MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
1899- MeJa,    Methyl jasmonate induces production of reactive oxygen species and alterations in mitochondrial dynamics that precede photosynthetic dysfunction and subsequent cell death
- in-vitro, Var, NA
ROS↑, MMP↓, eff↓, H2O2?,
8759- MeSA,    Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway
- in-vitro, Bladder, J82 - in-vitro, CRC, T24/HTB-9
tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑,
2457- MET,    Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- in-vitro, Lung, Calu-1
HK1↓, HK2↓, GlucoseCon↓, MMP↓, ATP↓,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
2242- MF,    Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair
- in-vitro, Nor, NA
*MMP↑, *Diff↑, *OXPHOS↑, *BMD↑, ATP∅,
8483- MF,    Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro Studies
- Review, Var, NA
Apoptosis↑, TumCP↓, Ferroptosis↑, TumCMig↓, EMT↓, ROS↝, ChemoSen↑, RadioS↑, Telomerase↓, selectivity↑, ROS↑, DNAdam↑, Casp↑, Ca+2↑, MMP↓, lysoMP↑, lipid-P↑, NA↑, other↑, ChemoSen↑, P53↑,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
4147- MF,    PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration
- in-vitro, AD, PC12
*ROS↓, *Catalase↑, *MMP↑, *Casp3↓, *p‑ERK↓, *cAMP↑, *p‑CREB↑, *BDNF↑, *neuroP↑,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
532- MF,    A 50 Hz magnetic field influences the viability of breast cancer cells 96 h after exposure
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
TumCP↓, MMP↓, ROS↑, eff↝, selectivity↑,
538- MF,    The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift
- in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, MSTO-211H
TumCG↓, Ca+2↑, COX2/PTGS2↓, ATP↑, MMP↑, ROS↑, OXPHOS↑, mitResp↑,
507- MF,    Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism
- in-vitro, Liver, HepG2 - in-vitro, Lung, A549 - in-vitro, Nor, GP-293
MMP↓, TumCG↓, ROS↑, *Ca+2↓, Ca+2↑, selectivity↑, i-pH↑,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,
4568- MF,    Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria
- Study, Var, NA
*ETC↓, *OCR↑, *MMP↑, *ROS⇅, *MMP⇅,
9267- MFrot,    EXTH-12. Oncomagnetic Monotherapy Mediated Anti-Tumor Immune Response in Glioblastoma
- Review, GBM, NA
TumCP↓, tumCV↓, ROS↑, MMP↓, ATP↓, DNAdam↑, TumCCA↑, TumCG↓, OS↑, Imm↑, CD4+↑, CD8+↑,
2259- MFrot,  MF,    Method and apparatus for oncomagnetic treatment
- in-vitro, GBM, NA
MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, ChemoSen↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,
3493- MFrot,  MF,    Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
- in-vivo, GBM, NA
TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,
186- MFrot,  MF,    Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields
- in-vitro, GBM, GBM - in-vitro, Lung, NA
mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
9154- MG, MIC-1,    Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
- in-vitro, BC, NA
Ingr↝, *TumCG↓, Cyt‑c↑, P53↑, cl‑Casp7↑, survivin↓, Bcl-2↓, Bcl-xL↓, MMP↓, ROS↑, PHB↑,
9073- MGF,    Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase
- in-vitro, MM, NA
TumVol↓, Apoptosis↑, Casp3↑, MMP↓, NF-kB↓, IκB↑, XIAP↓, survivin↓, Bcl-xL↓,
9087- MGF,    Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
- Review, Var, NA
TumCP↓, TumCI↓, angioG↓, *BioAv↓, *neuroP↑, *Inflam↓, *AntiCan↑, *ROS↓, *BioAv↑, *BioAv↝, *Half-Life↝, *BBB↓, CDK1↑, CycB/CCNB1↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, PI3K↓, Akt↓, mTOR↓, MMP↓, MOMP↑, Apoptosis↑, lipid-P↑, TCA↓, NRF2↑, NQO1↑, ROS↓, RadioS↑,
1891- MGO,    Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma
- in-vitro, SCC, NA
NADH↓, MMP↓, Cyt‑c↑, selectivity↑, Apoptosis↑, ROS↑, ATP↓,
6418- MLT,  RES,    Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1α pathway activation
- in-vivo, AD, NA
*neuroP↑, *DRP1/DNM1L↓, *FIS1↓, *ROS↓, *MMP↑, *SIRT1↑, *PGC-1α↑, *Synergy↑,
8658- MLT,    Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport
- vitro+vivo, SCC, CAL27 - in-vitro, Tong, SCC9
ROS?, ETC↓, mRET↑, MMP↑, CoQ10↝, compI↑, compII↑, other↑,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8685- MLT,    Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
- vitro+vivo, RCC, 786-O
Synergy↑, Casp↑, LC3II↑, TumAuto↑, Apoptosis↑, MAPK↑, TumCG↓, MMP?, Bax:Bcl2↑,
8679- MLT,    Targeting Melatonin to Mitochondria Mitigates Castration-Resistant Prostate Cancer by Inducing Pyroptosis
- in-vitro, Pca, NA
Synergy↑, ROS↑, MMP↝, mitResp↓, T-cadherin↓, OXPHOS↓, Glycolysis↓, Pyro↑,
3839- MO,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
- in-vitro, AD, NA
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
8907- MO,    Phenolic Extraction of Moringa Oleifera Leaves Induces Caspase-Dependent and Caspase-Independent Apoptosis through the Generation of Reactive Oxygen Species and the Activation of Intrinsic Mitochondrial Pathway in Human Melanoma Cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCP↓, selectivity↑, ROS↑, MMP↓, BAX↑, Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, AIF↑,
8910- MO,    Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study
- vitro+vivo, lymphoma, NA
TumCP↓, MMP↓, TumCCA↑, P53↑, P21↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↑, Apoptosis↑, MEK↓, ERK↓,
8897- MOR,    Morin promotes prostate cancer cells chemosensitivity to paclitaxel through miR-155/GATA3 axis
- vitro+vivo, Pca, DU145 - in-vitro, Pca, PC3
tumCV↓, GATA3↑, ChemoSen↑, Dose↝, miR-155↓, MMP?, Casp3↑, Casp9↑, P21↑, BAD↑, Bcl-xL↓, STAT3↓,
8874- MOR,    The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives
- Review, Var, NA
AntiCan↑, selectivity↑, *ROS↓, *Inflam↓, *p‑Akt↓, *NF-kB↓, ChemoSen↑, chemoPv↑, *toxicity↓, BioAv↑, BioAv↓, MRP1/ABCC1↝, BioAv↑, PCNA↓, hepatoP↑, NF-kB↓, TNF-α↓, IL6↓, PGE2↓, MMP2↓, MMP9↓, Apoptosis↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, ROS↑, MMP↓, BAX↑, Bcl-xL↓, Casp9↑, Casp3↑, EMT↓, Akt↓, Hippo↑,
8871- MOR,  MGF,    Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers
- in-vitro, AD, NA
*ROS↓, *Ca+2↓, *MMP↑, *Cyt‑c↓,
8868- MOR,  PacT,    Synergistic effect of morin and paclitaxel impedes cell proliferation through PI3K/AKT/STAT3 signaling axis inhibition in gastric cancer
- in-vitro, GC, HGC27
ChemoSen↑, ROS↑, MMP↓, Apoptosis↑, cFos↓, KRAS↓, p‑ERK↓, PI3K↓, Akt↓, STAT3↓, TumCP↓,
8863- MOR,    Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
- in-vitro, Colon, SW48
TumCP↓, Apoptosis↑, ROS↑, MMP↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, ATP↓, GlucoseCon↓, GLUT1↓, Warburg↓, Dose↝, Catalase↓, GSH↓, ADP:ATP↑, AMP↑,
8862- MOR,    The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells
- in-vitro, CRC, HCT116
Fas↑, Casp8↑, Casp9↑, Casp3↑, BID↑, MMP↓, BAX↑, Cyt‑c↑, ROS↑, Bcl-2↓, IAP1↓, Apoptosis↑, Akt↓,
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,
8878- MOR,    Investigating the Effects of Morin and Aminoimidazole Carboxamide Ribonucleotide on the AMPK/mTOR/ULK1 Signaling Pathway in Breast Cancer Cell Line (MCF-7)
- in-vitro, BC, MCF7
tumCV↓, p‑AMPK↑, p‑ULK1/ATG1↑, LC3B↑, p‑mTOR↓, mt-ROS↑, MMP↓, tumCV↓, TumCP↓, Apoptosis↑,
8780- MSM,    Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells
- in-vitro, CRC, HT-29
Apoptosis↑, TumCCA↑, CSCs↓, Dose↝, cl‑PARP↑, cl‑Casp9↑, MMP↓, SOX2↓, OCT4↓, Nanog↓,
8779- MSM,    Effect of Methylsulfonylmethane on Proliferation and Apoptosis of A549 Lung Cancer Cells Through G2/M Cell-cycle Arrest and Intrinsic Cell Death Pathway
- in-vitro, Lung, A549
*Inflam↑, *antiOx↑, tumCV↓, TumCCA↑, MMP↓, Cyt‑c↑,
8936- MushCha,    Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis
- vitro+vivo, Lung, LLC1
AMPK↑, tumCV↓, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, MMP↓, OXPHOS↓, Glycolysis↓, Dose?, MPT↑, ATP↓,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
8968- mushLions,    Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells
- in-vitro, lymphoma, U937
Ingr?, Apoptosis↑, TumCP↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, XIAP↓, IAP1↓, Cyt‑c↑, MMP↓, cl‑PARP↑,
8953- mushLions,    Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways
- in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1
Ingr↝, BAX↑, Bcl-2↓, MMP↓, cl‑Casp9↑, cl‑Casp3↑, ROS↑, eff↓, Ingr?,
9302- MushMait,    Black Maitake mushroom (Grifola frondosa) extract exerts anti-cancer effects and enhances the efficacy of chemotherapeutic drugs in 2D and 3D models of triple-negative breast cancer
- in-vitro, BC, MDA-MB-231
Apoptosis↑, MMP↓, TumCMig↓, ChemoSen↑, *toxicity↓,
5609- NaHCO3,    Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function
- in-vitro, Var, NA
eff↑, e-pH↑, MMP↓, OXPHOS↝, AMP↑, TumAuto↑, MPT↑, mtDam↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,

Showing Research Papers: 551 to 600 of 814
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 814

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 5,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 18,   Catalase↑, 4,   Ceru↓, 1,   Copper↑, 1,   CoQ10↝, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 4,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 17,   GSH↓, 76,   GSH↑, 7,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 7,   GSR↓, 2,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2?, 1,   H2O2↓, 1,   H2O2↑, 9,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 10,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 10,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   lipid-P↑, 32,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 13,   NADH↓, 5,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 20,   NRF2↑, 20,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   RNS↓, 1,   ROS?, 5,   ROS↓, 28,   ROS↑, 527,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 6,   m-ROS↑, 1,   mt-ROS↑, 16,   SOD↓, 22,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 4,   TAC↓, 3,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 5,   Trx↑, 2,   Trx1↓, 1,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 18,   TrxR↑, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2,   IronCh↑, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 3,   BCR↓, 1,   CDC2↓, 6,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 8,   compI↑, 1,   compII↓, 2,   compII↑, 1,   compIII↓, 5,   compV↓, 1,   EGF↓, 2,   ETC↓, 18,   ETC↝, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 2,   HTRA2/Omi/PARK13↑, 1,   IDH2↓, 1,   MFN2↓, 1,   mitResp↓, 9,   mitResp↑, 5,   MKK7↓, 1,   mRET↑, 1,   mtDam↓, 2,   mtDam↑, 56,   OCR↓, 20,   OCR↑, 1,   OXPHOS↓, 10,   OXPHOS↑, 4,   OXPHOS↝, 2,   OXPHOS∅, 1,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   p‑PDH↓, 2,   PGC-1α↑, 1,   PHB↑, 1,   PINK1↑, 6,   SDH↓, 1,   SIRT3↓, 3,   SIRT3↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 1,   ACC↓, 1,   ACC↑, 2,   ACSL4↑, 1,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 2,   AMPK↓, 1,   AMPK↑, 33,   p‑AMPK↑, 4,   p‑AMT/GCST/T-protein↑, 1,   ANXA7↑, 2,   ATP↓, 60,   ATP↑, 3,   ATP↝, 1,   ATP∅, 1,   e-ATP↑, 1,   BHB↑, 1,   CAIX/CA9↓, 1,   DHODH↓, 2,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 6,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 18,   GlucoseCon↑, 1,   GlutMet↓, 1,   Glycolysis↓, 41,   GSK‐3β↓, 7,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK1↓, 1,   HK2↓, 29,   HMG-CoA↓, 2,   HMGCS2↑, 1,   lactateProd↓, 18,   lactateProd↑, 3,   LDHA↓, 11,   LDL↓, 4,   NAD↓, 1,   NADPH↓, 1,   NADPH↑, 3,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDKs↓, 6,   PFK↓, 8,   PFKP↓, 1,   PKM2↓, 15,   PKM2↑, 1,   PKM2∅, 1,   PPP↓, 1,   SCD1↓, 2,   SIRT1↓, 13,   SIRT1↑, 4,   SIRT2↓, 1,   SIRT2↑, 1,   SLC25A1↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 1,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 36,   AIF↝, 1,   APAF1↑, 12,   Apoptosis?, 4,   Apoptosis↓, 8,   Apoptosis↑, 385,   mt-Apoptosis↑, 4,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 21,   Bak↓, 1,   Bak↑, 15,   BAX↓, 4,   BAX↑, 189,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 57,   Bcl-2↓, 196,   Bcl-2↑, 2,   Bcl-2∅, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 41,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 15,   p‑BID↓, 1,   cl‑BID↑, 3,   BIM↓, 1,   BIM↑, 10,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 2,   BOK↑, 1,   Casp↓, 2,   Casp↑, 76,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 2,   Casp12↑, 11,   cl‑Casp12↑, 1,   pro‑Casp12↓, 1,   Casp2↑, 1,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 276,   cl‑Casp3↓, 2,   cl‑Casp3↑, 51,   proCasp3↓, 1,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 2,   Casp6↑, 2,   Casp7↑, 20,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 65,   Casp8∅, 2,   cl‑Casp8↑, 10,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 178,   cl‑Casp9↓, 1,   cl‑Casp9↑, 23,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 7,   Cupro↑, 2,   Cyt‑c↓, 4,   Cyt‑c↑, 243,   Cyt‑c↝, 1,   Diablo↑, 14,   DR5↑, 29,   Endon↑, 5,   FADD↑, 8,   Fap1↓, 2,   Fas?, 1,   Fas↓, 3,   Fas↑, 32,   FasL↓, 1,   FasL↑, 16,   Ferroptosis↑, 17,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 15,   iNOS↑, 1,   Mcl-1↓, 20,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   p‑MDM2↓, 1,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 7,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 9,   NOXA↑, 3,   p38↓, 8,   p38↑, 27,   p‑p38↓, 2,   p‑p38↑, 5,   Paraptosis↑, 4,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 5,   RIP3↑, 3,   p‑RIP3↑, 2,   survivin↓, 49,   TNFR 1↑, 3,   TRAIL↑, 8,   TRAIL⇅, 1,   TRAILR↑, 5,   TumCD↑, 46,   TUNEL↑, 1,   XIAP↓, 31,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 145,   Akt↑, 5,   p‑Akt↓, 37,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 2,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 1,   p‑cMET↑, 1,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 51,   ERK↑, 9,   p‑ERK↓, 18,   p‑ERK↑, 7,   e-ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 1,   Hippo↓, 1,   Hippo↑, 1,   Hippo↝, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 3,   IKKα↑, 3,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 5,   JAK1↓, 2,   JAK1↑, 2,   JAK2↓, 7,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 8,   MAP2K1/MEK1↓, 1,   MAPK↓, 32,   MAPK↑, 19,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 71,   mTOR↑, 1,   p‑mTOR↓, 14,   mTORC2↓, 3,   NRAS↓, 1,   p70S6↓, 3,   p‑p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 99,   PI3K↑, 3,   p‑PI3K↓, 6,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 2,   PKCδ↓, 12,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 18,   Raf↓, 6,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 15,   Src↑, 1,   STAT↓, 3,   STAT3↓, 61,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 3,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 12,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 6,   p‑cJun↑, 2,   cMyc↓, 20,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 7,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 26,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC6↓, 2,   HDAC8↓, 2,   HMTs↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-203↑, 1,   miR-21↓, 4,   miR-22↑, 2,   miR-34a↑, 4,   MTA2↓, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 12,   other↓, 7,   other↑, 9,   other↝, 12,   sonoS↑, 1,   SOX2↓, 11,   SOX4↓, 3,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 2,   tumCV?, 2,   tumCV↓, 106,   tumCV↑, 1,   tumCV∅, 1,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   cl‑ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 38,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   eIF2α↓, 1,   eIF2α↑, 9,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 3,   ER Stress↑, 71,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 24,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 8,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 12,   HSP90↑, 2,   HSPs↓, 1,   HTRA↓, 1,   IRE1↑, 6,   PDI↑, 1,   PERK↑, 13,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 17,   XBP-1↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 3,   ATG5↑, 11,   ATG7↑, 3,   autoF↓, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 16,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 6,   LC3B-II↑, 3,   LC3II↑, 21,   LC3s↑, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↓, 1,   MitoP↑, 5,   p62↓, 11,   p62↑, 5,   PARK2↑, 5,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 71,   TumAuto⇅, 2,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 5,   BRCA1↓, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 2,   DNA-PK↑, 2,   DNAdam↓, 5,   DNAdam↑, 121,   mt-DNAdam↑, 1,   DNArepair↓, 2,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 113,   P53↝, 2,   P53∅, 1,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype∅, 1,   PARP↓, 10,   PARP↑, 22,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 109,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 30,   POLD1↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1?, 1,   TOP1↓, 13,   TOP1∅, 1,   TOP2↓, 5,   TP53↓, 3,   TP53↑, 4,   TRF2↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 18,   CDK1↑, 2,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 38,   CDK2↑, 2,   CDK4↓, 43,   p‑CDK4↓, 1,   CDK6↓, 15,   CDK6↑, 2,   CDK7↓, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   CHK1↝, 1,   Chk2↓, 2,   Chk2↑, 3,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 23,   CycB/CCNB1↑, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 79,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 22,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   MAD↓, 1,   mitA↓, 1,   mitA↑, 2,   p19↑, 1,   P21?, 2,   P21↓, 5,   P21↑, 71,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 27,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 287,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 7,   ALDH1A1↓, 2,   BMI1↓, 1,   CD133↓, 9,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 7,   CSCs?, 1,   CSCs↓, 51,   Diff↓, 2,   Diff↑, 2,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 6,   HH↓, 3,   HMGCR↓, 1,   IGF-1↓, 5,   p‑IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↑, 2,   Ki-67↓, 22,   Let-7↑, 3,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 13,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 3,   PTCH1↓, 2,   Shh↓, 5,   Smo↓, 4,   TumCG?, 3,   TumCG↓, 139,   TumCG↑, 3,   TumCP↓, 183,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 29,   Wnt↑, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 1,   AntiAg↓, 1,   AP-1↓, 6,   ASAP2↓, 1,   ATPase↓, 1,   ATPase↑, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 88,   Ca+2↝, 6,   i-Ca+2?, 1,   i-Ca+2↑, 5,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↑, 3,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↑, 1,   COL1↓, 2,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 40,   EMT↓, 65,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 12,   p‑FAK↓, 3,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 3,   LAMs↓, 2,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 4,   MET↓, 2,   MMP-10↓, 3,   MMP1↓, 3,   MMP13↓, 3,   MMP15↓, 1,   MMP2↓, 80,   MMP2↑, 1,   proMMP2↓, 1,   MMP3↓, 6,   MMP7↓, 8,   MMP9↓, 84,   MMP9↑, 1,   MMPs↓, 24,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 23,   PAK1↓, 3,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 2,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 27,   T-cadherin↓, 1,   talin?, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 3,   TIMP1↑, 8,   TIMP2↓, 5,   TIMP2↑, 8,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCI?, 1,   TumCI↓, 70,   TumCI↑, 1,   TumCMig↓, 74,   TumCMig↑, 1,   TumMeta↓, 61,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 16,   uPA↓, 18,   uPA↝, 1,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 34,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 81,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   EGR1↑, 1,   Endoglin↑, 2,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 57,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 2,   NO↑, 8,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 81,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 6,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 2,   EPR↝, 1,   GLUT1↓, 13,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT4↓, 4,   IBI↑, 1,   memfluid↓, 1,   MMP?, 4,   MMP↓, 695,   MMP↑, 15,   MMP↝, 4,   MMP∅, 4,   MPT↑, 19,   NHE1↓, 2,   OCLN↑, 1,   SMCT1∅, 1,   sonoP↑, 1,   TJ↑, 1,   TRPM7↓, 2,   TRPV1↑, 8,   TRPV1↝, 1,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 17,   CD47↓, 2,   CD59↑, 1,   CD8+↑, 6,   cDC2↓, 1,   cGAS–STING↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 61,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DCells↑, 1,   DR4↑, 9,   DR4∅, 1,   FOXP3↑, 2,   HMGB1↓, 3,   HMGB1↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 5,   IL12↑, 1,   IL17↓, 1,   IL1β↓, 14,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   Imm↝, 2,   Inflam↓, 33,   IRAK1↓, 1,   IRAK4↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 131,   NF-kB↑, 12,   p‑NF-kB↓, 3,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 1,   p‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 17,   PSA↓, 9,   RAGE↓, 1,   RANTES?, 1,   SOCS-3↓, 1,   T-Cell↑, 3,   TCF↓, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TIGIT↓, 1,   TLR1↑, 1,   TLR4↓, 8,   TNF-α↓, 28,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 2,   pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,   TAMS↝, 1,   Temp∅, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 10,   AR↑, 2,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 4,   RANKL↓, 1,   SXR↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 35,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 157,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 1,   Dose?, 7,   Dose↓, 3,   Dose↑, 9,   Dose⇅, 2,   Dose↝, 61,   Dose∅, 18,   DrugR↓, 1,   eff↓, 120,   eff↑, 127,   eff↝, 18,   GSTA1↓, 1,   Half-Life↓, 10,   Half-Life↝, 12,   MDR1↓, 7,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P-gp/ABCB1∅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 49,   RadioS↝, 1,   selectivity?, 1,   selectivity↓, 2,   selectivity↑, 167,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 105,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 10,   AR↑, 2,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BMD↑, 1,   BRCA1↓, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 3,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 9,   IL6↓, 37,   IL6↑, 1,   KRAS↓, 3,   LDH↓, 11,   LDH↑, 6,   LDH↝, 1,   e-LDH↑, 1,   i-LDH↓, 1,   Myc↓, 5,   PD-L1↓, 9,   PSA↓, 9,   PSADT↑, 1,   RAGE↓, 1,   TP53↓, 3,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 64,   antiNeop↑, 5,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 13,   chemoP↑, 29,   chemoPv↑, 27,   chemoPv⇅, 1,   ChemoSideEff↓, 3,   cognitive↑, 1,   fatigue∅, 1,   hepatoP↑, 11,   hepatoP∅, 1,   K17↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   Obesity↓, 2,   OS↑, 14,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   QoL∅, 1,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 18,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 6,   TumNum↓, 1,   TumVol↓, 23,   TumVol↑, 1,   TumW↓, 9,   Weight↑, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 3,   GutMicro↑, 4,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 6,  
Total Targets: 1128

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 105,   i-antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 47,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 25,   GPx1↑, 3,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 41,   GSR↑, 7,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 5,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 25,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 32,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 24,   MDA↑, 2,   MPO↓, 6,   NADH↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↑, 51,   p‑NRF2↑, 1,   Prx↑, 2,   RNS↓, 2,   ROS?, 2,   ROS↓, 137,   ROS↑, 12,   ROS⇅, 1,   ROS∅, 8,   mt-ROS?, 1,   mt-ROS↓, 3,   SOD↓, 2,   SOD↑, 53,   SOD1↑, 2,   SOD2↑, 3,   TAC↑, 5,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 2,   Trx1↑, 2,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   IronCh↝, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   compIV↑, 2,   DRP1/DNM1L↓, 2,   DRP1/DNM1L↑, 1,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   MFN1↓, 1,   MFN2↓, 1,   MFN2↑, 2,   mitResp↓, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 1,   OCR↑, 3,   OPA1↓, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   PGC-1α↑, 9,   PGC-1α↝, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ALAT↓, 12,   ALDOA↑, 1,   AMPK↑, 14,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 15,   ATP∅, 1,   BMAL1↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 4,   glucose↝, 2,   GlucoseCon↑, 2,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GPI↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↑, 2,   KeyT↝, 1,   LDHA↑, 2,   LDL↓, 4,   lipidLev↓, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   PFKL↑, 2,   PFKM↑, 1,   PFKP↑, 1,   PKM1↑, 1,   PKM2↑, 1,   SCFAs↑, 1,   SIRT1↑, 11,   SIRT2↑, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 22,   Apoptosis∅, 1,   mt-Apoptosis↓, 1,   ASC↓, 1,   BAX↓, 12,   BAX↑, 5,   Bax:Bcl2↓, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-2↑, 7,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Casp↓, 1,   Casp1↓, 2,   cl‑Casp1↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 18,   Casp3↑, 6,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Casp9↑, 2,   cl‑Casp9↓, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 3,   Cyt‑c∅, 3,   Fas↑, 2,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 16,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 3,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 6,   p‑Akt↓, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 4,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 4,   PI3K↑, 4,   p‑PI3K↑, 1,   PTEN↑, 1,   Src↓, 1,   STAT3↓, 1,   STAT3↑, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↓, 2,   other↑, 7,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSPs↑, 2,   IRE1↓, 2,   PDI↓, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 4,   PARK2↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   p16↓, 1,   P53↓, 2,   P53↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↓, 3,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   IGFBP3↑, 1,   neuroG↑, 1,   TumCG↓, 2,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   Ca+2?, 1,   Ca+2↓, 13,   Ca+2↑, 3,   Ca+2↝, 2,   i-Ca+2↓, 1,   cal2↓, 3,   Cartilage↑, 1,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 1,   PAI-1/SERPINE1↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 4,   E-sel↓, 1,   Hif1a↑, 2,   NO↓, 8,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 14,   BBB↝, 1,   BBB∅, 2,   CellMemb↑, 1,   CLDN5↓, 1,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 16,   MMP↑, 81,   MMP⇅, 1,   MMP↝, 2,   MMP∅, 4,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGCC↑, 1,   VGCC⇅, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCL12↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 4,   IL12↓, 2,   IL17↓, 3,   IL18↓, 4,   IL1β↓, 21,   IL2↓, 2,   IL22↓, 1,   IL4↓, 3,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm⇅, 1,   Inflam↓, 112,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 2,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NeuroI↓, 5,   NF-kB↓, 40,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 7,   p65↓, 1,   PAR-2↓, 1,   PGE2↓, 11,   PGE2↑, 1,   TLR1↓, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 29,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 4,   AChE↓, 20,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↑, 11,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 3,   NGF↑, 2,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 6,   XO↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   Estro↓, 1,   PPARα↑, 2,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 36,   BioAv↝, 15,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 2,   Dose⇅, 1,   Dose↝, 21,   Dose∅, 1,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 3,   AST↓, 14,   BG↓, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 4,   BP↝, 1,   BUN↓, 2,   creat↓, 6,   CRP↓, 4,   IL6↓, 19,   IL6↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 6,   LDH↑, 1,   NOS2↓, 2,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 19,   antiD↓, 1,   AntiDiabetic↑, 19,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 5,   ANXi↓, 1,   cardioP↓, 1,   cardioP↑, 35,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↑, 24,   cough?, 1,   hepatoP↑, 31,   Learn↑, 4,   memory↑, 24,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 88,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   radioP↑, 5,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 1,   Stroke↓, 8,   toxicity↓, 40,   toxicity↑, 4,   toxicity↝, 9,   toxicity∅, 7,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 8,   Bacteria↓, 20,   Diar↓, 1,   GutMicro↑, 13,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 517

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
32 Silver-NanoParticles
26 Quercetin
21 Betulinic acid
21 Capsaicin
18 Baicalein
18 Sulforaphane (mainly Broccoli)
17 Propolis -bee glue
17 Fisetin
16 Curcumin
16 Berberine
16 Magnetic Fields
15 Apigenin (mainly Parsley)
15 Emodin
15 Shikonin
15 Thymoquinone
12 Luteolin
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Phenethyl isothiocyanate
10 Electrical Pulses
10 Gambogic Acid
10 Graviola
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Ivermectin
9 Magnolol
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Cisplatin
8 Dichloroacetate
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Morin
7 Radiotherapy/Radiation
7 Benzyl isothiocyanate
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Juglone
7 Linalool
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 doxorubicin
6 Beta-Caryophyllene
6 Carvacrol
6 Lycopene
6 Magnetic Field Rotating
6 Melatonin
6 Parthenolide
5 Allyl isothiocyanate
5 Alpha-Lipoic-Acid
5 Artemisinin
5 Rosmarinic acid
5 Diindolylmethane
5 Indole-3-carbinol
5 Eugenol
5 Ferulic acid
5 isoorientin
5 Vitexin
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 Selenium
4 Crocetin
4 Copper and Cu NanoParticles
4 Date Fruit Extract
4 Ginkgo biloba-EGb 761
4 Evodiamine
4 Formononetin
4 Gallic acid
4 Garcinol
4 HydroxyTyrosol
4 Hyperoside
4 Isobavachalcone
4 Isorhamnetin
4 Licorice
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Isovitexin
3 Isothiocyanates
3 Boron
3 Thymol-Thymus vulgaris
3 Carvone
3 Cynaropicrin
3 Diclofenac
3 Ellagic acid
3 Fucoidan
3 Paclitaxel/Taxol
3 Geraniol
3 Gossypol/AT-101
3 Hibiscus sabdariffa
3 isoquercitrin
3 Photodynamic Therapy
3 Matrine
3 Methyl Jasmonate
3 Mangiferin
3 Moringa oleifera
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Bullatacin
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Chlorella (Chlorella vulgaris)
2 Fenbendazole
2 Flaxseed Oil
2 Ginkgo biloba
2 Ginseng
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hydrogen Gas
2 Hyperthermia
2 Methylene blue
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Nimbolide
2 Patchouli Oil (Pogostemon cablin)
2 Phycocyanin
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Spirulina(Arthrospira/Limnospira)
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Mistletoe/Viscum album Extracts
1 Disulfiram
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Salvia officinalis
1 Lemon Balm/Melissa officinalis
1 Ginger/6-Shogaol/Gingerol
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 iodine
1 phytic acid, Inositol hexakisphosphate
1 carboplatin
1 isoflavones
1 itraconazole
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 1,8-Cineole
1 Lutein
1 methylseleninic acid
1 Moringin
1 Methylglyoxal
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Rauwolfia serpentina/Indian Snakeroot
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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