Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓, *antiAll↑,
8149- lamb,    Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, TumCCA↑, AMPK↑, Akt↓, FOXM1↓, Bcl-2↓, CycB/CCNB1↓, APOE4↑,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8248- LCA,    Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress
- in-vitro, NSCLC, A549 - in-vitro, Lung, H460
tumCV↓, TumCG↓, TumCCA↑, MDM2↓, CycB/CCNB1↓, cDC2↓, CDC25↓, Casp3↑, PARP↑, ER Stress↑, p‑eIF2α↑, ATF4↑, TumCP↓, selectivity↑, Bcl-xL↓, Bcl-2↓,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,
8259- LCA,    Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid
- in-vitro, BC, MCF7 - in-vitro, AML, HL-60
ChemoSen↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, Bax:Bcl2↑,
8275- LCA,    Licochalcone A inhibits glioma migration, invasion, and growth by triggering mitochondrial dysfunction and ROS-mediated oxidative damage
- vitro+vivo, GBM, NA
AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, mtDam↑, Bcl-2↓, ROS↑,
8208- LCA,    Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells
- in-vitro, BC, MCF7
*Inflam↓, *AntiCan↑, *AntiP↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, Casp3↑, Bcl-2↓, TumAuto↑, Apoptosis↑, tumCV?,
8207- LCA,    Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, Apoptosis↑, eff↓, TrxR1↓, cDC2↓, Bcl-2↓, BAX↑, NRF2↓, p‑ASK1↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
8337- LDN,    Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway
- in-vitro, CRC, NA
OGFr↑, BAX↑, Casp9↑, Casp3↑, PARP↑, Bcl-2↓, survivin↓, Ki-67↓, Apoptosis↑,
8287- LE,    New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
- in-vitro, Nor, NA
*antiOx↑, *MDA↓, *lipid-P↓, *SOD?, *Catalase↑, *GSTs↑, *GPx↑, *GR↑, selectivity↑, tumCV↓, Casp8↑, Casp3↑, Bcl-2↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8262- LE,    Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of Glycyrrhiza glabra ethanolic extract
- in-vitro, Liver, HepG2
*Dose↝, *AntiBio↑, Dose↝, P53↑, BAX↑, Bcl-2↓, Apoptosis↑,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8279- LE,    18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, H460
tumCV↓, selectivity↑, Apoptosis↑, ROS↑, TumCCA↑, TumCMig↓, TumCP↓, MMP↓, BAD↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑STAT3↓, NF-kB↓,
1306- LE,    Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell
- in-vitro, BC, MCF7
Bcl-2↓, BAX↑, Apoptosis↑, TumCCA↑,
8133- LF,    Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin
- in-vitro, GC, SGC-7901
*AntiBio↑, AntiCan↑, Akt↓, NF-kB↓, Bcl-2↓, p‑GSK‐3β↑, p‑Casp9↑,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8295- lign,    Distribution, biosynthesis and therapeutic potential of lignans
- Review, Var, NA
*Ingr?, *BioAv↝, *antiOx↑, *AntiCan↑, *Inflam↓, *other?, Dose↝, AntiTum↑, pS2/TFF1↓, Bcl-2↓, IGF-1R↓, *radioP↑, *HO-1↑, GSTM1↑, NQO1↑, ChemoSen↑, *AntiDiabetic↑, *glucose↓, *GSH↑, *SOD↑, *MDA↓, *NO↓, *Bacteria↓, *AntiFungal↑,
8330- LIN,    SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
- in-vitro, GBM, U87MG
tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8386- LT,    Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway
- in-vitro, ALL, SUP-B15
tumCV↓, ROS↑, MMP↓, ATP↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, TumCP↓, eff↓, ChemoSen↑, FAK↓, Synergy↑, BioAv↓, BioAv↑,
8391- LT,    Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments
- in-vitro, NSCLC, NA
other↝, TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MDM2↓, Bcl-2↓, P53↑, BAX↑,
8403- LT,    Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- in-vitro, CRC, HT-29
tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,
8399- LT,    Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *cognitive↑, *neuroP↑, *Aβ↓, *mtDam↓, *Apoptosis↓, *PPARγ↑, *ROS↓, *SOD↑, *GSH↑, *NRF2↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *cl‑Casp9↓, *cl‑Casp3↓, *IDE↑, *BACE/β-secretase↓, *Aβ42↓,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
8369- LT,    Luteolin inhibits proliferation of lung cancer A549 cells by increasing ROS production and inhibiting the AKT/mTOR signaling pathway and HO-1 expression
- in-vitro, Lung, A549
tumCV↓, TumCP↓, ROS↑, BAX↑, cl‑Casp9↑, Beclin-1/ATG6↑, LC3B-II↑, Bcl-2↓, p62↓, TumAuto↑, p‑Akt↓, p‑mTOR↓, HO-1↓,
1317- LT,    Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2
- vitro+vivo, Ovarian, PA1
Bcl-2↓, BAX↑, Apoptosis↑, TumCG↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2917- LT,  Rad,    Luteolin acts as a radiosensitizer in non‑small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade
- in-vitro, Lung, NA
Bcl-2↓, Casp3↑, Casp8↑, Casp9↑, p‑p38↑, ROS↑, RadioS↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
8345- Lut,    Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, SOD2↓, HO-1↓, NRF2↓, p‑Akt↓, p‑ERK↓, NF-kB↓, Apoptosis↑, Casp3↑, Bcl-2↓, PARP↓, ROS↓, XBP-1↓, Dose↝, Risk↓, MMP↓, selectivity↑, p‑Akt↓,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,

Showing Research Papers: 551 to 600 of 856
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 856

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 4,   antiOx↑, 9,   antiOx⇅, 2,   ARE↓, 1,   ARE↑, 1,   Catalase↓, 15,   Catalase↑, 12,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 4,   GPx↑, 8,   GPx1↓, 1,   GPx4↓, 8,   GPx4↑, 1,   GSH↓, 51,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSTs↓, 2,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 7,   HO-1↓, 8,   HO-1↑, 14,   HO-1↝, 1,   Iron↑, 3,   i-Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 9,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 6,   MDA↑, 14,   MPO↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 7,   NRF2↓, 20,   NRF2↑, 21,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx6↑, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 4,   ROS↓, 28,   ROS↑, 346,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 4,   mt-ROS↑, 8,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 18,   SOD↑, 14,   SOD1↓, 2,   SOD1↑, 2,   SOD2↓, 6,   SOD2↑, 4,   TAC?, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 3,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 6,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 2,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 11,   CDC2↑, 1,   CDC25↓, 17,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   EGF↓, 5,   ETC↓, 4,   HSP60/HSPD1↓, 1,   MCU↓, 1,   mitResp↓, 3,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 27,   OCR↓, 6,   OXPHOS↓, 8,   mt-OXPHOS↓, 2,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   PHB↑, 1,   PINK1↑, 3,   SIRT3↓, 3,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 3,   5LO↓, 3,   ACC↑, 4,   p‑ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 26,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 23,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 10,   FBI-1↓, 1,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 3,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 3,   GlucoseCon↓, 7,   GlutaM↓, 1,   GlutMet↓, 2,   Glycolysis↓, 29,   GSK‐3β↓, 12,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 14,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 8,   LDL↓, 3,   lipidLev↓, 1,   MCT4↓, 1,   NAD↝, 1,   NADPH↓, 3,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 11,   PDKs↓, 1,   PFK↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PKM2↓, 12,   PLA2↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   SSAT↑, 1,   TCA?, 1,   TCA↓, 3,   TCA↑, 1,   TS↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   AIF↝, 1,   APAF1↑, 15,   Apoptosis?, 4,   Apoptosis↓, 16,   Apoptosis↑, 426,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   p‑ASK1↑, 1,   BAD?, 1,   BAD↓, 5,   BAD↑, 25,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 22,   BAX↓, 11,   BAX↑, 505,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2?, 1,   Bcl-2↓, 764,   Bcl-2↑, 18,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 116,   Bcl-xL↑, 3,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 17,   BIM↓, 1,   BIM↑, 17,   BNIP3?, 2,   BNIP3↑, 5,   BOK↑, 2,   Casp↓, 1,   Casp↑, 56,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 4,   Casp10↑, 2,   Casp12?, 1,   Casp12↑, 6,   Casp12↝, 1,   cl‑Casp12↑, 2,   Casp2↑, 3,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 331,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 93,   proCasp3↓, 3,   proCasp3↑, 3,   Casp6↑, 2,   Casp7?, 1,   Casp7↑, 32,   cl‑Casp7↑, 8,   Casp8↓, 1,   Casp8↑, 67,   cl‑Casp8↑, 14,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 194,   Casp9∅, 1,   p‑Casp9↑, 2,   cl‑Casp9↑, 37,   proCasp9↓, 1,   proCasp9↑, 3,   CellShr↑, 1,   cFLIP↓, 10,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 180,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 8,   DIDO1/DIO-1↑, 1,   DR5↑, 34,   FADD↑, 12,   Fas↓, 2,   Fas↑, 35,   FasL↓, 1,   FasL↑, 18,   Ferroptosis↑, 9,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME↑, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   HEY1↓, 2,   IAP1↓, 21,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 17,   iNOS↑, 2,   Mcl-1↓, 64,   MDM2↓, 16,   MDM2↑, 1,   p‑MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 8,   NAIP↓, 2,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 8,   p38↓, 7,   p38↑, 32,   p‑p38↓, 7,   p‑p38↑, 13,   Paraptosis↑, 2,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 118,   survivin↑, 1,   survivin↝, 1,   TNFR 1↑, 4,   TRAIL↑, 9,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 29,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 56,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 182,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 70,   p‑Akt↑, 1,   AKT1↓, 6,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 2,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   p‑cMET↑, 2,   cSrc↓, 4,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 60,   ERK↑, 17,   p‑ERK↓, 27,   p‑ERK↑, 6,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 1,   HRAS↓, 1,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 10,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 5,   JAK1↓, 8,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 5,   JNK↑, 33,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 10,   cl‑JNK↑, 1,   LATS1↓, 1,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 40,   MAPK↑, 20,   MAPK↝, 1,   p‑MAPK↓, 3,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 6,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   Mst1↑, 1,   mTOR↓, 91,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 22,   mTORC2↓, 4,   p‑p42↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 6,   p‑P70S6K↓, 2,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 3,   PI3K↓, 130,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 16,   p‑PI3K↑, 1,   PI3K/Akt↓, 9,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 2,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 3,   PTEN↑, 33,   PTEN↝, 2,   PTPN6↑, 1,   Raf↓, 8,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RTK-RAS↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 6,   STAT3↓, 88,   STAT3↑, 4,   p‑STAT3↓, 22,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT5↓, 2,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 4,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 16,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 1,   cMyc↓, 56,   cMyc↑, 2,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 7,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 2,   FOXO1↓, 1,   FOXO1↑, 4,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 3,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 26,   HDAC1↓, 9,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 2,   HES1↓, 1,   HOXB-AS1↓, 1,   IRF1↑, 1,   KCNQ1OT1↓, 1,   miR-106b↓, 2,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-125b↓, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 7,   miR-21↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 3,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 10,   miR-375↓, 1,   miR-375↝, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   miR-422a↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-590-3p↑, 1,   Myc↓, 7,   n-MYC↓, 2,   NR1D2↓, 1,   OCT4↓, 15,   OCT4↑, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 9,   PhotoS↑, 3,   Set9↑, 1,   sonoS↑, 2,   SOX2↓, 9,   SOX4↑, 1,   SOX9?, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 3,   tumCV↓, 112,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 36,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 10,   p‑eIF2α↓, 1,   p‑eIF2α↑, 6,   ER Stress↓, 1,   ER Stress↑, 48,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 13,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↑, 2,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 11,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 4,   PERK↑, 10,   p‑PERK↑, 2,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↑, 10,   ATG7↑, 4,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 29,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3A↑, 2,   LC3B↑, 2,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 3,   LC3II↑, 19,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 11,   p62↑, 5,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↑, 55,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 4,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 3,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 76,   mt-DNAdam↑, 1,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   p16↑, 3,   P53↓, 9,   P53↑, 177,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 10,   PARP↑, 35,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 134,   cl‑PARP∅, 1,   PARP1↓, 2,   PARP1↑, 2,   cl‑PARP1↑, 5,   PCNA↓, 51,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   RAD51↑, 1,   SIRT6↓, 1,   Telomerase↓, 11,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 5,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 29,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 44,   CDK2↑, 5,   CDK4↓, 51,   CDK4↑, 2,   CDK4/6↓, 3,   CDK6↓, 21,   CDK6↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 5,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 43,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 143,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   CycD3↓, 5,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 3,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 44,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 8,   P21↑, 92,   P21↝, 2,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 40,   PLK1↓, 1,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 3,   RB1↓, 2,   RB1↑, 3,   p‑RB1↓, 2,   cl‑RB1↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA↓, 8,   TumCCA↑, 289,   WEE1↑, 3,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 3,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 9,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 8,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 37,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli↓, 2,   Gli1↓, 20,   HH↓, 17,   HMGCR↓, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 44,   Let-7↑, 2,   MCM2↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 15,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 1,   PCLAF↓, 1,   PTCH1↓, 9,   PTCH2↓, 1,   SAL↑, 1,   Shh↓, 13,   Smo↓, 9,   p‑STAT1↓, 1,   Sufu↑, 1,   TumCG?, 3,   TumCG↓, 147,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 229,   TumCP↑, 4,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 34,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   AP-1↝, 2,   ATPase↓, 2,   AXL↓, 4,   Ca+2↓, 4,   Ca+2↑, 40,   Ca+2↝, 3,   i-Ca+2↑, 1,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↑, 4,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 3,   E-cadherin↓, 8,   E-cadherin↑, 57,   EMT↓, 72,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   p‑FAK↓, 3,   Fibronectin↓, 6,   GIT1↓, 1,   GLI2↓, 9,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 4,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 5,   MMP16↓, 1,   MMP2↓, 99,   MMP2↝, 1,   MMP3↓, 9,   MMP7↓, 10,   MMP9↓, 117,   MMPs↓, 32,   MRGPRF↓, 1,   MTA1↓, 2,   MUC4↓, 3,   N-cadherin↓, 37,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 2,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 4,   Rac1↓, 4,   RECK↑, 2,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 19,   SMAD2↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↑, 1,   Snail?, 1,   Snail↓, 31,   TET1↑, 2,   TGF-β↓, 16,   TGF-β↑, 3,   TIMP1↓, 3,   TIMP1↑, 10,   TIMP2↓, 2,   TIMP2↑, 13,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 3,   TumCA↑, 1,   TumCI?, 2,   TumCI↓, 102,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 105,   TumCMig↑, 1,   TumMeta↓, 68,   TumMeta↑, 5,   TumPF↓, 1,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 2,   uPA↓, 21,   uPAR↓, 2,   Vim?, 1,   Vim↓, 41,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 83,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 9,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 57,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 5,   VEGF↓, 125,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 17,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CellMemb↓, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 12,   GLUT1↑, 1,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT4↓, 2,   KCNH2/hERG↓, 1,   MMP↓, 198,   MMP↑, 1,   MPT↑, 5,   NHE1↓, 1,   SLC12A5↝, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 12,   CD8+↑, 4,   cDC2↓, 5,   COX2/PTGS2↓, 80,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR2↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 12,   FOXP3↓, 2,   FOXP3↑, 1,   HCAR2↑, 1,   HLA↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 1,   HMGB1↑, 1,   ICAM-1↓, 13,   IFN-γ↓, 4,   IFN-γ↑, 5,   IL1↓, 7,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 16,   IL1β↑, 3,   IL2↓, 2,   IL2↑, 7,   IL33↑, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   IL7↓, 1,   IL8↓, 13,   Imm↑, 12,   Imm↝, 1,   Inflam↓, 38,   Inflam↝, 1,   LTA/TNF-β↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 175,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 10,   p‑p65↓, 5,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 13,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 3,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR4↓, 6,   TLR4↝, 1,   TNF-α↓, 42,   TNF-α↑, 11,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 2,   TRAF1↓, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AhR↑, 1,   AR↓, 16,   AR↝, 1,   ER-α36↓, 2,   ERα/ESR1↓, 2,   ERβ/ESR2↑, 1,   GR↝, 1,   PPARα↓, 1,   PPARγ↓, 5,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 30,   BioAv↑, 33,   BioAv↝, 8,   BioEnh↑, 1,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 144,   ChemoSen↝, 1,   CompStab↑, 3,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 3,   Dose↑, 8,   Dose↝, 65,   Dose∅, 8,   eff↓, 88,   eff↑, 89,   eff↝, 8,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 7,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MDR1↑, 1,   MRP↓, 1,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 18,   P450↓, 2,   RadioS↑, 43,   selectivity↓, 1,   selectivity↑, 108,   Synergy?, 1,   Synergy↑, 99,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 16,   AR↝, 1,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BRAF↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 4,   E6↓, 3,   E7↓, 3,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   LDH?, 1,   LDH↓, 13,   LDH↑, 6,   LDH↝, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 7,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   PSADT↑, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 3,   AntiCan↑, 61,   AntiCan?, 1,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 2,   AntiTum↑, 34,   cachexia↓, 2,   cardioP↑, 11,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 33,   chemoPv↑, 19,   ChemoSideEff↓, 7,   ChemoSideEff∅, 1,   hepatoP↑, 15,   K17↓, 1,   neuroP↑, 8,   NKG2D↑, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 9,   Pain↓, 2,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 3,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 12,   Risk↓, 13,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 1,   toxicity↝, 12,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 43,   TumVol↑, 2,   TumW↓, 22,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   Bacteria↓, 5,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 11,  
Total Targets: 1240

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 90,   ARE↑, 1,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 52,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 38,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 49,   GSH/GSSG↑, 1,   GSR↑, 5,   GSTs↓, 1,   GSTs↑, 13,   H2O2↓, 5,   HDL↑, 2,   HO-1?, 2,   HO-1↓, 1,   HO-1↑, 26,   HO-2↓, 1,   Iron↓, 2,   Keap1↓, 5,   Keap1↑, 1,   lipid-P↓, 38,   MDA?, 1,   MDA↓, 39,   MDA↑, 1,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 3,   NRF2?, 1,   NRF2↑, 50,   Prx↑, 1,   RNS↓, 5,   ROS?, 1,   ROS↓, 118,   ROS↑, 3,   ROS∅, 3,   SOD?, 1,   SOD↓, 2,   SOD↑, 69,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 6,   TBARS↓, 4,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↑, 1,   PGC-1α↓, 2,   PGC-1α↑, 2,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ACSL4↓, 1,   ALAT↓, 15,   AMPK↓, 2,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 2,   ATP↑, 4,   mt-ATP↑, 1,   GAPDH↑, 1,   glucose↓, 5,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 3,   H2S↑, 2,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NH3↓, 1,   PFK↓, 1,   PLA2↓, 1,   SIRT1↑, 7,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 2,   Apoptosis↓, 31,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 48,   BAX↑, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 12,   Bcl-2↑, 58,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↑, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 35,   Casp3↑, 2,   cl‑Casp3↓, 9,   Casp8↓, 1,   Casp9↓, 10,   cl‑Casp9↓, 4,   Cyt‑c↓, 8,   Cyt‑c↑, 2,   Fas↓, 3,   FasL↓, 1,   Ferroptosis↓, 4,   GSDMD↓, 1,   iNOS↓, 20,   MLKL↓, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 7,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 1,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 2,   JAK2↑, 3,   JNK↓, 6,   JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   Mst1↓, 2,   mTOR↓, 1,   mTOR↑, 5,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 9,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 2,   STAT3↑, 6,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 2,   cJun↓, 1,   p‑cJun↓, 1,   FOXO3↑, 1,   HDAC↓, 2,   HDAC2↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 2,   other↑, 4,   other↝, 3,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 2,   IRE1↓, 2,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 2,   PARK2↑, 3,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 6,   p16↓, 1,   P53↓, 4,   P53↑, 2,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 5,   cal2↓, 2,   Cartilage↑, 1,   E-cadherin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP9↓, 2,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 2,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 2,   eNOS↑, 1,   Hif1a↓, 1,   NO?, 1,   NO↓, 15,   NO↑, 3,   VCAM-1↓, 3,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 9,   BBB↝, 2,   BBB∅, 2,   CLDN4↑, 1,   GastroP↑, 5,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 3,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 26,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 7,   IL10↑, 5,   IL13↑, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 31,   IL1β↑, 1,   IL2↓, 1,   IL22↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 38,   IL6↑, 1,   IL8↓, 8,   Imm↓, 1,   Imm↑, 6,   Inflam↓, 108,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 6,   NF-kB↓, 39,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 7,   PGE2↓, 9,   PGE2↑, 1,   PSA∅, 1,   RAGE↓, 4,   RANTES↓, 1,   TLR4↓, 6,   TNF-α↓, 55,   TNF-α↑, 1,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 4,   AChE↓, 21,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 16,   BDNF⇅, 1,   ChAT↑, 3,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 3,   Aβ↓, 18,   Aβ42↓, 3,   BACE/β-secretase↓, 7,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 3,   p‑tau↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↑, 3,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 27,   BioAv↑, 34,   BioAv↝, 20,   BioAv∅, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2D6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 13,   Dose∅, 1,   eff↓, 4,   eff↑, 9,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 14,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 4,   AST↓, 17,   Bil↓, 1,   BMD↑, 2,   BP↓, 4,   BUN?, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 4,   EGFR↓, 1,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6↓, 38,   IL6↑, 1,   LDH↓, 8,   NOS2↓, 1,   PSA∅, 1,   RAGE↓, 4,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 1,   antiAll↑, 12,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 20,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 6,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 5,   cognitive↑, 22,   diuretic↑, 3,   hepatoP↓, 2,   hepatoP↑, 33,   Learn↑, 4,   memory↑, 22,   motorD↑, 5,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 70,   Obesity↓, 8,   OS↑, 1,   Pain↓, 3,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 10,   toxicity?, 1,   toxicity↓, 21,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 9,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 12,   Bacteria↓, 20,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 12,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 489

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
36 Curcumin
32 Silver-NanoParticles
29 Thymoquinone
25 Quercetin
18 Luteolin
17 Apigenin (mainly Parsley)
15 Baicalein
15 EGCG (Epigallocatechin Gallate)
13 Allicin (mainly Garlic)
13 Sulforaphane (mainly Broccoli)
13 Betulinic acid
12 Fisetin
12 Shikonin
11 Berberine
11 Emodin
11 Honokiol
11 Silymarin (Milk Thistle) silibinin
10 Cisplatin
10 Melatonin
10 Resveratrol
10 Gambogic Acid
10 Garcinol
10 Licochalcone A
10 Matrine
9 Eugenol
9 Gossypol/AT-101
9 Lycopene
8 Capsaicin
8 Graviola
8 Magnolol
8 Morin
7 Magnetic Fields
7 Ashwagandha(Withaferin A)
7 D-limonene
7 Radiotherapy/Radiation
7 Beta-Caryophyllene
7 Carvacrol
7 Isoliquiritigenin
7 Juglone
7 Nimbolide
7 Piperlongumine
6 5-fluorouracil
6 Paclitaxel/Taxol
6 Phenethyl isothiocyanate
6 Boron
6 Cinnamon
6 Ursolic acid
6 Dandelion Root
6 Ferulic acid
6 Formononetin
6 Ginkgetin
6 Hibiscus sabdariffa
6 Hyperoside
6 isoorientin
6 Kaempferol
6 lambertianic acid
6 Licorice
5 Astragalus
5 Artemisinin
5 Astaxanthin
5 doxorubicin
5 Benzyl isothiocyanate
5 Boswellia (frankincense)
5 Carnosic acid
5 Cynaropicrin
5 Isobavachalcone
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Rosmarinic acid
5 Urolithin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Photodynamic Therapy
4 Alpha-Lipoic-Acid
4 Isovitexin
4 Metformin
4 Aloe anthraquinones
4 Biochanin A
4 Chemotherapy
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Crocetin
4 Ellagic acid
4 Eurycomanone
4 Geraniol
4 Ginkgolide B
4 HydroxyTyrosol
4 Indole-3-carbinol
4 Isorhamnetin
4 isoquercitrin
4 Ivermectin
4 Moringa oleifera
4 Propolis -bee glue
3 3-bromopyruvate
3 Açaí, Euterpe oleracea
3 Gemcitabine (Gemzar)
3 Allyl isothiocyanate
3 immunotherapy
3 Berbamine
3 Caffeic acid
3 Chlorogenic acid
3 chaetocin
3 chitosan
3 Chlorophyllin
3 Chrysin
3 Docetaxel
3 Evodiamine
3 Gallic acid
3 Ginkgolic acids
3 Ginger/6-Shogaol/Gingerol
3 Vitexin
3 L-Theanine
3 Laetrile B17 Amygdalin
3 Oleuropein
3 Patchouli Oil (Pogostemon cablin)
3 Phenylbutyrate
3 Selenite (Sodium)
3 VitK3,menadione
2 tamoxifen
2 Ajoene (compound of Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 DTS(dibenzyl trisulphide) from Anamu
2 Andrographis
2 beta-glucans
2 Baicalin
2 Brucea javanica
2 brusatol
2 Bromelain
2 borneol
2 Genistein (soy isoflavone)
2 Butyrate
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Citric Acid
2 Carvone
2 Polyphenols
2 Cucurbitacin
2 Electrical Pulses
2 Chlorella (Chlorella vulgaris)
2 Flaxseed/Linseed
2 carboplatin
2 Hydrogen Gas
2 iodine
2 itraconazole
2 Lactobacillus
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 SDG/lignans
2 Linalool
2 Lutein
2 Mangiferin
2 Methylglyoxal
2 Marjoram (Origanum majorana)
2 Propyl gallate
2 Phycocyanin
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Taurine
2 Vitamin K2
1 Coenzyme Q10
1 Acoschimperoside P, 2’-acetate
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 epirubicin
1 Isothiocyanates
1 selenomethionine
1 Black turtle bean
1 Zinc
1 Celastrol
1 Prebiotic
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Hydroxycinnamic-acid
1 Citicoline, CDP-Choline
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dichloroacetate
1 Deguelin
1 Date Fruit Extract
1 Diindolylmethane
1 Fenbendazole
1 olaparib/LYNPARZA
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Grapeseed extract
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 Huperzine A/Huperzia serrata
1 Rutin
1 Butein
1 Scopoletin
1 Vitamin C (Ascorbic Acid)
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Methylene blue
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Zeolite
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Shiitake, AHCC
1 Naringin
1 Neem
1 Oleocanthal
1 Orlistat
1 sericin
1 Physalin F & B
1 Piperine
1 Plumbagin
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 isoflavones
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Selenium NanoParticles
1 Sesamin
1 Auranofin
1 Salvia miltiorrhiza
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 Terpinen-4-ol / Tea Tree Oil
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Tomatine
1 Vitamin D3
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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