoptosis↑, 4,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 1,   GRP58↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 1,   p‑MAPK↑, 1,   Necroptosis↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   p62↓, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↑, 3,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   CREB2↓, 1,   EMT↓, 2,   p‑ERK↓, 2,   FOXO3↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC8↓, 1,   HMTs↑, 1,   mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↓, 1,   TumCG↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

CDH1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↑, 1,   MMP2↓, 3,   MMP9↓, 3,   p‑SMAD2↓, 2,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 1,   Snail↑, 1,   TGF-β↓, 2,   TumCI↓, 2,   TumCI↑, 1,   TumCMig↓, 4,   TumCP↓, 2,   TumCP↑, 1,   TumMeta↓, 2,   Twist↓, 2,   Twist↑, 1,   Vim↓, 1,   ZEB2↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,   EGFR↓, 4,   Hif1a↓, 1,   NO↓, 1,   PDI↑, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   Th1 response↓, 1,   Th2↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose↝, 4,   Dose∅, 1,   eff↓, 3,   eff↑, 2,   eff↝, 2,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 4,   ERα/ESR1↓, 1,   EZH2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

cachexia↓, 1,   chemoP↑, 1,   fatigue↓, 2,   fatigue↝, 2,   NP/CIPN↓, 2,   NP/CIPN↑, 2,   OS↑, 6,   OS↝, 1,   Pain↓, 1,   QoL↑, 3,   Strength↑, 1,   TumVol↓, 1,   Weight↑, 3,  
Total Targets: 156

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↝, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 3,   SOD↝, 1,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   Casp3↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,   PI3K↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

ADAM10↑, 1,   BDNF↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 3,   Half-Life↝, 1,  

Functional Outcomes ⓘ

cachexia↓, 1,   cognitive↓, 4,   cognitive↑, 3,   cognitive↝, 1,   Mood↝, 1,   neuroP↓, 1,   neuroP↑, 1,   Risk↓, 1,   Risk↑, 2,   toxicity↓, 2,  
Total Targets: 36

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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